Specialities

stem cell self-renewal、hematopoietic stem cell、Hematology、Experimental pathology

Speciality Keywords

stem cell self-renewal hematopoietic stem cell

Research Themes

Books

• 　Miyamoto K, Araki YK, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, and Hirao A.　Foxo3a is essential for maintenance of the hematopoietic stem cell pool.　1　1　101-112　2007/06
• 　Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A　Regulation of reactive oxygen species by atm is essential for proper response to DNA double-strand breaks in lymphocytes.　178　1　103-10　2007/01
• 　Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N, Hara E.　Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals　104　38　15034-9　2007/08
• 　Iwanaga A, Sato T, Sugihara K, Hirao A, Takakura N, Okamoto H, Asano M, Yoshioka K　Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.　429　1　43-8　2007/11
• 　Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T　Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells　12　4　446-51　2006/04

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Papers

• 　mTORC1 is essential for leukemia propagation but not stem cell self-renewal. 　122　2114-29　2012/06
• 　NKX2.2 suppresses self-renewal of glioma-initiating cells.　Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A　CANCER RESEARCH　2011/01
• 　TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeoid leukaemia. 　Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A　NATURE　2010/02
• 　Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.　Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A. 　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME
• 　 Identification of Stem Cells During Prepubertal Spermatogenesis Via Monitoring of　Nucleostemin Promoter Activity　Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A.　STEM CELLS

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Conference Presentations

Others

• 　Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.　Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW.　104　10　3805-10　2007/03
• 　ATM can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.　Keramaris E, Hirao A, Slack RS, Mak TW, Park DS.　278　39　37782-9　2003/09

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「核小体分子の発現・機能解析による正常および白血病幹細胞の未分化性維持機構の解明」(2006-)　
○「がん病理・病態学的特性の分子基盤の解析とそれに基づく診断・治療法の開発に関する研究」(2007-)　
○「細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化」(2009-)　
○「普遍的幹細胞制御機構と腫瘍細胞分化」(2008-)　
○「がんの幹細胞特性を支える栄養シグナル制御機構の解明」(2012-2014)　
○「がん幹細胞性獲得・維持機構とニッチシグナルのクロストーク」(2011-2012)　
○「マルチオミクス解析システムによる白血病幹細胞分化制御機構の解明」(2011-2011)　
○「腫瘍悪性度進展における未分化性獲得メカニズムの解明」(2010-2010)　
○「細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化」(2009-2011)　

Competitive research funding,Contribution

Collaborative research,Consignment study

○Identification of Cancer Stem Cells(2005-)

Classes (Bachelors)

Classes (Graduate Schools)

○Seminar on Tumor Biology(2017)
○Advanced Medical and Pharmaceutical Sciences(2017)
○Stem Cell Biology(2017)
○Advanced Medical and Pharmaceutical Sciences(2017)
○Stem Cell Biology(2017)
○Seminar on Tumor Biology(2017)
○Molecular Oncology(2017)
○Stem Cell Biology(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Biology of Cancer 2B(2017)
○Biology of Cancer 2A(2017)
○Molecular Medical Oncology(2017)
○Medical Sciences(2016)
○Stem Cell Biology(2016)
○Molecular Oncology(2016)
○Cancer molecular pathology 2(2016)
○Biology of Cancer 2A(2016)
○Biology of Cancer 2B(2016)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)