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Researcher Information

last modified:2024/03/29

Professor SUGIMOTO Naotoshi

Mail

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2314 FAX:076-262-1866

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 1995
【Academic background(Bachelor's Degree)】
Kanazawa University 1991

Career

Year & Month of Birth

1965/04

Academic Society


The Japanese Circulation Society



日本生気象学会

Award

日本生気象学会

Specialities

Physiology、Nutrition、Pediatorics

Speciality Keywords

Cell Biology, Homeostasis, Pathophysiology

Research Themes

Human Homeostasis

Signal transduction

Autoimmuno Disease

Gerontology

Cell Migration

Books

  •  Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Mitsugu Yoneda, Eri Sumiyoshi, Takako Ohno-Shosaku, Akihiro Yachie, Osamu Shido Functional Foods and Bioactive Compounds in Health and Disease: Science and Practice, Edited by Dankin M. Martirosyan.  Food Science Publisher 2017/03

Papers

  •  Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils CELL 114 2 201-214 2003/07
  •  Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled JOURNAL OF BIOLOGICAL CHEMISTRY In Press 2003/07
  •  Integral Role of RhoA Activation in Monocyte Adhesion-Triggered Tissue Factor Expression in Endothelial Cells Arterioscler Thromb Vasc Biol 23 4 681-687 2003/04
  •  The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities JOURNAL OF BIOCHEMISTRY 131 6 767-771 2002/06
  •  Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5 JOURNAL OF BIOLOGICAL CHEMISTRY 279 13 12300-12311 2004/03

