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Researcher Information

last modified：2024/11/29

Professor　TAJIMA, Atsushi

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Advanced Preventive Medical Sciences,Graduate School of Advanced Preventive Medical Sciences
Division of Medicine, Graduate School of Medical Science
School of Medical and Pharmaceutical Sciences, College of Medical,Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Bioinformatics and Genomics　TEL:076-265-2715　FAX:076-234-4249

Academic Background

【Academic background(Doctoral/Master's Degree)】
The Graduate University for Advanced Studies (Sokendai)　Doctor　School of Advanced Sciences　Department of Biosystems Science　200203　Completed
Kyoto University　Master　Faculty of Pharmaceutical Sciences　Department of Pharmacology　199203　Completed
【Academic background(Bachelor's Degree)】
Kyoto University　199003
【Degree】
Ph.D.

Career

The University of Tokushima Graduate School　Institute of Health Biosciences　Associate Professor(2010/11/01-2014/08/31)
Tokai University　School of Medicine(2006/10/01-2010/10/31)
The University of Tokyo　Institute of Medical Science(2004/04/01-2006/09/30)
The Graduate University for Advanced Studies　Department of Biosystems Sciences(2002/04/01-2004/03/31)
Toray Industries, Inc.　Basic Research Laboratories(1992/04/01-1999/03/31)

Year & Month of Birth

1967/12

Academic Society

The Japan Society of Human Genentics
The American Society of Human Genetics
The Genetics Society of Japan
Japanese Cancer Association
The Molecular Biology Society of Japan
Japan Society of Obstetrics and Gynecology

The Pharmaceutical Society of Japan

Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  • 　Oxytocin receptor polymorphism is associated with sleep apnea symptoms.　Goto H, Yamamoto Y, Tsujiguchi H, Sato T, Yamamoto R, Takeshita Y, Nakano Y, Kannon T, Hosomichi K, Suzuki K, Nakamura M, Kambayashi Y, Zhao J, Asai A, Katano K, Ogawa A, Fukushima S, Shibata A, Suzuki F, Tsuboi H, Hara A, Kometani M, Karashima S, Yoneda T, Tajima A, Nakamura H, Takamura T.　J Endocr Soc　9　1　bvae198　2025
  • 　Serum TNFα and IL-17A levels may predict increased depressive symptoms: findings from the Shika Study cohort project in Japan.　Tsuboi H, Sakakibara H, Minamida-Urata Y, Tsujiguchi H, Hara A, Suzuki K, Miyagi S, Nakamura M, Takazawa C, Kannon T, Zhao J, Shimizu Y, Shibata A, Ogawa A, Suzuki F, Kambayashi Y, Konoshita T, Tajima A, Nakamura H.　BioPsychoSoc Med　18　1　20　2024
  • 　Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.　Kimura K, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Katano K, Asai A, Kasahara T, Nakamura M, Takazawa C, Hayashi K, Hamagishi T, Shibata A, Sato T, Nomura A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Kobayashi T, Nakamura H.　J Nutr Sci　13　e45　2024
  • 　A supramolecular biosensor for rapid and high-throughput quantification of a disease-associated niacin metabolite.　Ueno M, Sugiyama H, Li F, Nishimura T, Arakawa H, Chen X, Cheng X, Takeuchi S, Takeshita Y, Takamura T, Miyagi S, Toyama T, Soga T, Masuo Y, Kato Y, Nakamura H, Tsujiguchi H, Hara A, Tajima A, Noguchi-Shinohara M, Ono K, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Maeda K, Ogoshi T, Hirao A.　Anal Chem　96　36　14499-14507　2024
  • 　Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells.　Lukyanchuk A, Muraki N, Kawai T, Sato T, Hata K, Ito T, Tajima A.　Epigenetics Chromatin　17　1　24　2024

