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last modified：2025/04/02
Associate Professor MASUO, Yusuke
Faculty, Affiliation
Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
TEL:076-264-6302
Academic Background
Career
Kanazawa University(2021/07/01-)
National Cancer Institute, National Institute of Health(2015/01/01-2015/12/31)
Kanazawa University(2013/04/01-2021/06/30)
Year & Month of Birth
1986/01
Academic Society
Award
Specialities
Medical pharmacy
Speciality Keywords
Research Themes
Books
Papers
- TrkB phosphorylation in serum extracellular vesicles correlates with cognitive function enhanced by ergothioneine in humans. Takahiro Ishimoto,Reiya Yamashita,Ruri Matsumoto,Satoshi Matsumoto,Yusuke Matsuo,Shunsuke Nakao,Yusuke Masuo,Makoto Suzuki,Yukio Kato NPJ science of food 8 1 11 2024/02/06
- The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset. Masato Yoshihara,Shigehiko Mizutani,Kunio Matsumoto,Yukio Kato,Yusuke Masuo,Arita Harumasa,Shohei Iyoshi,Sho Tano,Hidesuke Mizutani,Tomomi Kotani,Eita Mizutani,Kiyosumi Shibata,Hiroaki Kajiyama European journal of obstetrics & gynecology and reproductive biology: X 19 100210 2023/09
- l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis. Gyujin Park,Kazuya Fukasawa,Tetsuhiro Horie,Yusuke Masuo,Yuka Inaba,Takanori Tatsuno,Takanori Yamada,Kazuya Tokumura,Sayuki Iwahashi,Takashi Iezaki,Katsuyuki Kaneda,Yukio Kato,Yasuhito Ishigaki,Michihiro Mieda,Tomohiro Tanaka,Kazuma Ogawa,Hiroki Ochi,Shingo Sato,Yun-Bo Shi,Hiroshi Inoue,Hojoon Lee,Eiichi Hinoi JCI insight 8 7 2023/04/10
- Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice. Aya Hasan Alshammari,Yusuke Masuo,Shotaro Yoshino,Reiya Yamashita,Takahiro Ishimoto,Ken-Ichi Fujita,Yukio Kato Drug metabolism and pharmacokinetics 49 100483 2023/04
- A physiologically based pharmacokinetic and pharmacodynamic model for disposition of FF-10832. Takeshi Matsumoto,Yusuke Masuo,Anna Tanaka,Toshifumi Kimura,Tadaaki Ioroi,Tatsuya Yamakawa,Hiromu Kitahara,Yukio Kato International journal of pharmaceutics 627 122250 2022/11/05
- Crosstalk between foetal vasoactive peptide hormones and placental aminopeptidases regulates placental blood flow: Its significance in preeclampsia. Masato Yoshihara,Shigehiko Mizutani,Kunio Matsumoto,Yukio Kato,Yusuke Masuo,Sho Tano,Hidesuke Mizutani,Tomomi Kotani,Eita Mizutani,Kiyosumi Shibata,Hiroaki Kajiyama Placenta 121 32 2022/04
- Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition. Aya Hasan Alshammari,Yusuke Masuo,Ken-Ichi Fujita,Kazuhiro Shimada,Noriho Iida,Tomohiko Wakayama,Yukio Kato Biochemical pharmacology 197 114914 2022/03
- Identification of Food-Derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins. Rina Agustina,Yusuke Masuo,Yasuto Kido,Kyosuke Shinoda,Takahiro Ishimoto,Yukio Kato Drug metabolism and disposition: the biological fate of chemicals 49 11 972 2021/11
- Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis. Noriho Iida,Eishiro Mizukoshi,Tatsuya Yamashita,Masahiro Yutani,Jun Seishima,Ziyu Wang,Kuniaki Arai,Hikari Okada,Taro Yamashita,Yoshio Sakai,Yusuke Masuo,Rina Agustina,Yukio Kato,Yukako Fujinaga,Masanobu Oshima,Masao Honda,François Lebreton,Michael S Gilmore,Shuichi Kaneko Nature cancer 2 10 1039 2021/10
- Effects of Probenecid on Hepatic and Renal Disposition of Hexadecanedioate, an Endogenous Substrate of Organic Anion Transporting Polypeptide 1B in Rats. Azusa Futatsugi,Yusuke Masuo,Yukio Kato Journal of pharmaceutical sciences 110 5 2274 2021/05