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  •  Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP. BIOCHEMICAL JOURNAL 385 3 737-744 2005/02
  •  Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G12/13-Rho and Gi Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform. Molecula and Cellular Biology 23 5 1534-1545 2003/05
  •  Dense Methylation of Type 1 and Type 2 Regulatory Regions of the CD10 Gene Promoter in Infant Acute Lymphoblastic Leukemia with MLL/AF4 Fusion Gene. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY Inpress 2009
  •  Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma. INTERNATIONAL JOURNAL OF CANCER Inpress 2009
  •  Local Application of Olprinone for promotion of peripheral nerve regeneration. J. Orthpaedic Sci. Inpress 2009
  •  In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential. JOURNAL OF CELLULAR BIOCHEMISTRY 108  362-367 2009
  •  The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. CARDIOVASCULAR RESEARCH 78  301-307 2008
  •  G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. CARDIOVASCULAR RESEARCH 79  689-697 2008
  •  RhoA-dependent PAI-1 gene expression induced in endothelial cells by monocyte adhesion mediates geranylgeranyl transferase I and Ca2+ signaling. ATHEROSCLEROSIS 193  44-54 2007
  •  Ca2+-independent, inhibitory effects of cyclic adenosine 5'-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase C2alpha, Rho, and myosin phosphatase in vascular smooth muscle. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 320  907-916 2007
  •  Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells. MOLECULAR PHARMACOLOGY 71  912-920 2007
  •  Class II phosphoinositide 3-kinase alfa-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle. BIOCHEMICAL JOURNAL 394  581-592 2006
  •  Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi- inactivated CHO cells. EXPERIMENTAL CELL RESEARCH 312  1899-1908 2006
  •  Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase. ONCOGENE 25  5942-5952 2006
  •  Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 346  293-300 2006
  •  Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells. JOURNAL OF BIOLOGICAL CHEMISTRY 280  10182-10188 2005
  •  Endogenous NO blockade enhances tissue factor expression via increased Ca2+ influx through MCP-1 in endothelial cells by monocyte adhesion. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 25  2005-2011 2005
  •  Involvement of the betagamma subunits of G proteins in the cAMP response induced by stimulation of the histamine H(1) receptor. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 372  153-159 2005
  •  Endogenous cryogens exsiting in the blood of a hypothermic patient. JAPANESE JOURNAL OF PHYSIOLOGY 54  449-456 2004
  •  Angiopoietin-1 and -2 as markers for disease severity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli. Shimizu M, Inoue N, Kuroda M, Mizuta M, Sugimoto N, Kaneda H, Ohta K, Yachie A.  Clin Exp Nephrol. 21 1 76-82 2017/03
  •  Protein kinase A and Epac activation by cAMP regulate the expression of glial fibrillary acidic protein in glial cells.  Sugimoto N, Miwa S, Nakamura H, Tsuchiya H, Yachie A. Arch Biol Sci. 68 4 795-801 2016
  •  The paracrine effect of adipose-derived stem cells inhibits osteoarthritis progression. Kuroda K, Kabata T, Hayashi K, Maeda T, Kajino Y, Iwai S, Fujita K, Hasegawa K, Inoue D, Sugimoto N, Tsuchiya H. BMC Musculoskelet Disord. 16 0 236 2015
  •  The critical role of lipopolysaccharide in the upregulation of aquaporin 4 in glial cells treated with Shiga toxin. Sugimoto N, Leu H, Inoue N, Shimizu M, Toma T, Kuroda M, Saito T, Wada T, Yachie A. J Biomed Sci. 22 0 78 2015