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  • 　Identification of the hybrid gene LILRB5-3 by long-read sequencing and implication of its novel signaling function.　Hirayasu K, Khor SS, Kawai Y, Shimada M, Omae Y, Hasegawa G, Hashikawa Y, Tanimoto H, Ohashi J, Hosomichi K, Tajima A, Nakamura H, Nakamura M, Tokunaga K, Hanayama R, Nagasaki M.　Front Immunol　15　1398935　2024
  • 　Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells.　Hazawa M, Ikliptikawati DK, Iwashima Y, Lin DC, Jiang Y, Qiu Y, Makiyama K, Matsumoto K, Kobayashi A, Nishide G, Keesiang L, Yoshino H, Minamoto T, Suzuki T, Kobayashi I, Meguro-Horike M, Jiang YY, Nishiuchi T, Konno H, Koeffler HP, Hosomichi K, Tajima A, Horike SI, Wong RW.　Cell Chem Biol　31　4　792-804　2024
  • 　Medieval genomes from eastern Mongolia share a stable genetic profile over a millennium.　Lee J, Sato T, Tajima A, Amgalantugs T, Tsogtbaatar B, Nakagome S, Miyake T, Shiraishi N, Jeong C, Gakuhari T.　Hum Popul Genet Genom　4　1　0004　2024
  • 　Association between animal protein intake, oral frailty and calf circumference in middle-aged and older adults: a cross-sectional analysis from the Shika study.　Suzuki F, Okamoto S, Nakai S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kasahara T, Nakamura M, Takazawa C, Ogawa A, Shibata A, Kannon T, Tajima A, Tsuboi H, Ogino N, Konoshita T, Takamura T, Sato K, Nakamura H.　BMJ Open　14　2　e078129　2024
  • 　Identification of potential disease-associated variants in idiopathic generalized epilepsy using targeted sequencing.　Gamirova R, Shagimardanova E, Sato T, Kannon T, Gamirova R, Tajima A.　J Hum Genet　69　2　59-67　2024
  • 　Genetic characteristics contributing to lipoprotein(a) levels in the Japanese population.　Yamagami K, Tada H, Sato T, Nomura A, Sakata K, Usui S, Kawashiri MA, Tajima A, Takamura M.　J Coron Artery Dis　29　4　104-108　2023
  • 　Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells.　Mizumaki H, Tran DC, Hosokawa K, Hosomichi K, Zaimoku Y, Takamatsu H, Yamazaki H, Ishiyama K, Yamazaki R, Fujiwara H, Tajima A, Nakao S.　Blood Cancer J　13　1　165　2023
  • 　Distinct associations between dietary omega-3 and omega-6 fatty acids intake with chronic kidney disease in adults with and without diabetes: A cross-sectional study.　Hara A, Tsujiguchi H, Suzuki K, Nakamura M, Okada M, Zhao J, Takazawa C, Suzuki F, Kasahara T, Shimizu Y, Tsuboi H, Kannon T, Tajima A, Takamura T, Nakamura H.　Nutrition　115　112156　2023
  • 　An observational study on changes in the oral and gut microbiota through professional mechanical tooth cleaning, including tooth-brushing instructions in patients with multi-bracket appliances.　Okuwaki S, Hosomichi K, Tajima A, Yamaguchi T.　Appl Sci　13　19　10843　2023
  • 　Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation.　Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A.　Cell Death Dis　14　9　642　2023
  • 　Familial immune-mediated aplastic anaemia in six different families.　Imi T, Mizumaki H, Hosomichi K, Nannya Y, Zaimoku Y, Yoroidaka T, Katagiri T, Ishiyama K, Yamazaki H, Ogawa R, Kuroiwa M, Tajima A, Ogawa S, Nakao S.　eJHaem　4　3　714-718　2023
  • 　A comprehensive risk factor analysis using association rules in people with diabetic kidney disease.　Toyama T, Shimizu M, Yamaguchi T, Kurita H, Morita T, Oshima M, Kitajima S, Hara A, Sakai N, Hashiba A, Takayama T, Tajima A, Furuichi K, Wada T, Iwata Y.　Sci Rep　13　1　11690　2023
  • 　Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory.　Hattori T, Cherepanov SM, Sakaga R, Roboon J, Nguyen DT, Ishii H, Takarada-Iemata M, Nishiuchi T, Kannon T, Hosomichi K, Tajima A, Yamamoto Y, Okamoto H, Sugawara A, Higashida H, Hori O.　EMBO J　2023　e111247　2023
  • 　Genetic factors associated with serum amylase in a Japanese population: Combined analysis of copy-number and single-nucleotide variants.　Nayema Z, Sato T, Kannon T, Tsujiguchi H, Hosomichi K, Nakamura H, Tajima A.　J Hum Genet　68　5　313-319　2023
  • 　The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants.　Cui S, Hayashi K, Kobayashi I, Hosomichi K, Nomura A, Teramoto R, Usuda K, Okada H, Deng Y, Kobayashi-Sun J, Nishikawa T, Furusho H, Saito T, Hirase H, Ohta K, Fujimoto M, Horita Y, Kusayama T, Tsuda T, Tada H, Kato T, Usui S, Sakata K, Fujino N, Tajima A, Yamagishi M, Takamura M.　J Mol Cell Cardiol　177　50-61　2023
  • 　Nutrigenetic interaction between apolipoprotein C3 polymorphism and fat intake in people with non-alcoholic fatty liver disease.　Yamamoto R, Takeshita Y, Tsujiguchi H, Kannon T, Sato T, Hosomichi K, Suzuki K, Kita Y, Tanaka T, Goto H, Nakano Y, Yamashita T, Kaneko S, Tajima A, Nakamura H, Takamura T.　Curr Dev Nutr　7　4　100051　2023
  • 　Higher intake of vegetable protein and lower intake of animal fats reduce the incidence of diabetes in non-drinking males: A prospective epidemiological analysis of the Shika study.　Ogawa A, Tsujiguchi H, Nakamura M, Hayashi K, Hara A, Suzuki K, Miyagi S, Kannon T, Takazawa C, Zhao J, Kambayashi Y, Shimizu Y, Shibata A, Konoshita T, Suzuki F, Tsuboi H, Tajima A, Nakamura H.　Nutrients　15　4　1040　2023
  • 　Relationships among depressive symptoms, body weight, and chronic pain: A cross-sectional analysis of the Shika study.　Fukushima S, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Yanagisawa T, Oku F, Sato K, Nakamura M, Hayashi K, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H.　Behav Sci　13　2　86　2023