- 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients. Yusuke Masuo,Ken-Ichi Fujita,Kenji Mishiro,Natsumi Seba,Tatsuya Kogi,Hidenori Okumura,Natsumi Matsumoto,Munetaka Kunishima,Yukio Kato Drug metabolism and pharmacokinetics 35 6 555 2020/12
- Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice. Misa Nishiyama,Noritaka Nakamichi,Tomoyuki Yoshimura,Yusuke Masuo,Tomoe Komori,Takahiro Ishimoto,Jun-Ichi Matsuo,Yukio Kato Neurochemical research 45 11 2664 2020/11
- Static Model-Based Assessment of OATP1B1-Mediated Drug Interactions with Preincubation-Dependent Inhibitors Based on Inactivation and Recovery Kinetics. Takayuki Taguchi,Yusuke Masuo,Azusa Futatsugi,Yukio Kato Drug metabolism and disposition: the biological fate of chemicals 48 9 750 2020/09
- Oral administration of the food derived hydrophilic antioxidant ergothioneine enhances object recognition memory in mice. Noritaka Nakamichi,Shunsuke Nakao,Misa Nishiyama,Yuka Takeda,Takahiro Ishimoto,Yusuke Masuo,Satoshi Matsumoto,Makoto Suzuki,Yukio Kato Current molecular pharmacology 2020/02/11
- Higher Systemic Exposure to Unbound Active Metabolites of Regorafenib Is Associated With Short Progression-Free Survival in Colorectal Cancer Patients. Yutaro Kubota,Ken-Ichi Fujita,Takehiro Takahashi,Yu Sunakawa,Hiroo Ishida,Kazuyuki Hamada,Wataru Ichikawa,Takuya Tsunoda,Kazuhiro Shimada,Yusuke Masuo,Yukio Kato,Yasutsuna Sasaki Clinical pharmacology and therapeutics 2020/02/08
- Short-lasting inhibition of hepatic uptake transporter OATP1B1 by tyrosine kinase inhibitor pazopanib. Takayuki Taguchi,Yusuke Masuo,Yoshiyuki Sakai,Yukio Kato Drug metabolism and pharmacokinetics 34 6 372 2019/12
- Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein. Naoto Hashimoto,Noritaka Nakamichi,Hikari Nanmo,Kei-Ichi Kimura,Yusuke Masuo,Yasuyuki Sakai,Alfred H Schinkel,Shinichi Sato,Tomoyoshi Soga,Yukio Kato Pharmaceutical research 36 11 158 2019/09/11
- Maturational Characterization of Mouse Cortical Neurons Three-Dimensionally Cultured in Functional Polymer FP001-Containing Medium. Noritaka Nakamichi,Yuta Matsumoto,Takumi Kawanishi,Takahiro Ishimoto,Yusuke Masuo,Masato Horikawa,Yukio Kato Biological & pharmaceutical bulletin 42 9 1545 2019
- Bile Duct Obstruction Leads to Increased Intestinal Expression of Breast Cancer Resistance Protein With Reduced Gastrointestinal Absorption of Imatinib. Takumi Kawanishi,Hiroshi Arakawa,Yusuke Masuo,Noritaka Nakamichi,Yukio Kato Journal of pharmaceutical sciences 108 9 3130 2019/09
- Hydrolyzed Salmon Milt Extract Enhances Object Recognition and Location Memory Through an Increase in Hippocampal Cytidine Nucleoside Levels in Normal Mice. Noritaka Nakamichi,Shunsuke Nakao,Yusuke Masuo,Ayaka Koike,Naoto Matsumura,Misa Nishiyama,Aya Hasan Al-Shammari,Hirotaka Sekiguchi,Keita Sutoh,Koji Usumi,Yukio Kato Journal of medicinal food 22 4 408 2019/04
- Pazopanib interacts with irinotecan by inhibiting UGT1A1-mediated glucuronidation, but not OATP1B1-mediated hepatic uptake, of an active metabolite SN-38. Mariko Iwase,Ken-Ichi Fujita,Yuki Nishimura,Natsumi Seba,Yusuke Masuo,Hiroo Ishida,Yukio Kato,Yuji Kiuchi Cancer chemotherapy and pharmacology 83 5 993 2019/05
- Influx and Efflux Transporters Contribute to the Increased Dermal Exposure to Active Metabolite of Regorafenib After Repeated Oral Administration in Mice. Aya Hasan Al-Shammari,Yusuke Masuo,Ken-Ichi Fujita,Yuka Yoshikawa,Noritaka Nakamichi,Yutaro Kubota,Yasutsuna Sasaki,Yukio Kato Journal of pharmaceutical sciences 108 6 2173 2019/06
- Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells. Takahiro Ishimoto,Yusuke Masuo,Yukio Kato,Noritaka Nakamichi Cellular signalling 53 269 2019/01
