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Researcher Information

last modified:2021/04/19

Associate Professor DEMURA, Masashi


Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Health Sciences,Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


 TEL:076-265-2213 FAX:076-234-4232

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medical Sciences 200203 Completed
Doctor of Medical Science (DMSc)


Kanazawa University(2009/08/01-)
Kanazawa University Hospital(2008/04/01-)
Northwestern University Research Associate(2003/10/01-2006/10/10)
Kanazawa University Hospital(1995/05/01-1996/03/29)

Year & Month of Birth

Academic Society

Japan Endcorine Society


○3rd IAF-J award(2010/05/16)
○Young Investigator Award for International Symposium for Aldosterone and Related Substa(2010/03/24)
○Research presentation award from 4th Workshop on Hypertension and Coronary Artery Disease(2009/12/26)
○Travel Grant Award (ESH2009)(2009/06/12)
○The 2nd IAF-J awrad(2009/05/17)
○The Northwestern Memorial Foundation MD-Scientist Fellowship in Genetic Medicine(2006/04/01)
○Center for Genetic Medicine of Northwestern University(2005/06/15)
○the Gordon Research Conference on Hormone Action in Development and Cancer(2005/06/15)
○Travel grant award (ENDO2003)(2003/06/20)
○Travel grant award (ENDO2003)(2003/06/20)



Speciality Keywords

Research Themes

Molecular genetic mechanism in aldosterone production from cardiovascular tissues

Identification of target genes for aldosterone/mineralocorticoid receptor


  •  Demura M, Saijoh K Adv Exp Med Biol - Advances in Internal Medicine  2017
  •  Takeda, Y., Demura, M., Yoneda, T. Molecular Genetics, Endocrinology, and Translational Medicine 2014/01


  •  Regulation of serine protease inhibitor Kazal type-5 (SPINK5) gene expression in the keratinocytes.  Le NA, Katsuyama M, Demura M, Tanii H, Katsuyama H, Saijoh K.  Environ Health Prev Med 19 4 307-313 2014
  •  Repeated Exposure to Cruciferous Allyl Nitrile Protects against Chemically Induced Skin Inflammation in the Mouse. Hideji Tanii, Tomomi Higashi, Masashi Demura, Kiyofumi Saijoh Food and Nutrition Sciences 3 8 1037-42 2012/08
  •  A Humanized Pattern of Aromatase Expression Is Associated with Mammary Hyperplasia in Mice. Zhao H,Pearson EK,Brooks DC,Coon V JS,Chen D,Demura M,Zhang M,Clevenger CV,Xu X,Veenstra TD,Chatterton RT,Demayo FJ,Bulun SE ENDOCRINOLOGY 153 6 2701-13 2012/06
  •  Unilateral primary aldosteronism with spontaneous remission after long-term spironolactone therapy. Yoneda T,Demura M,Takata H,Kometani M,Karashima S,Yamagishi M,Takeda Y J Clin Endocrinol Metab 97 4 1109-13 2012/04
  •  Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats. Takata H,Takeda Y,Zhu A,Cheng Y,Yoneda T,Demura M,Yagi K,Karashima S,Yamagishi M Diabetes Obes Metab 14 2 155-62 2012/02

