last modified：2026/09/07
Associate Professor KOHNO, Susumu
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Laboratory
TEL:076-246-6751 FAX:076-234-4521
Academic Background
Career
Kanazawa Univ.(2011/06/01-2014/03/31)
Kanazawa Univ.(2015/04/01-2020/12/31)
Kanazawa Univ.(2021/01/01-)
Year & Month of Birth
Academic Society
Award
Specialities
Speciality Keywords
Research Themes
Books
Papers
- Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. Yutaro Obara,Wataru Nemoto,Susumu Kohno,Tomiyasu Murata,Norio Kaneda,Norimichi Nakahata Cellular signalling 23 4 666 2011/04
- Inhibitory effect of carbazolequinone derivatives on lipopolysaccharide and interferon-γ-induced nitric oxide production in mouse macrophage RAW264.7 cells Tomiyasu Murata,Susumu Kohno,Chihiro Ito,Masataka Itoigawa,Ayumi Sugiura,Kiyomi Hikita,Norio Kaneda Journal of Pharmacy and Pharmacology 65 8 1204 2013/08
- Establishment and characterization of a noradrenergic adrenal chromaffin cell line, tsAM5NE, immortalized with the temperature-sensitive SV40 T-antigen Susumu Kohno,Tomiyasu Murata,Naoshi Koide,Kiyomi Hikita,Norio Kaneda CELL BIOLOGY INTERNATIONAL 35 4 325 2011/04
- Methyl galbanate, a novel inhibitor of nitric oxide production in mouse macrophage RAW264.7 cells Susumu Kohno,Tomiyasu Murata,Ayumi Sugiura,Chihiro Ito,Mehrdad Iranshahi,Kiyomi Hikita,Norio Kaneda JOURNAL OF NATURAL MEDICINES 65 2 353 2011/04
- ATM Mediates pRB Function To Control DNMT1 Protein Stability and DNA Methylation Awad Shamma,Misa Suzuki,Naoyuki Hayashi,Masahiko Kobayashi,Nobunari Sasaki,Takumi Nishiuchi,Yuichiro Doki,Takahiro Okamoto,Susumu Kohno,Hayato Muranaka,Shunsuke Kitajima,Ken-ichi Yamamoto,Chiaki Takahashi MOLECULAR AND CELLULAR BIOLOGY 33 16 3113 2013/08
- Neuronal differentiation elicited by glial cell line-derived neurotrophic factor and ciliary neurotrophic factor in adrenal chromaffin cell line tsAM5D immortalized with temperature-sensitive SV40 T-antigen Tomiyasu Murata,Masaru Tsuboi,Naoshi Koide,Kiyomi Hikita,Susumu Kohno,Norio Kaneda JOURNAL OF NEUROSCIENCE RESEARCH 86 8 1694 2008/06
- Autocrine TGF-beta signaling is required for the GDNF/CNTF-induced neuronal differentiation of adrenal chromaffin tsAM5D cells expressing temperature-sensitive SV40 T-antigen Tomiyasu Murata,Naoshi Koide,Masaru Tsuboi,Susumu Kohno,Kiyomi Hikita,Norio Kaneda NEUROSCIENCE LETTERS 438 1 42 2008/06
- Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion. Li F,Kitajima S,Kohno S,Yoshida A,Tange S,Sasaki S,Okada N,Nishimoto Y,Muranaka H,Nagatani N,Suzuki M,Masuda S,Thai TC,Nishiuchi T,Tanaka T,Barbie DA,Mukaida N,Takahashi C Cancer research 79 15 3903 2019/08
- Cytotoxic activity of dimeric acridone alkaloids derived from Citrus plants towards human leukaemia HL-60 cells Tomiyasu Murata,Susumu Kohno,Kazuma Ogawa,Chihiro Ito,Masataka Itoigawa,Masafumi Ito,Kiyomi Hikita,Norio Kaneda Journal of Pharmacy and Pharmacology 72 10 1445 2020/09/10
- MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6 Akiyo Yoshida,Shunsuke Kitajima,Fengkai Li,Chaoyang Cheng,Yujiro Takegami,Susumu Kohno,Yuan Song Wan,Naoyuki Hayashi,Hayato Muranaka,Yuuki Nishimoto,Naoko Nagatani,Takumi Nishiuchi,Tran C. Thai,Sawako Suzuki,Shinji Nakao,Tomoaki Tanaka,Osamu Hirose,David A. Barbie,Chiaki Takahashi ONCOTARGET 8 8 13872 2017/02
- Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies Susumu Kohno,Shunsuke Kitajima,Nobunari Sasaki,Chiaki Takahashi WORLD JOURNAL OF STEM CELLS 8 4 170 2016/04
- Androgen-responsive FOXP4 is a target for endometrial carcinoma. Kayo Kayahashi,Mahadi Hasan,Anowara Khatun,Susumu Kohno,Jumpei Terakawa,Shin-Ichi Horike,Natsumi Toyoda,Ayumi Matsuoka,Takashi Iizuka,Takeshi Obata,Masanori Ono,Yasunari Mizumoto,Chiaki Takahashi,Hiroshi Fujiwara,Takiko Daikoku Communications biology 7 1 740 2024/06/18
- Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line. Masafumi Noguchi,Susumu Kohno,Anna Pellattiero,Yukino Machida,Keitaro Shibata,Norihito Shintani,Takashi Kohno,Noriko Gotoh,Chiaki Takahashi,Atsushi Hirao,Luca Scorrano,Atsuko Kasahara Cell death & disease 14 4 241 2023/04/05
- Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat. Swe Mar Oo,Hein Ko Oo,Hiroaki Takayama,Kiyo-Aki Ishii,Yumie Takeshita,Hisanori Goto,Yujiro Nakano,Susumu Kohno,Chiaki Takahashi,Hiroyuki Nakamura,Yoshiro Saito,Mami Matsushita,Yuko Okamatsu-Ogura,Masayuki Saito,Toshinari Takamura Cell reports 38 13 110566 2022/03/29
- Targeting RB1 Loss in Cancers Paing Linn,Susumu Kohno,Jindan Sheng,Nilakshi Kulathunga,Hai Yu,Zhiheng Zhang,Dominic Voon,Yoshihiro Watanabe,Chiaki Takahashi Cancers 13 15 3737 2021/07/25
- Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner. Naho Nomura,Chiaki Ito,Takako Ooshio,Yuko Tadokoro,Susumu Kohno,Masaya Ueno,Masahiko Kobayashi,Atsuko Kasahara,Yusuke Takase,Kenta Kurayoshi,Sha Si,Chiaki Takahashi,Masaaki Komatsu,Toru Yanagawa,Atsushi Hirao Scientific reports 11 1 1666 2021/01/18
- Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. Tatsunori Nishimura,Asuka Nakata,Xiaoxi Chen,Kurumi Nishi,Makiko Meguro-Horike,Soichiro Sasaki,Kenji Kita,Shin-Ichi Horike,Kaori Saitoh,Keiko Kato,Kaori Igarashi,Takahiko Murayama,Susumu Kohno,Chiaki Takahashi,Naofumi Mukaida,Seiji Yano,Tomoyoshi Soga,Arinobu Tojo,Noriko Gotoh Oncogene 38 14 2464 2019/04
- Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Naoto Nagata,Liang Xu,Susumu Kohno,Yusuke Ushida,Yudai Aoki,Ryohei Umeda,Nobuo Fuke,Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Chiaki Takahashi,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota Diabetes 66 5 1222 2017/05
- Regucalcin enhances adipocyte differentiation and attenuates inflammation in 3T3‐L1 cells Tomiyasu Murata,Masayoshi Yamaguchi,Susumu Kohno,Chiaki Takahashi,Watanabe Risa,Kanna Hatori,Kiyomi Hikita,Norio Kaneda FEBS Open Bio 10 10 1967 2020/10
- Peripubertal High Fat Diet Promotes c-Myc Stabilization in Mammary Gland Epithelium. Nilakshi Kulathunga,Susumu Kohno,Paing Linn,Yuuki Nishimoto,Shin-Ichi Horike,Mikhail I Zaraiskii,Sharad Kumar,Hayato Muranaka,Chiaki Takahashi Cancer science 2020/05/21
- An in vitro system to characterize prostate cancer progression identified signaling required for self-renewal Mohammed Salah,Yuuki Nishimoto,Susumu Kohno,Atsushi Kondoh,Shunsuke Kitajima,Hayato Muranaka,Takumi Nishiuchi,Ahmed Ibrahim,Akiyo Yoshida,Chiaki Takahashi MOLECULAR CARCINOGENESIS 55 12 1974 2016/12
- Control of undifferentiated state by RB tumor suppressor Susumu Kohno,Shunsuke Kitajima,Nobunari Sasaki,Chiaki Takahashi Seikagaku 88 3 335 2016
