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Researcher Information

last modified：2025/03/17

Associate Professor　NAGATA Naoto

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Department of Cellular and Molecular Function Analysis
Lecturer

College and School Educational Field


School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medical and Pharmaceutical Sciences, College of Medical,Pharmaceutical and Health Sciences

Laboratory

Department of Cellular and Molecular Function Analysis　TEL:076-265-2453

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　200703　Completed
【Academic background(Bachelor's Degree)】
Kanazawa Uiversity　200203

Career

Kanazawa University Graduate School of Natural Science　Assistant Professor(2007/04/01-2010/01/31)
University of California, Davis　Department of Nutrition　Postdoctoral fellow(2010/02/01-2012/08/31)
Kanazawa University　Assistant Professor(2012/10/01-2016/08/31)
Kanazawa University Graduate School of Medical Science　Department of Cellular and Molecular Function Analysis　Assistant professor(2016/09/01-2017/06/30)
Kanazawa University Graduate School of Medical Science　Department of Cellular and Molecular Function Analysis　Lecturer(2017/07/01-)

Year & Month of Birth

1978/09

Academic Society

Japanese Association for Protein Phosphatase Research
The Japanese Biochemical Society
The Japan Society of Hepatology

Award

Specialities

、、、

Speciality Keywords

NAFLD,Energy metabolism

Research Themes

Finding a new way to stimulate thermogenesis to combat obesity

Books

  • 　Naoto Nagata, Tsuguhito Ota　BIO INDUSTRY　2018/02/12
  • 　Naoto Nagata, Toshinari Takamura　Fatty liver and insulin resistance　IGAKU SHUPPAN　2013/09
  • 　Naoto Nagata, Toshinari Takamura　Medical Practice　Bunkodo　2007/04/01

Papers

  • 　Lenvatinib causes reduced expression of carnitine/organic cation transporter 2 and carnitine deficiency in the skeletal muscle of rats.　Zheng Jing,Hironao Okubo,Jun-Ichi Morishige,Pingping Xu,Nazmul Hasan,Naoto Nagata,Hitoshi Ando　Toxicology letters　2022/07/01
  • 　A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation.　Suratsawadee Promsuwan,Kazuki Sawamoto,Liang Xu,Mayumi Nagashimada,Naoto Nagata,Yumi Takiyama　Diabetology international　15　1　86　2024/01　
  • 　L-carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy.　Zheng Jing,Tomohiro Iba,Hisamichi Naito,Pingping Xu,Jun-Ichi Morishige,Naoto Nagata,Hironao Okubo,Hitoshi Ando　Frontiers in pharmacology　14　1182788　2023/04/06
  • 　Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes　Jun-ichi Morishige,Kazuaki Yoshioka,Hiroki Nakata,Kazuhiro Ishimaru,Naoto Nagata,Tamotsu Tanaka,Yoh Takuwa,Hitoshi Ando　Journal of Lipid Research　64　11　100450　2023/09
  • 　The mechanism of sustained hepatic inflammation in non-alcoholic fatty liver disease　Naoto Nagata　Journal of the Juzen Medical Society　132　1　16　2023/04