  • 　Association between bone mineral density and oral frailty on renal function: Findings from the Shika study.　Nakai S, Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kasahara T, Nakamura M, Takazawa C, Kannon T, Tajima A, Tsuboi H, Ogino N, Konoshita T, Takamura T, Nakamura H.　Healthcare　11　3　314　2023
  • 　Bone strength of the calcaneus is associated with dietary calcium intake in older Japanese men, but not women.　Suzuki K, Tsujiguchi H, Hara A, Miyagi S, Nguyen TTT, Kambayashi Y, Shimizu Y, Suzuki F, Takazawa C, Nakamura M, Tsuboi H, Kannon T, Tajima A, Nakamura H.　Nutrients　14　24　5225　2022
  • 　Relationship between social capital and depressive symptoms: Differences according to resilience and gender in the Shika study.　Sato K, Tsujiguchi H, Suzuki F, Hara A, Kannon T, Muto G, Hori D, Miyagi S, Suzuki K, Nakamura M, Takazawa C, Kasahara T, Tsuboi H, Matsui M, Tajima A, Nakamura H.　J Affect Disord Rep　10　100421　2022
  • 　Relationship between vitamin intake and resilience based on sex in middle-aged and older Japanese adults: Results of the Shika study.　Sato K, Suzuki F, Tsujiguchi H, Hara A, Kannon T, Miyagi S, Suzuki K, Nakamura M, Takazawa C, Shibata A, Tsuboi H, Shimizu Y, Nguyen TTT, Konoshita T, Ono Y, Hayashi K, Tajima A, Nakamura H.　Nutrients　14　23　5042　2022
  • 　Comprehensive genetic exploration of fused teeth by whole exome sequencing.　Park H, Hosomichi K, Kim Y-I, Hikita Y, Tajima A, Yamaguchi T.　Appl Sci　12　23　11899　2022
  • 　Hypertension and low body weight are associated with depressive symptoms only in females: Findings from the Shika study.　Yanagisawa T, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Oku F, Sato K, Nakamura M, Hayashi K, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H.　Behav Sci　12　11　413　2022
  • 　Isolation of ferret astrocytes reveals their morphological, transcriptional, and functional differences from mouse astrocytes.　Roboon J, Hattori T, Nguyen DT, Ishii H, Takarada-Iemata M, Kannon T, Hosomichi K, Maejima T, Saito K, Shinmyo Y, Mieda M, Tajima A, Kawasaki H, Hori O.　Front Cell Neurosci　16　877131　2022
  • 　Prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer using radiomics of pretreatment dynamic contrast-enhanced MRI.　Yoshida K, Kawashima H, Kannon T, Tajima A, Ohno N, Terada K, Takamatsu A, Adachi H, Ohno M, Miyati T, Ishikawa S, Ikeda H, Gabata T.　Magn Reson Imaging　92　19-25　2022
  • 　Elevated ratio of serum anandamide to arachidonic acid intake in community-dwelling women with high depressive symptoms.　Tsuboi H, Matsunaga M, Tsujiguchi H, Kannon T, Hosomichi K, Sato T, Tajima A, Yoshida N, Hara A, Nakamura H.　Neuro Endocrinol Lett　43　3　145-153　2022
  • 　Exploring the genetic basis of dens evaginatus using whole-exome sequencing.　Park H, Hosomichi K, Kim Y-I, Tajima A, Yamaguchi T.　Appl Sci　12　8　8962-8962　2022
  • 　RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia.　Pham LT, Peng H, Ueno M, Kohno S, Kasada A, Hosomichi K, Sato T, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Xiao B, Worley PF, Takahashi C, Tajima A, Hirao A.　Biochem Biophys Res Commun　621　74-79　2022
  • 　A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins.　Yamamura M, Sato Y, Takahashi K, Nguyen Canh H, Li Z, Hosomichi K, Tajima A, Terada T, Nakanuma Y, Harada K.　Hum Pathol Rep　29　300660　2022
  • 　Genome-wide survival analysis for macular neovascularization development in central serous chorioretinopathy revealed shared genetic susceptibility with polypoidal choroidal vasculopathy.　Mori Y, Miyake M, Hosoda Y, Miki A, Takahashi A, Muraoka Y, Miyata M, Sato T, Tamura H, Ooto S, Yamada R, Yamashiro K, Nakamura M, Tajima A, Nagasaki M, Honda S, Tsujikawa A.　Ophthalmology　129　9　1034-1042　2022
  • 　The role of polygenic susceptibility on air pollution-associated asthma between German and Japanese elderly women.　Kress S, Hara A, Wigmann C, Sato T, Suzuki K, Pham KO, Zhao Q, Areal A, Tajima A, Schwender H, Nakamura H, Schikowski T.　Int J Environ Res Public Health　19　16　9869　2022
  • 　Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells.　Suzuki C, Nishiyama A, Arai S, Tange S, Tajima A, Tanimoto A, Fukuda K, Takumi Y, Kotani H, Takeuchi S, Yanagimura N, Ohtsubo K, Yamamoto N, Omori K, Yano S.　Cancer Sci　113　7　2323-2335　2022
  • 　Association between dietary fat intake and hyperuricemia in men with chronic kidney disease.　Oku F, Hara A, Tsujiguchi H, Suzuki K, Pham KO, Suzuki F, Miyagi S, Nakamura M, Takazawa C, Sato K, Yanagisawa T, Kannon T, Tajima A, Nakamura H.　Nutrients　14　13　2637　2022
  • 　Relationship between fatty acid intake and chronic neck/shoulder/upper limb pain without elevated CRP in a Japanese population: a cross-sectional analysis of the Shika study.　Asai A, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Nakamura M, Shimizu Y, Nguyen TTT, Pham KO, Kasahara T, Nakai S, Hayashi K, Shibata A, Amatsu T, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H.　J Nutr Sci　11　e38　2022
  • 　Association between serum 25-hydroxyvitamin D concentrations, CDX2 polymorphism in promoter region of vitamin D receptor gene, and chronic pain in rural Japanese residents.　Suzuki K, Tsujiguchi H, Hara A, Pham OK, Miyagi S, Nguyen TTT, Nakamura H, Suzuki F, Kasahara T, Shimizu Y, Yamada Y, Kambayashi Y, Tsuboi H, Sato T, Kannon T, Hosomichi K, Tajima A, Takamura T, Nakamura H.　J Pain Res　15　1475-1485　2022
  • 　Association between vitamin intake and chronic kidney disease according to a variant located upstream of the PTGS1 gene: A cross-sectional analysis of Shika study.　Pham KO, Hara A, Tsujiguchi H, Suzuki K, Suzuki F, Miyagi S, Kannon T, Sato T, Hosomichi K, Tsuboi H, Nguyen TTT, Shimizu Y, Kambayashi Y, Nakamura M, Takazawa C, Nakamura H, Hamagishi T, Shibata A, Konoshita T, Tajima A, Nakamura H.　Nutrients　14　10　2082　2022