- Combination Metabolomics Approach for Identifying Endogenous Substrates of Carnitine/Organic Cation Transporter OCTN1. Yusuke Masuo,Yuri Ohba,Kohei Yamada,Aya Hasan Al-Shammari,Natsumi Seba,Noritaka Nakamichi,Takuo Ogihara,Munetaka Kunishima,Yukio Kato Pharmaceutical research 35 11 224 2018/10/02
- Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib. Waleed Elsayed Ahmed Ellawatty,Yusuke Masuo,Ken-Ichi Fujita,Erina Yamazaki,Hiroo Ishida,Hiroshi Arakawa,Noritaka Nakamichi,Ramadan Abdelwahed,Yasutsuna Sasaki,Yukio Kato Drug metabolism and disposition: the biological fate of chemicals 46 1 33 2018/01
- Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells. Takahiro Ishimoto,Noritaka Nakamichi,Hikari Nishijima,Yusuke Masuo,Yukio Kato Neurochemical research 43 1 116 2018/01
- Editor's Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway. Shogo Takahashi,Naoki Tanaka,Srujana Golla,Tatsuki Fukami,Kristopher W Krausz,Marianne A Polunas,Blair C Weig,Yusuke Masuo,Cen Xie,Changtao Jiang,Frank J Gonzalez Toxicological sciences : an official journal of the Society of Toxicology 158 2 334 2017/08/01
- Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites. Ken-Ichi Fujita,Yusuke Masuo,Erina Yamazaki,Toshiki Shibutani,Yutaro Kubota,Noritaka Nakamichi,Yasutsuna Sasaki,Yukio Kato Journal of pharmaceutical sciences 106 9 2632 2017/09
- VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body. Hideaki Yamamoto,Tappei Takada,Yoshihide Yamanashi,Masatsune Ogura,Yusuke Masuo,Mariko Harada-Shiba,Hiroshi Suzuki Scientific reports 7 1 633 2017/04/04
- Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans. Yusuke Masuo,Shushi Nagamori,Aoi Hasegawa,Kazuki Hayashi,Noriyoshi Isozumi,Noritaka Nakamichi,Yoshikatsu Kanai,Yukio Kato Pharmaceutical research 34 6 1233 2017/06
- P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids. Naoto Hashimoto,Noritaka Nakamichi,Erina Yamazaki,Masashi Oikawa,Yusuke Masuo,Alfred H Schinkel,Yukio Kato International journal of pharmaceutics 521 1-2 365 2017/04/15
- Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy. Tarek Kamal Abouzed,Seiichi Munesue,Ai Harashima,Yusuke Masuo,Yukio Kato,Khaled Khailo,Hiroshi Yamamoto,Yasuhiko Yamamoto Journal of diabetes research 2016 1786789 2016
- Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity. Noritaka Nakamichi,Takahiro Ishimoto,Yoshihide Yamauchi,Yusuke Masuo,Yukio Kato Biological & pharmaceutical bulletin 39 10 1638 2016
- Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. Shogo Takahashi,Tatsuki Fukami,Yusuke Masuo,Chad N Brocker,Cen Xie,Kristopher W Krausz,C Roland Wolf,Colin J Henderson,Frank J Gonzalez Journal of lipid research 57 12 2130 2016/12
- L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides. Azusa Futatsugi,Yusuke Masuo,Shiori Kawabata,Noritaka Nakamichi,Yukio Kato The Journal of pharmacy and pharmacology 68 9 1160 2016/09
- Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro-In Vivo Discrepancy in Its Drug Interaction Potential in Rats. Takayuki Taguchi,Yusuke Masuo,Tatsuya Kogi,Noritaka Nakamichi,Yukio Kato Journal of pharmaceutical sciences 105 7 2231 2016/07
- Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice. Noritaka Nakamichi,Keigo Nakayama,Takahiro Ishimoto,Yusuke Masuo,Tomohiko Wakayama,Hirotaka Sekiguchi,Keita Sutoh,Koji Usumi,Shoichi Iseki,Yukio Kato Brain and behavior 6 6 e00477 2016/06
- Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis. Yaliang Tang,Yusuke Masuo,Yoshio Sakai,Tomohiko Wakayama,Tomoko Sugiura,Ryuichi Harada,Azusa Futatsugi,Takuya Komura,Noritaka Nakamichi,Hirotaka Sekiguchi,Keita Sutoh,Koji Usumi,Shoichi Iseki,Shuichi Kaneko,Yukio Kato Journal of pharmaceutical sciences 105 5 1779 2016/05
