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last modified：2025/03/30
Professor TAKAMURA Toshinari
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Department of Endocrinology and Metabolism
Professor
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Endocrinology and Metabolism TEL:076-265-2711 FAX:076-234-4214
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Graduate School of Medical Sciences Doctor Kanazawa University Graduate School of Medical Sciences Internal Medicine 199207 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1988
Career
Tohoku University Department of Biochemistry(1993/04/01-1997/08/31)
Kanazawa University Graduate School of Medical Sciences Department of Endocrinology and Metabolism Professor(2014/03/01-)
Kanazawa University Graduate School of Medical Sciences Department of Disease and Homeostasis Associate Professor(2005/04/01-2014/02/28)
Year & Month of Birth
1963/04
Academic Society
Japan Diabetes Society
Japan Endocrine Society
Japan Society of Experimental Diabetes and Obesity
The Japanese Society of Clinical Nutrition
Asian Association for the Study of Diabetes
Award
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
Specialities
Metabolomics、Endocrinology、Pathological medical chemistry
Speciality Keywords
Diabetology, Endocrinology and Metabolism
Research Themes
Pathology of type 2 diabetes
Pathology of fatty liver and obesity
Books
- Takamura T*, Misu H, Kaneko S. Musculoskeletal Disease Associated with Diabetes Mellitus Springer Tokyo Heidelberg New York Dordrecht London 2016
- Molecular Diabetology 2005-from basic to clinic- 2005/04
- Yoshizawa M,Takamura T,Kobayashi K [Soluble VCAM-1]. 60 Suppl 8 498-503
- Shuichi Kaneko, Toshinari Takamura, Hirofumi Misu Non-Alcoholic Fatty Liver Diseases Wiley 2019
Papers
- Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Ishikura K,Misu H,Kumazaki M,Takayama H,Matsuzawa-Nagata N,Tajima N,Chikamoto K,Lan F,Ando H,Ota T,Sakurai M,Takeshita Y,Kato K,Fujimura A,Miyamoto KI,Saito Y,Kameo S,Okamoto Y,Takuwa Y,Takahashi K,Kidoya H,Takakura N,Kaneko S,Takamura T DIABETOLOGIA 2014/09
- LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. Lan F,Misu H,Chikamoto K,Takayama H,Kikuchi A,Mohri K,Takata N,Hayashi H,Matsuzawa-Nagata N,Takeshita Y,Noda H,Matsumoto Y,Ota T,Nagano T,Nakagen M,Miyamoto K,Takatsuki K,Seo T,Iwayama K,Tokuyama K,Matsugo S,Tang H,Saito Y,Yamagoe S,Kaneko S,Takamura T DIABETES 63 5 1649-64 2014/05
- Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Otoda T,Takamura T,Misu H,Ota T,Murata S,Hayashi H,Takayama H,Kikuchi A,Kanamori T,Shima KR,Lan F,Takeda T,Kurita S,Ishikura K,Kita Y,Iwayama K,Kato K,Uno M,Takeshita Y,Yamamoto M,Tokuyama K,Iseki S,Tanaka K,Kaneko S DIABETES 62 3 811-24 2013/03
- A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Misu H,Takamura T,Takayama H,Hayashi H,Matsuzawa-Nagata N,Kurita S,Ishikura K,Ando H,Takeshita Y,Ota T,Sakurai M,Yamashita T,Mizukoshi E,Yamashita T,Honda M,Miyamoto K,Kubota T,Kubota N,Kadowaki T,Kim HJ,Lee IK,Minokoshi Y,Saito Y,Takahashi K,Yamada Y,Takakura N,Kaneko S Cell Metab 12 5 483-95 2010/11
- Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes. Takayama H,Misu H,Iwama H,Chikamoto K,Saito Y,Murao K,Teraguchi A,Lan F,Kikuchi A,Saito R,Tajima N,Shirasaki T,Matsugo S,Miyamoto K,Kaneko S,Takamura T J Biol Chem 289 1 335-45 2014/01
- Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy. Shimizu M,Furuichi K,Toyama T,Kitajima S,Hara A,Kitagawa K,Iwata Y,Sakai N,Takamura T,Yoshimura M,Yokoyama H,Kaneko S,Wada T,Kanazawa Study Group for Renal Diseases and Hypertension DIABETES CARE 36 11 3655-62 2013/11
- ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes. Komura T,Sakai Y,Honda M,Takamura T,Wada T,Kaneko S Cell Immunol 282 1 44-52 2013/03
- Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H Eur J Nutr 53 1 251-8 2014/06
- Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Seki A,Sakai Y,Komura T,Nasti A,Yoshida K,Higashimoto M,Honda M,Usui S,Takamura M,Takamura T,Ochiya T,Furuichi K,Wada T,Kaneko S HEPATOLOGY 58 3 1133-42 2013/09
- Regulation of the physiological effects of peroxidovanadium(V) complexes by the electronic nature of ligands. Sugiyama H,Matsugo S,Misu H,Takamura T,Kaneko S,Kanatani Y,Kaido M,Mihara C,Abeywardana N,Sakai A,Sato K,Miyashita Y,Kanamori K J Inorg Biochem 121 66-76 2013/04
- Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis. Ando H,Otoda T,Ookami H,Nagai Y,Inano A,Takamura T,Ushijima K,Hosohata K,Matsushita E,Saito T,Kaneko S,Fujimura A Clin Exp Pharmacol Physiol 40 3 227-32 2013/03
- Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus. Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T J Gastroenterol 48 4 515-25 2013/04
- Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T₂ correction: phantom and clinical study with histologic assessment. Hayashi N,Miyati T,Minami T,Takeshita Y,Ryu Y,Matsuda T,Ohno N,Hamaguchi T,Kato K,Takamura T,Matsui O Radiol Phys Technol 6 1 219-25 2013/01
- Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease. Kato K,Takamura T,Takeshita Y,Ryu Y,Misu H,Ota T,Tokuyama K,Nagasaka S,Matsuhisa M,Matsui O,Kaneko S PLoS One 9 3 e92170 2014/03
- Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats. Hosohata K,Ando H,Takeshita Y,Misu H,Takamura T,Kaneko S,Fujimura A Diab Vasc Dis Res 11 4 243-250 2014/05
- Association between a serum thyroid-stimulating hormone concentration within the normal range and indices of obesity in Japanese men and women. Sakurai M,Nakamura K,Miura K,Yoshita K,Takamura T,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Nakashima M,Nogawa K,Suwazono Y,Nakagawa H Intern Med 53 7 669-74 2014
- The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial. Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S DIABETOLOGIA 57 5 878-90 2014/05
- Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics. Hellwege JN,Palmer ND,Ziegler JT,Langefeld CD,Lorenzo C,Norris JM,Takamura T,Bowden DW GENE 534 1 33-9 2014/01
- Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H Eur J Nutr 53 1 251-8 2014/06
- Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome. Nagai Y,Miyakoshi H,Ohsawa K,Ieki Y,Takamura T,Kobayashi K Endocrinol Jpn 39 1 129-32 1992/02
- Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice. Kato I,Takasawa S,Akabane A,Tanaka O,Abe H,Takamura T,Suzuki Y,Nata K,Yonekura H,Yoshimoto T J Biol Chem 270 50 30045-50 1995/12
- The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase, a second-messenger enzyme. Nata K,Sugimoto T,Tohgo A,Takamura T,Noguchi N,Matsuoka A,Numakunai T,Shikama K,Yonekura H,Takasawa S GENE 158 2 213-8 1995/06
- An adult case of neurohypophyseal ectopy presenting ACTH deficiency and partial GH deficiency. Takamura T,Ohsawa K,Nishimura Y,Yamagishi S,Komatsu Y,Iwata A,Osada S,Nagai Y,Miyakoshi H,Kobayashi K Endocr J 42 1 83-8 1995/02
- Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15. Nakagawara K,Mori M,Takasawa S,Nata K,Takamura T,Berlova A,Tohgo A,Karasawa T,Yonekura H,Takeuchi T Cytogenet Cell Genet 69 1-2 38-9 1995
- Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells. Nagai Y,Ohsawa K,Ohta M,Hisada A,Yamashita H,Yoshizawa M,Yamamoto Y,Takamura T,Kobayashi K Tohoku J Exp Med 180 4 337-46 1996/12
- Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. Nata K,Takamura T,Karasawa T,Kumagai T,Hashioka W,Tohgo A,Yonekura H,Takasawa S,Nakamura S,Okamoto H GENE 186 2 285-92 1997/02
- Elevated serum levels of soluble vascular cell adhesion molecule-1 in NIDDM patients with proliferative diabetic retinopathy. Yoshizawa M,Nagai Y,Ohsawa K,Ohta M,Yamashita H,Hisada A,Miyamoto I,Miura K,Takamura T,Kobayashi K Diabetes Res Clin Pract 42 1 65-70 1998/10
- Antibodies to GAD in diabetic patients with chronic hepatitis C. Ando H,Nagai Y,Yokoyama M,Takamura T,Kobayashi K Diabet Med 15 9 797 1998/09
- Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. Nagai Y,Ohta M,Yokoyama H,Takamura T,Kobayashi KI Endocr J 45 3 421-5 1998/06
- Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. Takamura T,Kato I,Kimura N,Nakazawa T,Yonekura H,Takasawa S,Okamoto H J Biol Chem 273 5 2493-6 1998/01
