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Researcher Information

last modified：2024/12/03

Professor　Goto, Noriko

Mail Laboratory Website
Laboratory Website
Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medicine, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering

Laboratory

　TEL:076-264-6731

Academic Background

Career

Year & Month of Birth

Academic Society







Award

Specialities

Pathological medical chemistry、Tumor biology

Speciality Keywords

caner stem cell, tumor microenvironment, breast cancer, lung cancer, signal transduction, receptor tyrosine kinase, adaptor protein, molecular target, patient-derived xenograft (PDX), cancer mouse model

Research Themes

Books

  • 　Gotoh, N　Encyclopedia of Signaling Molecules, 2rd Edition　Springer　2017
  • 　Gotoh N and Tsuchida N　Encyclopedia of Cancer, 3rd Edition　Springer　2016
  • 　後藤典子　がんにおける遺伝子発現ネットワーク解析　医歯薬出版　2014
  • 　EGF受容体のシグナル伝達。　29
  • 　チロシン、セリンリン酸化部位を認識するドメイン。　2537　2000

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  • 　EGF受容体などの受容体型チロシンキナーゼ。　314
  • 　後藤典子　受容体型チロシンキナーゼErbBと転写因子NF-κBによる乳癌幹細胞維持の分子機構　羊土社　2012/09
  • 　後藤典子,佐谷秀行　がん幹細胞研究の歴史および治療への展望　羊土社　2015
  • 　後藤典子　増殖因子による乳がん幹細胞制御の分子機構　Cytometory Research　2013
  • 　GOTOH Noriko　Possible signaling pathways in cancer stem cells in breast cancer.　In: Cancer Stem Cells Theories and Practice, Chapter 13, Nikolic, A. (Ed.), INTECH, NY, USA,　2011
  • 　Gotoh, N　FRS2.　Encyclopedia of Signaling Molecules, 2rd Edition, Springer, Heidelberg, Germany　2017
  • 　後藤典子　がん幹細胞におけるシグナルと可塑性のシステム的解析　羊土社　2013
  • 　村山貴彦,後藤典子　がん関連線維芽細胞によるがん幹細胞制御機構　Cytometry Research　2019
  • 　西村建徳,東條有伸,後藤典子　MTHFD2の酵素活性阻害によるがん治療　北隆館　2020/01
  • 　松尾勳,後藤典子　FGFシグナルの新たな制御機構　羊土社　2012/04
  • 　西村建徳,後藤典子　One-carbon metabolism　羊土社　2017
  • 　富永香菜,後藤典子　乳癌の癌幹細胞　メディカルレビュー社　2015
  • 　村山貴彦,後藤典子　乳がんの治療抵抗性のメカニズムとPDXモデル　ニューサイエンス社　2017
  • 　Gotoh N,Tsuchida N　Membrane-linked docking protein.　Encyclopedia of Cancer, 3rd Edition, Springer, Heidelberg, Germany　2016
  • 　後藤典子　カラー図説：がん幹細胞研究とシステム生物学　日本臨床社　2015
  • 　アポトーシスに関連する癌遺伝子と癌抑制遺伝子。　47
  • 　Gotoh, N　FRS2. In　Encyclopedia of Signaling Molecules. Springer, Heidelberg, Germany　2011
  • 　SH2, SH3ドメインとシグナル複合体。　1882　1887
  • 　チロシンキナーゼ型受容体。　21
  • 　後藤典子　がん幹細胞の研究と治療への応用　がん分子標的治療　2014
  • 　後藤典子　乳がん幹細胞とニッチの増殖因子シグナル　羊土社　2015
  • 　後藤典子　「EGF受容体」「FGF受容体」「HER2」　羊土社　2015/03
  • 　富永香菜,後藤典子　浸潤性粘液腺がん発症メカニズム　ニューサイエンス社　2017
  • 　村山貴彦,後藤典子　乳癌などのオルガノイド培養　羊土社　2019/07
  • 　チロシンリン酸化ペプチドを認識するドメイン構造。　13
  • 　西村建徳,Chen Xiaoxi,後藤典子　乳腺オルガノイド　羊土社　2018
  • 　村山貴彦,後藤典子　がん幹細胞を維持する細胞内シグナル伝達系　文光堂　2018

Papers

  • 　Drug resistant mechanisms of cancer stem-like cells and their therapeutic potential as drug targets　Murayama T, Gotoh N　Cancer Drug Resist　2　457-470　2019
  • 　Feedback inhibitors of epidermal growth factor receptor signaling pathways　Gotoh, N　Int. J. Biochem. Cell Biol.　41　511-515　2009
  • 　Patient-derived xenograft models of breast cancer and their application.　Murayama T, Gotoh N　Cells　8　6　E621　2019
  • 　Elucidation of breast cancer tissue diversity by comprehensive analysis of minimum unit omics. 　Gotoh N.　Impact,　2019　3　30-32　2019
  • 　Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.　Tominaga K, Minato H, Murayama T, Sasahara A, Nishimura T, Kiyokawa E, Kanauchi H, Shimizu S, Sato A, Nishioka K, Tsuji E, Yano M, Ogawa T, Ishii H, Mori M, Akashi K, Okamoto K, Tanabe M, Tada K, Tojo A, Gotoh N　Proc Natl Acad Sci, USA　116　2　625-630　2019