show all

  • 　An Update on the Chemokine System in the Development of NAFLD　Naoto Nagata,Guanliang Chen,Liang Xu,Hitoshi Ando　Medicina　58　6　761　2022/06/05　
  • 　CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status.　Yinhua Ni,Fen Zhuge,Liyang Ni,Naoto Nagata,Tatsuya Yamashita,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada　Metabolism: clinical and experimental　136　155272　2022/07/29
  • 　Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice　Nazmul Hasan,Koki Sugimoto,Koki Yamada,Jun-ichi Morishige,Kentaro Ushijima,Akio Fujimura,Naoto Nagata,Hitoshi Ando　Medicina　58　2　293　2022/02/15　
  • 　Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.　Takayoshi Shirasaki,Satoshi Yamagoe,Tetsuro Shimakami,Kazuhisa Murai,Ryu Imamura,Kiyo-Aki Ishii,Hiroaki Takayama,Yukako Matsumoto,Natsumi Tajima-Shirasaki,Naoto Nagata,Ryogo Shimizu,Souma Yamanaka,Atsushi Abe,Hitoshi Omura,Kazunori Kawaguchi,Hikari Okada,Taro Yamashita,Tomoki Yoshikawa,Kazuhiro Takimoto,Motoko Taharaguchi,Shogo Takatsuka,Yoshitsugu Miyazaki,Toshikatsu Tamai,Yamato Tanabe,Makoto Kurachi,Yasuhiko Yamamoto,Shuichi Kaneko,Kunio Matsumoto,Toshinari Takamura,Masao Honda　Nature communications　13　1　3176　2022/06/08
  • 　Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice　Hitoshi Ando,Naoto Nagata,Takashi Hosono,Nazmul Hasan,Jun-ichi Morishige,Takiko Daikoku,Yoshiko Maida,Masanori Ono,Tomoko Fujiwara,Hiroshi Fujiwara　Frontiers in Nutrition　9　966788　2022/08/22　
  • 　Edoxaban Dosing Time Affects Blood Coagulation Inhibition in Rats.　Naoto Nagata,Muneo Kawasumi,Akio Fujimura,Hitoshi Ando　TH open : companion journal to thrombosis and haemostasis　5　2　e107　2021/04/01
  • 　Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice.　Naoto Nagata,Liang Xu,Susumu Kohno,Yusuke Ushida,Yudai Aoki,Ryohei Umeda,Nobuo Fuke,Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Chiaki Takahashi,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota　Diabetes　66　5　1222　2017/05　
  • 　Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice.　Nazmul Hasan,Naoto Nagata,Jun-Ichi Morishige,Md Tarikul Islam,Zheng Jing,Ken-Ichi Harada,Michihiro Mieda,Masanori Ono,Hiroshi Fujiwara,Takiko Daikoku,Tomoko Fujiwara,Yoshiko Maida,Tsuguhito Ota,Shigeki Shimba,Shuichi Kaneko,Akio Fujimura,Hitoshi Ando　Molecular metabolism　49　101202　2021/07
  • 　CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice.　Liang Xu,Yongping Chen,Mayumi Nagashimada,Yinhua Ni,Fen Zhuge,Guanliang Chen,Haoran Li,Tongtong Pan,Tatsuya Yamashita,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota,Naoto Nagata　Metabolism: clinical and experimental　125　154914　2021/10/14
  • 　Edoxaban Dosing Time Affects Blood Coagulation Inhibition in Rats.　Naoto Nagata,Muneo Kawasumi,Akio Fujimura,Hitoshi Ando　TH open : companion journal to thrombosis and haemostasis　5　2　e107-e112　2021/04
  • 　Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.　Tomoki Nishikawa,Naoto Nagata,Tetsuro Shimakami,Takashi Shirakura,Chieko Matsui,Yinhua Ni,Fen Zhuge,Liang Xu,Guanliang Chen,Mayumi Nagashimada,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko,Tsuguhito Ota　Scientific reports　10　1　815　2020/01/21