  • 　Glucokinase-maturity onset diabetes mellitus in the young suggested by factory-calibrated glucose monitoring data: A case report.　Nomura N, Iizuka K, Goshima E, Hosomichi K, Tajima A, Kubota S, Liu Y, Takao K, Kato T, Mizuno M, Hirota T, Suwa T, Horikawa Y, Yabe D.　Endocr J　69　4　473-477　2022
  • 　Familial idiopathic basal ganglia calcification with a heterozygous missense variant (c.902C>T/p.P307L) in SLC20A2 showing widespread cerebrovascular lesions.　Sakai K, Ishida C, Hayashi K, Tsuji N, Kannon T, Hosomichi K, Takei N, Kakita A, Tajima A, Yamada M.　Neuropathology　42　2　126-133　2022
  • 　Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study.　Hara A, Nguyen PM, Tsujiguchi H, Nakamura M, Yamada Y, Suzuki K, Suzuki F, Kasahara T, Pham KO, Nakamura H, Kambayashi Y, Shimizu Y, Nguyen TTT, Miyagi S, Kannon T, Sato T, Hosomichi K, Tajima A, Nakamura H.　Obes Sci Pract　8　2　199-207　2022
  • 　Association of immunoglobulin E levels with smoking and trace element intake: A cross-sectional analysis of the Shika study.　Katano K, Suzuki F, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Pham KO, Asai A, Kasahara T, Nakamura M, Takazawa C, Hayashi K, Hamagishi T, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Kobayashi T, Nakamura H.　Glob J Nutri Food Sci　3　5　GJNFS.MS.ID.000571　2022
  • 　Localized astrogenesis regulates gyrification of the cerebral cortex.　Shinmyo Y, Saito K, Hamabe-Horiike T, Kameya N, Ando A, Kawasaki K, Duong TAD, Sakashita M, Roboon J, Hattori T, Kannon T, Hosomichi K, Slezak M, Holt MG, Tajima A, Hori O, Kawasaki H.　Sci Adv　8　10　eabi5209　2022
  • 　Decoding the diversity of killer immunoglobulin-like receptors by deep sequencing and a high-resolution imputation method.　Sakaue S, Hosomichi K, Hirata J, Nakaoka H, Yamazaki K, Yawata M, Yawata N, Naito T, Umeno J, Kawaguchi T, Matsui T, Motoya S, Suzuki Y, Inoko H, Tajima A, Morisaki T, Matsuda K, Kamatani Y, Yamamoto K, Inoue I, Okada Y.　Cell Genom　2　3　100101　2022
  • 　A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values.　Kasahara T, Tsujiguchi H, Takeshita Y, Hara A, Suzuki K, Narukawa N, Hayashi K, Miyagi M, Asai A, Yamada Y, Nakamura H, Suzuki F, Pham KO, Hamagishi T, Nakamura M, Shibata A, Shimizu Y, Nguyen TTT, Miyagi S, Kambayashi Y, Kannon T, Tajima A, Tsuboi H, Konoshita T, Takamura T, Nakamura H.　BMC Endocr Disord　22　1　40　2022
  • 　Relationship between alcohol intake and chronic pain with Depressive symptoms: A cross-sectional analysis of the Shika study.　Amatsu T, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Pham KO, Suzuki F, Kasahara T, Nakamura M, Hayashi K, Shibata A, Ogino N, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H.　Int J Environ Res Public Health　19　4　2024　2022
  • 　NOTCH alteration in EGFR-mutated lung adenocarcinoma leads to histological small-cell carcinoma transformation under EGFR-TKI treatment.　Koba H, Kimura H, Yoneda T, Ogawa N, Tanimura K, Tambo Y, Sone T, Hosomichi K, Tajima A, Kasahara K.　Transl Lung Cancer Res　10　11　4161-4173　2021
  • 　Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study.　Hayashi K, Noguchi-Shinohara M, Sato T, Hosomichi K, Kannon T, Abe C, Domoto C, Yuki-Nozaki S, Mori A, Horimoto M, Yokogawa M, Sakai K, Iwasa K, Komai K, Ishimiya M, Nakamura H, Ishida N, Suga Y, Ishizaki J, Ishigami A, Tajima A, Yamada M.　PLOS ONE　16　11　e0259663　2021
  • 　Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia.　Nomura A, Sato T, Tada H, Kannon T, Hosomichi K, Tsujiguchi H, Nakamura H, Takamura M, Tajima A, Kawashiri MA.　J Hum Genet　66　11　1079-1087　2021
  • 　A novel RFX6 heterozygous mutation (p.R652X) in maturity-onset diabetes mellitus: A case report.　Imaki S, Iizuka K, Horikawa Y, Yasuda M, Kubota S, Kato T, Liu Y, Takao K, Mizuno M, Hirota T, Suwa T, Hosomichi K, Tajima A, Fujiwara Y, Yamazaki Y, Kuwata H, Seino Y, Yabe D.　J Diabetes Investig　12　10　1914-1918　2021
  • 　Somatic mutations in oral squamous cell carcinomas in 98 Japanese patients and their clinical implications.　Osawa Y, Aoyama KI, Hosomichi K, Uchibori M, Tajima A, Kimura M, Ota Y.　Cancer Treat Res Commun　29　100456　2021
  • 　Whole genome sequencing of a 900-year-old human skeleton supports two past migration events from the Russian Far East to northern Japan.　Sato T, Adachi N, Kimura R, Hosomichi K, Yoneda M, Oota H, Tajima A, Toyoda A, Kanzawa-Kiriyama H, Matsumae H, Koganebuchi K, Shimizu KK, Shinoda KI, Hanihara T, Weber A, Kato H, Ishida H.　Genome Biol Evol　13　9　evab192　2021
  • 　Exploring correlations in genetic and cultural variation across language families in northeast Asia.　Matsumae H, Ranacher P, Savage PE, Blasi DE, Currie TE, Koganebuchi K, Nishida N, Sato T, Tanabe H, Tajima A, Brown S, Stoneking M, Shimizu KK, Oota H, Bickel B.　Sci Adv　7　34　eabd9223　2021
  • 　Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population.　Yamada Y, Nakamura H, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Sato T, Hosomichi K, Nguyen TTT, Kambayashi Y, Shimizu Y, Pham KO, Suzuki K, Suzuki F, Kasahara T, Tsuboi H, Tajima A, Nakamura H.　PLOS ONE　16　8　e0255444　2021
  • 　Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.　Hirayasu K, Sun J, Hasegawa G, Hashikawa Y, Hosomichi K, Tajima A, Tokunaga K, Ohashi J, Hanayama R.　J Hum Genet　66　7　739-748　2021