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  • 　Cancer stem-like properties and gefitinib-resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2　Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike S-I, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N　Oncogene,　38　14　2464-2481　2019
  • 　Polyamine flux suppresses histone lysine demethylases and enhances ID1 gene expression in cancer stem cells. 　Tamari K, Konno M, Asai A, Koseki J, Hayashi K, Kawamoto K, Murai N, Matsufuji S, Isohashi F, Satoh T, Goto N, Tanaka S, Doki Y, Mori M, Ogawa K, Ishii H　Cell Death Diifer　4　1-9　2018
  • 　Drug discovery of anti-cancer drugs targeting methylenetetrahydrofolage dehydrogenease 2. 　Asai A, Koseki J, Konno M, Nishimura T, Gotoh N, Satoh T, Doki Y, Mori M, Ishii H　Helion　4　e01021　2018
  • 　Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis　Garg A, Bansal M, Gotoh N, Feng G-S, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X.　PLoS Genet,　13　e1007047　2017
  • 　Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer　Yamamoto M, Sakane K, Tominaga K, Gotoh N, Niwa T, Kikuchi Y, Tada K, Goshima N, Semba K, Inoue J-I　Cancer Sci,　108　1210-1222　2017
  • 　The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. 　Kitajima S, Yoshida A, Kohno S, Suzuki S, Nagatani N, Li F, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Thai T, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M, Barbie D, Hirose O, Tanaka T, Takahashi C　Oncogene,　26　5145-5157　2017
  • 　FRS2　Gotoh, N　Encyclopedia of Signaling Molecules, 2rd Edition　2017
  • 　An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells.　Sasahara A, Tominga K, Nishimura T,Yano M, Kiyokawa E, Noguchi Miki, Noguchi Masakuni, Kanauchi H, Ogawa T, Minato H, Tada K, Seto Y, Tojo A, Gotoh N　Oncotarget,　8　24869-24881　2017
  • 　Long-term inflammation transforms intestinal epithelial cells of colonic organoids　Hibiya S, Tsuchiya K, Hayashi R, Fukushima K, Horita N, Nishimura T, Gotoh N, Okamoto R, Nakamura T and Watanabe M　J Crohns Colitis　11　621-630　2017
  • 　Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. 　Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji E, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada K, Ogawa T, Tojo A, Miyano S, Gotoh N.　Oncogene,　36　1276-1286　2017
  • 　Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer　Miyo M, Konno M, Nishida N, Sueda T, Noguchi K, Matsui H, Colvin H, Kawamoto K, Koseki J, Haraguchi N, Nishimura J, Hata T, Gotoh N, Matsuda F, Satoh T, Mizushima T, Shimizu H, Doki Y, Mori M, Ishii H　Sci Rep,　6　38415　2016
  • 　Intrinsic resistance to 5-Fluorouracil in a brain metastatic variant of human breast cancer cell line, MDA-MB-231BR　Sagara A, Igarashi K, Otsuka M, Karasawa T, Gotoh N, Narita M, Kuzumaki N, Narita M, Kato Y　PLoS One,　11　e0164250　2016
  • 　Intra-bone fibroblasts promote breast cancer bone metastasis by producing connective tissue growth factor/CCN2 under the influence of cancer cell-derived chemokine, CCL4　Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, Mukaida N　Cancer Lett,　378　23-32　2016
  • 　Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit,　Murayama T, Nakaoku T, Enari T, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T, Gotoh N　Cancer Res.　76　974-983　2016
  • 　Membrane-linked docking protein　Gotoh N and Tsuchida N　Encyclopedia of Cancer, 3rd Edition　2016
  • 　Cyclin G2: A novel independent prognostic marker in pancreatic cancer. 　Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Nishida N, Koseki J, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H　Oncol Lett,　10　2986-2990　2015
  • 　Pyruvate Kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells　Konno M, Ishii H, Koseki J, Tanuma N, Nishida N, Kawamoto K, Nishimura T, Nakata A, Matsui H, Noguchi K, Ozaki M, Noguchi Y, Shima H, Gotoh N, Nagano H, Doki Y, Mori M　Regenerative Therap　1　63-71　2015
  • 　A novel serum 4-microRNA signature for lung cancer detection.　Nadal E, Truini A, Nakata A, Lin J, Reddy RM, Chang A, Ramnath N, Gotoh N, Beer DG, Chen G:　Sci Rep　5　12464　2015
  • 　Embryonic MicroRNA-369 controls metabolic splicing factors and urges cellular reprogramming　Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi DL, Ozaki M, Noguchi Y, Mimori K, Gotoh N, Tanuma N, Shima H, Doki Y, Mori M, Ishii H　PLoS One,　10　e0132789　2015
  • 　Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. 　Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H　PLoS One,　10　e0127119　2015
  • 　MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer　Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H.　Br J Cancer,　111　1572-80　2014
  • 　Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma　Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S　Neuro. Oncol　16　960-70　2014
  • 　FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.　Ono K, Kita T, Sato S, O’Neill P, Mak S-S., Paschaki M, It, M, Gotoh, N, Kawakami K, Ladher RK　PLOS Genetics　10　e1004118　2014
  • 　Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development　Li H, Ta, C, Cai Z., Hertzler-Schaefer K, Collins TN, Wang F, Feng G-S, Gotoh N, Zhang X　J. Cell Sci　127　571-582　2014
  • 　The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell.　Shima T, Miyamoto T, Kikushige Y, Yoda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K.　Exp Hematol, 　42　955-965,　2014
  • 　Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition　Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, Yamamoto H, Doki Y, Mori M, Ishii H　Proc. Natl. Acad. Sci., USA　111　15526-31　2014
  • 　Effect of in vivo administration of reprogramming factors in the mouse liver.　Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohara K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashji S, Tanemura M, Doki Y, Mor, M, Ishii H, Nagano H　Oncol. Lett.　6　323-328　2013
  • 　Protooncogene TCL1b functions as an Akt kinase co-activator which exhibits oncogenic potency in vivo　Hashimoto M, Suizu F, Tokuyama W., Noguchi H, Hirata N, Matsuda-Lennikov M, Masuzawa M, Gotoh, N, Tanaka S. & Noguchi M　Oncogenesis　2　e70　2013
  • 　Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma.　Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F. & Zhang X　Development,　140　2711-2723　2013
  • 　An adaptor protein complex of FRS2beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.　Minegishi Y, Shibagaki Y, Mizutani A, Fujita F, Tezuka T, Kinoshita M, Kuroda M, Hattori S. & Gotoh N　Cancer Sci.　104　345-352　2013
  • 　Elevated beta-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs　Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama K, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N.　Sci Rep　5　13076　2015
  • 　Growth factor signaling regulates breast cancer stem cells. In Practical molecular target for suppression of cancer　Gotoh N　Publication in Forum on Immunopathological Diseases and Therapeutics　4　2013
  • 　The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein　Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R., Nakamura T. & Watanabe M　Biochem. Biophys. Res. Commun　432　175-181　2013
  • 　Systemically injected exosomes targeted to EGFR deliver anti-tumor microRNA to breast cancer cells.　Ohno, S., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A, Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., Gotoh, N. & Kuroda, M.　Molecular Therapy　21　185-191　2012
  • 　EGFR-targeted liposome for molecular imaging and therapy on NSCLC cells. 　Yokoyama T, Osato Y, Miyazawa K, Kiyasato A, Hayabe H, Nomura M, Gotoh N, Itoi T, Tauchi T, Ikeda N & Ohyashiki K　Cancer Res.　72　2904　2012