  •  β-amyloid infusion into lateral ventricle alters behavioral thermoregulation and attenuates acquired heat tolerance in rats. Matsuzaki K, Katakura M, Sugimoto N, Hara T, Hashimoto M, Shido O. Temperature 2 0 418-424 2015
  •  Rotavirus gastroenteritis-associated urinary ammonium acid urate crystals. Yokoyama T, Sugimoto N, Kato E, Ohta K, Ishikawa S, Ueno K, Shimizu M, Yachie A. Pediatr Int. 57 1 158-160 2015
  •  Fluorescence-guided surgery of prostate cancer bone metastasis. Miwa S, Matsumoto Y, Hiroshima Y, Yano S, Uehara F, Yamamoto M, Zhang Y, Kimura H, Hayashi K, Yamamoto N, Bouvet M, Sugimoto N, Tsuchiya H, Hoffman RM. J Surg Res 192 1 124-133 2014
  •  Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis. Ishikawa S, Shimizu M, Ueno K, Sugimoto N, Yachie A. Cytokine 62 272-277 2013
  •  Urinary neopterin: an immune activation marker in mesangial proliferative glomerulonephritis Ueno, Kazuyuki; Shimizu, Masaki; Yokoyama, Tadafumi; Ishikawa, Sayaka; Tasaki, Yuko; Inoue, Natsumi; Sugimoto, Naotoshi; Ohta, Kazuhide; Yachie, Akihiro Clinical and Experimental Nephrology 19 2 264-270 2014/05/25 
  •  Uncultured Autogenous Adipose-derived Regenerative Cells Promote Bone Formation During Distraction Osteogenesis in Rats Nomura, Issei; Watanabe, Koji; Matsubara, Hidenori; Hayashi, Katsuhiro; Sugimoto, Naotoshi; Tsuchiya, Hiroyuki Clinical Orthopaedics and Related Research? 472 12 3798-3806 2014/04/08 
  •  Theobromine, the primary methylxanthine found in theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B Sugimoto, Naotoshi; Miwa, Shinji; Hitomi, Yoshiaki; Nakamura, Hiroyuki; Tsuchiya, Hiroyuki; Yachie, Akihiro Nutrition and Cancer 66 3 419-423 2014/04/03 
  •  Shiga toxin-2 enhances heat-shock-induced apoptotic cell death in cultured and primary glial cells Sugimoto, Naotoshi; Toma, Tomoko; Shimizu, Masaki; Kuroda, Mondo; Wada, Taizo; Yachie, Akihiro Cell Biology and Toxicology 30 5 289-299 2014/01/01 
  •  Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells Sugimoto, Naotoshi; Shido, Osamu; Matsuzaki, Kentaro; Katakura, Masanori; Hitomi, Yoshiaki; Tanaka, Masao; Sawaki, Toshioki; Fujita, Yoshimasa; Kawanami, Takafumi; Masaki, Yasufumi; Okazaki, Toshiro; Nakamura, Hiroyuki; Koizumi, Shoichi; Yachie, Akihiro; Umehara, Hisanori Cell Biochemistry and Biophysics 70 1 301-307 2014/01/01 
  •  3-dimensional tissue is formed from cancer cells in vitro on gelfoam ?, but not on matrigelTM Tome, Yasunori; Uehara, Fuminari; Mii, Sumiyuki; Yano, Shuya; Zhang, Lei; Sugimoto, Naotoshi; Maehara, Hiroki; Bouvet, Michael; Tsuchiya, Hiroyuki; Kanaya, Fuminori; Hoffman, Robert M. Journal of Cellular Biochemistry 115 8 1362-1367 2014/01/01 
  •  Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy Miwa, Shinji; Yano, Shuya; Tome, Yasunori; Sugimoto, Naotoshi; Hiroshima, Yukihiko; Uehara, Fuminari; Mii, Sumiyuki; Kimura, Hiroaki; Hayashi, Katsuhiro; Efimova, Elena V.; Fujiwara, Toshiyoshi; Tsuchiya, Hiroyuki; Hoffman, Robert M. Journal of Cellular Biochemistry 114 11 2454-2460 2013/11/01 
  •  Lactobacillus casei cell wall extract directly stimulates the expression of COX2 independent of Toll-like receptor 2 in rat glial cells Sugimoto, Naotoshi; Ohta, Kunio; Saito, Takekatsu; Nakayama, Yuko; Nakamura, Taichi; Maeda, Akiko; Yachie, Akihiro Journal of Microbiology, Immunology and Infection 46 5 389-392 2013/10/01 
  •  High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of αvβ3 Integrin Tome, Yasunori; Kimura, Hiroaki; Maehara, Hiroki; Sugimoto, Naotoshi; Bouvet, Michael; Tsuchiya, Hiroyuki; Kanaya, Fuminori; Hoffman, Robert M. Anticancer Research 33 9 3623-3628 2013/09/01 