show all

  •  Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma. Karashima S,Takeda Y,Cheng Y,Yoneda T,Demura M,Kometani M,Ohe M,Mori S,Yagi K,Yamagishi M Steroids 76 12 1363-6 2011/12
  •  Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer. LUNG CANCER 2011/01
  •  A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: a case report. Demura M,Yoneda T,Karashima S,Higashikata T,Mabuchi H,Kawano M,Yamagishi M,Takeda Y J Med Case Reports 4 347 2010/10
  •  Ectopic Production of Parathyroid Hormone in a Patient with Sporadic Medullary Thyroid Cancer. ENDOCRINE JOURNAL 57 161-70 2010/01
  •  High aromatase expression in uterine leiomyoma tissues of African-American women. Ishikawa H, Reierstad S, Demura M, Rademaker AW, Kasai T, Inoue M, Usui H, Shozu M, Bulun SE. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 94 5 1752-6 2009/05
  •  Novel Promoter I.8 and Promoter Usage in the CYP19 (Aromatase) Gene.  Demura M, Reierstad S, Innes JE, Bulun SE. Reprod Science 15 10 1044-53 2008/12
  •  CpG dinucleotide methylation of the CYP19 I.3/II promoter modulates cAMP-stimulated aromatase activity. Demura M,Bulun SE Mol Cell Endocrinol 283 1-2 127-32 2008/02
  •  Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene. Demura M,Martin RM,Shozu M,Sebastian S,Takayama K,Hsu WT,Schultz RA,Neely K,Bryant M,Mendonca BB,Hanaki K,Kanzaki S,Rhoads DB,Misra M,Bulun SE Hum Mol Genet 16 21 2529-41 2007/11
  •  Aromatase excess in cancers of breast, endometrium and ovary. Bulun SE,Chen D,Lu M,Zhao H,Cheng Y,Demura M,Yilmaz B,Martin R,Utsunomiya H,Thung S,Su E,Marsh E,Hakim A,Yin P,Ishikawa H,Amin S,Imir G,Gurates B,Attar E,Reierstad S,Innes J,Lin Z J Steroid Biochem Mol Biol 106 1-5 81-96 2007/08
  •  Aromatase excess in cancers of breast, endometrium and ovary. Bulun SE, Lin Z, Imir G, Amin S, Demura M, Yilmaz B, Martin R, Utsunomiya H, Thung S, Gurates B, Tamura M, Langoi D, Deb S.  PHARMACOLOGICAL REVIEWS 57 3 359-83 2005/09
  •  Surgical stress-induced transient nephrogenic diabetes insipidus (NDI) associated with decreased Vasopressin receptor2 (AVPR2) expression linked to nonsense-mediated mRNA decay and incomplete skewed X-inactivation in a female patient with a heterozygous AVPR2 mutation (c. 89-90 delAC). Demura M,Takeda Y,Yoneda T,Oda N,Bando Y,Mabuchi H Clin Endocrinol (Oxf) 60 6 773-5 2004/06
  •  Completely skewed X-inactivation in a mentally retarded young female with pseudohypoparathyroidism type IB and juvenile renin-dependent hypertension. Demura M,Takeda Y,Yoneda T,Furukawa K,Tachi A,Mabuchi H J Clin Endocrinol Metab 88 7 3043-9 2003/07
  •  19-Noraldosterone in pregnancy-induced hypertension. Takeda Y,Yoneda T,Demura M,Furukawa K,Usukura M,Mabuchi H STEROIDS 67 7 605-10 2002/07
  •  Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency. Takeda Y,Yoneda T,Demura M,Furukawa K,Koshida H,Miyamori I,Mabuchi H Clin Endocrinol (Oxf) 54 6 751-8 2001/06
  •  Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats. Takeda Y, Yoneda T, Demura M, Furukawa K, Miyamori I, Mabuchi H. JOURNAL OF HYPERTENSION 19 3 Pt2 635-9 2001/03
  •  Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy. Takeda Y,Yoneda T,Demura M,Miyamori I,Mabuchi H ENDOCRINOLOGY 141 5 1901-4 2000/05
  •  Cardiac aldosterone production in genetically hypertensive rats. Takeda Y,Yoneda T,Demura M,Miyamori I,Mabuchi H HYPERTENSION 36 4 495-500 2000/04
  •  Effect of potassium on DNA methylation of aldosterone synthase gene Takeda, Yoshimichi Demura, Masashi Wang, Fen Karashima, Shigehiro Yoneda, Takashi Kometani, Mitsuhiro Aomo, Daisuke Hashimoto, Atsushi Horike, Shin-ichi Meguro-Horike, Makiko Takeda, Yoshiyu Journal of Hypertension 39 5 2021/05/03
  •  A case of renovascular hypertension with incidental primary bilateral macronodular adrenocortical hyperplasia. Higashitani, Takuya Karashima, Shigehiro Aono, Daisuke Konishi, Seigoh Kometani, Mitsuhiro Oka, Rie Demura, Masashi Furukawa, Kenji Yamazaki, Yuto Sasano, Hironobu Yoneda, Takashi Takeda, Yoshiyu Endocrinology, diabetes & metabolism case reports 2020 1 1-6 2020/08/06
  •  Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results. Nagase, Satoshi Karashima, Shigehiro Tsujiguchi, Hiromasa Tsuboi, Hirohito Miyagi, Sakae Kometani, Mitsuhiro Aono, Daisuke Higashitani, Takuya Demura, Masashi Sakakibara, Hiroyuki Yoshida, Akihiro Hara, Akinori Nakamura, Hiroyuki Takeda, Yoshiyu Nambo, Hidetaka Yoneda, Takashi Okamoto, Shigefumi Frontiers in medicine 7 475 2020/09/02