- Increased Plasma Concentrations of Unbound SN-38, the Active Metabolite of Irinotecan, in Cancer Patients with Severe Renal Failure. Ken-ichi Fujita,Yusuke Masuo,Hidenori Okumura,Yusuke Watanabe,Hiromichi Suzuki,Yu Sunakawa,Ken Shimada,Kaori Kawara,Yuko Akiyama,Masanori Kitamura,Munetaka Kunishima,Yasutsuna Sasaki,Yukio Kato Pharmaceutical research 33 2 269 2016/02
- Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice. Takuya Shimizu,Yusuke Masuo,Saki Takahashi,Noritaka Nakamichi,Yukio Kato Drug metabolism and pharmacokinetics 30 3 231 2015/06
- Gene ablation of carnitine/organic cation transporter 1 reduces gastrointestinal absorption of 5-aminosalicylate in mice. Takuya Shimizu,Ai Kijima,Yusuke Masuo,Takahiro Ishimoto,Tomoko Sugiura,Saki Takahashi,Noritaka Nakamichi,Yukio Kato Biological & pharmaceutical bulletin 38 5 774 2015
- NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy. Tappei Takada,Yoshihide Yamanashi,Kentaro Konishi,Takehito Yamamoto,Yu Toyoda,Yusuke Masuo,Hideaki Yamamoto,Hiroshi Suzuki Science translational medicine 7 275 275ra23 2015/02/18
- Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons. Takahiro Ishimoto,Noritaka Nakamichi,Hiroshi Hosotani,Yusuke Masuo,Tomoko Sugiura,Yukio Kato PloS one 9 2 e89434 2014
- Interaction of novel platelet-increasing agent eltrombopag with rosuvastatin via breast cancer resistance protein in humans. Kazuya Takeuchi,Tomoko Sugiura,Kazuki Matsubara,Ren Sato,Takuya Shimizu,Yusuke Masuo,Masato Horikawa,Noritaka Nakamichi,Norihisa Ishiwata,Yukio Kato Drug metabolism and disposition: the biological fate of chemicals 42 4 726 2014/04
- Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide. Yusuke Masuo,Kousei Ito,Takehito Yamamoto,Akihiro Hisaka,Masashi Honma,Hiroshi Suzuki Drug metabolism and disposition: the biological fate of chemicals 38 10 1828 2010/10
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「肝排出輸送体による活性代謝物輸送解析と機械学習メタボロミクスによる生体内基質探索」(2021-2023)
○「選択的メタボロミクスによる有機カチオン膜輸送体の生体内基質同定と生理的機能の解明」(2018-2020)
○「慢性腎障害患者での肝輸送体OATP機能低下の機序と血漿中薬物濃度変化の定量的予測」(2014-2015)
○「慢性腎障害時の肝膜輸送体・薬物代謝酵素の系統的な活性変動の解析と予測法開発」(2016-)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Drug Therapeutics 2(2023)
○Basic Anatomy(2023)
○Exercise of Therapeutic Drug Monitoring(2023)
○Experiments in Pharmaceutical Practice 3(2023)
○Seminar in Pharmaceutical Practice(2023)
○Clinical Pharmacy Practice(2023)
○Basic Anatomy(2022)
○Seminar in Pharmaceutical Practice(2022)
○Experiments in Pharmaceutical Practice 3(2022)
○Drug Therapeutics 2(2022)
○Seminar in Drug Therapeutics(2022)
○Exercise of Therapeutic Drug Monitoring(2022)
○Seminar in Pharmaceutical Practice(2021)
○Experiments in Pharmaceutical Practice 3(2021)
○Clinical Pharmacy Practice(2021)
○Drug Therapeutics 2(2021)
○Drug Therapeutics 2(2020)
○Experiments in Pharmaceutical Practice 3(2020)
○Seminar in Pharmaceutical Practice(2020)
○Seminar in Drug Therapeutics(2020)
○Clinical Pharmacy Practice(2020)
○Drug Therapeutics 2(2019)
○Experiments in Pharmaceutical Practice 3(2019)
○Clinical Pharmacy Practice(2019)
○Freshman Seminar I(2019)
○Drug Therapeutics 2(2018)
○Experiments in Pharmaceutical Practice 3(2018)
○Clinical Pharmacy Practice(2018)
○Experiments in Pharmaceutical Practice 3(2017)
○Experiments in Pharmaceutical Practice 3(2016)
○Freshman Seminar I(2016)
Classes (Graduate Schools)
○Experimental Techniques in Precision Medicine Research(2023)
○Experimental Techniques in Precision Medicine Research(2022)
○Advanced Course of Pharmacological Studies for Drug Development(2021)