- Top Page
- Profile
last modified：2025/04/02
Professor Goto, Noriko
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medicine, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering
Laboratory
TEL:076-264-6731
Academic Background
Career
Year & Month of Birth
Academic Society
Award
Specialities
Pathological medical chemistry、Tumor biology
Speciality Keywords
caner stem cell, tumor microenvironment, breast cancer, lung cancer, signal transduction, receptor tyrosine kinase, adaptor protein, molecular target, patient-derived xenograft (PDX), cancer mouse model
Research Themes
Books
- Gotoh, N Encyclopedia of Signaling Molecules, 2rd Edition Springer 2017
- Gotoh N and Tsuchida N Encyclopedia of Cancer, 3rd Edition Springer 2016
- EGF受容体のシグナル伝達。 29
- チロシン、セリンリン酸化部位を認識するドメイン。 2537 2000
- 村山貴彦,後藤典子 がん関連線維芽細胞によるがん幹細胞制御機構 Cytometry Research 2019
- 後藤典子 がんにおける遺伝子発現ネットワーク解析 医歯薬出版 2014
- 後藤典子 「EGF受容体」「FGF受容体」「HER2」 羊土社 2015/03
- 後藤典子 受容体型チロシンキナーゼErbBと転写因子NF-κBによる乳癌幹細胞維持の分子機構 羊土社 2012/09
- 村山貴彦,後藤典子 がん幹細胞を維持する細胞内シグナル伝達系 文光堂 2018
- EGF受容体などの受容体型チロシンキナーゼ。 314
- GOTOH Noriko Possible signaling pathways in cancer stem cells in breast cancer. In: Cancer Stem Cells Theories and Practice, Chapter 13, Nikolic, A. (Ed.), INTECH, NY, USA, 2011
- 後藤典子 がん幹細胞におけるシグナルと可塑性のシステム的解析 羊土社 2013
- Gotoh, N FRS2. Encyclopedia of Signaling Molecules, 2rd Edition, Springer, Heidelberg, Germany 2017
- 村山貴彦,後藤典子 乳がんの治療抵抗性のメカニズムとPDXモデル ニューサイエンス社 2017
- 後藤典子 増殖因子による乳がん幹細胞制御の分子機構 Cytometory Research 2013
- 西村建徳,東條有伸,後藤典子 MTHFD2の酵素活性阻害によるがん治療 北隆館 2020/01
- 松尾勳,後藤典子 FGFシグナルの新たな制御機構 羊土社 2012/04
- 富永香菜,後藤典子 乳癌の癌幹細胞 メディカルレビュー社 2015
- Gotoh N,Tsuchida N Membrane-linked docking protein. Encyclopedia of Cancer, 3rd Edition, Springer, Heidelberg, Germany 2016
- 西村建徳,後藤典子 One-carbon metabolism 羊土社 2017
- 後藤典子 カラー図説：がん幹細胞研究とシステム生物学 日本臨床社 2015
- 後藤典子,佐谷秀行 がん幹細胞研究の歴史および治療への展望 羊土社 2015
- アポトーシスに関連する癌遺伝子と癌抑制遺伝子。 47
- Gotoh, N FRS2. In Encyclopedia of Signaling Molecules. Springer, Heidelberg, Germany 2011
- SH2, SH3ドメインとシグナル複合体。 1882 1887
- チロシンキナーゼ型受容体。 21
- 後藤典子 がん幹細胞の研究と治療への応用 がん分子標的治療 2014
- 後藤典子 乳がん幹細胞とニッチの増殖因子シグナル 羊土社 2015
- 富永香菜,後藤典子 浸潤性粘液腺がん発症メカニズム ニューサイエンス社 2017
- 村山貴彦,後藤典子 乳癌などのオルガノイド培養 羊土社 2019/07
- チロシンリン酸化ペプチドを認識するドメイン構造。 13
- 西村建徳,Chen Xiaoxi,後藤典子 乳腺オルガノイド 羊土社 2018
Papers
- Drug resistant mechanisms of cancer stem-like cells and their therapeutic potential as drug targets Murayama T, Gotoh N Cancer Drug Resist 2 457-470 2019
- Feedback inhibitors of epidermal growth factor receptor signaling pathways Gotoh, N Int. J. Biochem. Cell Biol. 41 511-515 2009
- Patient-derived xenograft models of breast cancer and their application. Murayama T, Gotoh N Cells 8 6 E621 2019
- Elucidation of breast cancer tissue diversity by comprehensive analysis of minimum unit omics. Gotoh N. Impact, 2019 3 30-32 2019
- Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. Tominaga K, Minato H, Murayama T, Sasahara A, Nishimura T, Kiyokawa E, Kanauchi H, Shimizu S, Sato A, Nishioka K, Tsuji E, Yano M, Ogawa T, Ishii H, Mori M, Akashi K, Okamoto K, Tanabe M, Tada K, Tojo A, Gotoh N Proc Natl Acad Sci, USA 116 2 625-630 2019
- Cancer stem-like properties and gefitinib-resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2 Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike S-I, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N Oncogene, 38 14 2464-2481 2019
- Polyamine flux suppresses histone lysine demethylases and enhances ID1 gene expression in cancer stem cells. Tamari K, Konno M, Asai A, Koseki J, Hayashi K, Kawamoto K, Murai N, Matsufuji S, Isohashi F, Satoh T, Goto N, Tanaka S, Doki Y, Mori M, Ogawa K, Ishii H Cell Death Diifer 4 1-9 2018
- Drug discovery of anti-cancer drugs targeting methylenetetrahydrofolage dehydrogenease 2. Asai A, Koseki J, Konno M, Nishimura T, Gotoh N, Satoh T, Doki Y, Mori M, Ishii H Helion 4 e01021 2018
- Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis Garg A, Bansal M, Gotoh N, Feng G-S, Zhong J, Wang F, Kariminejad A, Brooks S, Zhang X. PLoS Genet, 13 e1007047 2017
- Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer Yamamoto M, Sakane K, Tominaga K, Gotoh N, Niwa T, Kikuchi Y, Tada K, Goshima N, Semba K, Inoue J-I Cancer Sci, 108 1210-1222 2017
- The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. Kitajima S, Yoshida A, Kohno S, Suzuki S, Nagatani N, Li F, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Thai T, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen M, Barbie D, Hirose O, Tanaka T, Takahashi C Oncogene, 26 5145-5157 2017
- FRS2 Gotoh, N Encyclopedia of Signaling Molecules, 2rd Edition 2017
- An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells. Sasahara A, Tominga K, Nishimura T,Yano M, Kiyokawa E, Noguchi Miki, Noguchi Masakuni, Kanauchi H, Ogawa T, Minato H, Tada K, Seto Y, Tojo A, Gotoh N Oncotarget, 8 24869-24881 2017
- Long-term inflammation transforms intestinal epithelial cells of colonic organoids Hibiya S, Tsuchiya K, Hayashi R, Fukushima K, Horita N, Nishimura T, Gotoh N, Okamoto R, Nakamura T and Watanabe M J Crohns Colitis 11 621-630 2017
- Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells. Tominaga K, Shimamura T, Kimura N, Murayama T, Matsubara D, Kanauchi H, Niida A, Shimizu S, Nishioka K, Tsuji E, Yano M, Sugano S, Shimono Y, Ishii H, Saya H, Mori M, Akashi K, Tada K, Ogawa T, Tojo A, Miyano S, Gotoh N. Oncogene, 36 1276-1286 2017
- Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer Miyo M, Konno M, Nishida N, Sueda T, Noguchi K, Matsui H, Colvin H, Kawamoto K, Koseki J, Haraguchi N, Nishimura J, Hata T, Gotoh N, Matsuda F, Satoh T, Mizushima T, Shimizu H, Doki Y, Mori M, Ishii H Sci Rep, 6 38415 2016
- Intrinsic resistance to 5-Fluorouracil in a brain metastatic variant of human breast cancer cell line, MDA-MB-231BR Sagara A, Igarashi K, Otsuka M, Karasawa T, Gotoh N, Narita M, Kuzumaki N, Narita M, Kato Y PLoS One, 11 e0164250 2016
- Intra-bone fibroblasts promote breast cancer bone metastasis by producing connective tissue growth factor/CCN2 under the influence of cancer cell-derived chemokine, CCL4 Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, Mukaida N Cancer Lett, 378 23-32 2016
- Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit, Murayama T, Nakaoku T, Enari T, Nishimura T, Tominaga K, Nakata A, Tojo A, Sugano S, Kohno T, Gotoh N Cancer Res. 76 974-983 2016
- Membrane-linked docking protein Gotoh N and Tsuchida N Encyclopedia of Cancer, 3rd Edition 2016
- Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Nishida N, Koseki J, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H Oncol Lett, 10 2986-2990 2015
- Pyruvate Kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells Konno M, Ishii H, Koseki J, Tanuma N, Nishida N, Kawamoto K, Nishimura T, Nakata A, Matsui H, Noguchi K, Ozaki M, Noguchi Y, Shima H, Gotoh N, Nagano H, Doki Y, Mori M Regenerative Therap 1 63-71 2015
- A novel serum 4-microRNA signature for lung cancer detection. Nadal E, Truini A, Nakata A, Lin J, Reddy RM, Chang A, Ramnath N, Gotoh N, Beer DG, Chen G: Sci Rep 5 12464 2015
- Embryonic MicroRNA-369 controls metabolic splicing factors and urges cellular reprogramming Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi DL, Ozaki M, Noguchi Y, Mimori K, Gotoh N, Tanuma N, Shima H, Doki Y, Mori M, Ishii H PLoS One, 10 e0132789 2015
- Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H PLoS One, 10 e0127119 2015
- MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H. Br J Cancer, 111 1572-80 2014
- Epiregulin enhances tumorigenicity activating ERK/MAPK pathway in glioblastoma Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, Tsuda M, Tanino M, Kimura T, Nishihara H, Gotoh N, Tanaka S Neuro. Oncol 16 960-70 2014
- FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation. Ono K, Kita T, Sato S, O’Neill P, Mak S-S., Paschaki M, It, M, Gotoh, N, Kawakami K, Ladher RK PLOS Genetics 10 e1004118 2014
- Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development Li H, Ta, C, Cai Z., Hertzler-Schaefer K, Collins TN, Wang F, Feng G-S, Gotoh N, Zhang X J. Cell Sci 127 571-582 2014
- The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. Shima T, Miyamoto T, Kikushige Y, Yoda J, Tochigi T, Yoshimoto G, Kato K, Takenaka K, Iwasaki H, Mizuno S, Goto N, Akashi K. Exp Hematol, 42 955-965, 2014
- Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, Yamamoto H, Doki Y, Mori M, Ishii H Proc. Natl. Acad. Sci., USA 111 15526-31 2014
- Effect of in vivo administration of reprogramming factors in the mouse liver. Tomokuni A, Eguchi H, Hoshino H, Dewi DL, Nishikawa S, Kano Y, Miyoshi N, Tojo A, Kobayashi S, Gotoh N, Hinohara K, Fusaki N, Saito T, Suemizu H, Wada H, Kobayashi S, Marubashji S, Tanemura M, Doki Y, Mor, M, Ishii H, Nagano H Oncol. Lett. 6 323-328 2013
- Protooncogene TCL1b functions as an Akt kinase co-activator which exhibits oncogenic potency in vivo Hashimoto M, Suizu F, Tokuyama W., Noguchi H, Hirata N, Matsuda-Lennikov M, Masuzawa M, Gotoh, N, Tanaka S. & Noguchi M Oncogenesis 2 e70 2013
- Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F. & Zhang X Development, 140 2711-2723 2013
- An adaptor protein complex of FRS2beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. Minegishi Y, Shibagaki Y, Mizutani A, Fujita F, Tezuka T, Kinoshita M, Kuroda M, Hattori S. & Gotoh N Cancer Sci. 104 345-352 2013
- Elevated beta-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama K, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N. Sci Rep 5 13076 2015
- Growth factor signaling regulates breast cancer stem cells. In Practical molecular target for suppression of cancer Gotoh N Publication in Forum on Immunopathological Diseases and Therapeutics 4 2013
- The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R., Nakamura T. & Watanabe M Biochem. Biophys. Res. Commun 432 175-181 2013
- Systemically injected exosomes targeted to EGFR deliver anti-tumor microRNA to breast cancer cells. Ohno, S., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A, Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., Gotoh, N. & Kuroda, M. Molecular Therapy 21 185-191 2012
- EGFR-targeted liposome for molecular imaging and therapy on NSCLC cells. Yokoyama T, Osato Y, Miyazawa K, Kiyasato A, Hayabe H, Nomura M, Gotoh N, Itoi T, Tauchi T, Ikeda N & Ohyashiki K Cancer Res. 72 2904 2012
- Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma Yamauchi, M., Yamaguchi, R., Nakata, A., Kohno, T., Nagasaki, M., Shimamura, T., Imoto S., Saito A., Ueno, K., Hatanaka, Y., Yoshida, R., Higuchi, T., Nomura, M., Beer, D.G., Yokota, J., Miyano, S. & Gotoh, N PLoS ONE, 7 e43923 2012
- Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer. Nakata, A. & Gotoh, N. Expert Opin. Ther. Targets 16 771-781 2012
- ErbB/NF-kB signaling controls mammosphere formation in human breast cancer. Hinorara K, Kobayashi S, Kanauchi H, Shimizu S, Nishioka K, Tsuji E, Tada K, Umezawa K, Mori M, Ogawa T, Inoue J, Tojo A. & Gotoh N Proc. Natl. Acad. Sci., USA 109 6584-6589 2012
- Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing. Kojima, K., Imoto, S., Yamaguchi, R., Fujita, A., Yamauchi, M., Gotoh, N. & Miyano, S BMC Genomics suppl 1 S6 2012
- Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinoma Okayama, H., Khono, T., Ishii, Y., Shimada, Y., Shiraishi, K., Iwakawa, R., Furuta, K., Tsuta, K., Shibata, T., Yamamoto, S., Watanabe, S., Sakamoto, H., Kumamoto, K., Takenoshita, S., Gotoh, N., Mizuno, H., Sarai, A., Kawano, S., Yamaguchi, R., Miyano, S. & Yokota, J Cancer Res. 72 100-111 2012
- Integrated quantitative analysis of the phoshpoproteome and transcriptome in tamoxifen-resistant breast cancer. Oyama, M., Nagashima, T., Suzuki, T., Kozuka-Hata, H., Yumoto, N., Shiraishi, Y., Ikeda, K., Kuroki, Y., Gotoh, N., Ishida, T., Inoue, S., Kitano, H. & Okada-Hatakeyama, M J. Biol. Chem 286 818-829 2011
- Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. Nomura, M., Fukuda, T, Fujii, K., Kawamura, T., Tojo, H., Kihara, M., Bando, Y., Gazdar, A.F., Tsuboi, M., Oshiro, H., Nagao, T., Ohira, T., Ikeda, N., Gotoh, N., Kato, H., Marko-Varga, G. & Nishimura, T Journal of Clinical Bioinformatics, 1 23 2011
- N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. Yamauchi, M., Yoshino, I., Yamaguchi, R., Shimamura, T., Nagasaki, M., Imoto, S., Niida, A., Koizumi, F., Kohno, T., Yokota, J., Miyano, S. & Gotoh, N Am. J. Cancer. Res 1 823-833 2011
- Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors Gotoh, N. Int. J. Clin. Exp. Pathol 4 403-409 2011
- FRS2 Gotoh, N Encyclopedia of Signaling Molecule 2011
- Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J., Yamamoto, T., Miyano, S., Sugano, S. and Oyama, M PLoS ONE, 5 11 e13926 2010
- Possible signaling pathways in cancer stem cells in breast cancer. Gotoh, N Cancer Stem Cells Theories and Practice, chapter 13 2011
- Inflammatory signaling pathways in self-renewing breast cancer stem cells. Hinohara, K. and Gotoh, N Curr. Opin. Pharmacol 10 650-654 2010
- Collocation-based sparse estimation for constructing dynamic gene networks. Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y., Gotoh, N., Miyano, S Genome Inform 24 164-178 2010
- FGF-FRS2alpha-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells Sato, T., Shimazaki, T., Naka, H, Fukami, S., Okano, H., Lax, I., Schlessinger, J. and Gotoh, N. Stem Cells 28 1661-1672 2010
- FRS2beta a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding. Iejima, D., Minegichi, Y., Takenaka, K., Siswanto, A., Watanabe, M., Huang, L., Watanabe, T., Tanaka, F., Kuroda, M. and Gotoh, N Oncogene 29 3087-3099 2010
- A state space representation of VAR models with sparse learning for dynamic gene networks. Kojima, K., Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T, Ueno, K., Higuchi, T., , Gotoh, N., Miyano, S Genome Inform 22 56-68 2010
- Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells Murohashi, M., Hinohara, K., Kuroda, M., Isagawa, T., Tsuji, S., Kobayashi, S., Umezawa, K., Tojo, A., Aburatani, H. and Gotoh, N Br J. Cancer 102 206-212 2010
- An FGF4-FRS2alpha-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N., Yamamoto, T., Shibuya, M., Schlessinger, J. and Gotoh, N Stem Cells 28 113-121 2010
- Gain-of-function of mutated c-Cbl tumor suppressor in myeloid neoplasms with 11q uniparental disomy Sanada, M., Suzuki, T., Shih, L.-Y., Otsu, M., Kato, M., Yamazaki, S., Tamura, A., Honda, H., Sakata-Yanagimoto, M., Kumano, K., Oda, H., Yamagata, T., Takita, J., Gotoh, N., Nakazaki, K., Kawamata, N., Onodera, M., Nobuyoshi, M., Hayashi, Y., Harada, H., Kurokawa, M., Chiba, S., Mori, H., Ozawa, K., Omine, M., Hirai, H., Nakauchi, H., Koeffler, P. and Ogawa, S Nature 460 904-909 2009