  • 　Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice　Naoto Nagata,Kosuke Matsuo,Ahmed Bettaieb,Jesse Bakke,Izumi Matsuo,James Graham,Yannan Xi,Siming Liu,Alexey Tomilov,Natalia Tomilova,Susan Gray,Dae Young Jung,Jon J. Ramsey,Jason K. Kim,Gino Cortopassi,Peter J. Havel,Fawaz G. Haj　ENDOCRINOLOGY　153　7　3158　2012/07
  • 　Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity　Naoto Matsuzawa-Nagata,Toshinari Takamura,Hitoshi Ando,Seiji Nakamura,Seiichiro Kurita,Hirofumi Misu,Tsuguhito Ota,Masayoshi Yokoyama,Masao Honda,Ken-ichi Miyamoto,Shuichi Kaneko　METABOLISM-CLINICAL AND EXPERIMENTAL　57　8　1071　2008/08　
  • 　Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet　Naoto Matsuzawa,Toshinari Takamura,Seiichiro Kurita,Hirofumi Misu,Hitoshi Ando,Masayoshi Yokoyama,Masao Honda,Yoh Zen,Yasuni Nakanuma,Ken-Ichi Miyamoto,Shuichi Kaneko　HEPATOLOGY　46　5　1392　2007/11
  • 　CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice　Mayumi Nagashimada,Kazuki Sawamoto,Yinhua Ni,Hironori Kitade,Naoto Nagata,Liang Xu,Masuko Kobori,Naofumi Mukaida,Tatsuya Yamashita,Shuichi Kaneko,Tsuguhito Ota　Endocrinology　162　6　2021/03/25　
  • 　DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice.　Yuriko Sakai,Guanliang Chen,Yinhua Ni,Fen Zhuge,Liang Xu,Naoto Nagata,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada　Endocrinology　161　10　2020/10/01
  • 　Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice.　Yinhua Ni,Fen Zhuge,Mayumi Nagashimada,Naoto Nagata,Liang Xu,Sayo Yamamoto,Nobuo Fuke,Yusuke Ushida,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota　Free radical biology & medicine　152　571　2020/05/20
  • 　Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability.　Yuriko Sakai,Hideyuki Arie,Yinhua Ni,Fen Zhuge,Liang Xu,Guanliang Chen,Naoto Nagata,Takuya Suzuki,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada　The Journal of endocrinology　247　2　169　2020/11/01
  • 　Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages.　Guanliang Chen,Yinhua Ni,Naoto Nagata,Fen Zhuge,Liang Xu,Mayumi Nagashimada,Sayo Yamamoto,Yusuke Ushida,Nobuo Fuke,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota　Molecular nutrition & food research　63　21　e1900602　2019/11
  • 　Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors.　Nobuo Fuke,Naoto Nagata,Hiroyuki Suganuma,Tsuguhito Ota　Nutrients　11　10　2277　2019/09/23
  • 　Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages.　Guanliang Chen,Yinhua Ni,Naoto Nagata,Liang Xu,Fen Zhuge,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota　Laboratory investigation; a journal of technical methods and pathology　99　9　1335　2019/09
  • 　Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet.　Liang Xu,Naoto Nagata,Guanliang Chen,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Yuriko Sakai,Shuichi Kaneko,Tsuguhito Ota　BMJ open diabetes research & care　7　1　e000783　2019
  • 　Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction.　Liang Xu,Naoto Nagata,Tsuguhito Ota　International journal of molecular sciences　20　23　5920　2019/11/25