- A patient with GH-producing pituitary adenoma presenting with a binasal superior quadrantanopsia. Nagai Y,Takamura T,Ando H,Nohara E,Yamashita H,Ieki Y,Takazakura E,Kobayashi K Endocr J 46 2 345-6 1999/04
- Serum soluble adhesion molecule concentrations are not regulated by acute hyperinsulinaemia in healthy men. Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K Diabet Med 16 7 618 1999/07
- Acute hyperinsulinemia reduces plasma concentrations of homocysteine in healthy men. Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K DIABETES CARE 22 6 1004 1999/06
- Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects. Hayakawa T,Nagai Y,Nohara E,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 48 5 655-7 1999/05
- Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men. Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 48 5 636-40 1999/05
- Adrenal insufficiency due to metastatic hepatocellular carcinoma. Takamura T,Nagai Y,Yamashita H,Nohara E,Ando H,Kagaya M,Urabe T,Kaneko S,Kobayashi K Endocr J 46 4 591-6 1999/08
- Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes. Takamura T,Ando H,Nagai Y,Yamashita H,Nohara E,Kobayashi K Diabetes Res Clin Pract 44 2 107-14 1999/05
- S20G mutation of the amylin gene in Japanese patients with type 2 diabetes. Hayakawa T,Nagai Y,Ando H,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi KI Diabetes Res Clin Pract 49 2-3 195-7 2000/08
- Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. Ando H,Takamura T,Ota T,Nagai Y,Kobayashi K J Pharmacol Exp Ther 294 3 1043-6 2000/09
- Plasma levels of vascular endothelial growth factor in patients with acromegaly. Nagai Y,Ando H,Nohara E,Yamashita H,Takamura T,Kobayashi K Horm Metab Res 32 8 326-9 2000/08
- Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men. Hayakawa T,Nagai Y,Kahara T,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 49 9 1215-8 2000/09
- Tumor necrosis factor-beta gene NcoI polymorphism decreases insulin resistance in Japanese men. Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 49 11 1506-9 2000/11
- Ischemic colitis probably induced by refractory constipation after voglibose administration in a patient with total gastrectomy. Nagai Y,Yamashita H,Nohara E,Takamura T,Kobayashi K Intern Med 39 10 861 2000/10
- Ketosis-onset diabetes without islet-associated autoantibodies in a patient with MELAS. Takamura T,Nagai Y,Torita M,Yamashita H,Kahara T,Koshino Y,Kobayashi K DIABETES CARE 23 7 1018-9 2000/07
- Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells. Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K Diabetes Res Clin Pract 48 3 171-6 2000/06
- Does acute hyperinsulinaemia change plasma adrenomedullin concentration in healthy men? Nagai Y,Yamashita H,Takamura T,Kobayashi KI Diabet Med 17 3 249-50 2000/03
- Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells. Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K Metabolism 49 2 163-6 2000/02
- Extramedullary plasmacytoma in the adrenal incidentaloma. Kahara T,Nagai Y,Yamashita H,Nohara E,Kobayashi K,Takamura T Clin Endocrinol (Oxf) 55 2 267-70 2001/08
- Stage-specific effects of a thiazolidinedione on proliferation, differentiation and PPARgamma mRNA expression in 3T3-L1 adipocytes. Takamura T,Nohara E,Nagai Y,Kobayashi K Eur J Pharmacol 422 1-3 23-9 2001/06
- Severe hypercholesterolemia in a double heterozygote for lipoprotein lipase deficiency (LPL(Arita)) and apolipoprotein epsilon4: a report of a family with LPL(Arita). Ando H,Nishimura Y,Nemoto T,Takamura T,Nagai Y,Kobayashi K Endocr J 48 1 113-8 2001/02
- A case of refractory hypothyroidism requiring daily intravenous thyroxine. Nagaoka T,Miyakoshi H,Takamura T,Nagai Y,Matsushita S,Kaneko S,Kobayashi K J Int Med Res 30 4 463-5 2002/07
- Preobesity in World Health Organization classification involves the metabolic syndrome in Japanese. Ota T,Takamura T,Hirai N,Kobayashi K DIABETES CARE 25 7 1252-3 2002/07
- Prediction of exercise-mediated changes in metabolic markers by gene polymorphism. Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K Diabetes Res Clin Pract 57 2 105-10 2002/08
- IL-6 gene polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men. Hayakawa T,Takamura T,Hisada A,Abe T,Nomura G,Kobayashi K DIABETOLOGIA 45 3 453-4 2002/03
- Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat. Yamashita H,Nagai Y,Takamura T,Nohara E,Kobayashi K Metabolism 51 4 403-8 2002/04
- Does pravastatin affect circulating levels of soluble TNF receptor 2 in hypercholesterolemic patients? Ando H,Takamura T,Kobayashi K,Misu H,Osawa K ATHEROSCLEROSIS 166 2 413-4 2003/02
- The transient appearance of anti-GAD antibody in a type 2 diabetic patient with empyema. Kahara T,Takamura T,Ando H,Misaki T,Komori K,Ohya N,Kobayashi K Intern Med 42 6 541-2 2003/06
- Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells. Hamaguchi E,Takamura T,Shimizu A,Nagai Y J Pharmacol Exp Ther 307 3 987-94 2003/12
- PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men. Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K Metabolism 52 2 209-12 2003/02
- Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Ota T,Takamura T,Ando H,Nohara E,Yamashita H,Kobayashi K DIABETOLOGIA 46 6 843-51 2003/06
- Fulminating onset type 1 diabetes with positivity for anti-GAD antibody and elevated pancreatic exocrine enzyme concentrations. Kahara T,Takamura T,Ando H,Sakurai M,Ota T,Misaki T,Oba S,Iguchi M,Komori K,Kobayashi K Intern Med 42 6 517-20 2003/06
- Predictive value of autoantibodies to IA-2 for insulin requirements in Japanese subjects with type 1 diabetes. Ota T,Takamura T,Bando Y,Usuda R,Nagai Y DIABETES CARE 26 11 3188-9 2003/11
- The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice. Ando H,Kurita S,Takamura T Life Sci 74 14 1817-27 2004/02
- Modulating effects of olanzapine on the development of diabetic ketoacidosis. Tsuchiyama N,Ando H,Ota T,Sakurai M,Takamura T Diabet Med 21 3 300-1 2004/03
- Prostaglandin E1 in lipid microspheres ameliorates diabetic peripheral neuropathy: clinical usefulness of Semmes-Weinstein monofilaments for evaluating diabetic sensory abnormality. Akahori H,Takamura T,Hayakawa T,Ando H,Yamashita H,Kobayashi K Diabetes Res Clin Pract 64 3 153-9 2004/06
- Gln27Glu polymorphism of the beta2 adrenergic receptor gene in healthy Japanese men is associated with the change of fructosamine level caused by exercise. Kahara T,Hayakawa T,Nagai Y,Shimizu A,Takamura T Diabetes Res Clin Pract 64 3 207-12 2004/06
- Effects of pravastatin on the expression of ATP-binding cassette transporter A1. Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A J Pharmacol Exp Ther 311 1 420-5 2004/10
- Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients. Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S DIABETOLOGIA 47 4 638-47 2004/04
- Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody. Ota T,Takamura T,Nagai Y,Bando Y,Usuda R Diabetes Res Clin Pract 67 1 63-9 2005/01
- Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet. Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A ATHEROSCLEROSIS 178 2 265-9 2005/02
- Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression. Akahori H,Ota T,Torita M,Ando H,Kaneko S,Takamura T J Pharmacol Exp Ther 314 2 514-21 2005/08
- Relationship between plasma hANP level and pretibial edema by pioglitazone treatment. Kahara T,Takamura T,Misaki T,Sakurai M,Takeshita Y,Shimizu A,Kaneko S Endocr J 52 3 373-6 2005/06
- Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes. Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S Diabetes Res Clin Pract 71 3 241-6 2006/03
- Daily rhythms of P-glycoprotein expression in mice. Ando H,Yanagihara H,Sugimoto K,Hayashi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A Chronobiol Int 22 4 655-65 2005
- cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation. Honda M,Kawai H,Shirota Y,Yamashita T,Takamura T,Kaneko S J Autoimmun 25 2 133-40 2005/09
- Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Ando H,Yanagihara H,Hayashi Y,Obi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A ENDOCRINOLOGY 146 12 5631-6 2005/12
- Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. Ando H,Tsuruoka S,Yanagihara H,Sugimoto K,Miyata M,Yamazoe Y,Takamura T,Kaneko S,Fujimura A Br J Clin Pharmacol 60 5 494-7 2005/11
- Subacute thyroiditis developed in identical twins two years apart. Hamaguchi E,Nishimura Y,Kaneko S,Takamura T Endocr J 52 5 559-62 2005/10
- Measurement of thyroid blood flow area is useful for diagnosing the cause of thyrotoxicosis. Kurita S,Sakurai M,Kita Y,Ota T,Ando H,Kaneko S,Takamura T THYROID 15 11 1249-52 2005/11
- Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes. Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S Diabetes Res Clin Pract 71 3 241-6 2006/03
- Gender differences in the association between anthropometric indices of obesity and blood pressure in Japanese. Sakurai M,Miura K,Takamura T,Ota T,Ishizaki M,Morikawa Y,Kido T,Naruse Y,Nakagawa H Hypertens Res 29 2 75-80 2006/02
- Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice. Ando H,Oshima Y,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A Biochem Biophys Res Commun 346 4 1297-302 2006/08
- Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes. Takamura T,Sakurai M,Nakamura M,Shimizu A,Ota T,Misu H,Takeshita Y,Tsuchiyama N,Kurita S,Ando H,Kaneko S Diabetes Res Clin Pract 75 3 278-84 2007/03
- Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy. Ando H,Takamura T,Nagai Y,Kaneko S,Kanazawa University Multicenter Diabetes Study Group J Diabetes Complications 20 6 367-70 2006/11
- Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Misu H,Takamura T,Matsuzawa N,Shimizu A,Ota T,Sakurai M,Ando H,Arai K,Yamashita T,Honda M,Yamashita T,Kaneko S DIABETOLOGIA 50 2 268-77 2007/02
- Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Ota T,Takamura T,Kurita S,Matsuzawa N,Kita Y,Uno M,Akahori H,Misu H,Sakurai M,Zen Y,Nakanuma Y,Kaneko S GASTROENTEROLOGY 132 1 282-93 2007/01
- Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease. Sakurai M,Takamura T,Ota T,Ando H,Akahori H,Kaji K,Sasaki M,Nakanuma Y,Miura K,Kaneko S J Gastroenterol 42 4 312-7 2007/04
- Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis. Takamura T,Shimizu A,Komura T,Ando H,Zen Y,Minato H,Matsushita E,Kaneko S Intern Med 46 9 579-81 2007
- Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. Komura T,Mizukoshi E,Kita Y,Sakurai M,Takata Y,Arai K,Yamashita T,Ohta T,Shimizu K,Nakamoto Y,Honda M,Takamura T,Kaneko S Am J Gastroenterol 102 9 1939-46 2007/09
- Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes. Takamura T,Honda M,Sakai Y,Ando H,Shimizu A,Ota T,Sakurai M,Misu H,Kurita S,Matsuzawa-Nagata N,Uchikata M,Nakamura S,Matoba R,Tanino M,Matsubara K,Kaneko S Biochem Biophys Res Commun 361 2 379-84 2007/09
- Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes. Tsuchiyama N,Takamura T,Ando H,Sakurai M,Shimizu A,Kato K,Kurita S,Kaneko S DIABETES CARE 30 10 2583-7 2007/10
- Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Matsuzawa N,Takamura T,Kurita S,Misu H,Ota T,Ando H,Yokoyama M,Honda M,Zen Y,Nakanuma Y,Miyamoto K,Kaneko S HEPATOLOGY 46 5 1392-403 2007/11
- New insulin sensitivity index from the oral glucose tolerance test. Kazama Y,Takamura T,Sakurai M,Shindo H,Ohkubo E,Aida K,Harii N,Taki K,Kaneshige M,Tanaka S,Shimura H,Endo T,Kobayashi T Diabetes Res Clin Pract 79 1 24-30 2008/01
- Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus. Kita Y,Mizukoshi E,Takamura T,Sakurai M,Takata Y,Arai K,Yamashita T,Nakamoto Y,Kaneko S Metabolism 56 12 1682-8 2007/12
- Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line. Shimizu A,Takamura T,Matsuzawa N,Nakamura S,Nabemoto S,Takeshita Y,Misu H,Kurita S,Sakurai M,Yokoyama M,Zen Y,Sasaki M,Nakanuma Y,Kaneko S Metabolism 56 11 1478-85 2007/11
- Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes. Takeshita Y,Takamura T,Ando H,Hamaguchi E,Takazakura A,Matsuzawa-Nagata N,Kaneko S Eur J Pharmacol 579 1-3 426-32 2008/01
- Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients. Ando H,Sugimoto K,Yanagihara H,Tsuruoka S,Saito T,Takamura T,Kaneko S,Fujimura A Clin Exp Pharmacol Physiol 35 9 1012-7 2008/09
- Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. Kurita S,Takamura T,Ota T,Matsuzawa-Nagata N,Kita Y,Uno M,Nabemoto S,Ishikura K,Misu H,Ando H,Zen Y,Nakanuma Y,Kaneko S Eur J Pharmacol 588 2-3 316-24 2008/07
- Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. Uno M,Kurita S,Misu H,Ando H,Ota T,Matsuzawa-Nagata N,Kita Y,Nabemoto S,Akahori H,Zen Y,Nakanuma Y,Kaneko S,Takamura T HEPATOLOGY 48 1 109-18 2008/07
- Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Matsuzawa-Nagata N,Takamura T,Ando H,Nakamura S,Kurita S,Misu H,Ota T,Yokoyama M,Honda M,Miyamoto K,Kaneko S Metabolism 57 8 1071-7 2008/08
- Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy. Takeshita Y,Takamura T,Minato H,Misu H,Ando H,Yamashita T,Ikeda H,Nakanuma Y,Kaneko S Intern Med 47 19 1709-12 2008
- SAGE application in the study of diabetes. Takamura T,Misu H,Yamashita T,Kaneko S Curr Pharm Biotechnol 9 5 392-9 2008/10
- Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. Takamura T,Misu H,Matsuzawa-Nagata N,Sakurai M,Ota T,Shimizu A,Kurita S,Takeshita Y,Ando H,Honda M,Kaneko S Obesity (Silver Spring) 16 12 2601-9 2008/12
- Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S DIABETOLOGIA 52 2 329-35 2009/02
- Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S DIABETOLOGIA 52 2 329-35 2009/02
- Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M Circ Cardiovasc Genet 3 1 68-77 2010/02
- CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes. Komura T,Sakai Y,Honda M,Takamura T,Matsushima K,Kaneko S DIABETES 59 3 634-43 2010/03
- Transient anti-GAD antibody positivity and acute pancreatitis with pancreas tail swelling in a patient with susceptible haplotype for type 1 diabetes mellitus. Kahara T,Takamura T,Otoda T,Ishikura K,Matsushita E Intern Med 48 21 1897-9 2009
- Influence of age on clock gene expression in peripheral blood cells of healthy women. Ando H,Ushijima K,Kumazaki M,Takamura T,Yokota N,Saito T,Irie S,Kaneko S,Fujimura A J Gerontol A Biol Sci Med Sci 65 1 9-13 2010/01
- J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: an 8-year follow-up of relatively lean Japanese individuals. Sakurai M,Miura K,Takamura T,Ishizaki M,Morikawa Y,Nakamura K,Yoshita K,Kido T,Naruse Y,Kaneko S,Nakagawa H Diabet Med 26 8 753-9 2009/08
- Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats. Ando H,Ushijima K,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A Clin Exp Hypertens 31 3 201-7 2009/05
- Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura S,Takamura T,Matsuzawa-Nagata N,Takayama H,Misu H,Noda H,Nabemoto S,Kurita S,Ota T,Ando H,Miyamoto K,Kaneko S J Biol Chem 284 22 14809-18 2009/05
- Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities. Sakurai M,Takamura T,Miura K,Kaneko S,Nakagawa H Metabolism 58 4 456-9 2009/04
- The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Nakamura S,Kumazaki M,Kurita S,Misu H,Togawa N,Fukushima T,Fujimura A,Kaneko S Biochem Biophys Res Commun 380 3 684-8 2009/03
- Influence of age on clock gene expression in peripheral blood cells of healthy women. Ando H,Ushijima K,Kumazaki M,Takamura T,Yokota N,Saito T,Irie S,Kaneko S,Fujimura A J Gerontol A Biol Sci Med Sci 65 1 9-13 2010/01
- Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. Hamaguchi E,Takamura T,Sakurai M,Mizukoshi E,Zen Y,Takeshita Y,Kurita S,Arai K,Yamashita T,Sasaki M,Nakanuma Y,Kaneko S DIABETES CARE 33 2 284-6 2010/02
- A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Misu H,Takamura T,Takayama H,Hayashi H,Matsuzawa-Nagata N,Kurita S,Ishikura K,Ando H,Takeshita Y,Ota T,Sakurai M,Yamashita T,Mizukoshi E,Yamashita T,Honda M,Miyamoto K,Kubota T,Kubota N,Kadowaki T,Kim HJ,Lee IK,Minokoshi Y,Saito Y,Takahashi K,Yamada Y,Takakura N,Kaneko S Cell Metab 12 5 483-95 2010/11
- Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with α-glucosidase inhibitor. Kobayashi D,Takamura M,Murai H,Usui S,Ikeda T,Inomata J,Takashima S,Kato T,Furusho H,Takeshita Y,Ota T,Takamura T,Kaneko S Auton Neurosci 158 1-2 86-91 2010/12
- Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. Ando H,Ushijima K,Kumazaki M,Eto T,Takamura T,Irie S,Kaneko S,Fujimura A Chronobiol Int 27 1 194-203 2010/01
- Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M Circ Cardiovasc Genet 3 1 68-77 2010/02
- CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes. Komura T,Sakai Y,Honda M,Takamura T,Matsushima K,Kaneko S DIABETES 59 3 634-43 2010/03
- Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes. Iwakami S,Misu H,Takeda T,Sugimori M,Matsugo S,Kaneko S,Takamura T PLoS One 6 11 e27401 2011
- Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Yasui K,Hashimoto E,Komorizono Y,Koike K,Arii S,Imai Y,Shima T,Kanbara Y,Saibara T,Mori T,Kawata S,Uto H,Takami S,Sumida Y,Takamura T,Kawanaka M,Okanoue T,Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan Clin Gastroenterol Hepatol 9 5 428-33; quiz e50 2011/05
- [The cutting-edge of medicine; clinical and molecular pathology of type 2 diabetic liver]. Takamura T,Misu H,Kaneko S Nihon Naika Gakkai Zasshi 100 6 1670-6 2011/06
- Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Kaneko S,Sasaki S,Nakagawa H Metabolism 61 1 47-55 2012/01
- Identification of blood biomarkers of aging by transcript profiling of whole blood. Nakamura S,Kawai K,Takeshita Y,Honda M,Takamura T,Kaneko S,Matoba R,Matsubara K Biochem Biophys Res Commun 418 2 313-8 2012/02
- Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression. Takeshita Y,Takamura T,Inoue O,Okumura M,Kato K,Sunagozaka H,Arai K,Misu H,Nakamura M,Nakanuma Y,Kaneko S Intern Med 51 1 79-82 2012
- CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Kitade H,Sawamoto K,Nagashimada M,Inoue H,Yamamoto Y,Sai Y,Takamura T,Yamamoto H,Miyamoto K,Ginsberg HN,Mukaida N,Kaneko S,Ota T DIABETES 61 7 1680-90 2012/07
- [Novel strategies that target hepatokines for treatment of type 2 diabetes]. Misu H,Takamura T,Kaneko S Nihon Rinsho 70 1 157-63 2012/01
- Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. Misu H,Ishikura K,Kurita S,Takeshita Y,Ota T,Saito Y,Takahashi K,Kaneko S,Takamura T PLoS One 7 4 e34952 2012
- Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: implications for type 2 diabetes. Takeshita Y,Takamura T,Kita Y,Ando H,Ueda T,Kato K,Misu H,Sunagozaka H,Sakai Y,Yamashita T,Mizukoshi E,Honda M,Kaneko S Metabolism 61 10 1388-94 2012/10
- Self-reported speed of eating and 7-year risk of type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H Metabolism 61 11 1566-71 2012/11
- Pharmacokinetics and pharmacodynamics of insulin aspart in patients with type 2 diabetes: assessment using a meal tolerance test under clinical conditions. Ando H,Kurita S,Shimizu A,Kato K,Ishikura K,Taji K,Uno M,Takeshita Y,Misu H,Fujimura A,Kaneko S,Takamura T Clin Exp Pharmacol Physiol 39 6 528-34 2012/06
- Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia. Kato K,Takeshita Y,Misu H,Ishikura K,Kakinoki K,Sawada-Kitamura S,Kaneko S,Takamura T Endocr J 59 9 791-6 2012
- Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. Kawaguchi T,Sumida Y,Umemura A,Matsuo K,Takahashi M,Takamura T,Yasui K,Saibara T,Hashimoto E,Kawanaka M,Watanabe S,Kawata S,Imai Y,Kokubo M,Shima T,Park H,Tanaka H,Tajima K,Yamada R,Matsuda F,Takeshi Okanoue,Japan Study Group of Nonalcoholic Fatty Liver Disease PLoS One 7 6 e38322 2012
- Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver. Takamura T,Misu H,Ota T,Kaneko S Endocr J 59 9 745-63 2012
- Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. Kita Y,Takamura T,Misu H,Ota T,Kurita S,Takeshita Y,Uno M,Matsuzawa-Nagata N,Kato K,Ando H,Fujimura A,Hayashi K,Kimura T,Ni Y,Otoda T,Miyamoto K,Zen Y,Nakanuma Y,Kaneko S PLoS One 7 9 e43056 2012
- Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus. Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T J Gastroenterol 48 4 515-25 2013/04
- ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes. Komura T,Sakai Y,Honda M,Takamura T,Wada T,Kaneko S Cell Immunol 282 1 44-52 2013/03
- Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Otoda T,Takamura T,Misu H,Ota T,Murata S,Hayashi H,Takayama H,Kikuchi A,Kanamori T,Shima KR,Lan F,Takeda T,Kurita S,Ishikura K,Kita Y,Iwayama K,Kato K,Uno M,Takeshita Y,Yamamoto M,Tokuyama K,Iseki S,Tanaka K,Kaneko S DIABETES 62 3 811-24 2013/03
- Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis. Ando H,Otoda T,Ookami H,Nagai Y,Inano A,Takamura T,Ushijima K,Hosohata K,Matsushita E,Saito T,Kaneko S,Fujimura A Clin Exp Pharmacol Physiol 40 3 227-32 2013/03
- Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T₂ correction: phantom and clinical study with histologic assessment. Hayashi N,Miyati T,Minami T,Takeshita Y,Ryu Y,Matsuda T,Ohno N,Hamaguchi T,Kato K,Takamura T,Matsui O Radiol Phys Technol 6 1 219-25 2013/01
- Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H Eur J Nutr 2014/06
- Regulation of the physiological effects of peroxidovanadium(V) complexes by the electronic nature of ligands. Sugiyama H,Matsugo S,Misu H,Takamura T,Kaneko S,Kanatani Y,Kaido M,Mihara C,Abeywardana N,Sakai A,Sato K,Miyashita Y,Kanamori K J Inorg Biochem 121 66-76 2013/04
- Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Seki A,Sakai Y,Komura T,Nasti A,Yoshida K,Higashimoto M,Honda M,Usui S,Takamura M,Takamura T,Ochiya T,Furuichi K,Wada T,Kaneko S HEPATOLOGY 58 3 1133-42 2013/09
- [Diabetes mellitus related common medical disorders: recent progress in diagnosis and treatment. Topics: I. Pathophysiology, diagnosis and treatment; 1. Nonalcoholic fatty liver disease]. Nihon Naika Gakkai Zasshi 102 4 836-44 2013/04
- Long-term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy. Shimizu M,Furuichi K,Toyama T,Kitajima S,Hara A,Kitagawa K,Iwata Y,Sakai N,Takamura T,Yoshimura M,Yokoyama H,Kaneko S,Wada T,and the Kanazawa Study Group for Renal Diseases and Hypertension DIABETES CARE 2013/11
- Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome. Nagai Y,Miyakoshi H,Ohsawa K,Ieki Y,Takamura T,Kobayashi K Endocrinol Jpn 39 1 129-32 1992/02
- Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice. Kato I,Takasawa S,Akabane A,Tanaka O,Abe H,Takamura T,Suzuki Y,Nata K,Yonekura H,Yoshimoto T J Biol Chem 270 50 30045-50 1995/12
- The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase, a second-messenger enzyme. Nata K,Sugimoto T,Tohgo A,Takamura T,Noguchi N,Matsuoka A,Numakunai T,Shikama K,Yonekura H,Takasawa S GENE 158 2 213-8 1995/06
- Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15. Nakagawara K,Mori M,Takasawa S,Nata K,Takamura T,Berlova A,Tohgo A,Karasawa T,Yonekura H,Takeuchi T Cytogenet Cell Genet 69 1-2 38-9 1995
- An adult case of neurohypophyseal ectopy presenting ACTH deficiency and partial GH deficiency. Takamura T,Ohsawa K,Nishimura Y,Yamagishi S,Komatsu Y,Iwata A,Osada S,Nagai Y,Miyakoshi H,Kobayashi K Endocr J 42 1 83-8 1995/02
- Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells. Nagai Y,Ohsawa K,Ohta M,Hisada A,Yamashita H,Yoshizawa M,Yamamoto Y,Takamura T,Kobayashi K Tohoku J Exp Med 180 4 337-46 1996/12
- Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing. Nata K,Takamura T,Karasawa T,Kumagai T,Hashioka W,Tohgo A,Yonekura H,Takasawa S,Nakamura S,Okamoto H GENE 186 2 285-92 1997/02
- Elevated serum levels of soluble vascular cell adhesion molecule-1 in NIDDM patients with proliferative diabetic retinopathy. Yoshizawa M,Nagai Y,Ohsawa K,Ohta M,Yamashita H,Hisada A,Miyamoto I,Miura K,Takamura T,Kobayashi K Diabetes Res Clin Pract 42 1 65-70 1998/10
- Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. Nagai Y,Ohta M,Yokoyama H,Takamura T,Kobayashi KI Endocr J 45 3 421-5 1998/06
- Antibodies to GAD in diabetic patients with chronic hepatitis C. Ando H,Nagai Y,Yokoyama M,Takamura T,Kobayashi K Diabet Med 15 9 797 1998/09
- Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. Takamura T,Kato I,Kimura N,Nakazawa T,Yonekura H,Takasawa S,Okamoto H J Biol Chem 273 5 2493-6 1998/01