  • 　HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.　Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S.　Blood　137　25　3576-3580　2021
  • 　The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity.　Nguyen DT, Le TM, Hattori T, Takarada-Iemata M, Ishii H, Roboon J, Tamatani T, Kannon T, Hosomichi K, Tajima A, Taniuchi S, Miyake M, Oyadomari S, Tanaka T, Kato N, Saito S, Mori K, Hori O.　Sci Rep　11　1　13086　2021
  • 　A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.　Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Anh Thi Nguyen M, Cao Tran D, Ibrahim Yousef Elbadry M, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S.　Haematologica　106　5　1581-1590　2021
  • 　Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men.　Miyagi S, Takamura T, Nguyen TTT, Tsujiguchi H, Hara A, Nakamura H, Suzuki K, Tajima A, Kannon T, Toyama T, Kambayashi Y, Nakamura H.　J Diabetes Investig　12　5　869-876　2021
  • 　Identification of candidate PAX2-regulated genes implicated in human kidney development.　Yamamura Y, Furuichi K, Murakawa Y, Hirabayashi S, Yoshihara M, Sako K, Kitajima S, Toyama T, Iwata Y, Sakai N, Hosomichi K, Murphy PM, Tajima A, Okita K, Osafune K, Kaneko S, Wada T.　Sci Rep　11　1　9123　2021
  • 　Molecular features of tumor-derived genetic alterations in circulating cell-free DNA in virtue of autopsy analysis.　Koba H, Kimura H, Yoneda T, Sone T, Ohkura N, Hara J, Hosomichi K, Tajima A, Kasahara K.　Sci Rep　11　1　8398　2021
  • 　Relationship between decreased mineral intake due to oral frailty and bone mineral density: Findings from Shika study.　Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Nakai S, Miyagi M, Kannon T, Tajima A, Tsuboi H, Konoshita T, Nakamura H.　Nutrients　13　4　1193　2021
  • 　Relationship between vitamin intake and health-related quality of life in a Japanese population: A cross-sectional analysis of the Shika study.　Narukawa N, Tsujiguchi H, Hara A, Miyagi S, Kannon T, Suzuki K, Shimizu Y, Nguyen TTT, Pham KO, Suzuki F, Asai A, Amatsu T, Kasahara T, Miyagi M, Nakamura M, Yamada Y, Nakamura H, Hayashi K, Hamagishi T, Shibata A, Konoshita T, Kambayashi Y, Tsuboi H, Tajima A, Nakamura H.　Nutrients　13　3　1023　2021
  • 　Protein intake in inhabitants with regular exercise is associated with sleep quality: Results of the Shika study.　Suzuki F, Morita E, Miyagi S, Tsujiguchi H, Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Kannon T, Tajima A, Matsumoto S, Ishihara A, Hori D, Doki S, Oi Y, Sasahara S, Satoh M, Matsuzaki I, Yanagisawa M, Ikaga T, Nakamura H.　PLOS ONE　16　2　e0247926　2021
  • 　Alcohol intake Is associated with elevated serum levels of selenium and selenoprotein P in humans.　Isobe Y, Asakura H, Tsujiguchi H, Kannon T, Takayama H, Takeshita Y, Ishii KA, Kanamori T, Hara A, Yamashita T, Tajima A, Kaneko S, Nakamura H, Takamura T.　Front Nutr　8　633703　2021
  • 　Gender difference in the association of dietary intake of antioxidant vitamins with kidney function in middle-aged and elderly Japanese.　Hara A, Tsujiguchi H, Suzuki K, Suzuki F, Kasahara T, Oanh PK, Miyagi S, Kannon T, Tajima A, Wada T, Nakamura H.　J Nutr Sci　10　e2　2021
  • 　Association between serum 25-hydroxyvitamin D concentrations and chronic pain: Effects of drinking habits.　Suzuki K, Tsujiguchi H, Miyagi S, Nguyen TTT, Hara A, Nakamura H, Shimizu Y, Hayashi K, Yamada Y, Nguyen PM, Tao Y, Kannon T, Tajima A, Nakamura H.　J Pain Res　13　2987-2996　2020
  • 　Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects: The Shika Study.　Hara A, Tsujiguchi H, Suzuki K, Tao Y, Nakamura H, Kasahara T, Nguyen TTT, Miyagi S, Shimizu Y, Kannon T, Tajima A, Wada T, Takamura T, Nakamura H.　Biomarkers　25　7　587-593　2020
  • 　A case of MODY5-like manifestations without mutations or deletions in coding and minimal promoter regions of the HNF1B gene.　Kuwabara-Ohmura Y, Iizuka K, Liu Y, Takao K, Nonomura K, Kato T, Mizuno M, Hosomichi K, Tajima A, Miyazaki T, Horikawa Y, Yabe D.　Endocr J　67　9　981-988　2020
  • 　A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14).　Romero VI, Pozo JC, Saenz S, Llamos-Paneque A, Liehr T, Hosomichi K, Tajima A.　Hum Genome Var　7　28　2020
  • 　Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations.　Gakuhari T, Nakagome S, Rasmussen S, Allentoft ME, Sato T, Korneliussen T, Chuinneagáin BN, Matsumae H, Koganebuchi K, Schmidt R, Mizushima S, Kondo O, Shigehara N, Yoneda M, Kimura R, Ishida H, Masuyama T, Yamada Y, Tajima A, Shibata H, Toyoda A, Tsurumoto T, Wakebe T, Shitara H, Hanihara T, Willerslev E, Sikora M, Oota H.　Commun Biol　3　1　437　2020
  • 　Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels.　Sato Y, Tajima A, Kiguchi M, Kogusuri S, Fujii A, Sato T, Nozawa S, Yoshiike M, Mieno M, Kojo K, Uchida M, Tsuchiya H, Yamasaki K, Imoto I, Iwamoto T.　J Hum Genet　65　8　683-691　2020
  • 　A targeted genetic association study of the rare type of osteomyelitis.　Yahara H, Horita S, Yanamoto S, Kitagawa Y, Asaka T, Yoda T, Morita K, Michi Y, Takechi M, Shimasue H, Maruoka Y, Kondo E, Kusukawa J, Tsujiguchi H, Sato T, Kannon T, Nakamura H, Tajima A, Hosomichi K, Yahara K.　J Dent Res　99　3　271-276　2020
  • 　Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy.　Hosoda Y, Miyake M, Schellevis RL, Boon CJF, Hoyng CB, Miki A, Meguro A, Sakurada Y, Yoneyama S, Takasago Y, Hata M, Muraoka Y, Nakanishi H, Oishi A, Ooto S, Tamura H, Uji A, Miyata M, Takahashi A, Ueda-Arakawa N, Tajima A, Sato T, Mizuki N, Shiragami C, Iida T, Khor CC, Wong TY, Yamada R, Honda S, de Jong EK, Hollander AID, Matsuda F, Yamashiro K, Tsujikawa A.　Commun Biol　2　468　2019