  •  Real-time imaging of αv integrin molecular dynamics in osteosarcoma cells in vitro and in vivo Tome, Yasunori; Sugimoto, Naotoshi; Yano, Shuya; Momiyama, Masashi; Mii, Sumiyuki; Maehara, Hiroki; Bouvet, Michael; Tsuchiya, Hiroyuki; Kanaya, Fuminori; Hoffman, Robert M. Anticancer Research 33 8 3021-3026 2013/08/01 
  •  Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats Sugimoto, Naotoshi;Matsuzaki, Kentaro;Ishibashi, Hiroaki;Tanaka, Masao;Sawaki, Toshioki;Fujita, Yoshimasa;Kawanami, Takafumi;Masaki, Yasufumi;Okazaki, Toshiro;Sekine, Joji;Koizumi, Shoichi;Yachie, Akihiro;Umehara, Hisanori;Shido, Osamu SCIENTIFIC REPORTS 3 0 0-0 2013 
  •  Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration. Sugamuma S, Tada K, Hayashi K, Takeuchi A, Sugimoto N, Ikeda K, Tsuchiya H.  J Orthop Sci. 18 1 145-151 2013/01
  •  Targeted activation of PKA and Epac promotes glioblastoma regression in vitro. Sugimoto N, Miwa S, Tsuchiya H, Hitomi Y, Nakamura H, Yachie A, Koizumi S.  Mol Clin Oncol. 1 2 281-285 2013/03
  •  The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis. Tanaka T, HitomiY, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata A, Sugimoto N, Hatta K, Eboshida A, Konoshita T, Nakamura H. Allergol Int 61 1 57-63 2012/03
  •  Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-B and MAPK activations and cell proliferation through protein kinase A- or exchange protein activated by cAMP-dependent signal pathway. Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomo Y, Nakamura H, Koizumi S, Yachie A. ScientificWorldJournal 2012 748572 2012/05
  •  Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells. Echigo R, Sugimoto N, Yachie A, Ohno-Shosaku T. ONCOLOGY REPORTS 28 4 1176-1180 2012/10
  •  Cellular heat acclimation regulates cell growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse fibroblast cells. Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A, Umehara H. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 30 2 450-457 2012/06
  •  Skewed production of IL-6 and TGFβ by cultured salivary gland epithelial cells from patients with Sjögren's syndrome. Kawanami T, Sawaki T, Sakai T, Miki M, Iwao H, Nakajima A, Nakamura T, Sato T, Tanaka M, Masaki Y, Fukushima T, Hirose Y, Sugimoto N, Okazaki T, Umehara H.  PLoS One 7 10 e45689 2012/10
  •  Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. Miwa S, Sugimoto N, Yamamoto N, Shirai T, Nishida H, Hayashi K, Kimura H, Takeuchi A, Igarashi K, Yachie A, Tsuchiya H. ANTICANCER RESEARCH 32 9 3643-3649 2012/09
  •  Isolated congenital megacystis without intestinal obstruction: a mild variant of chronic intestinal pseudoobstruction syndrome? Shimizu M, Nishio S, Ueno K, Yokoyama T, Sakai S, Nagaoki S, Sugimoto N, Ohta K,  JOURNAL OF PEDIATRIC SURGERY 46 11 e29-32 2011/11
  •  Effects of clozapine and N-desmethylclozapine on synaptic transmission at hippocampal inhibitory and excitatory synapses.  Ohno-Shosaku T, Sugawara Y, Muranishi C, Nagasawa K, Kubono K, Aoki N, Taguchi M, Echigo R, Sugimoto N, Kikuchi Y, Watanabe R, Yoneda M. BASIN RESEARCH 1421 66-77 2011/11
  •  Activity of bone morphogenetic protein-7 after treatment at various temperatures: freezing vs. pasteurization vs. allograft. Takata M, Sugimoto N, Yamamoto N, Shirai T, Hayashi K, Nishida H, Tanzawa Y, Kimura H, Miwa S, Takeuchi A, Tsuchiya H. Cryobiology 63 3 235-239 2011/12