  • 　Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma　Yamauchi, M., Yamaguchi, R., Nakata, A., Kohno, T., Nagasaki, M., Shimamura, T., Imoto S., Saito A., Ueno, K., Hatanaka, Y., Yoshida, R., Higuchi, T., Nomura, M., Beer, D.G., Yokota, J., Miyano, S. & Gotoh, N　PLoS ONE,　7　e43923　2012
  • 　Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer.　Nakata, A. & Gotoh, N.　Expert Opin. Ther. Targets　16　771-781　2012
  • 　ErbB/NF-kB signaling controls mammosphere formation in human breast cancer.　Hinorara K, Kobayashi S, Kanauchi H, Shimizu S, Nishioka K, Tsuji E, Tada K, Umezawa K, Mori M, Ogawa T, Inoue J, Tojo A. & Gotoh N　Proc. Natl. Acad. Sci., USA　109　6584-6589　2012
  • 　Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing.　Kojima, K., Imoto, S., Yamaguchi, R., Fujita, A., Yamauchi, M., Gotoh, N. & Miyano, S　BMC Genomics　suppl 1　S6　2012
  • 　Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinoma　Okayama, H., Khono, T., Ishii, Y., Shimada, Y., Shiraishi, K., Iwakawa, R., Furuta, K., Tsuta, K., Shibata, T., Yamamoto, S., Watanabe, S., Sakamoto, H., Kumamoto, K., Takenoshita, S., Gotoh, N., Mizuno, H., Sarai, A., Kawano, S., Yamaguchi, R., Miyano, S. & Yokota, J　Cancer Res.　72　100-111　2012
  • 　Integrated quantitative analysis of the phoshpoproteome and transcriptome in tamoxifen-resistant breast cancer.　Oyama, M., Nagashima, T., Suzuki, T., Kozuka-Hata, H., Yumoto, N., Shiraishi, Y., Ikeda, K., Kuroki, Y., Gotoh, N., Ishida, T., Inoue, S., Kitano, H. & Okada-Hatakeyama, M　J. Biol. Chem　286　818-829　2011
  • 　Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung.　Nomura, M., Fukuda, T, Fujii, K., Kawamura, T., Tojo, H., Kihara, M., Bando, Y., Gazdar, A.F., Tsuboi, M., Oshiro, H., Nagao, T., Ohira, T., Ikeda, N., Gotoh, N., Kato, H., Marko-Varga, G. & Nishimura, T　Journal of Clinical Bioinformatics,　1　23　2011
  • 　N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells.　Yamauchi, M., Yoshino, I., Yamaguchi, R., Shimamura, T., Nagasaki, M., Imoto, S., Niida, A., Koizumi, F., Kohno, T., Yokota, J., Miyano, S. & Gotoh, N　Am. J. Cancer. Res　1　823-833　2011
  • 　Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors　Gotoh, N.　Int. J. Clin. Exp. Pathol　4　403-409　2011
  • 　FRS2　Gotoh, N　Encyclopedia of Signaling Molecule　2011
  • 　Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling　Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J., Yamamoto, T., Miyano, S., Sugano, S. and Oyama, M　PLoS ONE,　5　11　e13926　2010
  • 　Possible signaling pathways in cancer stem cells in breast cancer.　Gotoh, N　Cancer Stem Cells Theories and Practice,　chapter 13　2011
  • 　Inflammatory signaling pathways in self-renewing breast cancer stem cells.　Hinohara, K. and Gotoh, N　Curr. Opin. Pharmacol　10　650-654　2010
  • 　Collocation-based sparse estimation for constructing dynamic gene networks.　Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y., Gotoh, N., Miyano, S　Genome Inform　24　164-178　2010
  • 　FGF-FRS2alpha-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells　Sato, T., Shimazaki, T., Naka, H, Fukami, S., Okano, H., Lax, I., Schlessinger, J. and Gotoh, N.　Stem Cells　28　1661-1672　2010
  • 　FRS2beta a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding. 　Iejima, D., Minegichi, Y., Takenaka, K., Siswanto, A., Watanabe, M., Huang, L., Watanabe, T., Tanaka, F., Kuroda, M. and Gotoh, N　Oncogene　29　3087-3099　2010
  • 　A state space representation of VAR models with sparse learning for dynamic gene networks.　Kojima, K., Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T, Ueno, K., Higuchi, T., , Gotoh, N., Miyano, S　Genome Inform　22　56-68　2010
  • 　Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells　Murohashi, M., Hinohara, K., Kuroda, M., Isagawa, T., Tsuji, S., Kobayashi, S., Umezawa, K., Tojo, A., Aburatani, H. and Gotoh, N　Br J. Cancer　102　206-212　2010
  • 　An FGF4-FRS2alpha-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos　Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N., Yamamoto, T., Shibuya, M., Schlessinger, J. and Gotoh, N　Stem Cells　28　113-121　2010
  • 　Gain-of-function of mutated c-Cbl tumor suppressor in myeloid neoplasms with 11q uniparental disomy　Sanada, M., Suzuki, T., Shih, L.-Y., Otsu, M., Kato, M., Yamazaki, S., Tamura, A., Honda, H., Sakata-Yanagimoto, M., Kumano, K., Oda, H., Yamagata, T., Takita, J., Gotoh, N., Nakazaki, K., Kawamata, N., Onodera, M., Nobuyoshi, M., Hayashi, Y., Harada, H., Kurokawa, M., Chiba, S., Mori, H., Ozawa, K., Omine, M., Hirai, H., Nakauchi, H., Koeffler, P. and Ogawa, S　Nature　460　904-909　2009
  • 　FRS2beta docking/scaffolding adaptor protein　Iejima, D. and Gotoh, N　Current research in cancer,　3　99-107　2009
  • 　FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.　Kameda, Y., Ito, M., Nishimaki, T. and Gotoh, N　Dev. Dyn　238　503-513　2009
  • 　Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates　Yamauchi, M., and Gotoh, N　Biomark. Med　3　139-151　2009
  • 　Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles　Minegishi, Y., Iwanari, H., Mochizuki, Y., Horii, T., Hoshino, T., Kodama, T., Hamakubo, T. and Gotoh, N.　FEBS lett　583　807-814　2009
  • 　The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment　Sato T. and Gotoh, N　Expert Opinion on Therapeutic Targets　13　689-700　2009
  • 　Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells.　Gotoh, N　Current Stem Cell Research & Therapy　4　9-15　2009
  • 　One-carbon metabolism　35　10　46-51　2017
  • 　乳がん幹細胞性を維持するシグナル伝達の解析　富永香菜、後藤典子　48　9　423-426　2017
  • 　乳癌の癌幹細胞　富永香菜、後藤典子　Surgery Frontier　22　4　61-67　2015
  • 　がん幹細胞研究の歴史および治療への展望　後藤典子、佐谷秀行　33　5　676-677　2015
  • 　乳がん幹細胞とニッチの増殖因子シグナル　33　5　712-717　2015
  • 　POSSIBLE INVOLVEMENT OF RECEPTOR-TYPE TYROSINE KINASES EGF-R AND FLT IN THE DEVELOPMENT OF BRAIN TUMORS　M SHIBUYA,H YAMAZAKI,N GOTOH,H MATSUSHIME,L SEETHARAN,B PAIN,Y ISHII　GROWTH FACTORS: CELL GROWTH, MORPHOGENESIS, AND TRANSFORMATION　42　42　139　1994
  • 　A UNIQUE SIGNAL-TRANSDUCTION FROM FLT TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR VEGF　L SEETHARAM,N GOTOH,Y MARU,G NEUFELD,S YAMAGUCHI,M SHIBUYA　Oncogene　10　1　135　1995/01
  • 　The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner　N Gotoh,K Muroya,S Hattori,S Nakamura,K Chida,M Shibuya　Oncogene　11　12　2525　1995/12
  • 　DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane　H Hasegawa,E Kiyokawa,S Tanaka,K Nagashima,N Gotoh,M Shibuya,T Kurata,M Matsuda　Molecular and Cellular Biology　16　4　1770　1996/04
  • 　A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3　N Gotoh,A Tojo,M Shibuya　EMBO Journal　15　22　6197　1996/11
  • 　Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation　N Gotoh,M Toyoda,M Shibuya　Molecular and Cellular Biology　17　4　1824　1997/04
  • 　STRUCTURAL DIVERSITY OF MURINE SERUM AMYLOID-A GENES - EVOLUTIONARY IMPLICATIONS　KI YAMAMOTO,N GOTO,J KOSAKA,M SHIROO,YD YEUL,S MIGITA　Journal of Immunology　139　5　1683　1987/09
  • 　POSSIBLE INVOLVEMENT OF VEGF-FLT TYROSINE KINASE RECEPTOR SYSTEM IN NORMAL AND TUMOR ANGIOGENESIS　M SHIBUYA,L SEETHARAM,Y ISHII,A SAWANO,N GOTOH,H MATSUSHIME,S YAMAGUCHI　MOLECULAR AND CELLULAR BASIS FOR CELL TO CELL INTERACTION: ITS SIGNIFICANCE IN CANCER　24　162　1994
  • 　A NEW COMMUNICATION-SYSTEM BETWEEN HEPATOCYTES AND SINUSOIDAL ENDOTHELIAL-CELLS IN LIVER THROUGH VASCULAR ENDOTHELIAL GROWTH-FACTOR AND FLT TYROSINE KINASE RECEPTOR FAMILY (FLT-1 AND KDR/FLK-1)　A YAMANE,L SEETHARAM,S YAMAGUCHI,N GOTOH,T TAKAHASHI,G NEUFELD,M SHIBUYA　ONCOGENE　9　9　2683　1994/09