  •  Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice Hashimoto, Atsushi Takeda, Yoshimichi Karashima, Shigehiro Kometani, Mitsuhiro Aono, Daisuke Demura, Masashi Higashitani, Takuya Konishi, Seigo Yoneda, Takashi Takeda, Yoshiyu Hypertens Res. 2020/10/01
  •  Renal artery aneurysm due to fenestration of a branch of the renal artery: A case study Karashima, S. Kometani, M. Aono, D. Higashitani, T. Nishimoto, Y. Konishi, S. Demura, M. Takeda, Y. Yoneda, T. Journal of the Endocrine Society 5 2 2021/02/01
  •  Effect of sodium–glucose cotransporter-2 inhibitors on aldosterone-to-renin ratio in diabetic patients with hypertension: a retrospective observational study Sawamura, Toshitaka Karashima, Shigehiro Nagase, Satoshi Nambo, Hidetaka Shimizu, Eiko Higashitani, Takuya Aono, Daisuke Ohbatake, Azusa Kometani, Mitsuhiro Demura, Masashi Furukawa, Kenji Takeda, Yoshiyu Yoneda, Takashi BMC Endocrine Disorders 20 1 2020/12/01
  •  Pregnancy-associated diabetes insipidus in Japan—a review based on quoting from the literatures reported during the period from 1982 to 2019 Takeda, Ryoyu Demura, Masashi Sugimura, Yoshihisa Miyamori, Isamu Konoshita, Tadashi Yamamoto, Hiroshi Endocrine Journal EJ20-0745 2021/04/01
  •  Primary aldosteronism subtype discordance between computed tomography and adrenal venous sampling. Aono D, Kometani M, Karashima S, Usukura M, Gondo Y, Hashimoto A, Demura M, Furukawa K, Takeda Y, Kawashiri M, Yoneda T. Hypertens Res. 2019/08/13
  •  Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia. Kometani M, Yoneda T, Demura M, Aono D, Gondoh Y, Karashima S, Nishimoto K, Yasuda M, Horike SI, Takeda Y. Steroids. 2019/08/07
  •  Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease. Karashima S, Tsuda T, Kometani M, Oka R, Demura M, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T. J Endocr Soc. 2 11 1246-1250 2018/09/17
  •  Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism. Kometani M, Yoneda T, Aono D, Karashima S, Demura M, Nishimoto K, Yamagishi M, Takeda Y. Oncotarget 9 40 26007-26018 2018/05
  •  Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II. Takeda Y, Demura M, Wang F, Karashima S, Yoneda T, Kometani M, Hashimoto A, Aono D, Horike SI, Meguro-Horike M, Yamagishi M, Takeda Y. JAHA 7 10 e008281 2018/05
  •  Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes. Sawada K, Karashima S, Kometani M, Oka R, Takeda Y, Sawamura T, Fujimoto A, Demura M, Wakayama A, Usukura M, Yagi K, Takeda Y, Yoneda T. Endocr J 2018/04
  •  Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis. Karashima S, Tsuda T, Wakabayashi Y, Kometani M, Demura M, Ichise T, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T.  J Endocr Soc 2 2 135-139 2017/12/06
  •  Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functions. Katsuyama M, Demura M, Katsuyama H, Tanii H, Saijoh K. Mol Med Rep. 16 1 873-880 2017/07
  •  Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people Ota Y, Korshunova N, Demura M, Katsuyama M, Katsuyama H, Rahayu SR, Saijoh K ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 22 1 1-8 2017/12
  •  Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia. Kometani M, Yoneda T, Demura M, Koide H, Nishimoto K, Mukai K, Gomez-Sanchez CE, Akagi T, Yokota T, Horike SI, Karashima S, Miyamori I, Yamagishi M, Takeda Y. Sci Rep. 7 1 11205 2017/09
  •  The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile.  Kometani M, Yoneda T, Demura M, Karashima S, Mori S, Oe M, Sawamura T, Okuda R, Yamagishi M, Takeda Y.  Intern Med 55 769-773 2016
  •  Impact of New Quick Gold Nanoparticle-Based Cortisol Assay During Adrenal Vein Sampling for Primary Aldosteronism.   Yoneda T, Karashima S, Kometani M, Usukura M, Demura M, Sanada J, Minami T, Koda W, Gabata T, Matsui O, Idegami K, Takamura Y, Tamiya E, Oe M, Nakai M, Mori S, Terayama N, Matsuda Y, Kamemura K, Fujii S, Seta T, Sawamura T, Okuda R, Takeda Y, Hayashi K, Yamagishi M, Takeda Y.  J Clin Endocrinol Metab 101 2254-2261 2016
  •  Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene.  Wang F, ✔Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y.  Hypertension 63 281-288 2014
  •  Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues Journal of Hypertension 29 6 1185-1195 2011/06/01 