- FRS2beta docking/scaffolding adaptor protein Iejima, D. and Gotoh, N Current research in cancer, 3 99-107 2009
- FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Kameda, Y., Ito, M., Nishimaki, T. and Gotoh, N Dev. Dyn 238 503-513 2009
- Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates Yamauchi, M., and Gotoh, N Biomark. Med 3 139-151 2009
- Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles Minegishi, Y., Iwanari, H., Mochizuki, Y., Horii, T., Hoshino, T., Kodama, T., Hamakubo, T. and Gotoh, N. FEBS lett 583 807-814 2009
- The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment Sato T. and Gotoh, N Expert Opinion on Therapeutic Targets 13 689-700 2009
- Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Gotoh, N Current Stem Cell Research & Therapy 4 9-15 2009
- One-carbon metabolism 35 10 46-51 2017
- 乳がん幹細胞性を維持するシグナル伝達の解析 富永香菜、後藤典子 48 9 423-426 2017
- 乳癌の癌幹細胞 富永香菜、後藤典子 Surgery Frontier 22 4 61-67 2015
- がん幹細胞研究の歴史および治療への展望 後藤典子、佐谷秀行 33 5 676-677 2015
- 乳がん幹細胞とニッチの増殖因子シグナル 33 5 712-717 2015
- Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor Y Hashimoto,H Katayama,E Kiyokawa,S Ota,T Kurata,N Gotoh,N Otsuka,M Shibata,M Matsuda Journal of Biological Chemistry 273 27 17186 1998/07
- Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptor S Murasawa,Y Mori,Y Nozawa,N Gotoh,M Shibuya,H Masaki,K Maruyama,Y Tsutsumi,Y Moriguchi,Y Shibazaki,Y Tanaka,T Iwasaka,M Inada,H Matsubara Circulation Research 82 12 1338 1998/06
- A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3 N Gotoh,A Tojo,M Shibuya EMBO Journal 15 22 6197 1996/11
- The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner N Gotoh,K Muroya,S Hattori,S Nakamura,K Chida,M Shibuya Oncogene 11 12 2525 1995/12
- A UNIQUE SIGNAL-TRANSDUCTION FROM FLT TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR VEGF L SEETHARAM,N GOTOH,Y MARU,G NEUFELD,S YAMAGUCHI,M SHIBUYA Oncogene 10 1 135 1995/01
- A NEW COMMUNICATION-SYSTEM BETWEEN HEPATOCYTES AND SINUSOIDAL ENDOTHELIAL-CELLS IN LIVER THROUGH VASCULAR ENDOTHELIAL GROWTH-FACTOR AND FLT TYROSINE KINASE RECEPTOR FAMILY (FLT-1 AND KDR/FLK-1) A YAMANE,L SEETHARAM,S YAMAGUCHI,N GOTOH,T TAKAHASHI,G NEUFELD,M SHIBUYA ONCOGENE 9 9 2683 1994/09
- Tyrosine phosphorylation sites on FRS2 alpha responsible for Shp2 recruitment are critical for induction of lens and retina N Gotoh,M Ito,S Yamamoto,Yoshino, I,N Song,Y Wang,Lax, I,J Schlessinger,M Shibuya,RA Lang Proceedings of the National Academy of Sciences, USA 101 49 17144 2004/12
- Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation N Gotoh,M Toyoda,M Shibuya Molecular and Cellular Biology 17 4 1824 1997/04
- STRUCTURAL DIVERSITY OF MURINE SERUM AMYLOID-A GENES - EVOLUTIONARY IMPLICATIONS KI YAMAMOTO,N GOTO,J KOSAKA,M SHIROO,YD YEUL,S MIGITA Journal of Immunology 139 5 1683 1987/09
- A HIGHLY CONSERVED TYROSINE RESIDUE AT CODON 845 WITHIN THE KINASE DOMAIN IS NOT REQUIRED FOR THE TRANSFORMING ACTIVITY OF HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR N GOTOH,A TOJO,M HINO,Y YAZAKI,M SHIBUYA Biochemical and Biophysical Research Communications 186 2 768 1992/07
- Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway A Hashimoto,M Kurosaki,N Gotoh,R Shibuya,T Kurosaki Journal of Biological Chemistry 274 29 20139 1999/07
- EPIDERMAL GROWTH FACTOR-RECEPTOR MUTANT LACKING THE AUTOPHOSPHORYLATION SITES INDUCES PHOSPHORYLATION OF SHC PROTEIN AND SHC-GRB2 ASH ASSOCIATION AND RETAINS MITOGENIC ACTIVITY N GOTOH,A TOJO,K MUROYA,Y HASHIMOTO,S HATTORI,S NAKAMURA,T TAKENAWA,Y YAZAKI,M SHIBUYA Proceedings of the National Academy of Sciences, USA 91 1 167 1994/01
- POSSIBLE INVOLVEMENT OF RECEPTOR-TYPE TYROSINE KINASES EGF-R AND FLT IN THE DEVELOPMENT OF BRAIN TUMORS M SHIBUYA,H YAMAZAKI,N GOTOH,H MATSUSHIME,L SEETHARAN,B PAIN,Y ISHII GROWTH FACTORS: CELL GROWTH, MORPHOGENESIS, AND TRANSFORMATION 42 42 139 1994
- POSSIBLE INVOLVEMENT OF VEGF-FLT TYROSINE KINASE RECEPTOR SYSTEM IN NORMAL AND TUMOR ANGIOGENESIS M SHIBUYA,L SEETHARAM,Y ISHII,A SAWANO,N GOTOH,H MATSUSHIME,S YAMAGUCHI MOLECULAR AND CELLULAR BASIS FOR CELL TO CELL INTERACTION: ITS SIGNIFICANCE IN CANCER 24 162 1994
- DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane H Hasegawa,E Kiyokawa,S Tanaka,K Nagashima,N Gotoh,M Shibuya,T Kurata,M Matsuda Molecular and Cellular Biology 16 4 1770 1996/04
- Involvement of MAP kinase-independent protein kinase C signaling pathway in the EGF-lnduced p21(WAF1/Cip1) expression and growth inhibition of A431 cells M Toyoda,N Gotoh,H Handa,M Shibuya Biochemical and Biophysical Research Communications 250 2 430 1998/09
- FRS2 alpha Is Required for the Separation, Migration, and Survival of Pharyngeal-Endoderm Derived Organs Including Thyroid, Ultimobranchial Body, Parathyroid, and Thymus Yoko Kameda,Masataka Ito,Toshiyuki Nishimaki,Noriko Gotoh Developmental Dynamics 238 3 503 2009/03
- Essential role of Shp2-binding sites on the docking protein FRS2α for mamalian corticogenesis and for FGF2-dependent proliferation of cultured neural progenitor cells. Yamamoto, S,Yoshino, I,Shimazaki, T,Murohashi, M,Hevner, R. F,Lax, I,Okano, H,Shibuya, M,Schlessinger, J,Gotoh, N Proceedings of the National Academy of Sciences, USA 102 44 15983 2005/09
- Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins Noriko Gotoh Cancer Science 99 7 1319 2008/07
- PREDICTING DIFFERENCES IN GENE REGULATORY SYSTEMS BY STATE SPACE MODELS Rui Yamaguchi,Seiya Imoto,Mai Yamauchi,Masao Nagasaki,Ryo Yoshida,Teppei Shimamura,Yosuke Hatanaka,Kazuko Ueno,Tomoyuki Higuchi,Noriko Gotoh,Satoru Miyano Genome Informatics 21 101 2008
- FRS2β docking/scaffolding adaptor protein. Iejima, D,Gotoh, N Current Research in Cancer, Research Media 3 99 2009/06
- FRS2 alpha(2F/2F) mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve Yoko Kameda,Masataka Ito,Toshiyuki Nishimaki,Noriko Gotoh Developmental Biology 314 1 236 2008/02
- N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells Mai Yamauchi,Ikuyo Yoshino,Rui Yamaguchi,Teppei Shimamura,Masao Nagasaki,Seiya Imoto,Atsushi Niida,Fumiaki Koizumi,Takashi Kohno,Jun Yokota,Satoru Miyano,Noriko Gotoh American Journal of Cancer Research 1 7 823 2011
- The docking protein FRS2 alpha is an essential component of multiple fibroblast growth factor responses during early mouse development N Gotoh,K Manova,S Tanaka,M Murohashi,Y Hadari,A Lee,Y Hamada,T Hiroe,M Ito,T Kurihara,H Nakazato,M Shibuya,Lax, I,E Lacy,J Schlessinger Molecular and Cellular Biology 25 10 4105 2005/05
- GAIN-OF-FUNCTION MUTATIONS OF C-CBL TUMOR SUPPRESSOR IN MDS AND MDS/MPD ASSOCIATED WITH 11Q UPD Sanada,M,Suzuki,T,Shih,L. Y,Otsu,M,Yamazaki,S,Kato,M,Honda,H,Sakata-Yanagimoto,M,Kumano,K,Oda,H,Takita,J,Goto,N,Kawamata,N,Uehara,E,Hayashi,Y,Harada,H,Kurokawa,M,Chiba,S,Mori,H,Ozawa,K,Omine,M,Nakauchi,H,Koeffler,H. P,Ogawa,S HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 94 Suppl. 2 488 2009/06
- Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer Masaaki Oyama,Takeshi Nagashima,Takashi Suzuki,Hiroko Kozuka-Hata,Noriko Yumoto,Yuichi Shiraishi,Kazuhiro Ikeda,Yoko Kuroki,Noriko Gotoh,Takanori Ishida,Satoshi Inoue,Hiroaki Kitano,Mariko Okada-Hatakeyama Journal of Biological Chemistry 286 1 818 2011/01