  • 　Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.　Elbadry MI, Mizumaki H, Hosokawa K, Espinoza JL, Nakagawa N, Chonabayashi K, Yoshida Y, Katagiri T, Hosomichi K, Zaimoku Y, Imi T, Nguyen MAT, Fujii Y, Tajima A, Ogawa S, Takenaka K, Akashi K, Nakao S.　Haematologica　104　10　e447-e450　2019
  • 　Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan.　Kanzawa-Kiriyama H, Jinam TA, Kawai Y, Sato T, Hosomichi K, Tajima A, Adachi N, Matsumura H, Kryukov K, Saitou N, Shinoda KI.　Anthropol Sci　127　2　83-108　2019
  • 　Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus.　Kasuga Y, Miyakoshi K, Tajima A, Saisho Y, Ikenoue S, Ochiai D, Matsumoto T, Arata N, Hata K, Tanaka M.　J Diabetes Investig　10　3　817-826　2019
  • 　Orthognathic surgery induces genomewide changes longitudinally in DNA methylation in saliva.　Yamaguchi T, Hosomichi K, Takahashi M, Haga S, Nakawaki T, Hikita Y, Maki K, Tajima A.　Oral Dis　25　2　508-514　2019
  • 　Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease.　Tada H, Kawashiri MA, Nomura A, Teramoto R, Hosomichi K, Nohara A, Inazu A, Mabuchi H, Tajima A, Yamagishi M.　J Clin Lipidol　12　6　1436-1444　2018
  • 　Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population.　Miki A, Sakurada Y, Tanaka K, Semba K, Mitamura Y, Yuzawa M, Tajima A, Nakatochi M, Yamamoto K, Matsuo K, Imoto I, Honda S.　Invest Ophthalmol Vis Sci　59　13　5542-5547　2018
  • 　A successful case of neoadjuvant chemotherapy and radical hysterectomy during pregnancy for advanced uterine cervical cancer accompanied by neonatal erythroderma.　Kayahashi K, Mizumoto Y, Myojo S, Mitani Y, Tajima A, Fujiwara H.　J Obstet Gynaecol Res　44　10　2003-2007　2018
  • 　Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes.　Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Maki K, Marazita ML, Weinberg SM, Tajima A.　Oral Dis　24　7　1303-1309　2018
  • 　Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology.　Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Marazita ML, Weinberg SM, Maki K, Tajima A.　Arch Oral Biol　96　33-38　2018
  • 　Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations.　Koba H, Kimura H, Nishikawa S, Sone T, Abo M, Hara J, Hosomichi K, Tajima A, Kasahara K.　Lung Cancer　122　146-150　2018
  • 　A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes.　Koganebuchi K, Gakuhari T, Takeshima H, Sato K, Fujii K, Kumabe T, Kasagi S, Sato T, Tajima A, Shibata H, Ogawa M, Oota H.　PLOS ONE　13　7　e0200170　2018
  • 　The prehistoric peopling of Southeast Asia.　McColl H, Racimo F, Vinner L, Demeter F, Gakuhari T, Moreno-Mayar JV, van Driem G, Gram Wilken U, Seguin-Orlando A, de la Fuente Castro C, Wasef S, Shoocongdej R, Souksavatdy V, Sayavongkhamdy T, Saidin MM, Allentoft ME, Sato T, Malaspinas AS, Aghakhanian FA, Korneliussen T, Prohaska A, Margaryan A, de Barros Damgaard P, Kaewsutthi S, Lertrit P, Nguyen TMH, Hung HC, Minh Tran T, Nghia Truong H, Nguyen GH, Shahidan S, Wiradnyana K, Matsumae H, Shigehara N, Yoneda M, Ishida H, Masuyama T, Yamada Y, Tajima A, Shibata H, Toyoda A, Hanihara T, Nakagome S, Deviese T, Bacon AM, Duringer P, Ponche JL, Shackelford L, Patole-Edoumba E, Nguyen AT, Bellina-Pryce B, Galipaud JC, Kinaston R, Buckley H, Pottier C, Rasmussen S, Higham T, Foley RA, Lahr MM, Orlando L, Sikora M, Phipps ME, Oota H, Higham C, Lambert DM, Willerslev E.　Science　361　6397　88-92　2018
  • 　Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation.　Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M.　Sci Rep　8　1　9745　2018
  • 　Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men.　Sato Y, Tajima A, Sato T, Nozawa S, Yoshiike M, Imoto I, Yamauchi A, Iwamoto T.　J Med Genet　55　6　415-421　2018
  • 　Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model.　Nishiyama A, Yamada T, Kita K, Wang R, Arai S, Fukuda K, Tanimoto A, Takeuchi S, Tange S, Tajima A, Furuya N, Kinoshita T, Yano S.　Clin Cancer Res　24　10　2357-2369　2018
  • 　Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia.　Imi T, Katagiri T, Hosomichi K, Zaimoku Y, Hoang Nguyen V, Nakagawa N, Tajima A, Yoshizato T, Ogawa S, Nakao S.　Blood Adv　2　9　1000-1012　2018
  • 　Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.　Tomioka Y, Numata S, Kinoshita M, Umehara H, Watanabe SY, Nakataki M, Iwayama Y, Toyota T, Ikeda M, Yamamori H, Shimodera S, Tajima A, Hashimoto R, Iwata N, Yoshikawa T, Ohmori T.　J Psychiatry Neurosci　43　3　194-200　2018
  • 　Elevated peripheral blood glutamate levels in major depressive disorder.　Inoshita M, Umehara H, Watanabe SY, Nakataki M, Kinoshita M, Tomioka Y, Tajima A, Numata S, Ohmori T.　Neuropsychiatr Dis Treat　14　945-953　2018
  • 　Association of TUSC1 and DPF3 gene polymorphisms with male infertility.　Sato Y, Hasegawa C, Tajima A, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Yamauchi A, Iwamoto T.　J Assist Reprod Genet　35　2　257-263　2018
  • 　In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.　Kita K, Arai S, Nishiyama A, Taniguchi H, Fukuda K, Wang R, Yamada T, Takeuchi S, Tange S, Tajima A, Nakada M, Yasumoto K, Motoo Y, Murakami T, Yano S.　Cancer Med　6　12　2972-2983　2017
  • 　Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer.　Kohmoto T, Masuda K, Naruto T, Tange S, Shoda K, Hamada J, Saito M, Ichikawa D, Tajima A, Otsuji E, Imoto I. 　J Med Invest　64　3.4　233-240　2017
  • 　Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.　Ali MAE, Fuse K, Tadokoro Y, Hoshii T, Ueno M, Kobayashi M, Nomura N, Vu HT, Peng H, Hegazy AM, Masuko M, Sone H, Arai F, Tajima A, Hirao A.　Sci Rep　7　1　11442　2017