Conference Presentations

  • miRNA-mediated crosstalk between Wnt3a and TGF beta 3 in osteoblast differentiation(conference:FASEB JOURNAL)(2017/04)
  • Immunohistochemical Analysis of Adrenal Subclinical Cushing's Syndrome with Aldosterone Excess(2017/10/20)
  • Epigenetic Regulation of Aldosterone Synthase Gene by Potassium(conference:ENDO 2019)(2019/03/24)


  •  The role of DNA methylation on Hypertension Masashi Demura 86 2 199 2020/05/10
  •  Epigenetics of aldosterone synthase gene Yoshimichi Takeda, Masashi Demura, Yoshiyu Takeda CARDIOANGIOLOGY 86 2 199 2019/08/28
  •  Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene. Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y. World Biomedical Frontiers 2015 Hypertension 2015
  •  Dynamic regulation of the angiotensinogen gene by DNA methylation, which is influe nced by various stimuli experienced in daily life. Demura M, Demura Y, Takeda Y, Saijoh K. Hypertens Res. 38 8 519-527 2015
  •  Epigenetics in aldosterone production 65 10 2253-2260 2010/10

Arts and Fieldwork


Theme to the desired joint research

○Molecular mechanisms for aldosterone production and effect of aldosterone on target organs

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Medical Ethics(2019)
○Medical Ethics(2018)
○Medical Ethics(2017)
○Medical Ethics(2017)
○Medical Ethics(2016)

Classes (Graduate Schools)

○Environment and Health(2019)
○Environmental and Molecular Bio-Informatics(2019)
○Environmental and Molecular Bio-Informatics(2019)
○Environmental and Molecular Bio-Informatics(2018)
○Environmental and Molecular Bio-Informatics(2017)
○Environmental and Molecular Bio-Informatics(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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