- Inflammatory signaling pathways in self-renewing breast cancer stem cells Kunihiko Hinohara,Noriko Gotoh Current Opinion in Pharmacology 10 6 650 2010/12
- Phosphoproteomics-Based Modeling Defines the Regulatory Mechanism Underlying Aberrant EGFR Signaling Shinya Tasaki,Masao Nagasaki,Hiroko Kozuka-Hata,Kentaro Semba,Noriko Gotoh,Seisuke Hattori,Jun-ichiro Inoue,Tadashi Yamamoto,Satoru Miyano,Sumio Sugano,Masaaki Oyama PLoS ONE 5 11 e13926 2010/11
- FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells. Takuya Sato,Takuya Shimazaki,Hayato Naka,Shin-Ichi Fukami,Yasushi Satoh,Hideyuki Okano,Irit Lax,Joseph Schlessinger,Noriko Gotoh Stem cells (Dayton, Ohio) 28 9 1661 2010/09
- An FGF4-FRS2 alpha-Cdx2 Axis in Trophoblast Stem Cells Induces Bmp4 to Regulate Proper Growth of Early Mouse Embryos Michiko Murohashi,Takahisa Nakamura,Satoshi Tanaka,Taeko Ichise,Nobuaki Yoshida,Tadashi Yamamoto,Masabumi Shibuya,Joseph Schlessinger,Noriko Gotoh Stem Cells 28 1 113 2010/01
- Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells M. Murohashi,K. Hinohara,M. Kuroda,T. Isagawa,S. Tsuji,S. Kobayashi,K. Umezawa,A. Tojo,H. Aburatani,N. Gotoh British Journal of Cancer 102 1 206 2010/01
- A state space representation of VAR models with sparse learning for dynamic gene networks. Kojima K,Yamaguchi R,Imoto S,Yamauchi M,Nagasaki M,Yoshida R,Shimamura T,Ueno K,Higuchi T,Gotoh N,Miyano S Genome Informatics 22 56 2010/01
- The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment Takuya Sato,Noriko Gotoh Expert Opinion on Therapeutic Targets 13 6 689 2009/06
- Molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates Mai Yamauchi,Noriko Gotoh Biomarkers in Medicine 3 2 139 2009/04
- Feedback inhibitors of the epidermal growth factor receptor signaling pathways Noriko Gotoh International Journal of Biochemistry & Cell Biology 41 3 511 2009/03
- Prominent expression of FRS2 beta protein in neural cells and its association with intracellular vesicles Yuriko Minegishi,Hiroko Iwanari,Yasuhiro Mochizuki,Takako Horii,Tomoko Hoshino,Tatsuhiko Kodama,Takao Hamakubo,Noriko Gotoh FEBS Letters 583 4 807 2009/02
- Control of Stemness by Fibroblast Growth Factor Signaling in Stem Cells and Cancer Stem Cells Noriko Gotoh Current Stem Cell Research & Therapy 4 1 9 2009/01
- EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition Eun-Sil Kang,Min-A Oh,Sin-Ae Lee,Tae Young Kim,Sung-Hoon Kim,Noriko Gotoh,Yong-Nyun Kim,Jung Weon Lee BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1773 6 833 2007/06
- Essential role of Shp2-binding sites on FRS2α for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells Yamamoto S,Yoshino I,Shimazaki T,Murohashi M,Hevner R. F,Lax I,Okano H,Shibuya M,Schlessinger J,Gotoh N Proceedings of the National Academy of Sciences, USA 102 44 15983 2005/11/01
- Membrane-linked docking protein. Gotoh N,Tsuchida N Encyclopedia of Cancer, 3rd Edition 1819 2008/07
- Frs2 alpha Sato T,Gotoh N The Signaling Gateway, Molecule Pages 2009/05
- Unique role of SNT-2/FRS2β/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways L. Huang,M. Watanabe,M. Chikamori,Y. Kido,T. Yamamoto,M. Shibuya,N. Gotoh,N. Tsuchida Oncogene 25 49 6457 2006/10/19
- Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms Masashi Sanada,Takahiro Suzuki,Lee-Yung Shih,Makoto Otsu,Motohiro Kato,Satoshi Yamazaki,Azusa Tamura,Hiroaki Honda,Mamiko Sakata-Yanagimoto,Keiki Kumano,Hideaki Oda,Tetsuya Yamagata,Junko Takita,Noriko Gotoh,Kumi Nakazaki,Norihiko Kawamata,Masafumi Onodera,Masaharu Nobuyoshi,Yasuhide Hayashi,Hiroshi Harada,Mineo Kurokawa,Shigeru Chiba,Hiraku Mori,Keiya Ozawa,Mitsuhiro Omine,Hisamaru Hirai,Hiromitsu Nakauchi,H. Phillip Koeffler,Seishi Ogawa Nature 460 7257 904 2009/08
- Collocation-based sparse estimation for constructing dynamic gene networks. Shimamura, T.,Imoto, S.,Nagasaki, M.,Yamauchi, M.,Yamaguchi, R.,Fujita, A.,Tamada, Y.,Gotoh, N.,Miyano, S. Genome informatics. International Conference on Genome Informatics 24 164 2010
- Frs2 beta. Minegishi, Y,Gotoh, N The Signaling Gateway, Molecule Pages 2009/05
- FRS2 beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding D. Iejima,Y. Minegishi,K. Takenaka,A. Siswanto,M. Watanabe,L. Huang,T. Watanabe,F. Tanaka,M. Kuroda,N. Gotoh ONCOGENE 29 21 3087 2010/05
- Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming. Masamitsu Konno,Jun Koseki,Koichi Kawamoto,Naohiro Nishida,Hidetoshi Matsui,Dyah Laksmi Dewi,Miyuki Ozaki,Yuko Noguchi,Koshi Mimori,Noriko Gotoh,Nobuhiro Tanuma,Hiroshi Shima,Yuichiro Doki,Masaki Mori,Hideshi Ishii PLoS ONE 10 7 e0132789 2015
- Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells. Masamitsu Konno,Hideshi Ishii,Jun Koseki,Nobuhiro Tanuma,Naohiro Nishida,Koichi Kawamoto,Tatsunori Nishimura,Asuka Nakata,Hidetoshi Matsui,Kozou Noguchi,Miyuki Ozaki,Yuko Noguchi,Hiroshi Shima,Noriko Gotoh,Hiroaki Nagano,Yuichiro Doki,Masaki Mori Regenerative Therapy 1 63 2015/06
- Adaptor protein complex of FRS2 beta and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation Yuriko Minegishi,Yoshio Shibagaki,Anna Mizutani,Koji Fujita,Tohru Tezuka,Masao Kinoshita,Masahiko Kuroda,Seisuke Hattori,Noriko Gotoh Cancer Science 104 3 345 2013/03
- Growth factor signaling regulates breast cancer stem cells GOTOH Noriko Cytometry Research 23 2 33 2013/09/25
- MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer. Hasegawa S,Eguchi H,Nagano H,Konno M,Tomimaru Y,Wada H,Hama N,Kawamoto K,Kobayashi S,Nishida N,Koseki J,Nishimura T,Gotoh N,Ohno S,Yabuta N,Nojima H,Mori M,Doki Y,Ishii H British Journal of Cancer 111 8 1572 2014/08
- EGFR-targeted liposome for molecular imaging and therapy on NSCLC cells. Yokoyama T,Osato Y,Miyazawa K,Kiyasato A,Hayabe H,Nomura M,Gotoh N,Itoi T,Tauchi T,Ikeda N,Ohyashiki K Cancer Research 72 8 2012/04
- A Novel Serum 4-microRNA Signature for Lung Cancer Detection Ernest Nadal,Anna Truini,Asuka Nakata,Jules Lin,Rishindra M. Reddy,Andrew C. Chang,Nithya Ramnath,Noriko Gotoh,David G. Beer,Guoan Chen Scientific Reports 5 12464 2015/07
- Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing Kaname Kojima,Seiya Imoto,Rui Yamaguchi,Andre Fujita,Mai Yamauchi,Noriko Gotoh,Satoru Miyano BMC Genomics 13 S6 2012/01
- A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage abnormalities observed in Ext2 heterozygous mutant mice. Nasirujjaman K,Kimura-Yoshida, C,Gotoh, N,Hiramatsu, R,Matsuo I Journal of Osaka Medical Center & Research Institute for Maternal & Child Health 26 2 101 2011/07
- The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein Yoshihito Kano,Kiichiro Tsuchiya,Xiu Zheng,Nobukatsu Horita,Keita Fukushima,Shuji Hibiya,Yuhki Yamauchi,Tatsunori Nishimura,Kunihiko Hinohara,Noriko Gotoh,Shinji Suzuki,Ryuichi Okamoto,Tetsuya Nakamura,Mamoru Watanabe Biochemical and Biophysical Research Communications 432 1 175 2013/03
- Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs Asuka Nakata,Ryo Yoshida,Rui Yamaguchi,Mai Yamauchi,Yoshinori Tamada,Andre Fujita,Teppei Shimamura,Seiya Imoto,Tomoyuki Higuchi,Masaharu Nomura,Tatsuo Kimura,Hiroshi Nokihara,Masahiko Higashiyama,Kazuya Kondoh,Hiroshi Nishihara,Arinobu Tojo,Seiji Yano,Satoru Miyano,Noriko Gotoh Scientific Reports 5 1 13076 2015/08
- Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells Shin-ichiro Ohno,Masakatsu Takanashi,Katsuko Sudo,Shinobu Ueda,Akio Ishikawa,Nagahisa Matsuyama,Koji Fujita,Takayuki Mizutani,Tadaaki Ohgi,Takahiro Ochiya,Noriko Gotoh,Masahiko Kuroda Molecular Therapy 21 1 185 2013/01
- Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing Kaname Kojima,Seiya Imoto,Rui Yamaguchi,André Fujita,Mai Yamauchi,Noriko Gotoh,Satoru Miyano Series on Advances in Bioinformatics and Computational Biology 13 2012
- MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. Hisataka Ogawa,Xin Wu,Koichi Kawamoto,Naohiro Nishida,Masamitsu Konno,Jun Koseki,Hidetoshi Matsui,Kozou Noguchi,Noriko Gotoh,Tsuyoshi Yamamoto,Kanjiro Miyata,Nobuhiro Nishiyama,Hiroaki Nagano,Hirofumi Yamamoto,Satoshi Obika,Kazunori Kataoka,Yuichiro Doki,Masaki Mori,Hideshi Ishii PLoS ONE 10 5 e0127119 2015
- Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma Shinji Kohsaka,Kunihiko Hinohara,Lei Wang,Tatsunori Nishimura,Masana Urushido,Kazuhiro Yachi,Masumi Tsuda,Mishie Tanino,Taichi Kimura,Hiroshi Nishihara,Noriko Gotoh,Shinya Tanaka Neuro-Oncology 16 7 960 2014/07
- Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo M. Hashimoto,F. Suizu,W. Tokuyama,H. Noguchi,N. Hirata,M. Matsuda-Lennikov,T. Edamura,M. Masuzawa,N. Gotoh,S. Tanaka,M. Noguchi Oncogenesis 2 1 2013/09
- The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell Takahiro Shima,Toshihiro Miyamoto,Yoshikane Kikushige,Junichiro Yuda,Taro Tochigi,Goichi Yoshimoto,Koji Kato,Katsuto Takenaka,Hiromi Iwasaki,Shinichi Mizuno,Noriko Goto,Koichi Akashi Experimental Hematology 42 11 955 2014/11
- Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study Masaharu Nomura,Tetsuya Fukuda,Kiyonaga Fujii,Takeshi Kawamura,Hiromasa Tojo,Makoto Kihara,Yasuhiko Bando,Adi F. Gazdar,Masahiro Tsuboi,Hisashi Oshiro,Toshitaka Nagao,Tatsuo Ohira,Norihiko Ikeda,Noriko Gotoh,Harubumi Kato,Gyorgy Marko-Varga,Toshihide Nishimura Journal of Clinical Bioinformatics 1 1 23 2011/09/03
- Possible signaling pathways in cancer stem cells in breast cancer. Gotoh, N Cancer Stem Cells Theories and Practice 261 2011/03
- Development of the prognostic system with gene signature in early stage lung cancer Nakata Asuka,Fujita André,Chen Guoan,Kohno Takashi,Tojo Arinobu,Beer David.G,Gotoh Noriko Japan Journal of Molecular Tumor Marker Research 30 45 2015
- Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors Noriko Gotoh International Journal of Clinical and Experimental Pathology 4 4 403 2011
- Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas Hirokazu Okayama,Takashi Kohno,Yuko Ishii,Yoko Shimada,Kouya Shiraishi,Reika Iwakawa,Koh Furuta,Koji Tsuta,Tatsuhiro Shibata,Seiichiro Yamamoto,Shun-ichi Watanabe,Hiromi Sakamoto,Kensuke Kumamoto,Seiichi Takenoshita,Noriko Gotoh,Hideaki Mizuno,Akinori Sarai,Shuichi Kawano,Rui Yamaguchi,Satoru Miyano,Jun Yokota Cancer Research 72 1 100 2012/01
- ErbB receptor tyrosine kinase/NF-kappa B signaling controls mammosphere formation in human breast cancer Kunihiko Hinohara,Seiichiro Kobayashi,Hajime Kanauchi,Seiichiro Shimizu,Kotoe Nishioka,Ei-ichi Tsuji,Kei-ichiro Tada,Kazuo Umezawa,Masaki Mori,Toshihisa Ogawa,Jun-ichiro Inoue,Arinobu Tojo,Noriko Gotoh Proceedings of the National Academy of Sciences, USA 109 17 6584 2012/04
- Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer Asuka Nakata,Noriko Gotoh Expert Opinion on Therapeutic Targets 16 8 771 2012/08
- Epidermal Growth Factor Receptor Tyrosine Kinase Defines Critical Prognostic Genes of Stage I Lung Adenocarcinoma Mai Yamauchi,Rui Yamaguchi,Asuka Nakata,Takashi Kohno,Masao Nagasaki,Teppei Shimamura,Seiya Imoto,Ayumu Saito,Kazuko Ueno,Yousuke Hatanaka,Ryo Yoshida,Tomoyuki Higuchi,Masaharu Nomura,David G. Beer,Jun Yokota,Satoru Miyano,Noriko Gotoh PLoS ONE 7 9 e43923 2012/09
- Growth factor signaling regulates breast cancer stem cells Noriko Gotoh Forum on Immunopathological Diseases and Therapeutics 4 1 1 2013
- Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma Zhigang Cai,Chenqi Tao,Hongge Li,Raj Ladher,Noriko Gotoh,Gen-Sheng Feng,Fen Wang,Xin Zhang Development 140 13 2711 2013/07
- Effect of in vivo administration of reprogramming factors in the mouse liver. Akira Tomokuni,Hidetoshi Eguchi,Hiromitsu Hoshino,Dyah Laksmi Dewi,Shinpei Nishikawa,Yoshihiro Kano,Norikatsu Miyoshi,Arinobu Tojo,Seiichiro Kobayashi,Noriko Gotoh,Kunihiko Hinohara,Noemi Fusaki,Toshiyuki Saito,Hiroshi Suemizu,Hiroshi Wada,Shogo Kobayashi,Shigeru Marubashi,Masahiro Tanemura,Yuichiro Doki,Masaki Mori,Hideshi Ishii,Hiroaki Nagano Oncology Letters 6 2 323 2013/08
- FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation Kazuya Ono,Tomoko Kita,Shigeru Sato,Paul O'Neill,Siu-Shan Mak,Marie Paschaki,Masataka Ito,Noriko Gotoh,Kiyoshi Kawakami,Yoshiki Sasai,Raj K. Ladher PLoS Genetics 10 1 e1004118 2014/01
- Frs2 alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development Hongge Li,Chenqi Tao,Zhigang Cai,Kristina Hertzler-Schaefer,Tamica N. Collins,Fen Wang,Gen-Sheng Feng,Noriko Gotoh,Xin Zhang Journal of Cell Science 127 3 571 2014/02
- Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition. Atsushi Hamabe,Masamitsu Konno,Nobuhiro Tanuma,Hiroshi Shima,Kenta Tsunekuni,Koichi Kawamoto,Naohiro Nishida,Jun Koseki,Koshi Mimori,Noriko Gotoh,Hirofumi Yamamoto,Yuichiro Doki,Masaki Mori,Hideshi Ishii Proceedings of the National Academy of Sciences, USA 111 43 15526 2014/10/28
- Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer. Mizuki Yamamoto,Kota Sakane,Kana Tominaga,Noriko Gotoh,Takayoshi Niwa,Yasuko Kikuchi,Keiichiro Tada,Naoki Goshima,Kentaro Semba,Jun-Ichiro Inoue Cancer Science 108 6 1210 2017/06
- NRG1融合遺伝子は肺がんにおけるがん幹細胞形質の促進に寄与する 中奥 敬史,村山 貴彦,中田 飛鳥,後藤 典子,河野 隆志 日本癌学会総会記事 75回 P 2016/10
- Elucidation of Breast Cancer Tissue Diversity by Comprehensive Analysis of Minimum Unit Omics Gotoh N Impact 2019 3 30 2019/03
- Oncogenic Fusion Gene CD74-NRG1 Confers Cancer Stem Cell-like Properties in Lung Cancer through a IGF2 Autocrine/Paracrine Circuit Takahiko Murayama,Takashi Nakaoku,Masato Enari,Tatsunori Nishimura,Kana Tominaga,Asuka Nakata,Arinobu Tojo,Sumio Sugano,Takashi Kohno,Noriko Gotoh Cancer Research 76 4 974 2016/02
- がん幹細胞 乳がん患者検体由来三次元培養細胞とがん間質細胞の共培養系を用いたがん幹細胞ニッチシグナルの解析(Cancer stem cell Cancer stem cell niche signals in cancer associated fibroblasts(CAFs) to maintain cancer stem-like cells(CSCs)) 後藤 典子,村山 貴彦,矢野 正雄,多田 敬一郎,池田 和博,岡本 康司,堀江 公仁子,井上 聡,東條 有伸 日本癌学会総会記事 78回 S14 2019/09
- HER2/HER3シグナル阻害によるNRG1遺伝子融合陽性肺がんの治療 中奥 敬史,蔦 幸治,村山 貴彦,中田 飛鳥,白石 航也,荻原 秀明,金 永学,三嶋 理晃,後藤 典子,河野 隆志 日本癌学会総会記事 74回 E 2015/10
- Cyclin G2: A novel independent prognostic marker in pancreatic cancer. Shinichiro Hasegawa,Hiroaki Nagano,Masamitsu Konno,Hidetoshi Eguchi,Akira Tomokuni,Yoshito Tomimaru,Hiroshi Wada,Naoki Hama,Koichi Kawamoto,Shogo Kobayashi,Shigeru Marubashi,Naohiro Nishida,Jun Koseki,Noriko Gotoh,Shouichi Ohno,Norikazu Yabuta,Hiroshi Nojima,Masaki Mori,Yuichiro Doki,Hideshi Ishii Oncology letters 10 5 2986 2015/11
- がん関連線維芽細胞由来液性因子によるがん幹細胞様細胞の維持(Maintenance of breast cancer stem-like cells by cancer associated fibroblast-derived soluble factors) 村山 貴彦,西村 建徳,矢野 正雄,笹原 麻子,多田 敬一郎,池田 和博,岡本 康司,堀江 公仁子,井上 聡,東條 有伸,後藤 典子 日本癌学会総会記事 77回 1955 2018/09