  • 　Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptor　S Murasawa,Y Mori,Y Nozawa,N Gotoh,M Shibuya,H Masaki,K Maruyama,Y Tsutsumi,Y Moriguchi,Y Shibazaki,Y Tanaka,T Iwasaka,M Inada,H Matsubara　Circulation Research　82　12　1338　1998/06
  • 　A HIGHLY CONSERVED TYROSINE RESIDUE AT CODON 845 WITHIN THE KINASE DOMAIN IS NOT REQUIRED FOR THE TRANSFORMING ACTIVITY OF HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR　N GOTOH,A TOJO,M HINO,Y YAZAKI,M SHIBUYA　Biochemical and Biophysical Research Communications　186　2　768　1992/07
  • 　EPIDERMAL GROWTH FACTOR-RECEPTOR MUTANT LACKING THE AUTOPHOSPHORYLATION SITES INDUCES PHOSPHORYLATION OF SHC PROTEIN AND SHC-GRB2 ASH ASSOCIATION AND RETAINS MITOGENIC ACTIVITY　N GOTOH,A TOJO,K MUROYA,Y HASHIMOTO,S HATTORI,S NAKAMURA,T TAKENAWA,Y YAZAKI,M SHIBUYA　Proceedings of the National Academy of Sciences, USA　91　1　167　1994/01
  • 　Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells　Yamamoto S,Yoshino I,Shimazaki T,Murohashi M,Hevner R. F,Lax I,Okano H,Shibuya M,Schlessinger J,Gotoh N　Proceedings of the National Academy of Sciences, USA　102　44　15983　2005/11/01
  • 　Feedback inhibitors of the epidermal growth factor receptor signaling pathways　Noriko Gotoh　International Journal of Biochemistry & Cell Biology　41　3　511　2009/03
  • 　Essential role of Shp2-binding sites on the docking protein FRS2α for mamalian corticogenesis and for FGF2-dependent proliferation of cultured neural progenitor cells.　Yamamoto, S,Yoshino, I,Shimazaki, T,Murohashi, M,Hevner, R. F,Lax, I,Okano, H,Shibuya, M,Schlessinger, J,Gotoh, N　Proceedings of the National Academy of Sciences, USA　102　44　15983　2005/09
  • 　Prominent expression of FRS2 beta protein in neural cells and its association with intracellular vesicles　Yuriko Minegishi,Hiroko Iwanari,Yasuhiro Mochizuki,Takako Horii,Tomoko Hoshino,Tatsuhiko Kodama,Takao Hamakubo,Noriko Gotoh　FEBS Letters　583　4　807　2009/02
  • 　Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins　Noriko Gotoh　Cancer Science　99　7　1319　2008/07
  • 　Unique role of SNT-2/FRS2β/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways　L. Huang,M. Watanabe,M. Chikamori,Y. Kido,T. Yamamoto,M. Shibuya,N. Gotoh,N. Tsuchida　Oncogene　25　49　6457　2006/10/19
  • 　Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor　Y Hashimoto,H Katayama,E Kiyokawa,S Ota,T Kurata,N Gotoh,N Otsuka,M Shibata,M Matsuda　Journal of Biological Chemistry　273　27　17186　1998/07
  • 　Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway　A Hashimoto,M Kurosaki,N Gotoh,R Shibuya,T Kurosaki　Journal of Biological Chemistry　274　29　20139　1999/07
  • 　GAIN-OF-FUNCTION MUTATIONS OF C-CBL TUMOR SUPPRESSOR IN MDS AND MDS/MPD ASSOCIATED WITH 11Q UPD　Sanada,M,Suzuki,T,Shih,L. Y,Otsu,M,Yamazaki,S,Kato,M,Honda,H,Sakata-Yanagimoto,M,Kumano,K,Oda,H,Takita,J,Goto,N,Kawamata,N,Uehara,E,Hayashi,Y,Harada,H,Kurokawa,M,Chiba,S,Mori,H,Ozawa,K,Omine,M,Nakauchi,H,Koeffler,H. P,Ogawa,S　HAEMATOLOGICA-THE HEMATOLOGY JOURNAL　94　Suppl. 2　488　2009/06
  • 　Molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates　Mai Yamauchi,Noriko Gotoh　Biomarkers in Medicine　3　2　139　2009/04
  • 　FRS2 alpha Is Required for the Separation, Migration, and Survival of Pharyngeal-Endoderm Derived Organs Including Thyroid, Ultimobranchial Body, Parathyroid, and Thymus　Yoko Kameda,Masataka Ito,Toshiyuki Nishimaki,Noriko Gotoh　Developmental Dynamics　238　3　503　2009/03
  • 　Control of Stemness by Fibroblast Growth Factor Signaling in Stem Cells and Cancer Stem Cells　Noriko Gotoh　Current Stem Cell Research & Therapy　4　1　9　2009/01
  • 　FRS2 alpha(2F/2F) mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve　Yoko Kameda,Masataka Ito,Toshiyuki Nishimaki,Noriko Gotoh　Developmental Biology　314　1　236　2008/02
  • 　PREDICTING DIFFERENCES IN GENE REGULATORY SYSTEMS BY STATE SPACE MODELS　Rui Yamaguchi,Seiya Imoto,Mai Yamauchi,Masao Nagasaki,Ryo Yoshida,Teppei Shimamura,Yosuke Hatanaka,Kazuko Ueno,Tomoyuki Higuchi,Noriko Gotoh,Satoru Miyano　Genome Informatics　21　101　2008
  • 　EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition　Eun-Sil Kang,Min-A Oh,Sin-Ae Lee,Tae Young Kim,Sung-Hoon Kim,Noriko Gotoh,Yong-Nyun Kim,Jung Weon Lee　BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH　1773　6　833　2007/06
  • 　Tyrosine phosphorylation sites on FRS2 alpha responsible for Shp2 recruitment are critical for induction of lens and retina　N Gotoh,M Ito,S Yamamoto,Yoshino, I,N Song,Y Wang,Lax, I,J Schlessinger,M Shibuya,RA Lang　Proceedings of the National Academy of Sciences, USA　101　49　17144　2004/12
  • 　Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-lnduced p21(WAF1/Cip1) expression and growth inhibition of A431 cells　M Toyoda,N Gotoh,H Handa,M Shibuya　Biochemical and Biophysical Research Communications　250　2　430　1998/09
  • 　Frs2 beta.　Minegishi, Y,Gotoh, N　The Signaling Gateway, Molecule Pages　2009/05
  • 　Membrane-linked docking protein.　Gotoh N,Tsuchida N　Encyclopedia of Cancer, 3rd Edition　1819　2008/07
  • 　Frs2 alpha　Sato T,Gotoh N　The Signaling Gateway, Molecule Pages　2009/05
  • 　The docking protein FRS2 alpha is an essential component of multiple fibroblast growth factor responses during early mouse development　N Gotoh,K Manova,S Tanaka,M Murohashi,Y Hadari,A Lee,Y Hamada,T Hiroe,M Ito,T Kurihara,H Nakazato,M Shibuya,Lax, I,E Lacy,J Schlessinger　Molecular and Cellular Biology　25　10　4105　2005/05
  • 　A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage abnormalities observed in Ext2 heterozygous mutant mice.　Nasirujjaman K,Kimura-Yoshida, C,Gotoh, N,Hiramatsu, R,Matsuo I　Journal of Osaka Medical Center & Research Institute for Maternal & Child Health　26　2　101　2011/07
  • 　Adaptor protein complex of FRS2 beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation　Yuriko Minegishi,Yoshio Shibagaki,Anna Mizutani,Koji Fujita,Tohru Tezuka,Masao Kinoshita,Masahiko Kuroda,Seisuke Hattori,Noriko Gotoh　Cancer Science　104　3　345　2013/03
  • 　FRS2 beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding　D. Iejima,Y. Minegishi,K. Takenaka,A. Siswanto,M. Watanabe,L. Huang,T. Watanabe,F. Tanaka,M. Kuroda,N. Gotoh　ONCOGENE　29　21　3087　2010/05
  • 　Phosphoproteomics-Based Modeling Defines the Regulatory Mechanism Underlying Aberrant EGFR Signaling　Shinya Tasaki,Masao Nagasaki,Hiroko Kozuka-Hata,Kentaro Semba,Noriko Gotoh,Seisuke Hattori,Jun-ichiro Inoue,Tadashi Yamamoto,Satoru Miyano,Sumio Sugano,Masaaki Oyama　PLoS ONE　5　11　e13926　2010/11
  • 　Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors　Noriko Gotoh　International Journal of Clinical and Experimental Pathology　4　4　403　2011
  • 　ErbB receptor tyrosine kinase/NF-kappa B signaling controls mammosphere formation in human breast cancer　Kunihiko Hinohara,Seiichiro Kobayashi,Hajime Kanauchi,Seiichiro Shimizu,Kotoe Nishioka,Ei-ichi Tsuji,Kei-ichiro Tada,Kazuo Umezawa,Masaki Mori,Toshihisa Ogawa,Jun-ichiro Inoue,Arinobu Tojo,Noriko Gotoh　Proceedings of the National Academy of Sciences, USA　109　17　6584　2012/04
  • 　Growth factor signaling regulates breast cancer stem cells　Noriko Gotoh　Forum on Immunopathological Diseases and Therapeutics　4　1　1　2013
  • 　The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment　Takuya Sato,Noriko Gotoh　Expert Opinion on Therapeutic Targets　13　6　689　2009/06
  • 　EGFR-targeted liposome for molecular imaging and therapy on NSCLC cells.　Yokoyama T,Osato Y,Miyazawa K,Kiyasato A,Hayabe H,Nomura M,Gotoh N,Itoi T,Tauchi T,Ikeda N,Ohyashiki K　Cancer Research　72　8　2012/04