  • 　Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance.　Liang Xu,Naoto Nagata,Tsuguhito Ota　Adipocyte　7　3　218　2018
  • 　A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice.　Liang Xu,Naoto Nagata,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Guanliang Chen,Junzo Kamei,Hiroki Ishikawa,Yasuhiko Komatsu,Shuichi Kaneko,Tsuguhito Ota　Oncotarget　9　19　15047　2018/03/13
  • 　Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis　Masafumi Uno,Seiichiro Kurita,Hirofumi Misu,Hitoshi Ando,Tsuguhito Ota,Naoto Matsuzawa-Nagata,Yuki Kita,Satoko Nabemoto,Hiroshi Akahori,Yoh Zen,Yasuni Nakanuma,Shuichi Kaneko,Toshinari Takamura　HEPATOLOGY　48　1　109　2008/07
  • 　Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.　Masaya Funaki,Juria Kitabayashi,Tetsuro Shimakami,Naoto Nagata,Yuriko Sakai,Kai Takegoshi,Hikari Okada,Kazuhisa Murai,Takayoshi Shirasaki,Takeru Oyama,Taro Yamashita,Tsuguhito Ota,Yoh Takuwa,Masao Honda,Shuichi Kaneko　Scientific reports　7　1　16978　2017/12/05
  • 　SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice.　Liang Xu,Naoto Nagata,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Guanliang Chen,Eric Mayoux,Shuichi Kaneko,Tsuguhito Ota　EBioMedicine　20　137　2017/06　
  • 　Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model　Kai Takegoshi,Masao Honda,Hikari Okada,Riuta Takabatake,Naoto Matsuzawa-Nagata,Jean S. Campbell,Masashi Nishikawa,Tetsuro Shimakami,Takayoshi Shirasaki,Yoshio Sakai,Taro Yamashita,Toshinari Takamura,Takuji Tanaka,Shuichi Kaneko　ONCOTARGET　8　11　18191　2017/03
  • 　Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet.　Hikari Okada,Riuta Takabatake,Masao Honda,Kai Takegoshi,Taro Yamashita,Mikiko Nakamura,Takayoshi Shirasaki,Yoshio Sakai,Tetsuro Shimakami,Naoto Nagata,Toshinari Takamura,Takuji Tanaka,Shuichi Kaneko　Oncotarget　8　25　39978　2017/06/20
  • 　β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice.　Wanpitak Pongkan,Osamu Takatori,Yinhua Ni,Liang Xu,Naoto Nagata,Siriporn C Chattipakorn,Soichiro Usui,Shuichi Kaneko,Masayuki Takamura,Minoru Sugiura,Nipon Chattipakorn,Tsuguhito Ota　Molecular nutrition & food research　61　10　2017/10
  • 　DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization　Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Naoto Nagata,Liang Xu,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota　Diabetes　65　10　2966　2016/10/01
  • 　Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease.　Guanliang Chen,Yinhua Ni,Naoto Nagata,Liang Xu,Tsuguhito Ota　International journal of molecular sciences　17　9　1379　2016/08/23
  • 　DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization.　Zhuge F,Ni Y,Nagashimada M,Nagata N,Xu L,Mukaida N,Kaneko S,Ota T　Diabetes　65　10　2966　2016/10
  • 　Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis　Tsuguhito Ota,Toshinari Takamura,Seiichiro Kurita,Naoto Matsuzawa,Yuki Kita,Masafumi Uno,Hiroshi Akahori,Hirofumi Misu,Masaru Sakurai,Yoh Zen,Yasuni Nakanuma,Shuichi Kaneko　GASTROENTEROLOGY　132　1　282　2007/01