- Intrinsic Resistance to 5-Fluorouracil in a Brain Metastatic Variant of Human Breast Cancer Cell Line, MDA-MB-231BR Atsunobu Sagara,Katsuhide Igarashi,Maky Otsuka,Takeshi Karasawa,Noriko Gotoh,Michiko Narita,Naoko Kuzumaki,Minoru Narita,Yoshinori Kato PLoS ONE 11 10 e0164250 2016/10
- Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2. Ayumu Asai,Jun Koseki,Masamitsu Konno,Tatsunori Nishimura,Noriko Gotoh,Taroh Satoh,Yuichiro Doki,Masaki Mori,Hideshi Ishii Heliyon 4 12 e01021 2018/12
- Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer. Masaaki Miyo,Masamitsu Konno,Naohiro Nishida,Toshinori Sueda,Kozo Noguchi,Hidetoshi Matsui,Hugh Colvin,Koichi Kawamoto,Jun Koseki,Naotsugu Haraguchi,Junichi Nishimura,Taishi Hata,Noriko Gotoh,Fumio Matsuda,Taroh Satoh,Tsunekazu Mizushima,Hiroshi Shimizu,Yuichiro Doki,Masaki Mori,Hideshi Ishii Scientific reports 6 38415 2016/12/07
- Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells K. Tominaga,T. Shimamura,N. Kimura,T. Murayama,D. Matsubara,H. Kanauchi,A. Niida,S. Shimizu,K. Nishioka,E-I Tsuji,M. Yano,S. Sugano,Y. Shimono,H. Ishii,H. Saya,M. Mori,K. Akashi,K-I Tada,T. Ogawa,A. Tojo,S. Miyano,N. Gotoh Oncogene 36 9 1276 2017/03
- An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Asako Sasahara,Kana Tominaga,Tatsunori Nishimura,Masao Yano,Etsuko Kiyokawa,Miki Noguchi,Masakuni Noguchi,Hajime Kanauchi,Toshihisa Ogawa,Hiroshi Minato,Keiichiro Tada,Yasuyuki Seto,Arinobu Tojo,Noriko Gotoh Oncotarget 8 15 24869 2017/04
- Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids Shuji Hibiya,Kiichiro Tsuchiya,Ryohei Hayashi,Keita Fukushima,Nobukatsu Horita,Sho Watanabe,Tomoaki Shirasaki,Ryu Nishimura,Natsuko Kimura,Tatsunori Nishimura,Noriko Gotoh,Shigeru Oshima,Ryuichi Okamoto,Tetsuya Nakamura,Mamoru Watanabe Journal of Crohn's & Colitis 11 5 621 2017/05
- The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity S. Kitajima,A. Yoshida,S. Kohno,F. Li,S. Suzuki,N. Nagatani,Y. Nishimoto,N. Sasaki,H. Muranaka,Y. Wan,T. C. Thai,N. Okahashi,F. Matsuda,H. Shimizu,T. Nishiuchi,Y. Suzuki,K. Tominaga,N. Gotoh,M. Suzuki,M. E. Ewen,D. A. Barbie,O. Hirose,T. Tanaka,C. Takahashi Oncogene 36 36 5145 2017/09
- Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. Kana Tominaga,Hiroshi Minato,Takahiko Murayama,Asako Sasahara,Tatsunori Nishimura,Etsuko Kiyokawa,Hajime Kanauchi,Seiichiro Shimizu,Ayaka Sato,Kotoe Nishioka,Ei-Ichi Tsuji,Masao Yano,Toshihisa Ogawa,Hideshi Ishii,Masaki Mori,Koichi Akashi,Koji Okamoto,Masahiko Tanabe,Kei-Ichiro Tada,Arinobu Tojo,Noriko Gotoh Proceedings of the National Academy of Sciences, USA 116 2 625 2019/01/08
- Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro-Horike,Soichiro Sasaki,Kenji Kita,Shin-Ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh Oncogene 38 14 2464 2019/04
- 複製因子MCM10は恒常的にDNA複製ストレスにさらされる乳がん幹細胞の維持に寄与する(The replicative factor MCM10 maintains breast cancer stem-like cells that constantly experience DNA replicative stress) 村山 貴彦,山脇 芳,西村 建徳,矢野 正雄,笹原 麻子,小川 利久,多田 敬一郎,鐘巻 将人,井上 聡,岡本 康司,東條 有伸,後藤 典子 日本癌学会総会記事 78回 E 2019/09
- CD74-NRG1はがん幹細胞性を促進する可能性のある腫瘍性タンパク質である 村山 貴彦,中奥 敬史,西村 建徳,富永 香菜,中田 飛鳥,東條 有伸,菅野 純夫,河野 隆志,後藤 典子 日本癌学会総会記事 74回 P 2015/10
- Polyamine flux suppresses histone lysine demethylases and enhances ID1 expression in cancer stem cells. Keisuke Tamari,Masamitsu Konno,Ayumu Asai,Jun Koseki,Kazuhiko Hayashi,Koichi Kawamoto,Noriyuki Murai,Senya Matsufuji,Fumiaki Isohashi,Taroh Satoh,Noriko Goto,Shinji Tanaka,Yuichiro Doki,Masaki Mori,Kazuhiko Ogawa,Hideshi Ishii Cell Death Discovery 4 104 2018
- Drug resistant mechanisms of cancer stem-like cells and their therapeutic potential as drug targets. Murayama T,Gotoh N Cancer Drug Resist 2 457 2019/07
- Patient-derived xenograft models of breast cancer and their applications. Murayama T,Gotoh N Cells 8 6 E621 2019/06
- 融合遺伝子産物CD74-NRG1はErbB-NFκB-IGF2経路を活性化し、がん幹細胞性を増強する 村山 貴彦,中奥 敬史,江成 政人,西村 建徳,富永 香菜,中田 飛鳥,東條 有伸,菅野 純夫,河野 隆志,後藤 典子 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 88回・38回 [4T18 2015/12
- Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis Soichiro Sasaki,Tomohisa Baba,Tatsunori Nishimura,Yoshihiro Hayakawa,Shin-ichi Hashimoto,Noriko Gotoh,Naofumi Mukaida Cancer Letters 378 1 23 2016/08
- Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis Ankur Garg,Mukesh Bansal,Noriko Gotoh,Gen-Sheng Feng,Jian Zhong,Fen Wang,Ariana Kariminejad,Steven Brooks,Xin Zhang PLoS Genetics 13 10 e1007047 2017/10/01
- MUSASHI‐2 confers resistance to third‐generation EGFR‐tyrosine kinase inhibitor osimertinib in lung adenocarcinoma Reheman Yiming,Yasuto Takeuchi,Tatsunori Nishimura,Mengjiao Li,Yuming Wang,Makiko Meguro‐Horike,Takashi Kohno,Shin‐ichi Horike,Asuka Nakata,Noriko Gotoh Cancer Science 2021/06/19
- Upregulation of S100A10 in metastasized breast cancer stem cells Hisano Yanagi,Takashi Watanabe,Tatsunori Nishimura,Takanori Hayashi,Seishi Kono,Hitomi Tsuchida,Munetsugu Hirata,Yuko Kijima,Shintaro Takao,Seiji Okada,Motoshi Suzuki,Kazuyoshi Imaizumi,Kenji Kawada,Hironobu Minami,Noriko Gotoh,Yohei Shimono Cancer Science 111 12 4359 2020/12
- Upregulation of S100A10 in metastasized breast cancer stem cells. Hisano Yanagi,Takashi Watanabe,Tatsunori Nishimura,Takanori Hayashi,Seiji Okada,Motoshi Suzuki,Hironobu Minami,Akira Suzuki,Kenji Kawada,Noriko Gotoh,Yohei Shimono Cancer Science 112 705 2021/02
- The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia. Kei Kozawa,Miho Sekai,Kenji Ohba,Shoko Ito,Hiroaki Sako,Takeshi Maruyama,Mai Kakeno,Takanobu Shirai,Keisuke Kuromiya,Tomoko Kamasaki,Koki Kohashi,Shinya Tanaka,Susumu Ishikawa,Nanami Sato,Shota Asano,Hironori Suzuki,Nobuyuki Tanimura,Yohei Mukai,Noriko Gotoh,Mishie Tanino,Shinya Tanaka,Ken Natsuga,Tomoyoshi Soga,Tomonori Nakamura,Yukihiro Yabuta,Mitinori Saitou,Takahiro Ito,Kenkyo Matsuura,Makoto Tsunoda,Toyone Kikumori,Tadashi Iida,Yasuyuki Mizutani,Yuki Miyai,Kozo Kaibuchi,Atsushi Enomoto,Yasuyuki Fujita Current Biology : CB 31 14 3086 2021/07/26
- Xenografts derived from patients with head and neck cancer recapitulate patient tumour properties. Haruna Makita,Kazuhira Endo,Yoshiya Kasahara,Asuka Nakata,Makiko Moriyama-Kita,Kazuya Ishikawa,Takayoshi Ueno,Yosuke Nakanishi,Satoru Kondo,Naohiro Wakisaka,Noriko Gotoh,Tomokazu Yoshizaki Oncology Letters 21 5 385 2021/05
- Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway. Tomohisa Baba,Takeshi Yoshida,Yamato Tanabe,Tatsunori Nishimura,Soji Morishita,Noriko Gotoh,Atsushi Hirao,Rikinari Hanayama,Naofumi Mukaida Cell Death & Disease 12 4 322 2021/03/26
- オルガノイドが駆動するがん研究 オルガノイドの乳がん研究への展開 下野 洋平,西村 建徳,河野 誠之,渋谷 尚樹,林 孝典,柳 久乃,渡辺 崇,前田 真男,掛地 吉弘,河田 健司,浅井 直也,高尾 信太郎,南 博信,喜島 祐子,鈴木 元,後藤 典子 日本癌学会総会記事 80回 [CS4 2021/09
- The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis Yasuto Takeuchi,Natsuko Kimura,Takahiko Murayama,Yukino Machida,Daisuke Iejima,Tatsunori Nishimura,Minoru Terashima,Yuming Wang,Mengjiao Li,Reiko Sakamoto,Mizuki Yamamoto,Naoki Itano,Yusuke Inoue,Masataka Ito,Nobuaki Yoshida,Jun-ichiro Inoue,Koichi Akashi,Hideyuki Saya,Koji Fujita,Masahiko Kuroda,Issay Kitabayashi,Dominic Voon,Takeshi Suzuki,Arinobu Tojo,Noriko Gotoh Proceedings of the National Academy of Sciences, USA 118 43 e2103658118 2021/10/26
- Large miRNA survival analysis reveals a prognostic four-biomarker signature for triple negative breast cancer Fernando Andrade,Asuka Nakata,Noriko Gotoh,André Fujita Genetics and Molecular Biology 43 1 2020 ?