  •  Molecular and immunohistochemical detection of rotavirus in urinary sediment cells of children with rotavirus gastroenteritis. Yokoyama T, Sugimoto N, Taniguchi K, Komoto S, Yuno T, Ohta K, Hashimoto H, Seno A, Ashida A, Fujieda M, Nishio S, Ueno K, Shimizu M, Yachie A. Clin Microbiol Infect 17 8 1190-1193 2011/08
  •  Caffeine activates tumor suppressor PTEN in sarcoma cells. Miwa S, Sugimoto N, Shirai T, Hayashi K, Nishida H, Ohnari I, Takeuchi A, Yachie A, Tsuchiya H. INTERNATIONAL JOURNAL OF ONCOLOGY 39 2 465-472 2011/08
  •  Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. Sugimoto N, Miwa S, Ohno-Shosaku T, Tsuchiya H, Hitomi Y, Nakamura H, Tomita K, Yachie A, Koizumi S. NEUROSCIENCE LETTERS 497 1 55-59 2011/06
  •  Effects of long-term treatment with dietary theobromine on rat skeletal muscles. Tanaka S, Sugioto N, Ohno-Shosaku T, Madokoro S, Inaoka PT, Yamazaki T. Mol Biol Rep 2022/02/28
  •  Safety and heat retention of arm warmers made of serpentine-containing fibers. Yoshinori Sato, Jun Hirayama, Naotoshi Sugimoto Journal of Wellness and Health Care 47 2 9-14 2023/12/31
  •  A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication. Tasaki Y, Tsujimoto H, Yokoyama T, Sugimoto N Front Immunol 15 1360855 2024/03/08
  •  Distinct roles of IL-18 and IL-1β in murine model of macrophage activation syndrome. Mizuta M, Inoue N, Shimizu M, Sakumura N, Yokoyama T, Kuroda R, Ikawa Y, Sugimoto N J Allergy Clin Immunol.  152 4 940-948 2023/06/22
  •  Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation. Yoshibumi Ueda, Yuri Miura, Nario Tomishige, Naotoshi Sugimoto, Megumi Murase, Genki Kawamura, Norihiko Sasaki, Toshiyuki Ishiwata, Takeaki Ozawa Cell Chem Biol 29 11 1576-1587 2022/11/17
  •  Increased spine PIP3 is sequestered from dendritic shafts. Ueda Y, Sugimoto N, Ozawa T Mol Brain 15 1 59 2022/07/04
  •  Theobromine Improves Working Memory by Activating the CaMKII/CREB/BDNF Pathway in Rats. Islam R, Matsuzaki K, Sumiyoshi E, Hossain ME, Hashimoto M, Katakura M, Sugimoto N, Shido O Nutrients 11 4 E888 2019/04/20
  •  Corticosterone inhibits the expression of cannabinoid receptor-1 and cannabinoid receptor agonist-induced decrease in cell viability in glioblastoma cells. Sugimoto N, Ishibashi H, Ueda Y, Nakamura H, Yachie A, Ohno-Shosaku T Oncol Lett 18 2 1557-1563 2019/06/07
  •  Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats. Matsuzaki K, Sugimoto N, Islam R, Hossain ME, Sumiyoshi E, Katakura M, Shido O Int J Mol Sci 21 3 E815 2020/01/27
  •  Heat attenuates sensitivity of mammalian cells to capsaicin Sugimoto N, Matsuzaki K, Katakura M, Nakamura H, Ueda Y, Yachie A, Shido O. J Biochem Mol Toxicol 2019/01/23
  •  Chronic administration of theobromine inhibits mTOR signal in rats. Sugimoto N, Katakura M, Matsuzaki K, Sumiyoshi E, Yachie A, Shido O. Basic Clin Pharmacol Toxicol. 2018/11/19
  •  Membrane Dynamics Induced by a Phosphatidylinositol 3,4,5-Trisphosphate Optogenetic Tool. Ueda Y, Ii T, Aono Y, Sugimoto N, Shinji S, Yoshida H, Sato M. Anal Sci 35 1 57-63 2019/01/10
  •  Hypoxia-induced inhibition of the endocannabinoid system in glioblastoma cells. Sugimoto N, Ishibashi H, Nakamura H, Yachie A, Ohno-Shosaku T. Oncol Rep. 38 6 3702-3708 2017/12
  •  Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro. Hossain ME, Matsuzaki K, Katakura M, Sugimoto N, Mamun AA, Islam R, Hashimoto M, Shido O. PLoS One 12 12 e0190356 2017/12
  •  In vivo imaging of T cell lymphoma infiltration process at the colon. Ueda Y, Ishiwata T, Shinji S, Arai T, Matsuda Y, Aida J, Sugimoto N, Okazaki T, Kikuta J, Ishii M, Sato M. Sci Rep 8 1 3978 2018/03