  • 　Epidermal Growth Factor Receptor Tyrosine Kinase Defines Critical Prognostic Genes of Stage I Lung Adenocarcinoma　Mai Yamauchi,Rui Yamaguchi,Asuka Nakata,Takashi Kohno,Masao Nagasaki,Teppei Shimamura,Seiya Imoto,Ayumu Saito,Kazuko Ueno,Yousuke Hatanaka,Ryo Yoshida,Tomoyuki Higuchi,Masaharu Nomura,David G. Beer,Jun Yokota,Satoru Miyano,Noriko Gotoh　PLoS ONE　7　9　e43923　2012/09
  • 　FRS2β docking/scaffolding adaptor protein.　Iejima, D,Gotoh, N　Current Research in Cancer, Research Media　3　99　2009/06
  • 　Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing　Kaname Kojima,Seiya Imoto,Rui Yamaguchi,Andre Fujita,Mai Yamauchi,Noriko Gotoh,Satoru Miyano　BMC Genomics　13　S6　2012/01
  • 　Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study　Masaharu Nomura,Tetsuya Fukuda,Kiyonaga Fujii,Takeshi Kawamura,Hiromasa Tojo,Makoto Kihara,Yasuhiko Bando,Adi F. Gazdar,Masahiro Tsuboi,Hisashi Oshiro,Toshitaka Nagao,Tatsuo Ohira,Norihiko Ikeda,Noriko Gotoh,Harubumi Kato,Gyorgy Marko-Varga,Toshihide Nishimura　Journal of Clinical Bioinformatics　1　1　23　2011/09/03
  • 　Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing　Kaname Kojima,Seiya Imoto,Rui Yamaguchi,André Fujita,Mai Yamauchi,Noriko Gotoh,Satoru Miyano　Series on Advances in Bioinformatics and Computational Biology　13　2012
  • 　Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells　Shin-ichiro Ohno,Masakatsu Takanashi,Katsuko Sudo,Shinobu Ueda,Akio Ishikawa,Nagahisa Matsuyama,Koji Fujita,Takayuki Mizutani,Tadaaki Ohgi,Takahiro Ochiya,Noriko Gotoh,Masahiko Kuroda　Molecular Therapy　21　1　185　2013/01
  • 　Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms　Masashi Sanada,Takahiro Suzuki,Lee-Yung Shih,Makoto Otsu,Motohiro Kato,Satoshi Yamazaki,Azusa Tamura,Hiroaki Honda,Mamiko Sakata-Yanagimoto,Keiki Kumano,Hideaki Oda,Tetsuya Yamagata,Junko Takita,Noriko Gotoh,Kumi Nakazaki,Norihiko Kawamata,Masafumi Onodera,Masaharu Nobuyoshi,Yasuhide Hayashi,Hiroshi Harada,Mineo Kurokawa,Shigeru Chiba,Hiraku Mori,Keiya Ozawa,Mitsuhiro Omine,Hisamaru Hirai,Hiromitsu Nakauchi,H. Phillip Koeffler,Seishi Ogawa　Nature　460　7257　904　2009/08
  • 　Possible signaling pathways in cancer stem cells in breast cancer.　Gotoh, N　Cancer Stem Cells Theories and Practice　261　2011/03
  • 　Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo　M. Hashimoto,F. Suizu,W. Tokuyama,H. Noguchi,N. Hirata,M. Matsuda-Lennikov,T. Edamura,M. Masuzawa,N. Gotoh,S. Tanaka,M. Noguchi　Oncogenesis　2　1　2013/09
  • 　Growth factor signaling regulates breast cancer stem cells　GOTOH Noriko　Cytometry Research　23　2　33　2013/09/25　
  • 　Effect of in vivo administration of reprogramming factors in the mouse liver.　Akira Tomokuni,Hidetoshi Eguchi,Hiromitsu Hoshino,Dyah Laksmi Dewi,Shinpei Nishikawa,Yoshihiro Kano,Norikatsu Miyoshi,Arinobu Tojo,Seiichiro Kobayashi,Noriko Gotoh,Kunihiko Hinohara,Noemi Fusaki,Toshiyuki Saito,Hiroshi Suemizu,Hiroshi Wada,Shogo Kobayashi,Shigeru Marubashi,Masahiro Tanemura,Yuichiro Doki,Masaki Mori,Hideshi Ishii,Hiroaki Nagano　Oncology Letters　6　2　323　2013/08
  • 　Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas　Hirokazu Okayama,Takashi Kohno,Yuko Ishii,Yoko Shimada,Kouya Shiraishi,Reika Iwakawa,Koh Furuta,Koji Tsuta,Tatsuhiro Shibata,Seiichiro Yamamoto,Shun-ichi Watanabe,Hiromi Sakamoto,Kensuke Kumamoto,Seiichi Takenoshita,Noriko Gotoh,Hideaki Mizuno,Akinori Sarai,Shuichi Kawano,Rui Yamaguchi,Satoru Miyano,Jun Yokota　Cancer Research　72　1　100　2012/01
  • 　Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma　Zhigang Cai,Chenqi Tao,Hongge Li,Raj Ladher,Noriko Gotoh,Gen-Sheng Feng,Fen Wang,Xin Zhang　Development　140　13　2711　2013/07
  • 　N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells　Mai Yamauchi,Ikuyo Yoshino,Rui Yamaguchi,Teppei Shimamura,Masao Nagasaki,Seiya Imoto,Atsushi Niida,Fumiaki Koizumi,Takashi Kohno,Jun Yokota,Satoru Miyano,Noriko Gotoh　American Journal of Cancer Research　1　7　823　2011
  • 　Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer　Masaaki Oyama,Takeshi Nagashima,Takashi Suzuki,Hiroko Kozuka-Hata,Noriko Yumoto,Yuichi Shiraishi,Kazuhiro Ikeda,Yoko Kuroki,Noriko Gotoh,Takanori Ishida,Satoshi Inoue,Hiroaki Kitano,Mariko Okada-Hatakeyama　Journal of Biological Chemistry　286　1　818　2011/01
  • 　Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer　Asuka Nakata,Noriko Gotoh　Expert Opinion on Therapeutic Targets　16　8　771　2012/08
  • 　Collocation-based sparse estimation for constructing dynamic gene networks.　Shimamura, T.,Imoto, S.,Nagasaki, M.,Yamauchi, M.,Yamaguchi, R.,Fujita, A.,Tamada, Y.,Gotoh, N.,Miyano, S.　Genome informatics. International Conference on Genome Informatics　24　164　2010
  • 　Inflammatory signaling pathways in self-renewing breast cancer stem cells　Kunihiko Hinohara,Noriko Gotoh　Current Opinion in Pharmacology　10　6　650　2010/12
  • 　A state space representation of VAR models with sparse learning for dynamic gene networks.　Kojima K,Yamaguchi R,Imoto S,Yamauchi M,Nagasaki M,Yoshida R,Shimamura T,Ueno K,Higuchi T,Gotoh N,Miyano S　Genome Informatics　22　56　2010/01
  • 　FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.　Takuya Sato,Takuya Shimazaki,Hayato Naka,Shin-Ichi Fukami,Yasushi Satoh,Hideyuki Okano,Irit Lax,Joseph Schlessinger,Noriko Gotoh　Stem cells (Dayton, Ohio)　28　9　1661　2010/09
  • 　An FGF4-FRS2 alpha-Cdx2 Axis in Trophoblast Stem Cells Induces Bmp4 to Regulate Proper Growth of Early Mouse Embryos　Michiko Murohashi,Takahisa Nakamura,Satoshi Tanaka,Taeko Ichise,Nobuaki Yoshida,Tadashi Yamamoto,Masabumi Shibuya,Joseph Schlessinger,Noriko Gotoh　Stem Cells　28　1　113　2010/01
  • 　Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells　M. Murohashi,K. Hinohara,M. Kuroda,T. Isagawa,S. Tsuji,S. Kobayashi,K. Umezawa,A. Tojo,H. Aburatani,N. Gotoh　British Journal of Cancer　102　1　206　2010/01
  • 　The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein　Yoshihito Kano,Kiichiro Tsuchiya,Xiu Zheng,Nobukatsu Horita,Keita Fukushima,Shuji Hibiya,Yuhki Yamauchi,Tatsunori Nishimura,Kunihiko Hinohara,Noriko Gotoh,Shinji Suzuki,Ryuichi Okamoto,Tetsuya Nakamura,Mamoru Watanabe　Biochemical and Biophysical Research Communications　432　1　175　2013/03
  • 　FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation　Kazuya Ono,Tomoko Kita,Shigeru Sato,Paul O'Neill,Siu-Shan Mak,Marie Paschaki,Masataka Ito,Noriko Gotoh,Kiyoshi Kawakami,Yoshiki Sasai,Raj K. Ladher　PLoS Genetics　10　1　e1004118　2014/01
  • 　CD74-NRG1はがん幹細胞性を促進する可能性のある腫瘍性タンパク質である　村山 貴彦,中奥 敬史,西村 建徳,富永 香菜,中田 飛鳥,東條 有伸,菅野 純夫,河野 隆志,後藤 典子　日本癌学会総会記事　74回　P　2015/10
  • 　Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis　Ankur Garg,Mukesh Bansal,Noriko Gotoh,Gen-Sheng Feng,Jian Zhong,Fen Wang,Ariana Kariminejad,Steven Brooks,Xin Zhang　PLoS Genetics　13　10　e1007047　2017/10/01
  • 　がん関連線維芽細胞由来液性因子によるがん幹細胞様細胞の維持(Maintenance of breast cancer stem-like cells by cancer associated fibroblast-derived soluble factors)　村山 貴彦,西村 建徳,矢野 正雄,笹原 麻子,多田 敬一郎,池田 和博,岡本 康司,堀江 公仁子,井上 聡,東條 有伸,後藤 典子　日本癌学会総会記事　77回　1955　2018/09
  • 　融合遺伝子産物CD74-NRG1はErbB-NFκB-IGF2経路を活性化し、がん幹細胞性を増強する　村山 貴彦,中奥 敬史,江成 政人,西村 建徳,富永 香菜,中田 飛鳥,東條 有伸,菅野 純夫,河野 隆志,後藤 典子　日本生化学会大会・日本分子生物学会年会合同大会講演要旨集　88回・38回　[4T18　2015/12
  • 　MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.　Hasegawa S,Eguchi H,Nagano H,Konno M,Tomimaru Y,Wada H,Hama N,Kawamoto K,Kobayashi S,Nishida N,Koseki J,Nishimura T,Gotoh N,Ohno S,Yabuta N,Nojima H,Mori M,Doki Y,Ishii H　British Journal of Cancer　111　8　1572　2014/08
  • 　NRG1融合遺伝子は肺がんにおけるがん幹細胞形質の促進に寄与する　中奥 敬史,村山 貴彦,中田 飛鳥,後藤 典子,河野 隆志　日本癌学会総会記事　75回　P　2016/10