- Efp promotes growth of triple-negative breast cancer cells Wataru Sato,Kazuhiro Ikeda,Noriko Gotoh,Satoshi Inoue,Kuniko Horie Biochemical and Biophysical Research Communications 624 81 2022/10
- Cryopreservation of tissues by slow-freezing using an emerging zwitterionic cryoprotectant. Ishizaki T,Takeuchi Y,Ishibashi K,Gotoh N,Hirata E,Kuroda K Scientific Reports 13 1 37 2023/01/02
- MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells Takahiko Murayama,Yasuto Takeuchi,Kaoru Yamawaki,Toyoaki Natsume,Mengjiao Li,Rojas‐Chaverra N. Marcela,Tatsunori Nishimura,Yuta Kogure,Asuka Nakata,Kana Tominaga,Asako Sasahara,Masao Yano,Satoko Ishikawa,Tetsuo Ohta,Kazuhiro Ikeda,Kuniko Horie‐Inoue,Satoshi Inoue,Masahide Seki,Yutaka Suzuki,Sumio Sugano,Takayuki Enomoto,Masahiko Tanabe,Kei‐ichiro Tada,Masato T. Kanemaki,Koji Okamoto,Arinobu Tojo,Noriko Gotoh Cancer Science 112 3 1209 2021/03
- Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma. Mitsuhito Hirano,Yoichi Imai,Yuta Kaito,Takahiko Murayama,Kota Sato,Tadao Ishida,Junichi Yamamoto,Takumi Ito,Muneyoshi Futami,Masaki Ri,Hiroshi Yasui,Tamami Denda,Yukihisa Tanaka,Yasunori Ota,Masanori Nojima,Yasuhiko Kamikubo,Noriko Gotoh,Shinsuke Iida,Hiroshi Handa,Arinobu Tojo Journal of Experimental & Clinical Cancer Research : CR 40 1 110 2021/03/23
- 乳がん幹細胞とがん関連線維芽細胞における相互作用の解明(Elucidation of interaction between breast cancer stem-like cells and cancer-associated fibroblasts.) 竹内 康人,村山 貴彦,西村 建徳,柏村 里沙,松本 寛加,矢野 正雄,田辺 真彦,石川 聡子,太田 哲生,多田 敬一郎,池田 和博,堀江 公仁子,井上 聡,岡本 康司,東條 有伸,後藤 典子 日本癌学会総会記事 81回 P 2022/09
- Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line. Masafumi Noguchi,Susumu Kohno,Anna Pellattiero,Yukino Machida,Keitaro Shibata,Norihito Shintani,Takashi Kohno,Noriko Gotoh,Chiaki Takahashi,Atsushi Hirao,Luca Scorrano,Atsuko Kasahara Cell death & disease 14 4 241 2023/04/05
- A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer Jin Lee,Xiaoxi Chen,Yuming Wang,Tatsunori Nishimura,Mengjiao Li,Satoko Ishikawa,Takiko Daikoku,Junya Kawai,Arinobu Tojo,Noriko Gotoh Biochemical and Biophysical Research Communications 584 7 2021/12
- トリプルネガティブ乳がん幹細胞の起源ルミナル前駆細胞は、Na+ポンプFXYD3を利用し抗がん剤耐性を獲得する(FXYD3, a subunit of Na+K+ pump, determines the root of triple-negative breast cancer stem-like cells) 李 梦嬌,西村 建徳,塩川 大介,矢野 正雄,石川 聡子,太田 哲生,田辺 真彦,多田 敬一郎,秋山 徹,島村 徹平,佐藤 慎哉,宮城 洋平,鈴木 穣,岡本 康司,東條 有伸,後藤 典子 日本癌学会総会記事 81回 P 2022/09
- Inflammatory cytokine‐enriched microenvironment plays key roles in the development of breast cancers Yasuto Takeuchi,Noriko Gotoh Cancer Science 114 5 1792 2023/02/08
- A model-based clustering algorithm with covariates adjustment and its application to lung cancer stratification Carlos E. M. Relvas,Asuka Nakata,Guoan Chen,David G. Beer,Noriko Gotoh,Andre Fujita Journal of Bioinformatics and Computational Biology 21 04 2023/08
- Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy. Yuming Wang,Tsunaki Hongu,Tatsunori Nishimura,Yasuto Takeuchi,Hiroshi Takano,Takiko Daikoku,Ryoji Yao,Noriko Gotoh Biochemical and biophysical research communications 674 183 2023/09/24
- FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. Li M,Nishimura T,Takeuchi Y,Hongu T,Wang Y,Shiokawa D,Wang K,Hirose H,Sasahara A,Yano M,Ishikawa S,Inokuchi M,Ota T,Tanabe M,Tada K-I,Akiyama T,Cheng X,Liu C-C,Yamashita T,Sugano S,Uchida Y,Chiba T,Asahara H,Nakagawa M,Sato S,Miyagi Y,Shimamura T,Nagai LAE,Kanai A,Katoh M,Nomura S,Nakato R,Suzuki S,Tojo A,Voon VC,Ogawa S,Okamoto K,Foukakis T,Gotoh N Journal of Clinical Investigation 2023/11
- Large miRNA survival analysis reveals a prognostic four-biomarker signature for triple negative breast cancer Andrade F, Nakata A, Gotoh N, Fujita A Genet Mol Biol, in press 2020
Conference Presentations
- Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit(conference：The international academic seminar of tumor basis and clinical translational medicine in Jinan university)(2016/10/12)
- 乳がんの三次元培養とPDXを用いたがん幹細胞制御機構解明(conference：細胞凝集研究会2018)(2018/07/27)
- Cancer stem-like cells derived from breast cancer or lung cancer(conference：第33回日本毒性病理学会総会)(2017/01/17)
- Growth factor signaling in cancer stem cells and niche(conference：The 47th International Symposium of the Princess Takamatsu Cancer Research Fund：Current Status and Perspective of Cancer Stem Cell Research)(2016/11/10)
- Dependence on the mitochondrial MTHFD2-mediated purine synthetic pathway in lung cancer(conference：革新的技術の融合によるがん治療抵抗性にむけた新しいアプローチ)(2016/12/06)
- がん幹細胞とそのニッチの制御機構(conference：千里ライフサイエンス新適塾ー「難病への挑戦」第36回会合)(2018/11/14)
- 微小環境と治療抵抗性メカニズム(conference：シンポジウム１５「ゲノム・エピゲノム解析の進歩」)(2019/07/12)
- 乳がん幹細胞の基礎と治療への応用(conference：第２４回日本産婦人科乳腺医学会)(2018/03/11)
- 乳がんスフェロイドとがん間質細胞培養を用いた腫瘍微小環境治療標的の探索(conference：がん三次元培養研究会)(2017/11/27)
- 増殖因子によるがん幹細胞とそのニッチ制御の分子機構(conference：第9回シグナルネットワーク研究会)(2017/05/13)
- がん幹細胞を標的とするがん根治療法戦略(conference：第15回新規素材探索研究会：特別講演)(2016/06)
- Stem cells, progenitor cells and cancer stem cells in breast tissues(conference：内分泌器官の組織幹細胞と腫瘍幹細胞)(2016/04/22)
- Maintenance of stemness of breast cancer stem-like cells by FRS2beta, a feedback inhibitor for HER, during mammary tumorigenesis(conference：2015 SNUCRI Cancer Sympotisum)(2015/04/03)
- グリシン-セリン代謝経路の創薬標的MTHFD2(conference：創薬)(2016/07/08)
- セリン・グリシン代謝経路MTHFD2による肺がん幹細胞の維持(conference：疾患マルチオミクス)(2016/10/21)
- 乳がんとがん幹細胞(conference：公開講座「がん研究の最前線」)(2015/05/23)
- Analysis of regulatory mechanisms in breast cancer-stem like cells by using spheroid cultures of patient-derived cancer cells and patient-derived xenograft (PDX) models(conference：International Symposium on Tumor Biology in Kanazawa)(2018/11/26)
- 一炭素代謝経路ミトコンドリア内酵素による肺がん幹細胞の維持(conference：難治がん〜治療標的の同定と創薬への展望〜)(2017/05/10)
- がん幹細胞—乳がんの癌幹細胞研究と臨床応用への展望(conference：合同シンポジウム：がん治療のゲノム個別化Precision Medicineを目指す多様な視点)(2015/10/30)
- 癌幹細胞の幹細胞性維持シグナルと創薬標的(conference：シンポジウム：乳癌幹細胞の制御機構と治療への展開)(2016/03/28)
- Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells”(conference：Symposium: The State-of-the-Art 3D Tissue Culture & Organoids)(2019/04/19)
- Semaphorin signaling via MICAL3 induces symmetric cell division of breast cancer stem-like cells(conference：The 1st Meeting of International Society of Precision Cancer Medicine (ISPCM))(2018/03/16)
- Molecular targets in the signaling and metabolism in cancer stem cells and their niche(conference：ワークショップ「がん治療抵抗性にむけた新しいアプローチ」)(2015/12/01)
- 乳がん幹細胞の制御機構とPatient-derived xenograft (PDX)モデル(conference：シンポジウム)(2018/05/18)
- 乳がんの1細胞解析(conference：シンポジウム「固形がんの1細胞解析」)(2019/05/25)
- Growth factor signaling controls breast cancer stem-like cells and their niche(conference：The Korean Sciety for Biochemistry and Molecular Biology (KSBMB) International Conference 2017)(2017/05/03)
- A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference：6th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2016/09)
- がん幹細胞とニッチ相互作用によるがん進展メカニズム(conference：特別講演会)(2015/03/06)
- ミトコンドリア１炭素代謝経路とがん幹細胞、薬剤抵抗性(conference：がんと代謝研究会)(2017/07/13)
- The replicative factor MCM10 maintains patient-derived breast cancer stem-like cells that constitutively experience DNA replicative stress(conference：講演会「患者由来がんモデル〜基礎研究から臨床応用まで〜」)(2019/07/31)
- がん関連線維芽細胞による乳がん幹細胞維持機構の解析(conference：2017生命科学系学会合同年次総会 (ConBio2017))(2017/12/07)
- Maintenance of stemness and niche environment of breast cancer cells by FRS2β, a feedback inhibitor for HER2-ERK pathway, during mammary tumorigenesis(conference：The 8th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2018/09/04)
- Critical roles of luminal progenitor cells in creating the cytokine-rich precancerous niche for mammary tumorigenesis(conference：International Society for Precision Cancer Medicine, 2019)(2019/03/14)
- Novel molecular targets in breast cancer stem cells in patient-derived sphere cells(conference：14th Japanese-German Workshop)(2014/11/14)
- Molecular targets in the signaling and metabolism in cancer stem cells and their niche(conference：特別シンポジウム・女性研究者による癌研究)(2015/10/09)