  • 　Folding of the cerebral cortex requires Cdk5 in upper-layer neurons in gyrencephalic mammals.　Shinmyo Y, Terashita Y, Dinh Duong TA, Horiike T, Kawasumi M, Hosomichi K, Tajima A, Kawasaki H.　Cell Rep　20　9　2131　2017
  • 　De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.　Nishi A, Numata S, Tajima A, Zhu X, Ito K, Saito A, Kato Y, Kinoshita M, Shimodera S, Ono S, Ochi S, Imamura A, Kurotaki N, Ueno SI, Iwata N, Fukui K, Imoto I, Kamiya A, Ohmori T.　Sci Rep　7　1　2887　2017
  • 　Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.　Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S.　Blood　129　21　2908-2916　2017
  • 　Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study.　Kasuga Y, Hata K, Tajima A, Ochiai D, Saisho Y, Matsumoto T, Arata N, Miyakoshi K, Tanaka M.　Endocr J　64　4　463-475　2017
  • 　Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis.　Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A.　J Neurochem　141　1　124-136　2017
  • 　An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies.　Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.　Hum Reprod Open　2017　1　hox002　2017
  • 　Effect of clozapine on DNA methylation in peripheral leukocytes from patients with treatment-resistant schizophrenia.　Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.　Int J Mol Sci　18　3　632　2017
  • 　A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan.　Kanzawa-Kiriyama H, Kryukov K, Jinam TA, Hosomichi K, Saso A, Suwa G, Ueda S, Yoneda M, Tajima A, Shinoda KI, Inoue I, Saitou N.　J Hum Genet　62　2　213-221　2017
  • 　Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals.　Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A.　Hum Genome Var　4　16046　2017
  • 　Cumulative effects of the plasma total homocysteine-related genetic variants on schizophrenia risk.　Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, Umehara H, Watanabe SY, Imoto I, Ohmori T.　Psychiatry Res　246　833-837　2016
  • 　A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men.　Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.　J Hum Genet　61　11　911-915　2016
  • 　Calcium signaling pathway is associated with the long-term clinical response to selective serotonin reuptake inhibitors (SSRI) and SSRI with antipsychotics in patients with obsessive-compulsive disorder.　Umehara H, Numata S, Tajima A, Nishi A, Nakataki M, Imoto I, Sumitani S, Ohmori T.　PLoS One　11　6　e0157232　2016
  • 　A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability.　Kawarai T, Tajima A, Kuroda Y, Saji N, Orlacchio A, Terasawa H, Shimizu H, Kita Y, Izumi Y, Mitsui T, Imoto I, Kaji R.　J Neurol Neurosurg Psychiatry　87　6　656-662　2016
  • 　CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation.　Shinmyo Y, Tanaka S, Tsunoda S, Hosomichi K, Tajima A, Kawasaki H.　Sci Rep　6　20611　2016
  • 　A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing.　Tada H, Hosomichi K, Okada H, Kawashiri M, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K.　Clin Chim Acta　453　194–196　2016
  • 　How 'circumpolar' is Ainu music? Musical and genetic perspectives on the history of the Japanese archipelago.　Savage PE, Matsumae H, Oota H, Stoneking M, Currie TE, Tajima A, Gillan M, Brown S.　Ethnomusicology Forum　24　3　443-467　2015
  • 　The impact of next-generation sequencing technologies on HLA research.　Hosomichi K, Shiina T, Tajima A, Inoue I.　J Hum Genet　60　11　665-673　2015
  • 　No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.　Umehara H, Numata S, Tajima A, Kinoshita M, Nakaaki S, Imoto I, Sumitani S, Ohmori T.　Hum Psychopharmacol Clin Exp　30　5　372-376　2015
  • 　Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis.　Numata S, Kinoshita M, Tajima A, Nishi A, Imoto I, Ohmori T.　BMC Med Genet　16　54　2015
  • 　Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions.　Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Yamamori H, Hashimoto R, Imoto I, Ohmori T.　Biol Sex Differ　6　11　2015
  • 　An association study of four candidate loci for human male fertility traits with male infertility.　Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.　Hum Reprod　30　6　1510-1514　2015
  • 　Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study.　Sato Y, Tajima A, Tsunematsu K, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.　Hum Reprod　30　6　1505-1509　2015
  • 　Model-based verification of hypotheses on the origin of modern Japanese revisited by Bayesian inference based on genome-wide SNP data.　Nakagome S, Sato T, Ishida H, Hanihara T, Yamaguchi T, Kimura R, Mano S, Oota H; The Asian DNA Repository Consortium.　Mol Biol Evol　32　6　1533-1543　2015
  • 　Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation.　Numata S, Ishii K, Tajima A, Iga JI, Kinoshita M, Watanabe S, Umehara H, Fuchikami M, Okada S, Boku S, Hishimoto A, Shimodera S, Imoto I, Morinobu S, Ohmori T.　Epigenetics　10　2　135-141　2015
  • 　Comparative proteomics and network analysis identify PKC epsilon underlying long-chain fatty acid signaling.　Yonezawa T, Kurata R, Tajima A, Cui X, Maruta H, Nakaoka H, Nakajima K, Inoko H.　Journal of Proteomics & Bioinformatics　7　11　340-346　2014
  • 　Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions.　Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Takeda M, Ohmori T.　Neuromolecular Med　16　4　697-703　2014
  • 　Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.　Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T.　Schizophr Bull　40　5　1154-1163　2014