  • 　Prevention and reversal of lipotoxicity-induced nonalcoholic steatohepatitis by an antioxidant carotenoid, β-cryptoxanthin.　Ni Y,Nagashimada M,Zhan L,Nagata N,Kobori M,Sugiura M,Ogawa K,Kaneko S,Ota T　135　1　67　2015
  • 　Prevention and Reversal of Lipotoxicity-Induced Hepatic Insulin Resistance and Steatohepatitis in Mice by an Antioxidant Carotenoid, beta-Cryptoxanthin　Yinhua Ni,Mayumi Nagashimada,Lili Zhan,Naoto Nagata,Masuko Kobori,Minoru Sugiura,Kazunori Ogawa,Shuichi Kaneko,Tsuguhito Ota　ENDOCRINOLOGY　156　3　987　2015/03
  • 　Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E　Yinhua Ni,Mayumi Nagashimada,Fen Zhuge,Lili Zhan,Naoto Nagata,Akemi Tsutsui,Yasuni Nakanuma,Shuichi Kaneko,Tsuguhito Ota　SCIENTIFIC REPORTS　5　5　17192　2015/11　
  • 　Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor　Kumi Kimura,Mamoru Tanida,Naoto Nagata,Yuka Inaba,Hitoshi Watanabe,Mayumi Nagashimada,Tsuguhito Ota,Shun-ichiro Asahara,Yoshiaki Kido,Michihiro Matsumoto,Koji Toshinai,Masamitsu Nakazato,Toshishige Shibamoto,Shuichi Kaneko,Masato Kasuga,Hiroshi Inoue　CELL REPORTS　14　10　2362　2016/03
  • 　LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance.　Fei Lan,Hirofumi Misu,Keita Chikamoto,Hiroaki Takayama,Akihiro Kikuchi,Kensuke Mohri,Noboru Takata,Hiroto Hayashi,Naoto Matsuzawa-Nagata,Yumie Takeshita,Hiroyo Noda,Yukako Matsumoto,Tsuguhito Ota,Toru Nagano,Masatoshi Nakagen,Ken-ichi Miyamoto,Kanako Takatsuki,Toru Seo,Kaito Iwayama,Kunpei Tokuyama,Seiichi Matsugo,Hong Tang,Yoshiro Saito,Satoshi Yamagoe,Shuichi Kaneko,Toshinari Takamura　Diabetes　63　5　1649　2014/05
  • 　LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance　Fei Lan,Hirofumi Misu,Keita Chikamoto,Hiroaki Takayama,Akihiro Kikuchi,Kensuke Mohri,Noboru Takata,Hiroto Hayashi,Naoto Matsuzawa-Nagata,Yumie Takeshita,Hiroyo Noda,Yukako Matsumoto,Tsuguhito Ota,Toru Nagano,Masatoshi Nakagen,Ken-ichi Miyamoto,Kanako Takatsuki,Toru Seo,Kaito Iwayama,Kunpei Tokuyama,Seiichi Matsugo,Hong Tang,Yoshiro Saito,Satoshi Yamagoe,Shuichi Kaneko,Toshinari Takamura　DIABETES　63　5　1649　2014/05
  • 　Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells　Kazuhide Ishikura,Hirofumi Misu,Masafumi Kumazaki,Hiroaki Takayama,Naoto Matsuzawa-Nagata,Natsumi Tajima,Keita Chikamoto,Fei Lan,Hitoshi Ando,Tsuguhito Ota,Masaru Sakurai,Yumie Takeshita,Kenichiro Kato,Akio Fujimura,Ken-ichi Miyamoto,Yoshiro Saito,Satomi Kameo,Yasuo Okamoto,Yoh Takuwa,Kazuhiko Takahashi,Hiroyasu Kidoya,Nobuyuki Takakura,Shuichi Kaneko,Toshinari Takamura　DIABETOLOGIA　57　9　1968　2014/09
  • 　Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B　Jesse Bakke,Ahmed Bettaieb,Naoto Nagata,Kosuke Matsuo,Fawaz G. Haj　CELL COMMUNICATION AND SIGNALING　11　57　2013/08
  • 　Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis　Yuki Kita,Toshinari Takamura,Hirofumi Misu,Tsuguhito Ota,Seiichiro Kurita,Yumie Takeshita,Masafumi Uno,Naoto Matsuzawa-Nagata,Ken-ichiro Kato,Hitoshi Ando,Akio Fujimura,Koji Hayashi,Toru Kimura,Yinhua Ni,Toshiki Otoda,Ken-ichi Miyamoto,Yoh Zen,Yasuni Nakanuma,Shuichi Kaneko　PLOS ONE　7　9　e43056　2012/09　