- Metabolic characterization of cultured mammalian cells by mass balance analysis, tracer labeling experiments and computer-aided simulations Nobuyuki Okahashi,Susumu Kohno,Shunsuke Kitajima,Fumio Matsuda,Chiaki Takahashi,Hiroshi Shimizu JOURNAL OF BIOSCIENCE AND BIOENGINEERING 120 6 725 2015/12
- A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling H. Muranaka,A. Hayashi,K. Minami,S. Kitajima,S. Kohno,Y. Nishimoto,N. Nagatani,M. Suzuki,L. A. N. Kulathunga,N. Sasaki,N. Okada,T. Matsuzaka,H. Shimano,H. Tada,C. Takahashi ONCOGENESIS 6 6 e350 2017/06
- Chemical inducer of regucalcin attenuates lipopolysaccharide‐induced inflammatory responses in pancreatic MIN6 β‐cells and RAW264.7 macrophages Tomiyasu Murata,Kazunori Hashimoto,Susumu Kohno,Chiaki Takahashi,Masayoshi Yamaguchi,Chihiro Ito,Itoigawa Masataka,Roji Kojima,Kiyomi Hikita,Norio Kaneda FEBS Open Bio 12 1 175 2022/01
- Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts Shunsuke Kitajima,Susumu Kohno,Atsushi Kondoh,Nobunari Sasaki,Yuuki Nishimoto,Fengkai Li,Mohammed Salah Abdallah Mohammed,Hayato Muranaka,Naoko Nagatani,Misa Suzuki,Yukiharu Kido,Chiaki Takahashi STEM CELLS 33 5 1657 2015/05
- RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia Loc Thi Pham,Hui Peng,Masaya Ueno,Susumu Kohno,Atuso Kasada,Kazuyoshi Hosomichi,Takehiro Sato,Kenta Kurayoshi,Masahiko Kobayashi,Yuko Tadokoro,Atsuko Kasahara,Mahmoud I. Shoulkamy,Bo Xiao,Paul F. Worley,Chiaki Takahashi,Atsushi Tajima,Atsushi Hirao Biochemical and Biophysical Research Communications 621 74 2022/09
- Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion. Susumu Kohno,Paing Linn,Naoko Nagatani,Yoshihiro Watanabe,Sharad Kumar,Tomoyoshi Soga,Chiaki Takahashi Oncogene 39 34 5690 2020/08
- Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells Tomiyasu Murata,Masayoshi Yamaguchi,Susumu Kohno,Chiaki Takahashi,Mitsumi Kakimoto,Yukiko Sugimura,Mako Kamihara,Kiyomi Hikita,Norio Kaneda FEBS Open Bio 8 3 349 2018/03/01
- RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells Linxiang Gong,Dominic Chih‐Cheng Voon,Joji Nakayama,Chiaki Takahashi,Susumu Kohno Cancer Science 115 5 1576 2024/03/11
- NFYA promotes malignant behavior of triple-negative breast cancer in mice through the regulation of lipid metabolism. Nobuhiro Okada,Chihiro Ueki,Masahiro Shimazaki,Goki Tsujimoto,Susumu Kohno,Hayato Muranaka,Kiyotsugu Yoshikawa,Chiaki Takahashi Communications biology 6 1 596 2023/06/02
- The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity. Kitajima S,Yoshida A,Kohno S,Li F,Suzuki S,Nagatani N,Nishimoto Y,Nishimoto Y,Sasaki N,Muranaka H,Wan Y,Nishiuchi T,Suzuki Y,Tominaga K,Gotoh N,Suzuki M,Ewen M,Baebie D,Hirose O,Tanaka T,Takahashi C Oncogene 36 36 5145 2017/09
- Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy. Jindan Sheng,Susumu Kohno,Nobuhiro Okada,Nobuyuki Okahashi,Kana Teranishi,Fumio Matsuda,Hiroshi Shimizu,Paing Linn,Naoko Nagatani,Minako Yamamura,Kenichi Harada,Shin-Ichi Horike,Hiroshi Inoue,Seiji Yano,Sharad Kumar,Shunsuke Kitajima,Itsuki Ajioka,Chiaki Takahashi Hepatology (Baltimore, Md.) 74 4 1971 2021/10
- Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance Ahmed M. Hegazy,Daisuke Yamada,Masahiko Kobayashi,Susumu Kohno,Masaya Ueno,Mohamed A. E. Ali,Kumiko Ohta,Yuko Tadokoro,Yasushi Ino,Tomoki Todo,Tomoyoshi Soga,Chiaki Takahashi,Atsushi Hirao JOURNAL OF BIOLOGICAL CHEMISTRY 291 41 21496 2016/10