Conference Presentations

  • Exploring correlations in genetic and cultural variation across language families in Northeast Asia(conference：Cultural Evolution Society Conference 2021)(2021/06/09)
  • Clonal hematopoiesis by HLA class I allele-lacking hematopoietic stem cells and concomitant aberrant stem cells is rarely associated with clonal evolution to secondary myelodysplastic syndrome and acute myeloid leukemia in patients with acquired aplastic anemia(conference：62th ASH Annual Meeting and Exposition)(2020/12/05)
  • Project S.H.I.P: a prospective genome-cohort study in Kanazawa(conference：The 2nd Japan - Germany Symposium on Advanced Preventive Medicine 2019)(2019/10/03)
  • Genome-wide association study in Japanese cohort identifies variants near amylase genes associated with serum amylase level(conference：[BC]2 at BASEL LIFE 2019)(2019/09/10)
  • Leveraging transcriptome sequencing for detecting novel disease-related pathways using human cardiac sarcoidosis myocardium biopsies(conference：ESC Congress 2019)(2019/09/02)

show all

  • Complex population history links to high linguistic diversity in the Pacific coast of North Asia(conference：Asia Pacific Conference on Human Evolution (APCHE))(2019/06/25)
  • Human population history in the southwestern coastal region of Sea of Okhotsk, inferred from ancient genome analysis(conference：SMBE 2018)(2018/07/11)
  • Complex human histories of Northeast Asia revealed by correlations between genes, languages and music(conference：SMBE 2018)(2018/07/11)
  • Comprehensive genotyping and phenotyping in patients with severe hypercholesterolemiaHuman genome analysis of supernumerary teeth(conference：ESC Congress 2017)(2017/08/28)
  • New NGS HLA typing by targeted enrichment procedure, capture method(conference：42nd Annual Meeting of the American Society for Histocompatibility & Immunogenetics)(2016/09/27)
  • Association analysis of polymorphisms with high-risk group of gestational diabetes mellitus in a Japanese population(conference：68th Annual Congress of the Japan Society of Obstetrics and Gynecology)(2016/04/22)
  • A multi-omics approach toward understanding the genetic and epigenetic bases of human complex disease and traits(conference：Scientific lectures in China Agricultural University)(2016/01/08)
  • Trio-based exome sequencing identified de novo non-synonymous missense mutations in schizophrenia(conference：Neuroscience 2015)(2015/10/15)
  • Cancer 'omics' in biomarker identification(conference： International Symposium on Tumor Biology in Kanazawa)(2015/04/08)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「疾患ハイリスク群の同定におけるエクスポソームワイド・リスクスコアの有用性評価」(2023-2024)　
○「生活習慣病の精密医療に向けた多層オミックス解析による新規リスク評価法の開発研究」(2023-2025)　
○「糖尿病人口急増地域における糖尿病発症リスクのゲノム解析：バングラデシュ調査研究」(2019-2023)　
○「多検体日本人口腔癌のエクソーム解析に基づく移植マウスモデルを用いた発がん機構解析」(2019-2023)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Lecture on Life in Campus and Society(2023)
○Introduction to Graduation Research in Medical and Pharmaceutical Sciences(2023)
○Academic Skills(2023)
○GS English Language Courses for Undergraduates Ⅰ(English in Medical and Pharmaceutical Sciences 1)(2023)
○Human Genetics 1(2023)
○Human Genetics 2(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅡＡ(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＤ(2023)
○Special Excercise in Medical and Pharmaceutical Sciences(2023)
○Medical and Pharmaceutical Sciences Researcher Training 1(2023)
○Seminar in Genome Analysis(2023)
○Graduation Thesis in Medical and Pharmaceutical Sciences(2023)
○Basic Health Science 1(2023)
○Basic Health Science 2(2023)
○Human Genetics(2023)
○Lecture on Life in Campus and Society(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＤ(2022)
○Special Excercise in Medical and Pharmaceutical Sciences(2022)
○Human Genetics 1(2022)
○Human Genetics 2(2022)
○Introduction to Graduation Research in Medical and Pharmaceutical Sciences(2022)
○Medical and Pharmaceutical Sciences Researcher Training 1(2022)
○Basic Health Science 2(2022)
○English in Medical and Pharmaceutical Sciences 1(2022)
○Basic Health Science 1(2022)
○Domestic Active Learning in Biomedical Sciences 1(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅡＡ(2022)
○Domestic Active Learning in Biomedical Sciences 2(2022)
○Academic Skills(2022)
○Human Genetics(2022)
○Basic Health Science 1(2022)
○Basic Health Science 2(2022)
○Lecture on Life in Campus and Society(2021)
○Basic Health Science 1(2021)
○Basic Health Science 2(2021)
○Human Genetics(2021)
○Academic Skills(2021)
○Basic Health Science 2(2021)
○Basic Health Science 1(2021)

Classes (Graduate Schools)

○Preemptive Nano-Medicine(2023)
○Genome Practical Training(2023)
○Advanced Course of Cancer Genome Medicine(2023)
○Introductory of Environmental and Genetic Factors in Relation to Health(2023)
○Medical Sciences(2023)
○Itemized Lectures of Bioinformatics and Genomics(2023)
○Introduction to Basic Medical Science(2023)
○omics(2023)
○Bioinformatics(2023)
○Environment and Heredity(2023)
○Environment and Health(2023)
○Basic Training on Medical Researches(2023)
○Intensive Lectures on Medical Researches(2023)
○Laboratory RotationⅡ(2023)
○Preventive Medicine(2023)
○Laboratory RotationⅠ(2023)
○Introductory of Environmental and Genetic Factors in Relation to Health(2022)
○Itemized Lectures of Bioinformatics and Genomics(2022)
○Advanced Course of Cancer Genome Medicine(2022)
○Bioinformatics(2022)
○omics(2022)
○Environment and Heredity(2022)
○Genome Practical Training(2022)
○Preemptive Nano-Medicine(2022)
○Preventive Medicine(2022)
○omics(2021)
○Genome Practical Training(2021)
○Training Program for Russia-East Asia Innovative Leaders in Preemptive Medicine(Doctoral Course)(2021)
○Itemized Lectures of Bioinformatics and Genomics(2021)
○Environment and Health -Introductory(2021)
○Advanced Course of Cancer Genome Medicine(2021)
○Introduction to Basic Medical Science(2021)
○Bioinformatics(2021)
○Preventive Medicine(2021)
○Environment and Heredity(2021)
○Preemptive Nano-Medicine(2021)

International Project

International Students

Lecture themes

Others (Social Activities)

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