- CD74-NRG1, an oncogenic fusion gene product, leads to insulin-like growth factor 2 autocrine/paracrine circuit and confers cancer stem cell properties(conference：The 20th Korea-Japan Cancer Research Workshop)(2015/11/30)
- Semaphorin signal via MICAL3 induces symmetrical cell division of cancer stem-like cells(conference：Symposium “Tumor Stem Cell Biology”)(2017/04/15)
- Growth factor signaling controls breast cancer stem-like cells(conference：ジャクソン研究所・HUGO共同シンポジウム)(2017/03/23)
- 乳がん幹細胞を標的とした治療戦略(conference：乳がん研究の新展開：基礎科学から臨床医学へ)(2014/09/25)
- 乳がんのアカデミア創薬(conference：モーニングレクチャー)(2018/09/28)
- 乳がん、肺がんのがん幹細胞様細胞の分子標的(conference：ワークショップ：がん幹細胞を標的にした治療)(2016/06/01)
- Novel therapeutic strategies to eradicate tumors by targeting cancer stem-like cells(conference：第14回日本臨床腫瘍学会学術集会シンポジウム：日本癌学会・日本臨床腫瘍学会合同シンポジウム)(2016/07/29)
- 乳がんの三次元培養とPDXを用いたがん幹細胞制御機構の解明(conference：講演会：新しい治療法の開発を目指す患者由来がんモデル)(2018/06/28)
- 増殖因子によるシグナル制御から得られた耐性克服のための新規分子標的(conference：シンポジウム・肺癌のトランスレーショナルリサーチ（分子標的薬の耐性克服）)(2015/11/27)
- MICAL3 regulates stemness of human breast cancer(conference：シンポジウム「がん幹細胞の分子標的・免疫制御の新展開」)(2015/07/16)
- Novel molecular targets for breast and lung cancer stem cells(conference：第８回高度医療都市を創出する未来技術国際シンポジウム)(2015/02/06)
- A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference：代謝を標的としたがんの制御)(2016/10/06)
- 乳がんの三次元培養とPDXを用いたがん幹細胞制御機構解明へのアプローチ(conference：ワークショップ「新たな技術がもたらすがん治療難治性の克服にむけた新しいアプローチ」)(2018/11/28)
- セリン・グリシン代謝経路MTHFD2による肺がん幹細胞の維持(conference：第12回TRワークショップ)(2017/01/25)
- Growth factor and cytokine signaling regulates breast cancer stem cells and their niche(conference：第７回Cancer Stem Cell Symposium)(2018/12/14)
- The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis(2021/12/03)
- FXYX3, a subunit of Na+ pump, determines the origin of triple-negative breast cancer stem-like cells, the preeminent driver of drug resistance(conference：The 19th Stem Cell Research Symposium)(2022/05/27)
- Key molecular targets in cancer stem-like cells in triple-negative breast cancer(2021/09/30)
- Growth factor signaling regulates cancer stem cells and their niche(conference：The 6th Symposium on Anti-tumor Agents and Individual Therapy)(2019/11/24)
- Microenvironment creates premalignant mammary tissues and therapy-resistant persistent tumor cells in breast cancer(2022/09/30)
- The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis(conference：Symposium on World Cancer Research 2022)(2022/05/06)
- Growth factor signaling regulates cancer stem cells(conference：International Symposium of Advances in Cancer Stem Cell Therapeutics)(2019/08/24)
- Opening lecture from a senior female scientist about her experience of being a leader in Japan(conference：EMBO Laboratory Leadership Course)(2022/12/05)
- 乳がん三次元培養を用いたがんの微小環境、不均一性の解明(conference：第３回がん三次元培養研究会)(2019/11/15)
- One carbon metabolic enzymes play important roles for cancer cells and cancer stem-like cells(conference：3rd World Congress on Cancer)(2019/09/24)
- 乳がん臨床検体由来がん幹細胞濃縮細胞群の1細胞解析(conference：ワークショップ「技術革新がもたらすがん治療難治性の理解克服へむけた新しい方向性」)(2019/12/03)
- 乳がん患者検体由来三次元培養細胞とがん間質細胞の共培養系を用いたがん幹細胞ニッチシグナルの解析(conference：シンポジウム１４「Cancer Stem Cell」)(2019/09/27)
- プリン合成経路にあるミトコンドリア内酵素MTHFD2は、がん幹細胞性とゲフィチニブ耐性を賦与する(conference：シンポジウム「ミトコンドリア生化学が切り開く新たな疾患病態」)(2019/09)
- Growth factor signaling regulates cancer stem cells and their niche(conference：The 6th Symposium on Anti-tumor Agents and Individual Therapy)(2019/11/24)
- One carbon metabolic enzymes play important roles for cancer cells and cancer stem-like cells(conference：3rd World Congress on Cancer)(2019/09/23)
- Growth factor signaling regulates cancer stem cells and their niche(conference：International Symposium of Advances in Cancer Stem Cell Therapeutics)(2019/08/24)
- The replicative factor MCM10 maintains patient-derived breast cancer stem-like cells that constitutively experience DNA replicative stress(2019/07/31)
- Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells(conference：Symposium: The State-of-the-Art 3D Tissue Culture & Organoids)(2019/03/18)
- Critical roles of luminal progenitor cells in creating the cytokine-rich precancerous niche for mammary tumorigenesis(conference：International Society for Precision Cancer Medicine, 2019)(2019/03/14)
- Growth factor and cytokine signaling regulates breast cancer stem-like cells and their niche(conference：第７回Cancer Stem Cell Symposium)(2018/12/14)
- Analysis of regulatory mechanisms in breast cancer-stem like cells by using spheroid cultures of patient-derived cancer cells and patient-derived xenograft (PDX) models(conference：International Symposium on Tumor Biology in Kanazawa)(2018/11/26)
- Maintenance of stemness and niche environment of breast cancer cells by FRS2β, a feedback inhibitor for HER2-ERK pathway, during mammary tumorigenesis(conference：The 8th FUSCC-CRIKU Joint Symposium on Tumor Biolog)(2018/09/04)
- Semaphorin signaling via MICAL3 induces symmetric cell division of breast cancer stem-like cells(conference：The 1st Meeting of International Society of Precision Cancer Medicine (ISPCM))(2017/03/16)
- Growth factor signaling controls breast cancer stem-like cells and their niche(conference：The Korean Sciety for Biochemistry and Molecular Biology (KSBMB) International Conference 2017)(2017/05)
- Semaphorin signal via MICAL3 induces symmetrical cell division of cancer stem-like cells(conference：2017 AACR Annual Meeting, Symposium “Tumor Stem Cell Biology”)(2017/04)
- Growth factor signaling controls breast cancer stem-like cells(2017/03)
- Cancer stem-like cells derived from breast cancer or lung cancer(2017/01)
- Growth factor signaling in cancer stem-like cells and their niche(conference：The 47th International Symposium of the Princess Takamatsu Cancer Research Fund：Current Status and Perspective of Cancer Stem Cell Research)(2016/11/10)
- Oncogenic fusion gene CD74-NRG1 confers cancer stem cell-like properties in lung cancer through a IGF2 autocrine/paracrine circuit(conference：The international academic seminar of tumor basis and clinical translational medicine in Jinan university)(2016/10/12)
- A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(conference：6th FUSCC-CRIKU Joint Symposium on Tumor Biology)(2016/09)
- Dependence on the mitochondrial MTHFD2-mediated purine synthetic pathway in lung cancer(2016/12/02)
- A serine-glycine metabolic enzyme MTHFD2 is a novel molecular target for overcoming resistance in lung cancer(2016/10/06)
- Novel therapeutic strategies to eradicate tumors by targeting cancer stem-like cells(2016/07/29)
- Stem cells, progenitor cells and cancer stem cells in breast tissues(2016/04/22)
- CD74-NRG1, an oncogenic fusion gene product, leads to insulin-like growth factor 2 autocrine/paracrine circuit and confers cancer stem cell properties(conference：The 20th Korea-Japan Cancer Research Workshop)(2015/11/30)
- Molecular targets in the signaling and metabolism in cancer stem cells and their niche(2015/12/01)
- Molecular targets in the signaling and metabolism in cancer stem cells and their niche(2015/10/09)
- MICAL3 regulates stemness of human breast cancer(2015/07/16)
- Maintenance of stemness of breast cancer stem-like cells by FRS2beta, a feedback inhibitor for HER, during mammary tumorigenesis(conference：2015 SNUCRI Cancer Symposium)(2015/04/03)
- Novel molecular targets for breast and lung cancer stem cells(2015/02/06)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Biology of Cancer 1B(2017)
○Molecular Oncology(2017)
○Cancer molecular pathology 1(2017)
○Molecular Medical Oncology(2017)
○Biology of Cancer 1A(2017)
○Molecular and Cellular Pathology(2017)
○Molecular Pathology(2017)
○Molecular Pathology(2017)
○Biology of Cancer 1B(2016)
○Molecular Oncology(2016)
○Molecular Medical Oncology(2016)
○Molecular Pathology(2016)
○Molecular and Cellular Pathology(2016)
○Molecular Pathology(2016)
○Biology of Cancer 1A(2016)
○Cancer molecular pathology 1(2016)