  •  Capsaicin partially mimics heat in mouse fibroblast cells in vitro. Sugimoto N, Katakura M, Matsuzaki K, Nakamura H, Yachie A, Shido O. Naunyn Schmiedebergs Arch Pharmacol. 330 3 281-289 2017/03
  •  Use of αv integrin linked to GFP to image molecular dynamics in trafficking cancer-cell embol. Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. J Cell Biochem 118 1 26-30 2017/01
  •  Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. Yoneda M, Sugimoto N, Katakura M, Matsuzaki K, Tanigami H, Yachie A, Ohno-Shosaku T, Shido O. J Nutr Biochem. 39 110-116 2017/01
  •  The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. Oncotarget 7 52 87031-87036 2016/12
  •  Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice. Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM. Anticancer Res. 36 8 3811-3816 2016/08
  •  Effect of theobromine intake on proliferation and bone differentiation abilities of bone marrow-derived somatic stem cells Functional Food Research 16 57-64 2020/06
  •  Ginger facilitates cell migration and heat tolerance in mouse fibroblast cells. Sugimoto N, Katakura M, Matsuzaki K, Miyamoto M, Sumiyoshi E, Wada T, Yachie A, Nakamura H, Shido O. Mol Med Rep. 23 4 1 2021/02
  •  Serum insulin-like growth factor-binding protein 2 levels as an indicator for disease severity in enterohemorrhagic Escherichia coli induced hemolytic uremic syndrome Tasaki, Y., Inoue, N., Shimizu, M., Sugimoto, N., Ishikawa, S., Mizuta, M., Yokoyama, T., Kuroda, M., Ohta, K., Yachie, A., Wada, T. Renal Failure 43 1 382-387 2021/02
  •  Our life in hot environments Naotoshi Sugimoto Jpn. J. Biometeor. 57 2 61-65 2020/10
  •  Combinational therapy with antibiotics and antibiotic-loaded adipose-derived stem cells reduce abscess formation in implant-related infection in rats Yoshitani J, Kabata T, Arakawa H, Kato Y, Nojima T, Hayashi K, Tokoro M, Sugimoto N, Kajino Y, Inoue D, Ueoka K, Yamamuro Y, Tsuchiya H. Sci Rep. 10 1 11182 2020/06
  •  Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial. Sumiyoshi E, Matsuzaki K, Sugimoto N, Tanabe Y, Hara T, Katakura M, Miyamoto M, Mishima S, Shido O. Nutrients 11 11 E2800 2019/11/16
  •  Interleukin-33/ST2 signaling contributes to the severity of hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli. Yamada S, Shimizu M, Kuroda M, Inoue N, Sugimoto N, Yachie A Clin Exp Nephrol. 2018/11/22
  •  Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. Matsuzaki K, Sugimoto N, Katakura M, Sumiyoshi E, Hara T, Hashimoto M, Shido O. FEBS Open Bio 8 1 85-93 2017/12
  •  Neural progenitor cell proliferation in the hypothalamus is involved in acquired heat tolerance in long-term heat-acclimated rats. Matsuzaki K, Katakura M, Sugimoto N, Hara T, Hashimoto M, Shido O. PLoS One 12 6 e0178787 2017/06
  •  Serum ferritin as an indicator of the development of encephalopathy in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome. Shimizu M, Inoue N, Kuroda M, Irabu H, Takakura M, Kaneda H, Sugimoto N, Ohta K, Yachie A. Clin Exp Nephrol. 2017
  •  Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with Echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. Tome Y, Kimura H, Kiyuna T, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM. Oncotarget 7 29 46315-46320 2016/07
  •  Tumor necrosis factor-α modifies the effects of Shiga toxin on glial cells. Leu H, Sugimoto N, Shimizu M, Toma T, Wada T, Ohta K, Yachie A. Int Immunopharmacol. 38 139-143 2016/06
  •  Rapid molecular diagnosis of Parechovirus infection using the reverse transcription loop-mediated isothermal amplification technique. Yokoyama T, Tasaki Y, Inoue N, Sugimoto N, Nariai E, Kuramoto S, Wada T. PLoS One.  2021/11/29