  • 　Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs　Asuka Nakata,Ryo Yoshida,Rui Yamaguchi,Mai Yamauchi,Yoshinori Tamada,Andre Fujita,Teppei Shimamura,Seiya Imoto,Tomoyuki Higuchi,Masaharu Nomura,Tatsuo Kimura,Hiroshi Nokihara,Masahiko Higashiyama,Kazuya Kondoh,Hiroshi Nishihara,Arinobu Tojo,Seiji Yano,Satoru Miyano,Noriko Gotoh　Scientific Reports　5　1　13076　2015/08
  • 　Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2.　Ayumu Asai,Jun Koseki,Masamitsu Konno,Tatsunori Nishimura,Noriko Gotoh,Taroh Satoh,Yuichiro Doki,Masaki Mori,Hideshi Ishii　Heliyon　4　12　e01021　2018/12
  • 　The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity　S. Kitajima,A. Yoshida,S. Kohno,F. Li,S. Suzuki,N. Nagatani,Y. Nishimoto,N. Sasaki,H. Muranaka,Y. Wan,T. C. Thai,N. Okahashi,F. Matsuda,H. Shimizu,T. Nishiuchi,Y. Suzuki,K. Tominaga,N. Gotoh,M. Suzuki,M. E. Ewen,D. A. Barbie,O. Hirose,T. Tanaka,C. Takahashi　Oncogene　36　36　5145　2017/09
  • 　Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer.　Mizuki Yamamoto,Kota Sakane,Kana Tominaga,Noriko Gotoh,Takayoshi Niwa,Yasuko Kikuchi,Keiichiro Tada,Naoki Goshima,Kentaro Semba,Jun-Ichiro Inoue　Cancer Science　108　6　1210　2017/06
  • 　Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells　K. Tominaga,T. Shimamura,N. Kimura,T. Murayama,D. Matsubara,H. Kanauchi,A. Niida,S. Shimizu,K. Nishioka,E-I Tsuji,M. Yano,S. Sugano,Y. Shimono,H. Ishii,H. Saya,M. Mori,K. Akashi,K-I Tada,T. Ogawa,A. Tojo,S. Miyano,N. Gotoh　Oncogene　36　9　1276　2017/03
  • 　Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR　Atsunobu Sagara,Katsuhide Igarashi,Maky Otsuka,Takeshi Karasawa,Noriko Gotoh,Michiko Narita,Naoko Kuzumaki,Minoru Narita,Yoshinori Kato　PLoS ONE　11　10　e0164250　2016/10
  • 　Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis　Soichiro Sasaki,Tomohisa Baba,Tatsunori Nishimura,Yoshihiro Hayakawa,Shin-ichi Hashimoto,Noriko Gotoh,Naofumi Mukaida　Cancer Letters　378　1　23　2016/08
  • 　Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.　Masamitsu Konno,Jun Koseki,Koichi Kawamoto,Naohiro Nishida,Hidetoshi Matsui,Dyah Laksmi Dewi,Miyuki Ozaki,Yuko Noguchi,Koshi Mimori,Noriko Gotoh,Nobuhiro Tanuma,Hiroshi Shima,Yuichiro Doki,Masaki Mori,Hideshi Ishii　PLoS ONE　10　7　e0132789　2015
  • 　Oncogenic Fusion Gene CD74-NRG1 Confers Cancer Stem Cell-like Properties in Lung Cancer through a IGF2 Autocrine/Paracrine Circuit　Takahiko Murayama,Takashi Nakaoku,Masato Enari,Tatsunori Nishimura,Kana Tominaga,Asuka Nakata,Arinobu Tojo,Sumio Sugano,Takashi Kohno,Noriko Gotoh　Cancer Research　76　4　974　2016/02
  • 　MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells.　Hisataka Ogawa,Xin Wu,Koichi Kawamoto,Naohiro Nishida,Masamitsu Konno,Jun Koseki,Hidetoshi Matsui,Kozou Noguchi,Noriko Gotoh,Tsuyoshi Yamamoto,Kanjiro Miyata,Nobuhiro Nishiyama,Hiroaki Nagano,Hirofumi Yamamoto,Satoshi Obika,Kazunori Kataoka,Yuichiro Doki,Masaki Mori,Hideshi Ishii　PLoS ONE　10　5　e0127119　2015
  • 　Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma　Shinji Kohsaka,Kunihiko Hinohara,Lei Wang,Tatsunori Nishimura,Masana Urushido,Kazuhiro Yachi,Masumi Tsuda,Mishie Tanino,Taichi Kimura,Hiroshi Nishihara,Noriko Gotoh,Shinya Tanaka　Neuro-Oncology　16　7　960　2014/07
  • 　Frs2 alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development　Hongge Li,Chenqi Tao,Zhigang Cai,Kristina Hertzler-Schaefer,Tamica N. Collins,Fen Wang,Gen-Sheng Feng,Noriko Gotoh,Xin Zhang　Journal of Cell Science　127　3　571　2014/02
  • 　The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell　Takahiro Shima,Toshihiro Miyamoto,Yoshikane Kikushige,Junichiro Yuda,Taro Tochigi,Goichi Yoshimoto,Koji Kato,Katsuto Takenaka,Hiromi Iwasaki,Shinichi Mizuno,Noriko Goto,Koichi Akashi　Experimental Hematology　42　11　955　2014/11
  • 　Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids　Shuji Hibiya,Kiichiro Tsuchiya,Ryohei Hayashi,Keita Fukushima,Nobukatsu Horita,Sho Watanabe,Tomoaki Shirasaki,Ryu Nishimura,Natsuko Kimura,Tatsunori Nishimura,Noriko Gotoh,Shigeru Oshima,Ryuichi Okamoto,Tetsuya Nakamura,Mamoru Watanabe　Journal of Crohn's & Colitis　11　5　621　2017/05
  • 　An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells　Asako Sasahara,Kana Tominaga,Tatsunori Nishimura,Masao Yano,Etsuko Kiyokawa,Miki Noguchi,Masakuni Noguchi,Hajime Kanauchi,Toshihisa Ogawa,Hiroshi Minato,Keiichiro Tada,Yasuyuki Seto,Arinobu Tojo,Noriko Gotoh　Oncotarget　8　15　24869　2017/04
  • 　HER2/HER3シグナル阻害によるNRG1遺伝子融合陽性肺がんの治療　中奥 敬史,蔦 幸治,村山 貴彦,中田 飛鳥,白石 航也,荻原 秀明,金 永学,三嶋 理晃,後藤 典子,河野 隆志　日本癌学会総会記事　74回　E　2015/10
  • 　Cyclin G2: A novel independent prognostic marker in pancreatic cancer.　Shinichiro Hasegawa,Hiroaki Nagano,Masamitsu Konno,Hidetoshi Eguchi,Akira Tomokuni,Yoshito Tomimaru,Hiroshi Wada,Naoki Hama,Koichi Kawamoto,Shogo Kobayashi,Shigeru Marubashi,Naohiro Nishida,Jun Koseki,Noriko Gotoh,Shouichi Ohno,Norikazu Yabuta,Hiroshi Nojima,Masaki Mori,Yuichiro Doki,Hideshi Ishii　Oncology letters　10　5　2986　2015/11
  • 　Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.　Atsushi Hamabe,Masamitsu Konno,Nobuhiro Tanuma,Hiroshi Shima,Kenta Tsunekuni,Koichi Kawamoto,Naohiro Nishida,Jun Koseki,Koshi Mimori,Noriko Gotoh,Hirofumi Yamamoto,Yuichiro Doki,Masaki Mori,Hideshi Ishii　Proceedings of the National Academy of Sciences, USA　111　43　15526　2014/10/28
  • 　A Novel Serum 4-microRNA Signature for Lung Cancer Detection　Ernest Nadal,Anna Truini,Asuka Nakata,Jules Lin,Rishindra M. Reddy,Andrew C. Chang,Nithya Ramnath,Noriko Gotoh,David G. Beer,Guoan Chen　Scientific Reports　5　12464　2015/07
  • 　Development of the prognostic system with gene signature in early stage lung cancer　Nakata Asuka,Fujita André,Chen Guoan,Kohno Takashi,Tojo Arinobu,Beer David.G,Gotoh Noriko　Japan Journal of Molecular Tumor Marker Research　30　45　2015　
  • 　Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells.　Keisuke Tamari,Masamitsu Konno,Ayumu Asai,Jun Koseki,Kazuhiko Hayashi,Koichi Kawamoto,Noriyuki Murai,Senya Matsufuji,Fumiaki Isohashi,Taroh Satoh,Noriko Goto,Shinji Tanaka,Yuichiro Doki,Masaki Mori,Kazuhiko Ogawa,Hideshi Ishii　Cell Death Discovery　4　104　2018
  • 　Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer.　Masaaki Miyo,Masamitsu Konno,Naohiro Nishida,Toshinori Sueda,Kozo Noguchi,Hidetoshi Matsui,Hugh Colvin,Koichi Kawamoto,Jun Koseki,Naotsugu Haraguchi,Junichi Nishimura,Taishi Hata,Noriko Gotoh,Fumio Matsuda,Taroh Satoh,Tsunekazu Mizushima,Hiroshi Shimizu,Yuichiro Doki,Masaki Mori,Hideshi Ishii　Scientific reports　6　38415　2016/12/07
  • 　Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.　Masamitsu Konno,Hideshi Ishii,Jun Koseki,Nobuhiro Tanuma,Naohiro Nishida,Koichi Kawamoto,Tatsunori Nishimura,Asuka Nakata,Hidetoshi Matsui,Kozou Noguchi,Miyuki Ozaki,Yuko Noguchi,Hiroshi Shima,Noriko Gotoh,Hiroaki Nagano,Yuichiro Doki,Masaki Mori　Regenerative Therapy　1　63　2015/06
  • 　トリプルネガティブ乳がん幹細胞の起源ルミナル前駆細胞は、Na+ポンプFXYD3を利用し抗がん剤耐性を獲得する(FXYD3, a subunit of Na+K+ pump, determines the root of triple-negative breast cancer stem-like cells)　李 梦嬌,西村 建徳,塩川 大介,矢野 正雄,石川 聡子,太田 哲生,田辺 真彦,多田 敬一郎,秋山 徹,島村 徹平,佐藤 慎哉,宮城 洋平,鈴木 穣,岡本 康司,東條 有伸,後藤 典子　日本癌学会総会記事　81回　P　2022/09
  • 　Xenografts derived from patients with head and neck cancer recapitulate patient tumour properties.　Haruna Makita,Kazuhira Endo,Yoshiya Kasahara,Asuka Nakata,Makiko Moriyama-Kita,Kazuya Ishikawa,Takayoshi Ueno,Yosuke Nakanishi,Satoru Kondo,Naohiro Wakisaka,Noriko Gotoh,Tomokazu Yoshizaki　Oncology Letters　21　5　385　2021/05