- Adrenal insufficiency due to metastatic hepatocellular carcinoma. Takamura T,Nagai Y,Yamashita H,Nohara E,Ando H,Kagaya M,Urabe T,Kaneko S,Kobayashi K Endocr J 46 4 591-6 1999/08
- A patient with GH-producing pituitary adenoma presenting with a binasal superior quadrantanopsia. Nagai Y,Takamura T,Ando H,Nohara E,Yamashita H,Ieki Y,Takazakura E,Kobayashi K Endocr J 46 2 345-6 1999/04
- Serum soluble adhesion molecule concentrations are not regulated by acute hyperinsulinaemia in healthy men. Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K Diabet Med 16 7 618 1999/07
- Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes. Takamura T,Ando H,Nagai Y,Yamashita H,Nohara E,Kobayashi K Diabetes Res Clin Pract 44 2 107-14 1999/05
- Acute hyperinsulinemia reduces plasma concentrations of homocysteine in healthy men. Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K DIABETES CARE 22 6 1004 1999/06
- Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects. Hayakawa T,Nagai Y,Nohara E,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 48 5 655-7 1999/05
- Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men. Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 48 5 636-40 1999/05
- Does acute hyperinsulinaemia change plasma adrenomedullin concentration in healthy men? Nagai Y,Yamashita H,Takamura T,Kobayashi KI Diabet Med 17 3 249-50 2000/03
- Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells. Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K Metabolism 49 2 163-6 2000/02
- Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men. Hayakawa T,Nagai Y,Kahara T,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 49 9 1215-8 2000/09
- Plasma levels of vascular endothelial growth factor in patients with acromegaly. Nagai Y,Ando H,Nohara E,Yamashita H,Takamura T,Kobayashi K Horm Metab Res 32 8 326-9 2000/08
- Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. Ando H,Takamura T,Ota T,Nagai Y,Kobayashi K J Pharmacol Exp Ther 294 3 1043-6 2000/09
- Ketosis-onset diabetes without islet-associated autoantibodies in a patient with MELAS. Takamura T,Nagai Y,Torita M,Yamashita H,Kahara T,Koshino Y,Kobayashi K DIABETES CARE 23 7 1018-9 2000/07
- Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells. Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K Diabetes Res Clin Pract 48 3 171-6 2000/06
- Ischemic colitis probably induced by refractory constipation after voglibose administration in a patient with total gastrectomy. Nagai Y,Yamashita H,Nohara E,Takamura T,Kobayashi K Intern Med 39 10 861 2000/10
- Tumor necrosis factor-beta gene NcoI polymorphism decreases insulin resistance in Japanese men. Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K Metabolism 49 11 1506-9 2000/11
- Extramedullary plasmacytoma in the adrenal incidentaloma. Kahara T,Nagai Y,Yamashita H,Nohara E,Kobayashi K,Takamura T Clin Endocrinol (Oxf) 55 2 267-70 2001/08
- Severe hypercholesterolemia in a double heterozygote for lipoprotein lipase deficiency (LPL(Arita)) and apolipoprotein epsilon4: a report of a family with LPL(Arita). Ando H,Nishimura Y,Nemoto T,Takamura T,Nagai Y,Kobayashi K Endocr J 48 1 113-8 2001/02
- Stage-specific effects of a thiazolidinedione on proliferation, differentiation and PPARgamma mRNA expression in 3T3-L1 adipocytes. Takamura T,Nohara E,Nagai Y,Kobayashi K Eur J Pharmacol 422 1-3 23-9 2001/06
- A case of refractory hypothyroidism requiring daily intravenous thyroxine. Nagaoka T,Miyakoshi H,Takamura T,Nagai Y,Matsushita S,Kaneko S,Kobayashi K J Int Med Res 30 4 463-5 2002/07
- Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat. Yamashita H,Nagai Y,Takamura T,Nohara E,Kobayashi K Metabolism 51 4 403-8 2002/04
- IL-6 gene polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men. Hayakawa T,Takamura T,Hisada A,Abe T,Nomura G,Kobayashi K DIABETOLOGIA 45 3 453-4 2002/03
- Prediction of exercise-mediated changes in metabolic markers by gene polymorphism. Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K Diabetes Res Clin Pract 57 2 105-10 2002/08
- Preobesity in World Health Organization classification involves the metabolic syndrome in Japanese. Ota T,Takamura T,Hirai N,Kobayashi K DIABETES CARE 25 7 1252-3 2002/07
- Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells. Hamaguchi E,Takamura T,Shimizu A,Nagai Y J Pharmacol Exp Ther 307 3 987-94 2003/12
- Predictive value of autoantibodies to IA-2 for insulin requirements in Japanese subjects with type 1 diabetes. Ota T,Takamura T,Bando Y,Usuda R,Nagai Y DIABETES CARE 26 11 3188-9 2003/11
- Does pravastatin affect circulating levels of soluble TNF receptor 2 in hypercholesterolemic patients? Ando H,Takamura T,Kobayashi K,Misu H,Osawa K ATHEROSCLEROSIS 166 2 413-4 2003/02
- PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men. Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K Metabolism 52 2 209-12 2003/02
- Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Ota T,Takamura T,Ando H,Nohara E,Yamashita H,Kobayashi K DIABETOLOGIA 46 6 843-51 2003/06
- Fulminating onset type 1 diabetes with positivity for anti-GAD antibody and elevated pancreatic exocrine enzyme concentrations. Kahara T,Takamura T,Ando H,Sakurai M,Ota T,Misaki T,Oba S,Iguchi M,Komori K,Kobayashi K Intern Med 42 6 517-20 2003/06
- The transient appearance of anti-GAD antibody in a type 2 diabetic patient with empyema. Kahara T,Takamura T,Ando H,Misaki T,Komori K,Ohya N,Kobayashi K Intern Med 42 6 541-2 2003/06
- Modulating effects of olanzapine on the development of diabetic ketoacidosis. Tsuchiyama N,Ando H,Ota T,Sakurai M,Takamura T Diabet Med 21 3 300-1 2004/03
- The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice. Ando H,Kurita S,Takamura T Life Sci 74 14 1817-27 2004/02
- Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients. Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S DIABETOLOGIA 47 4 638-47 2004/04
- Effects of pravastatin on the expression of ATP-binding cassette transporter A1. Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A J Pharmacol Exp Ther 311 1 420-5 2004/10
- Gln27Glu polymorphism of the beta2 adrenergic receptor gene in healthy Japanese men is associated with the change of fructosamine level caused by exercise. Kahara T,Hayakawa T,Nagai Y,Shimizu A,Takamura T Diabetes Res Clin Pract 64 3 207-12 2004/06
- Prostaglandin E1 in lipid microspheres ameliorates diabetic peripheral neuropathy: clinical usefulness of Semmes-Weinstein monofilaments for evaluating diabetic sensory abnormality. Akahori H,Takamura T,Hayakawa T,Ando H,Yamashita H,Kobayashi K Diabetes Res Clin Pract 64 3 153-9 2004/06
- Relationship between plasma hANP level and pretibial edema by pioglitazone treatment. Kahara T,Takamura T,Misaki T,Sakurai M,Takeshita Y,Shimizu A,Kaneko S Endocr J 52 3 373-6 2005/06
- Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression. Akahori H,Ota T,Torita M,Ando H,Kaneko S,Takamura T J Pharmacol Exp Ther 314 2 514-21 2005/08
- Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet. Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A ATHEROSCLEROSIS 178 2 265-9 2005/02
- Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody. Ota T,Takamura T,Nagai Y,Bando Y,Usuda R Diabetes Res Clin Pract 67 1 63-9 2005/01
- Measurement of thyroid blood flow area is useful for diagnosing the cause of thyrotoxicosis. Kurita S,Sakurai M,Kita Y,Ota T,Ando H,Kaneko S,Takamura T THYROID 15 11 1249-52 2005/11
- Subacute thyroiditis developed in identical twins two years apart. Hamaguchi E,Nishimura Y,Kaneko S,Takamura T Endocr J 52 5 559-62 2005/10
- Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. Ando H,Tsuruoka S,Yanagihara H,Sugimoto K,Miyata M,Yamazoe Y,Takamura T,Kaneko S,Fujimura A Br J Clin Pharmacol 60 5 494-7 2005/11
- Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes. Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S Diabetes Res Clin Pract 71 3 241-6 2006/03
- Daily rhythms of P-glycoprotein expression in mice. Ando H,Yanagihara H,Sugimoto K,Hayashi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A Chronobiol Int 22 4 655-65 2005
- cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation. Honda M,Kawai H,Shirota Y,Yamashita T,Takamura T,Kaneko S J Autoimmun 25 2 133-40 2005/09
- Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Ando H,Yanagihara H,Hayashi Y,Obi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A ENDOCRINOLOGY 146 12 5631-6 2005/12
- Gender differences in the association between anthropometric indices of obesity and blood pressure in Japanese. Sakurai M,Miura K,Takamura T,Ota T,Ishizaki M,Morikawa Y,Kido T,Naruse Y,Nakagawa H Hypertens Res 29 2 75-80 2006/02
- Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes. Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S Diabetes Res Clin Pract 71 3 241-6 2006/03
- Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes. Takamura T,Sakurai M,Nakamura M,Shimizu A,Ota T,Misu H,Takeshita Y,Tsuchiyama N,Kurita S,Ando H,Kaneko S Diabetes Res Clin Pract 75 3 278-84 2007/03
- Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy. Ando H,Takamura T,Nagai Y,Kaneko S,Kanazawa University Multicenter Diabetes Study Group J Diabetes Complications 20 6 367-70 2006/11
- Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Ota T,Takamura T,Kurita S,Matsuzawa N,Kita Y,Uno M,Akahori H,Misu H,Sakurai M,Zen Y,Nakanuma Y,Kaneko S GASTROENTEROLOGY 132 1 282-93 2007/01
- Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes. Misu H,Takamura T,Matsuzawa N,Shimizu A,Ota T,Sakurai M,Ando H,Arai K,Yamashita T,Honda M,Yamashita T,Kaneko S DIABETOLOGIA 50 2 268-77 2007/02
- Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line. Takeshita Y,Takamura T,Hamaguchi E,Shimizu A,Ota T,Sakurai M,Kaneko S Metabolism 55 11 1464-72 2006/11
- Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice. Ando H,Oshima Y,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A Biochem Biophys Res Commun 346 4 1297-302 2006/08
- Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes. Tsuchiyama N,Takamura T,Ando H,Sakurai M,Shimizu A,Kato K,Kurita S,Kaneko S DIABETES CARE 30 10 2583-7 2007/10
- Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. Komura T,Mizukoshi E,Kita Y,Sakurai M,Takata Y,Arai K,Yamashita T,Ohta T,Shimizu K,Nakamoto Y,Honda M,Takamura T,Kaneko S Am J Gastroenterol 102 9 1939-46 2007/09
- Pioglitazone in nonalcoholic steatohepatitis. Ota T,Takamura T,Kaneko S N Engl J Med 356 10 1068; author reply 1068-9 2007/03
- Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis. Takamura T,Shimizu A,Komura T,Ando H,Zen Y,Minato H,Matsushita E,Kaneko S Intern Med 46 9 579-81 2007
- Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease. Sakurai M,Takamura T,Ota T,Ando H,Akahori H,Kaji K,Sasaki M,Nakanuma Y,Miura K,Kaneko S J Gastroenterol 42 4 312-7 2007/04
- New insulin sensitivity index from the oral glucose tolerance test. Kazama Y,Takamura T,Sakurai M,Shindo H,Ohkubo E,Aida K,Harii N,Taki K,Kaneshige M,Tanaka S,Shimura H,Endo T,Kobayashi T Diabetes Res Clin Pract 79 1 24-30 2008/01
- Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes. Takamura T,Honda M,Sakai Y,Ando H,Shimizu A,Ota T,Sakurai M,Misu H,Kurita S,Matsuzawa-Nagata N,Uchikata M,Nakamura S,Matoba R,Tanino M,Matsubara K,Kaneko S Biochem Biophys Res Commun 361 2 379-84 2007/09
- Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line. Shimizu A,Takamura T,Matsuzawa N,Nakamura S,Nabemoto S,Takeshita Y,Misu H,Kurita S,Sakurai M,Yokoyama M,Zen Y,Sasaki M,Nakanuma Y,Kaneko S Metabolism 56 11 1478-85 2007/11
- Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Matsuzawa N,Takamura T,Kurita S,Misu H,Ota T,Ando H,Yokoyama M,Honda M,Zen Y,Nakanuma Y,Miyamoto K,Kaneko S HEPATOLOGY 46 5 1392-403 2007/11
- Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes. Takeshita Y,Takamura T,Ando H,Hamaguchi E,Takazakura A,Matsuzawa-Nagata N,Kaneko S Eur J Pharmacol 579 1-3 426-32 2008/01
- Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus. Kita Y,Mizukoshi E,Takamura T,Sakurai M,Takata Y,Arai K,Yamashita T,Nakamoto Y,Kaneko S Metabolism 56 12 1682-8 2007/12
- Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Matsuzawa-Nagata N,Takamura T,Ando H,Nakamura S,Kurita S,Misu H,Ota T,Yokoyama M,Honda M,Miyamoto K,Kaneko S Metabolism 57 8 1071-7 2008/08
- Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. Uno M,Kurita S,Misu H,Ando H,Ota T,Matsuzawa-Nagata N,Kita Y,Nabemoto S,Akahori H,Zen Y,Nakanuma Y,Kaneko S,Takamura T HEPATOLOGY 48 1 109-18 2008/07
- Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy. Takeshita Y,Takamura T,Minato H,Misu H,Ando H,Yamashita T,Ikeda H,Nakanuma Y,Kaneko S Intern Med 47 19 1709-12 2008
- Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. Kurita S,Takamura T,Ota T,Matsuzawa-Nagata N,Kita Y,Uno M,Nabemoto S,Ishikura K,Misu H,Ando H,Zen Y,Nakanuma Y,Kaneko S Eur J Pharmacol 588 2-3 316-24 2008/07
- Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S DIABETOLOGIA 52 2 329-35 2009/02
- SAGE application in the study of diabetes. Takamura T,Misu H,Yamashita T,Kaneko S Curr Pharm Biotechnol 9 5 392-9 2008/10
- Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients. Takamura T,Misu H,Matsuzawa-Nagata N,Sakurai M,Ota T,Shimizu A,Kurita S,Takeshita Y,Ando H,Honda M,Kaneko S Obesity (Silver Spring) 16 12 2601-9 2008/12
- Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients. Ando H,Sugimoto K,Yanagihara H,Tsuruoka S,Saito T,Takamura T,Kaneko S,Fujimura A Clin Exp Pharmacol Physiol 35 9 1012-7 2008/09
- Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S DIABETOLOGIA 52 2 329-35 2009/02
- J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: an 8-year follow-up of relatively lean Japanese individuals. Sakurai M,Miura K,Takamura T,Ishizaki M,Morikawa Y,Nakamura K,Yoshita K,Kido T,Naruse Y,Kaneko S,Nakagawa H Diabet Med 26 8 753-9 2009/08
- Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats. Ando H,Ushijima K,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A Clin Exp Hypertens 31 3 201-7 2009/05
- Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Nakamura S,Takamura T,Matsuzawa-Nagata N,Takayama H,Misu H,Noda H,Nabemoto S,Kurita S,Ota T,Ando H,Miyamoto K,Kaneko S J Biol Chem 284 22 14809-18 2009/05
- Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities. Sakurai M,Takamura T,Miura K,Kaneko S,Nakagawa H Metabolism 58 4 456-9 2009/04
- The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Nakamura S,Kumazaki M,Kurita S,Misu H,Togawa N,Fukushima T,Fujimura A,Kaneko S Biochem Biophys Res Commun 380 3 684-8 2009/03
- Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Kaneko S,Sasaki S,Nakagawa H Metabolism 2010/01
- Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis. Hamaguchi E,Takamura T,Sakurai M,Mizukoshi E,Zen Y,Takeshita Y,Kurita S,Arai K,Yamashita T,Sasaki M,Nakanuma Y,Kaneko S DIABETES CARE 33 2 284-6 2010/02
- Influence of age on clock gene expression in peripheral blood cells of healthy women. Ando H,Ushijima K,Kumazaki M,Takamura T,Yokota N,Saito T,Irie S,Kaneko S,Fujimura A J Gerontol A Biol Sci Med Sci 65 1 9-13 2008/01
- Abnormal liver function tests and metabolic syndrome--is fatty liver related to risks for atherosclerosis beyond obesity? Sakurai M,Takamura T,Miura K,Kaneko S,Nakagawa H Intern Med 48 18 1573-4 2009
- Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Kaneko S,Sasaki S,Nakagawa H Metabolism 2012/01
- Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M Circ Cardiovasc Genet 3 1 68-77 2010/02
- Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. Ando H,Ushijima K,Kumazaki M,Eto T,Takamura T,Irie S,Kaneko S,Fujimura A Chronobiol Int 27 1 194-203 2010/01
- Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with α-glucosidase inhibitor. Kobayashi D,Takamura M,Murai H,Usui S,Ikeda T,Inomata J,Takashima S,Kato T,Furusho H,Takeshita Y,Ota T,Takamura T,Kaneko S Auton Neurosci 158 1-2 86-91 2010/12
- Transient anti-GAD antibody positivity and acute pancreatitis with pancreas tail swelling in a patient with susceptible haplotype for type 1 diabetes mellitus. Kahara T,Takamura T,Otoda T,Ishikura K,Matsushita E Intern Med 48 21 1897-9 2009
- Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma. Yasui K,Hashimoto E,Komorizono Y,Koike K,Arii S,Imai Y,Shima T,Kanbara Y,Saibara T,Mori T,Kawata S,Uto H,Takami S,Sumida Y,Takamura T,Kawanaka M,Okanoue T,Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan Clin Gastroenterol Hepatol 9 5 428-33; quiz e50 2011/05
- [The cutting-edge of medicine; clinical and molecular pathology of type 2 diabetic liver]. Takamura T,Misu H,Kaneko S Nihon Naika Gakkai Zasshi 100 6 1670-6 2011/06
- Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum. Tanaka M, Saito Y, Misu H, Kato S, Kita Y, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Takamura T, Kaneko S, Takahashi K, Matsuyama N. J Clin Lab Anal. 30 2 114-122 2016/03
- EARTH study group.. Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study). Konaka H, Sugimoto K, Orikasa H, Iwamoto T, Takamura T, Takeda Y, Shigehara K, Iijima M, Koh E, Namiki M Asian J Androl. 18 1 25-34 2016/01
- Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease. Kato K, Takeshita Y, Misu H, Zen Y, Kaneko S, Takamura T. J Diabetes Investig. 6 2 158-163 2015/03
- Establishment of Rationale for Antiaging Diabetic Medicine (ERA-DM) Study Chapter 2 Group.. Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: A randomized, parallel-group study. Takeshita Y, Takamura T, Kita Y, Otoda T, Kato K, Wakakuri H, Yamada M, Misu H, Matsushima Y, Kaneko S J Diabetes Investig. 6 2 192-200 2015/03
- Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene. Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K. Atherosclerosis. 240 2 324-329 2015/01
- Physiological roles of peroxido-vanadium complexes: Leitmotif as their signal transduction pathway. Matsugo S, Kanamori K, Sugiyama H, Misu H, Takamura T. J Inorg Biochem. 147 93-98 2015/06
- Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy. Takazakura A, Sakurai M, Bando Y, Misu H, Takeshita Y, Kita Y, Shimizu A, Hayakawa T, Kato K, Kaneko S, Takamura T. J Diabetes Investig. 6 3 346-353 2015/05
- Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide is non-inferior to once-daily liraglutide and superior to placebo in Japanese patients with type 2 diabetes: a 26-week randomized phase III study. Miyagawa J, Odawara M, Takamura T, Iwamoto N, Takita Y, Imaoka T. Diabetes Obes Metab 17 10 974-983 2015/10
- Sitagliptin versus mitiglinide switched from mealtime dosing of a rapid-acting insulin analog in patients with type 2 diabetes: a randomized, parallel-group study. Takeshita Y, Takamura T, Kita Y, Takazakura A, Kato K, Isobe Y, Kaneko S. BMJ Open Diabetes Res Care. 3 1 e000122- 2015/08
- Bending of a vertical cannula without alarm during insulin pump therapy as a cause of unexpected hyperglycemia: A Japanese issue? Kuroda K, Takeshita Y, Kaneko S, Takamura T. J Diabetes Investig. 6 6 739-740 2015/11
- Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide significantly decreases glycated haemoglobin compared with once-daily liraglutide in Japanese patients with type 2 diabetes: 52 weeks of treatment in a randomized phase III study. Odawara M, Miyagawa J, Iwamoto N, Takita Y, Imaoka T, Takamura T. Diabetes Obes Metab. 18 3 249-257 2016/03
- Pleiotropic effects of sitagliptin versus voglibose in patients with type 2 diabetes inadequately controlled via diet and/or a single oral antihyperglycemic agent: a multicenter, randomized trial. Matsushima Y, Takeshita Y, Kita Y, Otoda T, Kato K, Toyama-Wakakuri H, Akahori H, Shimizu A, Hamaguchi E, Nishimura Y, Kanamori T, Kaneko S, Takamura T. BMJ Open Diabetes Res Care. 4 1 e000190 2016/04
- Dietary carbohydrate intake, presence of obesity and the incident risk of type 2 diabetes in Japanese men. Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Sasaki S, Nakagawa H. J Diabetes Investig. 7 3 343-351 2016/05/07
- Fat-free mass and calf circumference as body composition indices to determine non-exercise activity thermogenesis in patients with diabetes. Isobe Y, Sakurai M, Kita Y, Takeshita Y, Misu H, Kaneko S, Takamura T. J Diabetes Investig. 7 3 352-358 2016/05/07
- Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice. Chikamoto K, Misu H, Takayama H, Kikuchi A, Ishii KA, Lan F, Takata N, Tajima-Shirasaki N, Takeshita Y, Tsugane H, Kaneko S, Matsugo S, Takamura T. Biochem Biophys Res Commun. 478 3 1310-1316 2016/09/23
- Where does liver fat go? A possible molecular link between fatty liver and diabetes. Kikuchi A, Takamura T. J Diabetes Investig. 2016/08
- Association between coefficients of variation of the R-R intervals on electrocardiograms and post-challenge hyperglycemia in patients with newly diagnosed type 2 diabetes Nakade, Yusuke; Takamura, Toshinari; Sakurai, Masaru; Misu, Hirofumi; Nagata, Mitsuko; Nanbu, Yuko; Oe, Hiroyasu; Takamura, Toshiji; Sakai, Yoshio; Kaneko, Shuichi; Wada, Takashi Journal of Diabetes Investigation 2 4 324-327 2011/08/01
- Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum Tanaka, Mutsumi; Saito, Yoshiro; Misu, Hirofumi; Kato, Seiji; Kita, Yuki; Takeshita, Yumie; Kanamori, Takehiro; Nagano, Toru; Nakagen, Masatoshi; Urabe, Takeshi; Takamura, Toshinari; Kaneko, Shuichi; Takahashi, Kazuhiko; Matsuyama, Naoto Journal of Clinical Laboratory Analysis 2015/01/01
- Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis Ando, Hitoshi; Otoda, Toshiki; Ookami, Hitoshi; Nagai, Yukihiro; Inano, Akihiro; Takamura, Toshinari; Ushijima, Kentarou; Hosohata, Keiko; Matsushita, Eiki; Saito, Tetsuo; Kaneko, Shuichi; Fujimura, Akio Clinical and Experimental Pharmacology and Physiology 40 3 227-232 2013/03/01
- Development of the automated gold-linked electrochemical immunoassay system for blood monitoring Shiohara, Suguru; Chikae, Miyuki; Ukita, Yoshiaki; Ushijima, Hiromi; Fukumura, Yasukazu; Takamura, Toshinari; Takamura, Yuzuru Microsystem Technologies 20 2 273-279 2014/02/01
- [Diabetes mellitus related common medical disorders: recent progress in diagnosis and treatment. Topics: I. Pathophysiology, diagnosis and treatment; 1. Nonalcoholic fatty liver disease]. Takamura, Toshinari Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 102 4 836-844 2013/04/10
- Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes Takeshita, Yumie; Takamura, Toshinari; Kita, Yuki; Ando, Hitoshi; Ueda, Teruyuki; Kato, Kenichiro; Misu, Hirofumi; Sunagozaka, Hajime; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Metabolism: Clinical and Experimental 61 10 1388-1394 2012/10/01
- Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus Shima, Toshihide; Uto, Hirofumi; Ueki, Kohjiro; Takamura, Toshinari; Kohgo, Yutaka; Kawata, Sumio; Yasui, Kohichiroh; Park, Hyohun; Nakamura, Naoto; Nakatou, Tatsuaki; Tanaka, Nobuyoshi; Umemura, Atsushi; Mizuno, Masayuki; Tanaka, Junko; Okanoue, Takeshi Journal of Gastroenterology 48 4 515-525 2013/04/01
- Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease Kato, Kenichiro; Takamura, Toshinari; Takeshita, Yumie; Ryu, Yasuji; Misu, Hirofumi; Ota, Tsuguhito; Tokuyama, Kumpei; Nagasaka, Shoichiro; Matsuhisa, Munehide; Matsui, Osamu; Kaneko, Shuichi PLoS ONE 9 3 2014/03/20
- Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver Takamura, Toshinari; Misu, Hirofumi; Ota, Tsuguhito; Kaneko, Shuichi Endocrine Journal 59 9 745-763 2012/10/31
- [Novel strategies that target hepatokines for treatment of type 2 diabetes]. Misu, Hirofumi; Takamura, Toshinari; Kaneko, Shuichi Nihon rinsho. Japanese journal of clinical medicine 70 1 157-163 2012/01/01
- Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: A unique combination of endocrine neoplasia Kato, Kenichiro; Takeshita, Yumie; Misu, Hirofumi; Ishikura, Kazuhide; Kakinoki, Kaheita; Sawada-Kitamura, Seiko; Kaneko, Shuichi; Takamura, Toshinari Endocrine Journal 59 9 791-796 2012/10/31
- Marked improvement of insulin resistance after weight loss by diet and exercise therapy in an obese diabetic patient with charcot-marie-tooth disease Kanamori, Takehiro; Takeshita, Yumie; Misu, Hirofumi; Kato, Kenichiro; Ota, Tsuguhito; Kaneko, Shuichi; Takamura, Toshinari Journal of the Japan Diabetes Society 55 10 803-808 2012/10/01
- Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese Kawaguchi, Takahisa; Sumida, Yoshio; Umemura, Atsushi; Matsuo, Keitaro; Takahashi, Meiko; Takamura, Toshinari; Yasui, Kohichiroh; Saibara, Toshiji; Hashimoto, Etsuko; Kawanaka, Miwa; Watanabe, Sumio; Kawata, Sumio; Imai, Yasuharu; Kokubo, Miki; Shima, Toshihide; Park, Hyohun; Tanaka, Hideo; Tajima, Kazuo; Yamada, Ryo; Matsuda, Fumihiko; Okanoue, Takeshi PLoS ONE 7 6 2012/06/14
- Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis Kita, Yuki; Takamura, Toshinari; Misu, Hirofumi; Ota, Tsuguhito; Kurita, Seiichiro; Takeshita, Yumie; Uno, Masafumi; Matsuzawa-Nagata, Naoto; Kato, Kenichiro; Ando, Hitoshi; Fujimura, Akio; Hayashi, Koji; Kimura, Toru; Ni, Yinhua; Otoda, Toshiki; Miyamoto, Kenichi; Zen, Yoh; Nakanuma, Yasuni; Kaneko, Shuichi PLoS ONE 7 9 2012/09/18
- Postoperative diabetes insipidus associated with pituitary apoplexy during pregnancy Kita, Daisuke; Hayashi, Yasuhiko; Sano, Hiroki; Takamura, Toshinari; Hayashi, Yutaka; Tachibana, Osamu; Hamada, Junichiro Neuroendocrinology Letters 33 2 107-112 2012/06/20
- Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T 2 correction: Phantom and clinical study with histologic assessment Hayashi, Norio; Miyati, Tosiaki; Minami, Takashi; Takeshita, Yumie; Ryu, Yasuji; Matsuda, Tsuyoshi; Ohno, Naoki; Hamaguchi, Takashi; Kato, Kenichiro; Takamura, Toshinari; Matsui, Osamu Radiological Physics and Technology 6 1 219-225 2013/01/01
- The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: A randomised controlled trial Takeshita, Yumie; Takamura, Toshinari; Honda, Masao; Kita, Yuki; Zen, Yoh; Kato, Kenichiro; Misu, Hirofumi; Ota, Tsuguhito; Nakamura, Mikiko; Yamada, Kazutoshi; Sunagozaka, Hajime; Arai, Kuniaki; Yamashita, Tatsuya; Mizukoshi, Eishiro; Kaneko, Shuichi Diabetologia 57 5 878-890 2014/01/01
- Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats Hosohata, Keiko; Ando, Hitoshi; Takeshita, Yumie; Misu, Hirofumi; Takamura, Toshinari; Kaneko, Shuichi; Fujimura, Akio Diabetes and Vascular Disease Research 11 4 243-250 2014/01/01
- Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus Shima, Toshihide;Uto, Hirofumi;Ueki, Kohjiro;Takamura, Toshinari;Kohgo, Yutaka;Kawata, Sumio;Yasui, Kohichiroh;Park, Hyohun;Nakamura, Naoto;Nakatou, Tatsuaki;Tanaka, Nobuyoshi;Umemura, Atsushi;Mizuno, Masayuki;Tanaka, Junko;Okanoue, Takeshi JOURNAL OF GASTROENTEROLOGY 48 4 515-525 2013
- Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis Yamada, Kazutoshi;Mizukoshi, Eishiro;Sunagozaka, Hajime;Arai, Kuniaki;Yamashita, Tatsuya;Takeshita, Yumie;Misu, Hirofumi;Takamura, Toshinari;Kitamura, Seiko;Zen, Yoh;Nakanuma, Yasuni;Honda, Masao;Kaneko, Shuichi LIVER INTERNATIONAL 35 2 582-590 2015/01/01
- Association between coefficients of variation of the R-R intervals on electrocardiograms and post-challenge hyperglycemia in patients with newly diagnosed type 2 diabetes Nakade, Yusuke;Takamura, Toshinari;Sakurai, Masaru;Misu, Hirofumi;Nagata, Mitsuko;Nanbu, Yuko;Oe, Hiroyasu;Takamura, Toshiji;Sakai, Yoshio;Kaneko, Shuichi;Wada, Takashi JOURNAL OF DIABETES INVESTIGATION 2 4 324-327 2011
- Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes Misu, Hirofumi; Ishikura, Kazuhide; Kurita, Seiichiro; Takeshita, Yumie; Ota, Tsuguhito; Saito, Yoshiro; Takahashi, Kazuhiko; Kaneko, Shuichi; Takamura, Toshinari PLoS ONE 7 4 2012/04/04
- Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma Yasui, Kohichiroh;Hashimoto, Etsuko;Komorizono, Yasuji;Koike, Kazuhiko;Arii, Shigeki;Imai, Yasuharu;Shima, Toshihide;Kanbara, Yoshihiro;Saibara, Toshiji;Mori, Takahiro;Kawata, Sumio;Uto, Hirofumi;Takami, Shiro;Sumida, Yoshio;Takamura, Toshinari;Kawanaka, Miwa;Okanoue, Takeshi;Japan NASH Study Grp;Minist Hlth Labour & Welfare Japan CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 9 5 428-433 2011
- Remodeling of nutrient homeostasis by unfolded protein response Takamura, Toshinari Diabetes 63 3 841-843 2014/03/01
- Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells Ishikura, Kazuhide; Misu, Hirofumi; Kumazaki, Masafumi; Takayama, Hiroaki; Matsuzawa-Nagata, Naoto; Tajima, Natsumi; Chikamoto, Keita; Lan, Fei; Ando, Hitoshi; Ota, Tsuguhito; Sakurai, Masaru; Takeshita, Yumie; Kato, Kenichiro; Fujimura, Akio; Miyamoto, Kenichi; Saito, Yoshiro; Kameo, Satomi; Okamoto, Yasuo; Takuwa, Yoh; Takahashi, Kazuhiko; Kidoya, Hiroyasu; Takakura, Nobuyuki; Kaneko, Shuichi; Takamura, Toshinari Diabetologia 57 9 1968-1976 2014/01/01
- Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics Hellwege, Jacklyn N.; Palmer, Nicholette D.; Ziegler, Julie T.; Langefeld, Carl D.; Lorenzo, Carlos; Norris, Jill M.; Takamura, Toshinari; Bowden, Donald W. Gene 534 1 33-39 2014/01/15
- Identification of blood biomarkers of aging by transcript profiling of whole blood Nakamura, Seiji; Kawai, Kozo; Takeshita, Yumie; Honda, Masao; Takamura, Toshinari; Kaneko, Shuichi; Matoba, Ryo; Matsubara, Kenichi Biochemical and Biophysical Research Communications 418 2 313-318 2012/02/10
- Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes: Assessment using a meal tolerance test under clinical conditions Ando, Hitoshi; Kurita, Seiichiro; Shimizu, Akiko; Kato, Kenichiro; Ishikura, Kazuhide; Taji, Koumei; Uno, Masafumi; Takeshita, Yumie; Misu, Hirofumi; Fujimura, Akio; Kaneko, Shuichi; Takamura, Toshinari Clinical and Experimental Pharmacology and Physiology 39 6 528-534 2012/06/01
- Long-term outcomes of japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy Shimizu, Miho; Furuichi, Kengo; Toyama, Tadashi; Kitajima, Shinji; Hara, Akinori; Kitagawa, Kiyoki; Iwata, Yasunori; Sakai, Norihiko; Takamura, Toshinari; Yoshimura, Mitsuhiro; Yokoyama, Hitoshi; Kaneko, Shuichi; Wada, Takashi Diabetes Care 36 11 3655-3662 2013/11/01
Conference Presentations
- Efficacy and Safety of Once-weekly Dulaglutide versus Once-daily Liraglutide in Japanese patients with Type 2 Diabetes(conference：75th Scientific Sessions American Diabetes Association (ADA))(2015/06/04)
- 篁 俊成
Others
- Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis 273 5 2493 1998/01
Arts and Fieldwork
Patent
○Candidate genes coding liver-derived secretory proteins associated with type 2 diabetes and obesity
Theme to the desired joint research
○Pathology of diabetes, obesity and fatty liver
○Functional analyses of hepatokines (selenoprotein P, LECT2)
○Molecular pathology of insulin resistance
Grant-in-Aid for Scientific Research
○「細胞内蛋白分解系のエネルギー代謝恒常性維持における統合的役割の解明」(2014-2016)
○「内分泌器官としての肝臓病学の確立」(2014-2018)
○「肥満による肝インスリン抵抗性形成におけるプロテアソーム機能異常の意義」(2011-2013)
○「セレノプロテインＰ測定試薬の開発－インスリン抵抗性バイオマーカーを用いた糖尿病の予防・治療への応用」(2011-2013)
○「過栄養状態の肝臓が産生するタンパクと生活習慣病の関連」(2011-2013)
○「インスリン抵抗性と血管合併症を形成する肝臓由来新規ホルモンの機能解析」(2008-2010)
○「過栄養状態における肝臓機能の破綻と生活習慣病の研究」(2006-2010)
○「2型糖尿病患者の肝臓における酸化的リン酸化を制御するマスター遺伝子の同定」(2005-)
○「胚シグナルに対する免疫応答異常を共通の病因とする新しい疾患群の同定と解析」(2019-2020)
○「肝臓-骨格筋連関を標的とした運動効果増強薬の開発」(2018-2020)
○「酸化・還元バランスの破綻による糖尿病病態形成機構の解明」(2017-2021)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Endocrinology & Metabolism(2017)
○Endocrinology & Metabolism(2016)
Classes (Graduate Schools)
○Comprehensive Metabology(2017)
○Comprehensive Metabology(2017)
○Comprehensive Metabology(2017)
○Introduction to Medicine(2017)
○Topics in Biochemical Engineering 1(2017)
○Disease and Nutrient Metabolism(2017)
○omics(2017)
○Environment and Heredity(2017)
○Environment and Health -Introductory(2017)
○Introduction to Medicine(2016)
○Topics in Biochemical Engineering 1(2016)
○Environment and Heredity(2016)
○Disease and Nutrient Metabolism(2016)
○Comprehensive Metabology(2016)
○Environment and Health -Introductory(2016)
○Comprehensive Metabology(2016)
○Comprehensive Metabology(2016)
International Project
○WHO Consultation on Advancing Universal Health Coverage and the Future Research Directions of the WHO Centre for Health DevelopmentWHO(20141114-20141114)WHO Consultation on Advancing Universal Health Coverage and the Future Research Directions of the WHO Centre for Health Development