Conference Presentations

  • Theobromine-containing diet enhances learning and memory in senessence-accelerated mouse-prone 8 (SAMP8) mice.(conference:Europhysiology2022)(2022/09/17)
  • Effect of CO2 on the Expression of cyclooxygenase in Vascular Smooth Muscle Cells(conference:Experimental Biology 2021)(2021/04/06)
  • Behavioural response to heat and heat acclimation from the point of view of thermal perception(conference:virtual 8th International Conference on the Physiology and Pharmacology of Temperature Regulation (vPPTR) 2020)(2020/10/27)
  • Effect of CO2 on the Expression of Heme Oxygenase‐1 in Vascular Smooth Muscle Cells(conference:Experimental Biology 2020)(2020/04/05)
  • Role of CO2 in the Expression of TRPV1 in Vascular Smooth Muscle Cells(conference:Experimental Biology 2020)(2020/04/05)

show all

  • Corticosterone reduces antitumour activity of endocannabinoids through the downregulation of cannabinoid receptor type 1 in glioblastoma cells(conference:Pharmacology 2019)(2019/12/15)
  • Ginger powder extracts prevent heat shock-induced cell death in mouse fibroblast cells(conference:Pharmacology2018)(2018/12/19)
  • A THEOBROMINE-CONTAINING DIET STIMULATES CENTRAL CREB/BDNF PATHWAYS AND MOTOR LEARNING IN YOUNG MICE(conference:The 14th Asian Pan-Pacific Society of Pediatric Gastroenterology, Hepatology and Nutrition Meeting)(2018/10/24)
  • Hypoxia downregulates cannabinoid receptors, upregulates COX-2, and attenuates cannabinoid receptor agonist-induced cell death in glioblastoma cells(conference:8th International Congress of Pathphysiology)(2018/09/08)
  • Heat facilitates TNF-α induced the phosphorylation of Heat Shock Factor-27 (HSP27) in vascular smooth muscle cells(conference:第12回国際川崎病シンポジウム)(2018/06/13)
  • Effect of Ginger Powder Extracts on Actin Assembly In Vitro(conference:Experimental Biology 2018 (EB2018))(2018/04/26)
  • Effect of ginger powder extracts on signal transduction in vitro(conference:Pharmacology 2017)(2017/12/11)
  • Lipopolysaccharide increases the expression level of the aquaporin-4 water channel.(conference:Experimental Biology 2017)(2017/04/26)
  • Theobromine crosses the blood brain barrier resulting in increased phosphorylation of vasodilator-stimulated phosphoprotein and cAMP-response element-binding protein in the mouse brain(conference:FFC’s 21st International Conference)(2017/03/26)
  • Theobromine crosses the blood brain barrier in vivo resulting in increased phosphorylation of vasodilator-stimulated phosphoprotein in the mouse brain (conference:Physiology 2016)(2016/07/29)
  • TNF-α augments STX-induced response in glial cells(conference:118th Japanese Pediatrics Sociaty)(2016/05/15)
  • Theobromine, the primary methylxanthine found in Theobroma cacao, can pass through the blood-brain barrier in mice(conference:Experimental Biology 2016)(2016/04/06)
  • Review of Long-term Care Insurance in Japan(conference:The 2015 Conference of Long-term Care and Social Care)(2015/10/16)
  • The effect of exposure to mild heat stress on culture cells(conference:Experimental Biology 2015)(2015/04/01)
  • Theobromine, the primary methylxanthine found in Theobroma cacao, inhibits malignant glioblastoma cell growth by negatively regulating Akt/mammalian target of rapamycin kinase(conference:Experimental Biology 2014)(2014/04/30)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「アスリート・パラアスリートを暑熱障害から守る -炭酸を用いた総合戦略-」(2021-2023) 
○「慢性腎不全による多臓器合併症の組織幹細胞への影響とω3系不飽和脂肪酸の予防効果」(2022-2024) 
○「レプチン(ob gene 産生蛋白質)による体温の上昇は調節されたものか」(1998-1998) 
○「関節リウマチ滑膜の上皮間葉移行の新規制御分子DIP2Cの解析と治療作用点の検討」(2019-2021) 
○「嗜好食品による抗老化作用と認知機能促進の分子基盤及び機能的形態学的機序の解明」(2017-2020) 
○「嗜好食品ががん化、老化、発達障害を予防する―メチルキサンチン誘導体を中心として―」(2013-2016) 
○「スポーツ活動中の消化管水チャネル分子の動態と水吸収効率を主眼とした熱中症予防戦略」(2016-) 
○「高齢者の水のホメオスターシス(恒常性維持)と高齢者骨格筋のニュー・コンセプト」(2015-2018) 
○「関節リウマチ滑膜の上皮間葉移行の分子機構の解析と新規治療法への応用」(2015-2017) 
○「レプチン(ob gene産生蛋白質)による体温の上昇は調節されたものか」(1999-1999) 
○「G蛋白質共役型スフィンゴシン1リン酸受容体の構造活性相関の解析」(2000-2000) 
○「G蛋白質共役型スフィンゴシン1リン酸受容体の構造活性相関の解析」(2001-2001) 
○「心筋炎治療へ向けたリン酸ジエステル加水分解酵素阻害薬抗炎症効果の基礎研究」(2016-2018) 
○「おとり遺伝子による癌の血管新生抑制を標的とした純国産型遺伝子治療法の開発」(2012-2015) 
○「光・温度環境が閉経後女性の心身の健康に与える影響とそのメカニズムの解明」(2016-2019) 
○「S1P合成・分解酵素トランスジェニックマウスを用いた癌転移・血管新生の研究」(2007-2009) 
○「リン酸ジエステル加水分解酵素(PDE)阻害剤は川崎病冠動脈瘤形成を抑制するか?」(2012-2014) 
○「S1P合成・分解酵素トランスジェニックマウスを用いた癌転移・血管新生の研究」(2008-2010) 
○「細胞遊走を負に制御する新規細胞内シグナリング機構の探索」(2004-2006) 
○「香辛料によるTRPチャネルを介した口腔乾燥改善への挑戦―アクアポリン誘導と機能―」(2012-2013) 
○「おとり遺伝子による多分子同時阻害を標的とした純国産型癌遺伝子治療法の開発」(2016-2019) 
○「細胞遊走を負に制御する新規細胞内シグナリング機構の探索」(2005-2007) 
○「生理活性脂質S1P受容体群Edgファミリーによる両方向性細胞運動制御の分子基盤」(2002-2003) 
○「生理活性脂質S1P受容体群Edgファミリーによる両方向性細胞運動制御の分子基盤」(2003-2004) 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Practice of Occupational Therapy for Developmental Disorders(2023)
○Practice of Occupational Therapy for Developmental Disorders(2023)
○Introduction to Infection Control(2023)
○Human Physiology Practice(2023)
○Introduction to Infection Control(2023)
○Human Physiology Practice(2023)
○Developmental Pathophysiology(2023)
○Nutritional Biochemistry and Pharmacology(2023)
○Laboratory Physiology(2023)
○Human Physiology(2023)
○Nutritional Biochemistry and Pharmacology(2023)
○Human Physiology(2023)
○Laboratory Physiology(2023)
○Human Development(2023)
○Teaching Methods of Health for Preschool Children(2023)
○Teaching Methods of Health for Preschool Children(2023)
○Introduction to Region-studies(2022)
○Teaching Methods of Health for Preschool Children(2022)
○Teaching Methods of Health for Preschool Children(2022)
○Human Physiology Practice(2022)
○Human Physiology Practice(2022)
○Nutritional Biochemistry and Pharmacology(2022)
○Human Physiology(2022)
○Nutritional Biochemistry and Pharmacology(2022)
○Developmental Pathophysiology(2022)
○Laboratory Physiology(2022)
○Human Physiology(2022)
○Human Development(2022)
○Laboratory Physiology(2022)