  • 　Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue　Ahmed Bettaieb,Naoto Nagata,Daniel AbouBechara,Samah Chahed,Christophe Morisseau,Bruce D. Hammock,Fawaz G. Haj　JOURNAL OF BIOLOGICAL CHEMISTRY　288　20　14189　2013/05
  • 　Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation　Ahmed Bettaieb,Jesse Bakke,Naoto Nagata,Kosuke Matsuo,Yannan Xi,Siming Liu,Daniel AbouBechara,Ramzi Melhem,Kimber Stanhope,Bethany Cummings,James Graham,Andrew Bremer,Sheng Zhang,Costas A. Lyssiotis,Zhong-Yin Zhang,Lewis C. Cantley,Peter J. Havel,Fawaz G. Haj　JOURNAL OF BIOLOGICAL CHEMISTRY　288　24　17360　2013/06
  • 　Altered Glucose Homeostasis in Mice with Liver-specific Deletion of Src Homology Phosphatase 2　Kosuke Matsuo,Mirela Delibegovic,Izumi Matsuo,Naoto Nagata,Siming Liu,Ahmed Bettaieb,Yannan Xi,Kazushi Araki,Wentian Yang,Barbara B. Kahn,Benjamin G. Neel,Fawaz G. Haj　JOURNAL OF BIOLOGICAL CHEMISTRY　285　51　39750　2010/12
  • 　Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B　Kosuke Matsuo,Ahmed Bettaieb,Naoto Nagata,Izumi Matsuo,Heike Keilhack,Fawaz G. Haj　PLOS ONE　6　1　e16446　2011/01
  • 　Differential Regulation of Endoplasmic Reticulum Stress by Protein Tyrosine Phosphatase 1B and T Cell Protein Tyrosine Phosphatase　Ahmed Bettaieb,Siming Liu,Yannan Xi,Naoto Nagata,Kosuke Matsuo,Izumi Matsuo,Samah Chahed,Jesse Bakke,Heike Keilhack,Tony Tiganis,Fawaz G. Haj　JOURNAL OF BIOLOGICAL CHEMISTRY　286　11　9225　2011/03
  • 　Adipose-specific deletion of Src homology phosphatase 2 does not significantly alter systemic glucose homeostasis　Ahmed Bettaieb,Kosuke Matsuo,Izumi Matsuo,Naoto Nagata,Samah Chahed,Siming Liu,Fawaz G. Haj　METABOLISM-CLINICAL AND EXPERIMENTAL　60　8　1193　2011/08　
  • 　A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance　Hirofumi Misu,Toshinari Takamura,Hiroaki Takayama,Hiroto Hayashi,Naoto Matsuzawa-Nagata,Seiichiro Kurita,Kazuhide Ishikura,Hitoshi Ando,Yumie Takeshita,Tsuguhito Ota,Masaru Sakurai,Tatsuya Yamashita,Eishiro Mizukoshi,Taro Yamashita,Masao Honda,Ken-ichi Miyamoto,Tetsuya Kubota,Naoto Kubota,Takashi Kadowaki,Han-Jong Kim,In-Kyu Lee,Yasuhiko Minokoshi,Yoshiro Saito,Kazuhiko Takahashi,Yoshihiro Yamada,Nobuyuki Takakura,Shuichi Kaneko　CELL METABOLISM　12　5　483　2010/11
  • 　Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity　Hiromu Katsuda,Mariko Yamashita,Hideyuki Katsura,Jia Yu,Yoshihiro Waki,Naoto Nagata,Yoshimichi Sai,Ken-Ichi Miyamoto　Biological and Pharmaceutical Bulletin　33　11　1867　2010
  • 　The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis　Hitoshi Ando,Toshinari Takamura,Naoto Matsuzawa-Nagata,Kosuke R. Shima,Seiji Nakamura,Masafumi Kumazaki,Seiichiro Kurita,Hirofumi Misu,Naoyuki Togawa,Tatsunobu Fukushima,Akio Fujimura,Shuichi Kaneko　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　380　3　684　2009/03
  • 　Clock gene expression in peripheral leucocytes of patients with type 2 diabetes　H. Ando,T. Takamura,N. Matsuzawa-Nagata,K. R. Shima,T. Eto,H. Misu,M. Shiramoto,T. Tsuru,S. Irie,A. Fujimura,S. Kaneko　DIABETOLOGIA　52　2　329　2009/02