  • 　MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells　Takahiko Murayama,Yasuto Takeuchi,Kaoru Yamawaki,Toyoaki Natsume,Mengjiao Li,Rojas‐Chaverra N. Marcela,Tatsunori Nishimura,Yuta Kogure,Asuka Nakata,Kana Tominaga,Asako Sasahara,Masao Yano,Satoko Ishikawa,Tetsuo Ohta,Kazuhiro Ikeda,Kuniko Horie‐Inoue,Satoshi Inoue,Masahide Seki,Yutaka Suzuki,Sumio Sugano,Takayuki Enomoto,Masahiko Tanabe,Kei‐ichiro Tada,Masato T. Kanemaki,Koji Okamoto,Arinobu Tojo,Noriko Gotoh　Cancer Science　112　3　1209　2021/03　
  • 　がん幹細胞 乳がん患者検体由来三次元培養細胞とがん間質細胞の共培養系を用いたがん幹細胞ニッチシグナルの解析(Cancer stem cell Cancer stem cell niche signals in cancer associated fibroblasts(CAFs) to maintain cancer stem-like cells(CSCs))　後藤 典子,村山 貴彦,矢野 正雄,多田 敬一郎,池田 和博,岡本 康司,堀江 公仁子,井上 聡,東條 有伸　日本癌学会総会記事　78回　S14　2019/09
  • 　オルガノイドが駆動するがん研究 オルガノイドの乳がん研究への展開　下野 洋平,西村 建徳,河野 誠之,渋谷 尚樹,林 孝典,柳 久乃,渡辺 崇,前田 真男,掛地 吉弘,河田 健司,浅井 直也,高尾 信太郎,南 博信,喜島 祐子,鈴木 元,後藤 典子　日本癌学会総会記事　80回　[CS4　2021/09
  • 　Drug resistant mechanisms of cancer stem-like cells and their therapeutic potential as drug targets.　Murayama T,Gotoh N　Cancer Drug Resist　2　457　2019/07
  • 　Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway.　Tomohisa Baba,Takeshi Yoshida,Yamato Tanabe,Tatsunori Nishimura,Soji Morishita,Noriko Gotoh,Atsushi Hirao,Rikinari Hanayama,Naofumi Mukaida　Cell Death & Disease　12　4　322　2021/03/26
  • 　Upregulation of S100A10 in metastasized breast cancer stem cells　Hisano Yanagi,Takashi Watanabe,Tatsunori Nishimura,Takanori Hayashi,Seishi Kono,Hitomi Tsuchida,Munetsugu Hirata,Yuko Kijima,Shintaro Takao,Seiji Okada,Motoshi Suzuki,Kazuyoshi Imaizumi,Kenji Kawada,Hironobu Minami,Noriko Gotoh,Yohei Shimono　Cancer Science　111　12　4359　2020/12　
  • 　The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis　Yasuto Takeuchi,Natsuko Kimura,Takahiko Murayama,Yukino Machida,Daisuke Iejima,Tatsunori Nishimura,Minoru Terashima,Yuming Wang,Mengjiao Li,Reiko Sakamoto,Mizuki Yamamoto,Naoki Itano,Yusuke Inoue,Masataka Ito,Nobuaki Yoshida,Jun-ichiro Inoue,Koichi Akashi,Hideyuki Saya,Koji Fujita,Masahiko Kuroda,Issay Kitabayashi,Dominic Voon,Takeshi Suzuki,Arinobu Tojo,Noriko Gotoh　Proceedings of the National Academy of Sciences, USA　118　43　e2103658118　2021/10/26　
  • 　乳がん幹細胞とがん関連線維芽細胞における相互作用の解明(Elucidation of interaction between breast cancer stem-like cells and cancer-associated fibroblasts.)　竹内 康人,村山 貴彦,西村 建徳,柏村 里沙,松本 寛加,矢野 正雄,田辺 真彦,石川 聡子,太田 哲生,多田 敬一郎,池田 和博,堀江 公仁子,井上 聡,岡本 康司,東條 有伸,後藤 典子　日本癌学会総会記事　81回　P　2022/09
  • 　MUSASHI‐2 confers resistance to third‐generation EGFR‐tyrosine kinase inhibitor osimertinib in lung adenocarcinoma　Reheman Yiming,Yasuto Takeuchi,Tatsunori Nishimura,Mengjiao Li,Yuming Wang,Makiko Meguro‐Horike,Takashi Kohno,Shin‐ichi Horike,Asuka Nakata,Noriko Gotoh　Cancer Science　2021/06/19
  • 　Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma.　Mitsuhito Hirano,Yoichi Imai,Yuta Kaito,Takahiko Murayama,Kota Sato,Tadao Ishida,Junichi Yamamoto,Takumi Ito,Muneyoshi Futami,Masaki Ri,Hiroshi Yasui,Tamami Denda,Yukihisa Tanaka,Yasunori Ota,Masanori Nojima,Yasuhiko Kamikubo,Noriko Gotoh,Shinsuke Iida,Hiroshi Handa,Arinobu Tojo　Journal of Experimental & Clinical Cancer Research : CR　40　1　110　2021/03/23
  • 　Upregulation of S100A10 in metastasized breast cancer stem cells.　Hisano Yanagi,Takashi Watanabe,Tatsunori Nishimura,Takanori Hayashi,Seiji Okada,Motoshi Suzuki,Hironobu Minami,Akira Suzuki,Kenji Kawada,Noriko Gotoh,Yohei Shimono　Cancer Science　112　705　2021/02
  • 　Large miRNA survival analysis reveals a prognostic four-biomarker signature for triple negative breast cancer　Fernando Andrade,Asuka Nakata,Noriko Gotoh,André Fujita　Genetics and Molecular Biology　43　1　2020　
  • 　Patient-derived xenograft models of breast cancer and their applications.　Murayama T,Gotoh N　Cells　8　6　E621　2019/06
  • 　Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.　Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro-Horike,Soichiro Sasaki,Kenji Kita,Shin-Ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh　Oncogene　38　14　2464　2019/04
  • 　複製因子MCM10は恒常的にDNA複製ストレスにさらされる乳がん幹細胞の維持に寄与する(The replicative factor MCM10 maintains breast cancer stem-like cells that constantly experience DNA replicative stress)　村山 貴彦,山脇 芳,西村 建徳,矢野 正雄,笹原 麻子,小川 利久,多田 敬一郎,鐘巻 将人,井上 聡,岡本 康司,東條 有伸,後藤 典子　日本癌学会総会記事　78回　E　2019/09
  • 　Elucidation of Breast Cancer Tissue Diversity by Comprehensive Analysis of Minimum Unit Omics　Gotoh N　Impact　2019　3　30　2019/03
  • 　The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.　Kei Kozawa,Miho Sekai,Kenji Ohba,Shoko Ito,Hiroaki Sako,Takeshi Maruyama,Mai Kakeno,Takanobu Shirai,Keisuke Kuromiya,Tomoko Kamasaki,Koki Kohashi,Shinya Tanaka,Susumu Ishikawa,Nanami Sato,Shota Asano,Hironori Suzuki,Nobuyuki Tanimura,Yohei Mukai,Noriko Gotoh,Mishie Tanino,Shinya Tanaka,Ken Natsuga,Tomoyoshi Soga,Tomonori Nakamura,Yukihiro Yabuta,Mitinori Saitou,Takahiro Ito,Kenkyo Matsuura,Makoto Tsunoda,Toyone Kikumori,Tadashi Iida,Yasuyuki Mizutani,Yuki Miyai,Kozo Kaibuchi,Atsushi Enomoto,Yasuyuki Fujita　Current Biology : CB　31　14　3086　2021/07/26
  • 　Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.　Kana Tominaga,Hiroshi Minato,Takahiko Murayama,Asako Sasahara,Tatsunori Nishimura,Etsuko Kiyokawa,Hajime Kanauchi,Seiichiro Shimizu,Ayaka Sato,Kotoe Nishioka,Ei-Ichi Tsuji,Masao Yano,Toshihisa Ogawa,Hideshi Ishii,Masaki Mori,Koichi Akashi,Koji Okamoto,Masahiko Tanabe,Kei-Ichiro Tada,Arinobu Tojo,Noriko Gotoh　Proceedings of the National Academy of Sciences, USA　116　2　625　2019/01/08
  • 　A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer　Jin Lee,Xiaoxi Chen,Yuming Wang,Tatsunori Nishimura,Mengjiao Li,Satoko Ishikawa,Takiko Daikoku,Junya Kawai,Arinobu Tojo,Noriko Gotoh　Biochemical and Biophysical Research Communications　584　7　2021/12
  • 　Cryopreservation of tissues by slow-freezing using an emerging zwitterionic cryoprotectant.　Ishizaki T,Takeuchi Y,Ishibashi K,Gotoh N,Hirata E,Kuroda K　Scientific Reports　13　1　37　2023/01/02
  • 　Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy.　Yuming Wang,Tsunaki Hongu,Tatsunori Nishimura,Yasuto Takeuchi,Hiroshi Takano,Takiko Daikoku,Ryoji Yao,Noriko Gotoh　Biochemical and biophysical research communications　674　183　2023/09/24
  • 　A model-based clustering algorithm with covariates adjustment and its application to lung cancer stratification　Carlos E. M. Relvas,Asuka Nakata,Guoan Chen,David G. Beer,Noriko Gotoh,Andre Fujita　Journal of Bioinformatics and Computational Biology　21　04　2023/08　
  • 　FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.　Li M,Nishimura T,Takeuchi Y,Hongu T,Wang Y,Shiokawa D,Wang K,Hirose H,Sasahara A,Yano M,Ishikawa S,Inokuchi M,Ota T,Tanabe M,Tada K-I,Akiyama T,Cheng X,Liu C-C,Yamashita T,Sugano S,Uchida Y,Chiba T,Asahara H,Nakagawa M,Sato S,Miyagi Y,Shimamura T,Nagai LAE,Kanai A,Katoh M,Nomura S,Nakato R,Suzuki S,Tojo A,Voon VC,Ogawa S,Okamoto K,Foukakis T,Gotoh N　Journal of Clinical Investigation　2023/11
  • 　Inflammatory cytokine‐enriched microenvironment plays key roles in the development of breast cancers　Yasuto Takeuchi,Noriko Gotoh　Cancer Science　114　5　1792　2023/02/08　
  • 　Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.　Masafumi Noguchi,Susumu Kohno,Anna Pellattiero,Yukino Machida,Keitaro Shibata,Norihito Shintani,Takashi Kohno,Noriko Gotoh,Chiaki Takahashi,Atsushi Hirao,Luca Scorrano,Atsuko Kasahara　Cell death & disease　14　4　241　2023/04/05
  • 　Efp promotes growth of triple-negative breast cancer cells　Wataru Sato,Kazuhiro Ikeda,Noriko Gotoh,Satoshi Inoue,Kuniko Horie　Biochemical and Biophysical Research Communications　624　81　2022/10
  • 　Large miRNA survival analysis reveals a prognostic four-biomarker signature for triple negative breast cancer　Andrade F, Nakata A, Gotoh N, Fujita A　Genet Mol Biol,　in press　2020