Classes (Graduate Schools)

○Advanced Analytics for Recovery of Function and Ability:Research(2023)
○Advanced Analytics for Physiological Function:Seminar(2023)
○Advanced Analytics for Recovery of Function and Ability:Research(2023)
○Advanced Analytics for Physiological Function:Seminar(2023)
○Advanced Analytics for Physiological Function:Lecture(2023)
○Advanced Analytics for Physiological Function:Lecture(2023)
○Advanced Analytics for Recovery of Function and Ability:Research(2023)
○Advanced Pediatrics(2023)
○Neonatal and Developmental Medicine(2023)
○Advanced Pediatrics(2023)
○Neonatal and Developmental Medicine(2023)
○Advanced Pediatrics(2023)
○Neonatal and Developmental Medicine(2023)
○Advanced Pediatrics(2023)
○Neonatal and Developmental Medicine(2023)
○Analytics for Recovery of Function and Ability:Research(2023)
○Analytics for Physiological Function:Seminar(2023)
○Analytics for Recovery of Function and Ability:Research(2023)
○Analytics for Physiological Function:Lecture(2023)
○Analytics for Recovery of Function and Ability:Research(2023)
○Laboratory Rotation Ⅱ(2023)
○Laboratory Rotation I(2023)
○Research Design in Occupational Therapy: Lecture(2023)
○Analytics for Recovery of Function and Ability:Research(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○First Aid and Health education /Physiology(2022)
○Advanced Analytics for Recovery of Function and Ability:Research(2022)
○Advanced Analytics for Physiological Function:Seminar(2022)
○Advanced Analytics for Recovery of Function and Ability:Research(2022)
○Advanced Analytics for Physiological Function:Seminar(2022)
○Advanced Analytics for Physiological Function:Lecture(2022)
○Advanced Analytics for Recovery of Function and Ability:Research(2022)
○Advanced Pediatrics(2022)
○Neonatal and Developmental Medicine(2022)
○Advanced Pediatrics(2022)
○Neonatal and Developmental Medicine(2022)
○Advanced Pediatrics(2022)
○Neonatal and Developmental Medicine(2022)
○Advanced Pediatrics(2022)
○Neonatal and Developmental Medicine(2022)
○Neonatal and Developmental Medicine(2022)
○Neonatal and Developmental Medicine(2022)
○Neonatal and Developmental Medicine(2022)
○Human Body: Functions(2022)
○Analytics for Recovery of Function and Ability:Research(2022)
○Analytics for Physiological Function:Seminar(2022)
○Analytics for Physiological Function:Seminar(2022)
○Analytics for Recovery of Function and Ability:Research(2022)
○Analytics for Physiological Function:Lecture(2022)
○Analytics for Recovery of Function and Ability:Research(2022)
○Analytics for Recovery of Function and Ability:Research(2022)
○Analytics for Physiological Function:Lecture(2022)
○Research Design in Occupational Therapy: Lecture(2022)

International Project

International Students

Lecture themes

Others (Social Activities)

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