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last modified：2025/04/13
Associate Professor MATSUMURA, Takuhiro
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Bacteriology
Academic Background
Career
(2007/04-2011/03)
Kanazawa University(2016/02-2022/10)
Kanazawa University(2022/11-)
(2011/04-2016/01)
Year & Month of Birth
Academic Society
The Japanese Biochemical Society
The Japanese Association for Infectious Diseases
Japanese Society for Bacteriology
Award
Japanese Society for Bacteriology
Japanese Society for Bacteriology
Japanese Society for Bacteriology
Specialities
Bacteriology (including mycology)
Speciality Keywords
bacterial toxin,Clostridium botulinum,neurotoxin,intestinal absorption,monoclonal antibody
Research Themes
Books
Papers
- Botulinum neurotoxin X lacks potency in mice and in human neurons. Gregg BM, Matsumura T, Wentz TG, Tepp WH, Bradshaw M, Stenmark P, Johnson EA, Fujinaga Y, Pellett S. mBio 15 3 e0310623 2024/03/13
- Adult-onset botulism in a Japanese woman with prolonged spore excretion. Kihara K, Kajiyama Y, Kimura Y, Okazaki S, Esa N, Nobe R, Shimizu K, Ohno K, Motooka D, Matsumura T, Shimazu T, Nakamura S, Fujinaga Y, Mochizuki H. J Infect Chemother. 12 1172 2023/12/29
- Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin Amatsu S, Matsumura T, Zuka M, Fujinaga Y. J Biol Chem 299 3 102944 2023
- Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro Kobayashi N, Abe K, Akagi S, Kitamura M, Shiraishi Y, Yamaguchi A, Yutani M, Amatsu S, Matsumura T, Nomura N, Ozaki N, Obana N, Fujinaga Y. Front Microbiol. 13 7203038 2022
- Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene Takemori-Sakai Y, Satou K, Senda Y, Nakamura Y, Otani H, Maekawa A, Oe H, Oshima M, Yoneda-Nakagawa S, Miyagawa T, Sato K, Ogura H, Mori M, Wada T, Sakai Y, Yutani M, Matsumura T, Fujinaga Y, Gabata T, Wada T, Iwata Y. J Infect Chemother. 22 00026-5 2022
- Effects of antibiotics on the viability of and toxin production by Clostridium botulinum Yutani M, Matsumura T, Fujinaga Y. Microbiol Immunol. 65 10 432-437 2021
- Functional Analysis of Botulinum Hemagglutinin (HA). Matsumura T, Fujinaga Y. Methods Mol Biol. 2020
- Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B. Matsumura T, Amatsu S, Misaki R, Yutani M, Du A, Kohda T, Fujiyama K, Ikuta K, Fujinaga Y. Toxins (Basel). 2020
- Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, Yutani M, Fujinaga Y, Hase A, Morita H, Ohta T, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Kaneko S, Wada T. Int J Infect Dis. 2019
- [Mechanism of intestinal absorption of botulinum neurotoxin complex]. Takuhiro Matsumura Nihon Saikingaku Zasshi 2019
- Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption. Amatsu S, Matsumura T, Yutani M, Fujinaga Y. Microbiology and Immunology 2017/12/08
- Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Takuhiro Matsumura,Yo Sugawara,Masahiro Yutani,Sho Amatsu,Hideo Yagita,Tomoko Kohda,Shin-Ichi Fukuoka,Yutaka Nakamura,Shinji Fukuda,Koji Hase,Hiroshi Ohno,Yukako Fujinaga Nature communications 6 6255 2015/02/17
- Functional dissection of the Clostridium botulinum type B hemagglutinin complex: identification of the carbohydrate and E-cadherin binding sites. Yo Sugawara,Masahiro Yutani,Sho Amatsu,Takuhiro Matsumura,Yukako Fujinaga PloS one 9 10 e111170 2014
- Crystal structure of Clostridium botulinum whole hemagglutinin reveals a huge triskelion-shaped molecular complex. Sho Amatsu,Yo Sugawara,Takuhiro Matsumura,Kengo Kitadokoro,Yukako Fujinaga The Journal of biological chemistry 288 49 35617 2013/12/06
- Molecular characterization of binding subcomponents of Clostridium botulinum type C progenitor toxin for intestinal epithelial cells and erythrocytes. Yukako Fujinaga,Kaoru Inoue,Shinobu Watarai,Yoshihiko Sakaguchi,Hideyuki Arimitsu,Jae-Chul Lee,Yingji Jin,Takuhiro Matsumura,Yuko Kabumoto,Toshihiro Watanabe,Tohru Ohyama,Atsushi Nishikawa,Keiji Oguma Microbiology (Reading, England) 150 Pt 5 1529 2004/05
- Disruption of the epithelial barrier by botulinum haemagglutinin (HA) proteins - differences in cell tropism and the mechanism of action between HA proteins of types A or B, and HA proteins of type C. Yingji Jin,Yuki Takegahara,Yo Sugawara,Takuhiro Matsumura,Yukako Fujinaga Microbiology (Reading, England) 155 Pt 1 35 2009/01
- Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. Yasunori Iwata,Kenji Satou,Kengo Furuichi,Ikuko Yoneda,Takuhiro Matsumura,Masahiro Yutani,Yukako Fujinaga,Atsushi Hase,Hidetoshi Morita,Toshiko Ohta,Yasuko Senda,Yukiko Sakai-Takemori,Taizo Wada,Shinichi Fujita,Taito Miyake,Haruka Yasuda,Norihiko Sakai,Shinji Kitajima,Tadashi Toyama,Yasuyuki Shinozaki,Akihiro Sagara,Taro Miyagawa,Akinori Hara,Miho Shimizu,Yasutaka Kamikawa,Kazuho Ikeo,Shigeyuki Shichino,Satoshi Ueha,Takuya Nakajima,Kouji Matsushima,Shuichi Kaneko,Takashi Wada International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 91 22 2020/02
- Functional Analysis of Botulinum Hemagglutinin (HA). Takuhiro Matsumura,Yukako Fujinaga Methods in molecular biology (Clifton, N.J.) 2132 191 2020
- Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections T. Nakayama,D. Takeuchi,T. Matsumura,Y. Akeda,Y. Fujinaga,K. Oishi Microbial Pathogenesis 65 14 2013/12
- Uptake of botulinum neurotoxin in the intestine. Yukako Fujinaga,Yo Sugawara,Takuhiro Matsumura Current topics in microbiology and immunology 364 45 2013
- Crystallization and preliminary crystallographic studies of the HA3 subcomponent of the type B botulinum neurotoxin complex. Kohsuke Nishimura,Kengo Kitadokoro,Yuki Takegahara,Yo Sugawara,Takuhiro Matsumura,Hajime Karatani,Yukako Fujinaga Acta crystallographica. Section F, Structural biology and crystallization communications 67 Pt 10 1244 2011/10/01
- The HA proteins of botulinum toxin disrupt intestinal epithelial intercellular junctions to increase toxin absorption. Takuhiro Matsumura,Yingji Jin,Yuko Kabumoto,Yuki Takegahara,Keiji Oguma,Wayne I Lencer,Yukako Fujinaga Cellular microbiology 10 2 355 2008/02
- Human milk SIgA binds to botulinum type B 16S toxin and limits toxin adherence on T84 cells. Takuhiro Matsumura,Yukako Fujinaga,Yingji Jin,Yuko Kabumoto,Keiji Oguma Biochemical and biophysical research communications 352 4 867 2007/01/26
- Neutralization mechanism of human monoclonal antibodies against type B botulinum neurotoxin Takuhiro Matsumura,Mayu Kitamura,Sho Amatsu,Aki Yamaguchi,Nobuhide Kobayashi,Masahiro Yutani,Yukako Fujinaga Microbiology and Immunology 2024/09/06
- Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3. Yo Sugawara,Masao Iwamori,Takuhiro Matsumura,Masahiro Yutani,Sho Amatsu,Yukako Fujinaga The FEBS journal 282 17 3334 2015/09
Conference Presentations
- Neutralization mechanism of human monoclonal antibodies against type B botulinum neurotoxin (2024/08/07)
- Endogenous production and neurotoxicity of novel botulinum neurotoxin (BoNT/X) in a clinical isolate.(2023/03/16)
- The relationship between infant botulism and sudden infant death syndrome (SIDS)(2020/11/07)
- The relationship between infant botulism and sudden infant death syndrome (SIDS)(2020/02/19)
- FULLY HUMAN MONOCLONAL ANTIBODIES EFFECTIVELY NEUTRALIZE BOTULINUM NEUROTOXIN SEROTYPE B(conference：Toxins 2019)(2019/01/16)
- Therapeutic and preventive effect of fully human monoclonal antibodies against type B botulinum intoxication(conference：Interagency Botulism Research Coordinating Committee (IBRCC) Meeting 2018)(2018/10/21)
- Intestinal absorption mechanism of type B1 botulinum progenitor toxin produced by strain Okra.(conference：Intergency Botulinum Research Coordinating Committee Meeting (IBRCC) 2017)(2017/10/22)
- Intestinal absorption mechanisms of type A and type B botulinum toxin(conference：The 90th Annual Meeting of Japanese Society for Bacteriology)(2017/03/19)
- Invasion mechanism of type A botulinum neurotoxin complex(conference：The 39th Annual Meeting of the Molecular Biology Society of Japan)(2016/11/30)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「抗毒素製剤に関する総合的な対策に資する研究」(2022-2025)
○「ボツリヌス症を治療するヒト型抗体製剤の開発に向けた基盤研究」(2021-2023)
○「腸管感染型ボツリヌス症を制御する腸内因子のin vivoを中心とした解析」(2021-2023)
○「Analysis of neurotoxicity of a putative novel botulinum neurotoxin」(2020-2021)
○「ボツリヌス菌の病原性関連遺伝子領域に存在する機能未知遺伝子群の解析」(2018-2020)
○「ボツリヌス毒素の体内侵入機構を利用した粘膜ワクチンの開発」(2018-2020)
○「ボツリヌス神経毒素複合体と腸管免疫系細胞との相互作用の解析」(2016-2018)
○「腸管上皮バリアを破壊するボツリヌス HA の基質分子の探索及び作用機序の解析」(2008-2010)
○「共生細菌による病原性クロストリジウム属菌の腸管感染制御とその機構の解明」(2024-2026)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Medical Bacteriology(2022)
○Medical Bacteriology(2022)
○Medical Bacteriology(2022)
○Medical Bacteriology(2022)
○Medical Bacteriology(2022)
○Medical Bacteriology(2022)
○Medical Bacteriology 1(2022)
○Medical Bacteriology 1(2022)
○Medical Bacteriology(2021)
○Medical Bacteriology(2020)
○Medical Bacteriology(2019)
○Medical Bacteriology(2018)
○Medical Bacteriology(2017)
○Medical Bacteriology(2016)
Classes (Graduate Schools)
○Bacterial Infections(2022)
○Intensive Lectures on Medical Researches(2021)
○Bacterial Infections(2020)
○Bacterial Infections(2019)
○The Human Body in Health and Disease Curriculum 3(2018)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Bacterial Infections(2016)
○Bacterial Infections(2016)