Conference Presentations

  • Novel molecular targets in breast cancer stem cells in patient-derived sphere cells(conference：14th Japanese-German Workshop)(2014/11/14)
  • 乳がん幹細胞を標的とした治療戦略(conference：乳がん研究の新展開：基礎科学から臨床医学へ)(2014/09/25)
  • 増殖因子によるがん幹細胞とそのニッチ制御の分子機構(conference：第9回シグナルネットワーク研究会)(2017/05/13)
  • Cancer stem-like cells derived from breast cancer or lung cancer(conference：第33回日本毒性病理学会総会)(2017/01/17)
  • One carbon metabolic enzymes play important roles for cancer cells and cancer stem-like cells(conference：3rd World Congress on Cancer)(2019/09/24)

show all

  • Growth factor signaling regulates cancer stem cells(conference：International Symposium of Advances in Cancer Stem Cell Therapeutics)(2019/08/24)
  • がん幹細胞を標的とするがん根治療法戦略(conference：第15回新規素材探索研究会：特別講演)(2016/06)
  • がん幹細胞とそのニッチの制御機構(conference：千里ライフサイエンス新適塾ー「難病への挑戦」第36回会合)(2018/11/14)
  • Molecular targets in the signaling and metabolism in cancer stem cells and their niche(conference：特別シンポジウム・女性研究者による癌研究)(2015/10/09)
  • 乳がんの1細胞解析(conference：シンポジウム「固形がんの1細胞解析」)(2019/05/25)
  • Molecular targets in the signaling and metabolism in cancer stem cells and their niche(conference：ワークショップ「がん治療抵抗性にむけた新しいアプローチ」)(2015/12/01)
  • 乳がんの三次元培養とPDXを用いたがん幹細胞制御機構の解明(conference：講演会：新しい治療法の開発を目指す患者由来がんモデル)(2018/06/28)
  • CD74-NRG1, an oncogenic fusion gene product, leads to insulin-like growth factor 2 autocrine/paracrine circuit and confers cancer stem cell properties(conference：The 20th Korea-Japan Cancer Research Workshop)(2015/11/30)
  • The replicative factor MCM10 maintains patient-derived breast cancer stem-like cells that constitutively experience DNA replicative stress(conference：講演会「患者由来がんモデル〜基礎研究から臨床応用まで〜」)(2019/07/31)
  • 乳がん臨床検体由来がん幹細胞濃縮細胞群の1細胞解析(conference：ワークショップ「技術革新がもたらすがん治療難治性の理解克服へむけた新しい方向性」)(2019/12/03)
  • A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference：6th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2016/09)
  • がん幹細胞—乳がんの癌幹細胞研究と臨床応用への展望(conference：合同シンポジウム：がん治療のゲノム個別化Precision Medicineを目指す多様な視点)(2015/10/30)
  • Semaphorin signaling via MICAL3 induces symmetric cell division of breast cancer stem-like cells(conference：The 1st Meeting of International Society of Precision Cancer Medicine (ISPCM))(2018/03/16)
  • 微小環境と治療抵抗性メカニズム(conference：シンポジウム１５「ゲノム・エピゲノム解析の進歩」)(2019/07/12)
  • Analysis of regulatory mechanisms in breast cancer-stem like cells by using spheroid cultures of patient-derived cancer cells and patient-derived xenograft (PDX) models(conference：International Symposium on Tumor Biology in Kanazawa)(2018/11/26)
  • Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells”(conference：Symposium: The State-of-the-Art 3D Tissue Culture & Organoids)(2019/04/19)
  • プリン合成経路にあるミトコンドリア内酵素MTHFD2は、がん幹細胞性とゲフィチニブ耐性を賦与する(conference：シンポジウム「ミトコンドリア生化学が切り開く新たな疾患病態」)(2019/09)
  • 増殖因子によるシグナル制御から得られた耐性克服のための新規分子標的(conference：シンポジウム・肺癌のトランスレーショナルリサーチ（分子標的薬の耐性克服）)(2015/11/27)
  • Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit(conference：The international academic seminar of tumor basis and clinical translational medicine in Jinan university)(2016/10/12)
  • Growth factor signaling controls breast cancer stem-like cells and their niche(conference：The Korean Sciety for Biochemistry and Molecular Biology (KSBMB) International Conference 2017)(2017/05/03)
  • 一炭素代謝経路ミトコンドリア内酵素による肺がん幹細胞の維持(conference：難治がん〜治療標的の同定と創薬への展望〜)(2017/05/10)
  • グリシン-セリン代謝経路の創薬標的MTHFD2(conference：創薬)(2016/07/08)
  • Growth factor signaling controls breast cancer stem-like cells(conference：ジャクソン研究所・HUGO共同シンポジウム)(2017/03/23)
  • 乳がん、肺がんのがん幹細胞様細胞の分子標的(conference：ワークショップ：がん幹細胞を標的にした治療)(2016/06/01)
  • A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference：代謝を標的としたがんの制御)(2016/10/06)
  • Opening lecture from a senior female scientist about her experience of being a leader in Japan(conference：EMBO Laboratory Leadership Course)(2022/12/05)
  • 乳がん幹細胞の制御機構とPatient-derived xenograft (PDX)モデル(conference：シンポジウム)(2018/05/18)
  • 癌幹細胞の幹細胞性維持シグナルと創薬標的(conference：シンポジウム：乳癌幹細胞の制御機構と治療への展開)(2016/03/28)
  • Growth factor signaling in cancer stem cells and niche(conference：The 47th International Symposium of the Princess Takamatsu Cancer Research Fund：Current Status and Perspective of Cancer Stem Cell Research)(2016/11/10)
  • 乳がん患者検体由来三次元培養細胞とがん間質細胞の共培養系を用いたがん幹細胞ニッチシグナルの解析(conference：シンポジウム１４「Cancer Stem Cell」)(2019/09/27)
  • がん幹細胞とニッチ相互作用によるがん進展メカニズム(conference：特別講演会)(2015/03/06)
  • Novel therapeutic strategies to eradicate tumors by targeting cancer stem-like cells(conference：第14回日本臨床腫瘍学会学術集会シンポジウム：日本癌学会・日本臨床腫瘍学会合同シンポジウム)(2016/07/29)
  • Critical roles of luminal progenitor cells in creating the cytokine-rich precancerous niche for mammary tumorigenesis(conference：International Society for Precision Cancer Medicine, 2019)(2019/03/14)
  • 乳がんとがん幹細胞(conference：公開講座「がん研究の最前線」)(2015/05/23)
  • セリン・グリシン代謝経路MTHFD2による肺がん幹細胞の維持(conference：第12回TRワークショップ)(2017/01/25)
  • FXYX3, a subunit of Na+ pump, determines the origin of triple-negative breast cancer stem-like cells, the preeminent driver of drug resistance(conference：The 19th Stem Cell Research Symposium)(2022/05/27)
  • Microenvironment creates premalignant mammary tissues and therapy-resistant persistent tumor cells in breast cancer(2022/09/30)
  • Key molecular targets in cancer stem-like cells in triple-negative breast cancer(2021/09/30)
  • Stem cells, progenitor cells and cancer stem cells in breast tissues(conference：内分泌器官の組織幹細胞と腫瘍幹細胞)(2016/04/22)
  • Dependence on the mitochondrial MTHFD2-mediated purine synthetic pathway in lung cancer(conference：革新的技術の融合によるがん治療抵抗性にむけた新しいアプローチ)(2016/12/06)
  • Novel molecular targets for breast and lung cancer stem cells(conference：第８回高度医療都市を創出する未来技術国際シンポジウム)(2015/02/06)
  • The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis(2021/12/03)
  • Growth factor signaling regulates cancer stem cells and their niche(conference：The 6th Symposium on Anti-tumor Agents and Individual Therapy)(2019/11/24)
  • 乳がんの三次元培養とPDXを用いたがん幹細胞制御機構解明へのアプローチ(conference：ワークショップ「新たな技術がもたらすがん治療難治性の克服にむけた新しいアプローチ」)(2018/11/28)
  • The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis(conference：Symposium on World Cancer Research 2022)(2022/05/06)
  • Maintenance of stemness and niche environment of breast cancer cells by FRS2β, a feedback inhibitor for HER2-ERK pathway, during mammary tumorigenesis(conference：The 8th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2018/09/04)
  • セリン・グリシン代謝経路MTHFD2による肺がん幹細胞の維持(conference：疾患マルチオミクス)(2016/10/21)
  • Maintenance of stemness of breast cancer stem-like cells by FRS2beta, a feedback inhibitor for HER, during mammary tumorigenesis(conference：2015 SNUCRI Cancer Sympotisum)(2015/04/03)
  • Growth factor and cytokine signaling regulates breast cancer stem cells and their niche(conference：第７回Cancer Stem Cell Symposium)(2018/12/14)
  • ミトコンドリア１炭素代謝経路とがん幹細胞、薬剤抵抗性(conference：がんと代謝研究会)(2017/07/13)
  • Semaphorin signal via MICAL3 induces symmetrical cell division of cancer stem-like cells(conference：Symposium “Tumor Stem Cell Biology”)(2017/04/15)
  • MICAL3 regulates stemness of human breast cancer(conference：シンポジウム「がん幹細胞の分子標的・免疫制御の新展開」)(2015/07/16)
  • がん関連線維芽細胞による乳がん幹細胞維持機構の解析(conference：2017生命科学系学会合同年次総会 (ConBio2017))(2017/12/07)
  • 乳がん三次元培養を用いたがんの微小環境、不均一性の解明(conference：第３回がん三次元培養研究会)(2019/11/15)
  • 乳がんのアカデミア創薬(conference：モーニングレクチャー)(2018/09/28)
  • 乳がんの三次元培養とPDXを用いたがん幹細胞制御機構解明(conference：細胞凝集研究会2018)(2018/07/27)
  • 乳がんスフェロイドとがん間質細胞培養を用いた腫瘍微小環境治療標的の探索(conference：がん三次元培養研究会)(2017/11/27)
  • 乳がん幹細胞の基礎と治療への応用(conference：第２４回日本産婦人科乳腺医学会)(2018/03/11)
  • Growth factor signaling regulates cancer stem cells and their niche(conference：The 6th Symposium on Anti-tumor Agents and Individual Therapy)(2019/11/24)
  • One carbon metabolic enzymes play important roles for cancer cells and cancer stem-like cells(conference：3rd World Congress on Cancer)(2019/09/23)
  • Growth factor signaling regulates cancer stem cells and their niche(conference：International Symposium of Advances in Cancer Stem Cell Therapeutics)(2019/08/24)
  • The replicative factor MCM10 maintains patient-derived breast cancer stem-like cells that constitutively experience DNA replicative stress(2019/07/31)
  • Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells(conference：Symposium: The State-of-the-Art 3D Tissue Culture & Organoids)(2019/03/18)
  • Critical roles of luminal progenitor cells in creating the cytokine-rich precancerous niche for mammary tumorigenesis(conference：International Society for Precision Cancer Medicine, 2019)(2019/03/14)
  • Growth factor and cytokine signaling regulates breast cancer stem-like cells and their niche(conference：第７回Cancer Stem Cell Symposium)(2018/12/14)
  • Analysis of regulatory mechanisms in breast cancer-stem like cells by using spheroid cultures of patient-derived cancer cells and patient-derived xenograft (PDX) models(conference：International Symposium on Tumor Biology in Kanazawa)(2018/11/26)
  • Maintenance of stemness and niche environment of breast cancer cells by FRS2β, a feedback inhibitor for HER2-ERK pathway, during mammary tumorigenesis(conference：The 8th FUSCC-CRIKU Joint Symposium on Tumor Biolog)(2018/09/04)
  • Semaphorin signaling via MICAL3 induces symmetric cell division of breast cancer stem-like cells(conference：The 1st Meeting of International Society of Precision Cancer Medicine (ISPCM))(2017/03/16)
  • Growth factor signaling controls breast cancer stem-like cells and their niche(conference：The Korean Sciety for Biochemistry and Molecular Biology (KSBMB) International Conference 2017)(2017/05)
  • Semaphorin signal via MICAL3 induces symmetrical cell division of cancer stem-like cells(conference：2017 AACR Annual Meeting, Symposium “Tumor Stem Cell Biology”)(2017/04)
  • Growth factor signaling controls breast cancer stem-like cells(2017/03)
  • Cancer stem-like cells derived from breast cancer or lung cancer(2017/01)
  • Growth factor signaling in cancer stem-like cells and their niche(conference：The 47th International Symposium of the Princess Takamatsu Cancer Research Fund：Current Status and Perspective of Cancer Stem Cell Research)(2016/11/10)
  • Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit(conference：The international academic seminar of tumor basis and clinical translational medicine in Jinan university)(2016/10/12)
  • A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference：6th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2016/09)
  • Dependence on the mitochondrial MTHFD2-mediated purine synthetic pathway in lung cancer(2016/12/02)
  • A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(2016/10/06)
  • Novel therapeutic strategies to eradicate tumors by targeting cancer stem-like cells(2016/07/29)
  • Stem cells, progenitor cells and cancer stem cells in breast tissues(2016/04/22)
  • CD74-NRG1, an oncogenic fusion gene product, leads to insulin-like growth factor 2 autocrine/paracrine circuit and confers cancer stem cell properties(conference：The 20th Korea-Japan Cancer Research Workshop)(2015/11/30)
  • Molecular targets in the signaling and metabolism in cancer stem cells and their niche(2015/12/01)
  • Molecular targets in the signaling and metabolism in cancer stem cells and their niche(2015/10/09)
  • MICAL3 regulates stemness of human breast cancer(2015/07/16)
  • Maintenance of stemness of breast cancer stem-like cells by FRS2beta, a feedback inhibitor for HER, during mammary tumorigenesis(conference：2015 SNUCRI Cancer Symposium)(2015/04/03)
  • Novel molecular targets for breast and lung cancer stem cells(2015/02/06)

Others

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Patent

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Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Cancer molecular pathology 1(2017)
○Molecular Pathology(2017)
○Molecular Pathology(2017)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Molecular Medical Oncology(2017)
○Biology of Cancer 1A(2017)
○Biology of Cancer 1B(2017)
○Molecular and Cellular Pathology(2017)
○Cancer molecular pathology 1(2017)
○Molecular Oncology(2017)
○Biology of Cancer 1A(2016)
○Cancer molecular pathology 1(2016)
○Molecular Oncology(2016)
○Molecular Medical Oncology(2016)
○Molecular Pathology(2016)
○Molecular and Cellular Pathology(2016)
○Molecular Pathology(2016)
○Biology of Cancer 1B(2016)

International Project

International Students

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