  • 　Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria　Seiji Nakamura,Toshinari Takamura,Naoto Matsuzawa-Nagata,Hiroaki Takayama,Hirofumi Misu,Hiroyo Noda,Satoko Nabemoto,Seiichiro Kurita,Tsuguhito Ota,Hitoshi Ando,Ken-ichi Miyamoto,Shuichi Kaneko　JOURNAL OF BIOLOGICAL CHEMISTRY　284　22　14809　2009/05
  • 　Soybean fat supplementation controls insulin resistance caused by fat-free total parenteral nutrition　Hiroko Ohkawa,Chie Fukuwa,Naoto Matsuzawa-Nagata,Koichi Yokogawa,Kenji Omura,Ken-ichi Miyamoto　JOURNAL OF PHARMACY AND PHARMACOLOGY　60　4　461　2008/04
  • 　Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects　Seiichiro Kurita,Toshinari Takamura,Tsuguhito Ota,Naoto Matsuzawa-Nagata,Yuki Kita,Masafumi Uno,Satoko Nabemoto,Kazuhide Ishikura,Hirofumi Misu,Hitoshi Ando,Yoh Zen,Yasuni Nakanuma,Shuichi Kaneko　EUROPEAN JOURNAL OF PHARMACOLOGY　588　2-3　316　2008/07
  • 　Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients　Toshinari Takamura,Hirofumi Misu,Naoto Matsuzawa-Nagata,Masaru Sakurai,Tsuguhito Ota,Akiko Shimizu,Seiichiro Kurita,Yumie Takeshita,Hitoshi Ando,Masao Honda,Shuichi Kaneko　OBESITY　16　12　2601　2008/12
  • 　Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes　Yurnie Takeshita,Toshinari Takamura,Hitoshi Ando,Erika Hamaguchi,Akiko Takazakura,Naoto Matsuzawa-Nagata,Shuichi Kaneko　EUROPEAN JOURNAL OF PHARMACOLOGY　579　1-3　426　2008/01
  • 　Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells　Masaaki Nomura,Tatsuo Takahashi,Naoto Nagata,Kikue Tsutsumi,Shinjiro Kobayashi,Tetsuo Akiba,Koichi Yokogawa,Shuzo Moritani,Ken-ichi Miyamoto　BIOLOGICAL & PHARMACEUTICAL BULLETIN　31　7　1403　2008/07
  • 　Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line　Akiko Shimizu,Toshinari Takamura,Naoto Matsuzawa,Seiji Nakamura,Satoko Nabemoto,Yurnie Takeshita,Hirofumi Misu,Seiichiro Kurita,Masaru Sakurai,Masayoshi Yokoyama,Yoh Zen,Motoko Sasaki,Yasuni Nakanuma,Shuichi Kaneko　METABOLISM-CLINICAL AND EXPERIMENTAL　56　11　1478　2007/11
  • 　Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes　Toshinari Takamura,Masao Honda,Yoshio Sakai,Hitoshi Ando,Akiko Shimizu,Tsuguhito Ota,Masaru Sakurai,Hirofumi Misu,Seiichiro Kurita,Naoto Matsuzawa-Nagata,Masahiro Uchikata,Seiji Nakamura,Ryo Matoba,Motohiko Tanino,Ken-ichi Matsubara,Shuichi Kaneko　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　361　2　379　2007/09
  • 　Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes　H. Misu,T. Takamura,N. Matsuzawa,A. Shimizu,T. Ota,M. Sakurai,H. Ando,K. Arai,T. Yamashita,M. Honda,T. Yamashita,S. Kaneko　DIABETOLOGIA　50　2　268　2007/02
  • 　Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients　36　4　213　2010/01/01　
  • 　Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts.　Kotomi Miura,Jun-Ichi Morishige,Jotaro Abe,Pingping Xu,Yifan Shi,Zheng Jing,Naoto Nagata,Ryo Miyazaki,Naoki Sakane,Michihiro Mieda,Masanori Ono,Yoshiko Maida,Tomoko Fujiwara,Hiroshi Fujiwara,Hitoshi Ando　Journal of pharmacological sciences　153　4　215　2023/12
  • 　Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice.　Guanliang Chen,Yanwen Yu,Yuqin Zhu,Mayumi Nagashimada,Yajiao Wang,Naoto Nagata,Liang Xu　Endocrinology　165　7　2024/05/27

