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last modified：2025/04/05
Assistant Professor NAGASHIMADA, Mayumi
Faculty, Affiliation
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Medical Science
Department of Laboratory Sciences，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Academic Background
Career
Year & Month of Birth
Academic Society
JAPAN SOCIETY FOR THE STUDY OF OBESITY
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Award
Specialities
Speciality Keywords
Research Themes
Books
Papers
- CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status. Yinhua Ni,Fen Zhuge,Liyang Ni,Naoto Nagata,Tatsuya Yamashita,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada Metabolism: clinical and experimental 136 155272 2022/07/29
- CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice. Liang Xu,Yongping Chen,Mayumi Nagashimada,Yinhua Ni,Fen Zhuge,Guanliang Chen,Haoran Li,Tongtong Pan,Tatsuya Yamashita,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota,Naoto Nagata Metabolism: clinical and experimental 125 154914 2021/12
- LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Noboru Takata,Kiyo-Aki Ishii,Hiroaki Takayama,Mayumi Nagashimada,Kyoko Kamoshita,Takeo Tanaka,Akihiro Kikuchi,Yumie Takeshita,Yukako Matsumoto,Tsuguhito Ota,Yasuhiko Yamamoto,Satoshi Yamagoe,Akihiro Seki,Yoshio Sakai,Shuichi Kaneko,Toshinari Takamura Scientific reports 11 1 555 2021/01/12
- Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease. Toshihiro Uesaka,Mitsumasa Okamoto,Mayumi Nagashimada,Yoshihiro Tsuda,Miho Kihara,Hiroshi Kiyonari,Hideki Enomoto Glia 69 11 2575 2021/11
- Effect of Microbiome on Non-Alcoholic Fatty Liver Disease and the Role of Probiotics, Prebiotics, and Biogenics. Mayumi Nagashimada,Masao Honda International journal of molecular sciences 22 15 2021/07/27
- CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice. Mayumi Nagashimada,Kazuki Sawamoto,Yinhua Ni,Hironori Kitade,Naoto Nagata,Liang Xu,Masuko Kobori,Naofumi Mukaida,Tatsuya Yamashita,Shuichi Kaneko,Tsuguhito Ota Endocrinology 162 6 2021/06/01
- Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability. Yuriko Sakai,Hideyuki Arie,Yinhua Ni,Fen Zhuge,Liang Xu,Guanliang Chen,Naoto Nagata,Takuya Suzuki,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada The Journal of endocrinology 247 2 169 2020/11
- Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice. Tomoki Nishikawa,Naoto Nagata,Tetsuro Shimakami,Takashi Shirakura,Chieko Matsui,Yinhua Ni,Fen Zhuge,Liang Xu,Guanliang Chen,Mayumi Nagashimada,Taro Yamashita,Yoshio Sakai,Tatsuya Yamashita,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko,Tsuguhito Ota Scientific reports 10 1 815 2020/01/21
- DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice. Yuriko Sakai,Guanliang Chen,Yinhua Ni,Fen Zhuge,Liang Xu,Naoto Nagata,Shuichi Kaneko,Tsuguhito Ota,Mayumi Nagashimada Endocrinology 161 10 2020/10/01
- Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. Yinhua Ni,Fen Zhuge,Mayumi Nagashimada,Naoto Nagata,Liang Xu,Sayo Yamamoto,Nobuo Fuke,Yusuke Ushida,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota Free radical biology & medicine 2019/11/29
- Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages. Guanliang Chen,Yinhua Ni,Naoto Nagata,Fen Zhuge,Liang Xu,Mayumi Nagashimada,Sayo Yamamoto,Yusuke Ushida,Nobuo Fuke,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota Molecular nutrition & food research 63 21 e1900602 2019/11
- Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages. Guanliang Chen,Yinhua Ni,Naoto Nagata,Liang Xu,Fen Zhuge,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota Laboratory investigation; a journal of technical methods and pathology 99 9 1335 2019/09
- Role of vitamin E in nonalcoholic fatty liver disease. Nagashimada M,Ota T IUBMB life 71 4 516 2019/04
- Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet. Liang Xu,Naoto Nagata,Guanliang Chen,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Yuriko Sakai,Shuichi Kaneko,Tsuguhito Ota BMJ open diabetes research & care 7 1 e000783 2019
- TAF7 is a heat-inducible unstable protein and is required for sustained expression of heat shock protein genes. Nagashimada M,Ueda T,Ishita Y,Sakurai H The FEBS journal 285 17 3215 2018/09
- A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice. Liang Xu,Naoto Nagata,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Guanliang Chen,Junzo Kamei,Hiroki Ishikawa,Yasuhiko Komatsu,Shuichi Kaneko,Tsuguhito Ota Oncotarget 9 19 15047 2018/03/13
- SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. Liang Xu,Naoto Nagata,Mayumi Nagashimada,Fen Zhuge,Yinhua Ni,Guanliang Chen,Eric Mayoux,Shuichi Kaneko,Tsuguhito Ota EBioMedicine 20 137 2017/06
- Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E Masuko Kobori,Yumiko Takahashi,Mutsumi Sakurai,Yinhua Ni,Guanliang Chen,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 5 2017/05
- Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Naoto Nagata,Liang Xu,Susumu Kohno,Yusuke Ushida,Yudai Aoki,Ryohei Umeda,Nobuo Fuke,Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Chiaki Takahashi,Hiroyuki Suganuma,Shuichi Kaneko,Tsuguhito Ota Diabetes 66 5 1222 2017/05
- Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E Masuko Kobori,Yumiko Takahashi,Mutsumi Sakurai,Yinhua Ni,Guanliang Chen,Mayumi Nagashimada,Shuichi Kaneko,Tsuguhito Ota INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 3 2017/03
- DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization Fen Zhuge,Yinhua Ni,Mayumi Nagashimada,Naoto Nagata,Liang Xu,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota DIABETES 65 10 2966 2016/10
- DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization. Zhuge F,Ni Y,Nagashimada M,Nagata N,Xu L,Mukaida N,Kaneko S,Ota T Diabetes 65 10 2966 2016/07
- Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis Yinhua Ni,Fen Zhuge,Mayumi Nagashimada,Tsuguhito Ota NUTRIENTS 8 7 2016/07
- Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor Kumi Kimura,Mamoru Tanida,Naoto Nagata,Yuka Inaba,Hitoshi Watanabe,Mayumi Nagashimada,Tsuguhito Ota,Shun-ichiro Asahara,Yoshiaki Kido,Michihiro Matsumoto,Koji Toshinai,Masamitsu Nakazato,Toshishige Shibamoto,Shuichi Kaneko,Masato Kasuga,Hiroshi Inoue CELL REPORTS 14 10 2362 2016/03
- Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E Yinhua Ni,Mayumi Nagashimada,Fen Zhuge,Lili Zhan,Naoto Nagata,Akemi Tsutsui,Yasuni Nakanuma,Shuichi Kaneko,Tsuguhito Ota SCIENTIFIC REPORTS 5 17192 2015/11
- Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System Toshihiro Uesaka,Mayumi Nagashimada,Hideki Enomoto JOURNAL OF NEUROSCIENCE 35 27 9879 2015/07
- Prevention and Reversal of Lipotoxicity-Induced Hepatic Insulin Resistance and Steatohepatitis in Mice by an Antioxidant Carotenoid, beta-Cryptoxanthin Yinhua Ni,Mayumi Nagashimada,Lili Zhan,Naoto Nagata,Masuko Kobori,Minoru Sugiura,Kazunori Ogawa,Shuichi Kaneko,Tsuguhito Ota ENDOCRINOLOGY 156 3 987 2015/03
- Prevention and reversal of lipotoxicity-induced nonalcoholic steatohepatitis by an antioxidant carotenoid, β-cryptoxanthin. Ni Y,Nagashimada M,Zhan L,Nagata N,Kobori M,Sugiura M,Ogawa K,Kaneko S,Ota T 135 1 67 2015
- beta-Cryptoxanthin Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Suppressing Inflammatory Gene Expression in Mice Masuko Kobori,Yinhua Ni,Yumiko Takahashi,Natsumi Watanabe,Minoru Sugiura,Kazunori Ogawa,Mayumi Nagashimada,Shuichi Kaneko,Shigehiro Naito,Tsuguhito Ota PLOS ONE 9 5 e98294 2014/05
- GDNF Signaling Levels Control Migration and Neuronal Differentiation of Enteric Ganglion Precursors Toshihiro Uesaka,Mayumi Nagashimada,Hideki Enomoto JOURNAL OF NEUROSCIENCE 33 41 16372 2013/10
- Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression Mayumi Nagashimada,Hiroshi Ohta,Chong Li,Kazuki Nakao,Toshihiro Uesaka,Jean-Francois Brunet,Jeanne Amiel,Delphine Trochet,Teruhiko Wakayama,Hideki Enomoto JOURNAL OF CLINICAL INVESTIGATION 122 9 3145 2012/09
- CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status Hironori Kitade,Kazuki Sawamoto,Mayumi Nagashimada,Hiroshi Inoue,Yasuhiko Yamamoto,Yoshimichi Sai,Toshinari Takamura,Hiroshi Yamamoto,Ken-ichi Miyamoto,Henry N. Ginsberg,Naofumi Mukaida,Shuichi Kaneko,Tsuguhito Ota DIABETES 61 7 1680 2012/07
- Diminished Ret expression compromises neuronal survival in the colon and causes intestinal aganglionosis in mice. Uesaka T,Nagashimada M,Yonemura S,Enomoto H The Journal of clinical investigation 118 5 1890 2008/05
- Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis Bhupinder P. S. Vohra,Keiji Tsuji,Mayumi Nagashimada,Toshihiro Uesaka,Daniel Wind,Ming Fu,Jennifer Armon,Hideki Enomoto,Robert O. Heuckeroth DEVELOPMENTAL BIOLOGY 298 1 259 2006/10
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「運動と非アルコール性脂肪肝炎の改善をつなぐ制御分子機構の解明」(2022-2026)
○「マクロファージ極性をM2へと導く新規転写因子の機能解明と生活習慣病創薬への展開」(2019-2021)
○「自然発症メタボリック症候群モデルを用いたカロテノイドの新たな生体調節機能の解明」(2015-2018)
○「インスリン抵抗性の制御におけるフラクタルカインと受容体の役割 」(2013-2015)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Lecture on Clinical Laboratory Management(2023)
○Clinical Chemistry Laboratory(2023)
○Clinical Chemistry Laboratory(2023)
○Experimental Course in Physiology(2023)
○Experimental Course in Physiology(2023)
○Introduction to Region-studies(2017)