- Cholesterol synthesis is essential for the growth of liver metastasis-prone colorectal cancer cells. Kumiko Taniguchi,Kei Sugihara,Takashi Miura,Daisuke Hoshi,Susumu Kohno,Chiaki Takahashi,Eishu Hirata,Etsuko Kiyokawa Cancer science 2024/09/22
- Enhancer of zeste 2 polycomb repressive complex 2 subunit overexpression suppresses apoptosis in canine T-cell lymphoma: an in vitro functional analysis Honoka Kawamura,Rina Ishikawa-Shinohara,Asuka Okamura,Susumu Kohno,Viviana Gonzalez-Astudillo,Ayako Wakabayashi,Yukiko Aikawa,Issay Kitabayashi,Takuya Mizuno,Noriko Gotoh,Masaki Michishita,Yukino Machida Frontiers in Veterinary Science 13 2026/06/12
- RECK attenuates CAF-mediated promotion of epithelial-mesenchymal transition in breast cancer. Nada H Hussein,Mahadi Hasan,Renata Akhmetzianova,Hai Yu,Susumu Kohno,Takiko Daikoku,Akira Orimo,Chiaki Takahashi Biochemical and biophysical research communications 810 153498 2026/04/23
- Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells. Erika Matsuda,Shiho Hasebe,Takashi Matsuzaka,Akio Hayashi,Hiroshi Ohno,Kaori Motomura,Shotaro Sakka,Susumu Kohno,Hayato Muranaka,Minako Yamamura,Asuka Suzuki,Yoshinori Takeuchi,Yoshinori Osaki,Takafumi Miyamoto,Motohiro Sekiya,Hirohito Sone,Naoya Yahagi,Yoshimi Nakagawa,Satoshi Nitta,Shuya Kandori,Takahiro Kojima,Chiaki Takahashi,Hiroyuki Nishiyama,Hitoshi Shimano Biochimica et biophysica acta. Molecular basis of disease 1871 8 168023 2025/11
- Metabolic flux and flux balance analyses indicate the relevance of metabolic thermogenesis and aerobic glycolysis in cancer cells. Nobuyuki Okahashi,Tomoki Shima,Yuya Kondo,Chie Araki,Shuma Tsuji,Akane Sawai,Hikaru Uehara,Susumu Kohno,Hiroshi Shimizu,Chiaki Takahashi,Fumio Matsuda Metabolic engineering 92 185 2025/11
- Bmal1 regulates thermogenic function by modulation of lipolytic and OXPHOS gene expression in male mice brown adipocytes Naoto Nagata,Ryuya Sugiyama,Susumu Kohno,Takeru Yamazaki,Satoshi Arai,Gai Sasaki,Pingping Xu,Jun-ichi Morishige,Tomohiro Iba,Ryo Miyazaki,Chiaki Takahashi,Young-Tae Chang,Tomoko Fujiwara,Hiroshi Fujiwara,Hitoshi Ando Endocrinology 2026/02/26
- Deprivation of EGFR signal causes senolysis in PDAC with CDK4/6 inhibition. Yuanyuan Zhang,Susumu Kohno,Keqi Gao,Mahadi Hasan,Tomohisa Baba,Zixue Zhang,Nao Sankoda,Hai Yu,Junjian Pan,Noriko Gotoh,Makoto Nakanishi,Yasuhiro Yamada,Jindan Sheng,Takiko Daikoku,Yoshikazu Johmura,Chiaki Takahashi Cell death and differentiation 2025/12/18
- RB1 controls differentiation through positive regulation of phosphoglycerate mutases Susumu Kohno,Nobuyuki Okahashi,Yuansong Wan,Hai Yu,Yujiro Takegami,Paing Linn,Naoko Nagatani,Shunsuke Kitajima,Teruo Kawada,Fumio Matsuda,Hiroshi Shimizu,Chiaki Takahashi Cell Death & Disease 16 1 2025/07/24
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RECK/GPR124 ‐drivenWNT signaling in pancreatic and gastric cancer cells Hai Yu,Susumu Kohno,Dominic Chih‐Cheng Voon,Nada Hamdy Hussein,Yuanyuan Zhang,Joji Nakayama,Yujiro Takegami,Chiaki Takahashi Cancer Science 2024/06/26 - 3P Metabolic reprogramming induced by KEAP1 mutation in NSCLC R. Akhmetzianova,S. Kohno,C. Takahashi Annals of Oncology 35 S216 2024/09