Conference Presentations

  • Glucoraphanin has the therapeutic potential of resolving hepatic steatosis in a murine model of diet-induced obesity(conference：IDF2021)(2021/12/07)
  • Nrf2 activation by glucoraphanin alleviates high-fat diet-induced obesity and insulin resistance through adipose tissue browning.(conference：Environmental Response V)(2019/09/12)
  • Down-regulation of Ptpn11 in myeloid cells mitigates diet-induced steatohepatitis in mice (conference：Workshop on Frontiers in Phosphatase Research and Drug Discovery)(2018/10/23)
  • Down-regulation of Ptpn11 in myeloid cells mitigates hepatic fibrosis in mice fed a CDAA diet(conference：The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase)(2017/11/18)
  • Sulforaphane-mediated Nrf2 activation ameliorates obesity and fatty liver disease in obese mice(conference：ConBio2017)(2017/12/09)

show all

  • Nrf2 activation improves high fat diet-induced inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status in liver(conference：ADA76th Scientific Session)(2016/06)
  • Broccoli sprouts improve high fat diet-induced inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status in liver(conference：ACN2015)(2015/05)
  • Lycopene Attenuates the Inflammatory Adipose Tissue Response to High Fat Feeding by Regulating both Macrophage Recruitment and M1/M2 Status(conference：ADA74th Scientific Session)(2014/06)
  • Astaxanthin ameliorates hepatic insulin resistance and inhibits the progression of lipotoxic model of nonalcoholic steatohepatitis(conference：IDF2013)(2013/12)
  • 抗アレルギー薬トラニラストはラットNASHモデルのマクロファージ活性化と肝病理進展を阻止する(conference：肝臓)(2008/04/30)
  • 小児における抗真菌剤ボリコナゾールの体内動態(conference：日本医療薬学会年会講演要旨集)(2008/09/01)
  • 活性酸素種産生遺伝子の発現上昇は,肥満・インスリン抵抗性の発症に先行する(conference：日本薬学会年会要旨集)(2008/03/05)
  • 乳酸菌S‐PT84株は腸管透過性を保持し,肝臓M2マクロファージを増加させ,NASHの進展を抑止する(conference：糖尿病(Web))(2017)
  • Sulforaphane-mediated Nrf2 activation ameliorates obesity and fatty liver disease in obese mice(conference：ConBio2017)(2017/12/09)
  • Down-regulation of Ptpn11 in myeloid cells mitigates hepatic fibrosis in mice fed a CDAA diet(conference：3rd Japan-Taiwan protein phosphatase meeting)(2017/11/19)
  • スルフォラファンによる転写因子Nrf2活性化を介したエネルギー代謝調節機構の検討(conference：日本栄養・食糧学会大会講演要旨集)(2017/04/28)
  • 3T3‐L1成熟脂肪細胞の脂質代謝に及ぼすSalacia reticulataエキスの効果(conference：日本薬学会年会要旨集)(2010/03/05)
  • Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients(conference：医療薬学)(2010/04/10)
  • カロテノイドによる自然免疫への作用と非アルコール性脂肪肝炎の進展抑止(conference：日本内分泌学会雑誌)(2015/04/01)
  • 抗酸化素材アスタキサンチンは肝インスリン抵抗性を改善し,lipotoxic NASHモデルの進展を抑止する(conference：糖尿病合併症)(2013/08/20)
  • 小細胞肺癌の腫瘍形成および血管新生亢進におけるbFGFの関与(conference：日本薬学会年会要旨集)(2010/03/05)
  • 肥満形成・脂肪肝・慢性炎症に与えるSGLT2阻害薬のインパクト~高脂肪食モデルによる検討から~(conference：糖尿病(Web))(2016)
  • Lycopene Attenuates the Inflammatory Adipose Tissue Response to High Fat Feeding by Regulating both Macrophage Recruitment and M1/M2 Status(conference：ADA74th Scientific Session)(2014/06)
  • Nrf2 activation by glucoraphanin alleviates obesity and insulin resistance through increased energy expenditure and alternative activation of macrophage.(conference：Keystone Symposia Conference G1: New Therapeutics for Diabetes and Obesity)(2016/04/17)
  • Glucoraphanin-mediated Nrf2 activation reduces obesity and insulin resistance by increasing energy expenditure and limiting endotoxemia-related chronic inflammation.(conference：EASD2016)(2016/09/12)
  • Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarising M2 macrophages in mice (2017/09/15)
  • Empagliflozin promotes fat browning and attenuates chronic inflammation in obesity (2017/10/07)
  • Empagliflozin promotes fat utilization and attenuates insulin resistance by polarizing M2 macrophages in obese mice (conference：2017 international diabetes federation (IDF) Abu Dhabi )(2017/12/05)
  • Pirfenidone reduces lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice (2017/05/20)
  • Dipeptidyl peptidase-4 inhibitor anagliptin alleviates lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice (conference：American Diabetes Association’s 77th Scientific Sessions)(2017/06/11)
  • Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages in mice (conference：American Diabetes Association’s 77th Scientific Sessions)(2017/06/11)
  • Pirfenidone reduces lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice (2017/05/20)
  • Empagliflozin attenuates adiposity and insulin resistance by promoting fat utilization and polarizing M2 macrophages (2017/05/18)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「酸化ストレス応答転写因子Nrf2によるエネルギー代謝調節機構の解明」(2018-2021)　
○「ブロッコリースプラウト抽出物による炎症制御及びエネルギー代謝調節機構の解明」(2015-2017)　
○「タンパク質チロシンフォスファターゼShp2による炎症制御機構の解明」(2013-2014)　
○「脂肪肝炎の新規治療法の開発－酪酸菌のプロバイオティクス効果の検討 」(2008-2010)　
○「Nrf2による腸管からの脂肪吸収抑制機構の解明と肥満治療への応用に向けた基礎研究」(2022-2024)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Academic Skills(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅡＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＤ(2022)
○Special Excercise in Medical and Pharmaceutical Sciences(2022)
○English in Medical and Pharmaceutical Sciences 1(2022)
○Basic Practice for Medical and Pharmaceutical Sciences(2022)
○Pharmacology(2022)
○Academic Skills(2021)
○Pharmacology(2021)
○Pharmacology(2020)
○Pharmacology(2019)
○Pharmacology(2018)
○Pharmacology(2017)
○Pharmacology(2016)

Classes (Graduate Schools)

○Molecular Function Analysis(2022)
○Molecular Function Analysis(2021)
○Molecular Function Analysis(2020)
○Molecular Function Analysis(2020)
○The Human Body in Health and Disease Curriculum 4(2020)
○The Human Body in Health and Disease Curriculum 3(2020)
○Molecular Function Analysis(2019)
○Molecular Function Analysis(2019)
○The Human Body in Health and Disease Curriculum 3(2018)
○The Human Body in Health and Disease Curriculum 3(2018)
○Molecular Function Analysis(2018)
○Molecular Function Analysis(2017)
○Molecular Function Analysis(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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