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Researcher Information

last modified:2017/05/23

Professor HONDA, Masao

Mail

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences,Graduate School of Medical Science
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 1992

Career

Year & Month of Birth

1962/08

Academic Society






Award



Specialities

Liver Disease、Gastroenterology、Collagenous pathology/Allergology、Virology

Speciality Keywords

Liver Disease

Research Themes

Study on viral hepatitis

Molecular biology of hepatocellular carcinoma

Books

Papers

  •  Inhibition of Hepatitis C Virus Replication by Acyclic Retinoid Shimakami, Tetsuro;Honda, Masao;Shirasaki, Takayoshi;Lemon, Stanley;Kaneko, Shuichi HEPATOLOGY 56 0 713A-714A 2012
  •  The Evolution of Diverse Cancer Stem Cells in Human Liver Cancer Yamashita, Taro;Honda, Masao;Nakamoto, Yasunari;Nio, Kouki;Hara, Yasumasa;Zeng, Sha Sha;Hayashi, Takehiro;Yamashita, Tatsuya;Mizukoshi, Eishiro;Wang, Xin W.;Kaneko, Shuichi HEPATOLOGY 56 0 443A-443A 2012
  •  POSITIVE ANTI-GP210 ANTIBODIES IS A SIGNIFICANT RISK FACTOR FOR BILE DUCT LOSS, HEPATITIS AND POOR BIOCHEMICAL RESPONSE TO URSODEOXYCHOLIC ACID TREATMENT THAT LEAD TO MORE SEVERE PROGRESSION IN JAPANESE PATIENTS WITH PRIMARY BILIARY CIRRHOSIS Nakamura, Minoru;Ito, Masahiro;Kondo, Hisayoshi;Yamamoto, Kazuhide;Ohira, Hiromasa;Zeniya, Mikio;Tanaka, Atsushi;Hashimoto, Etsuko;Honda, Masao;Kaneko, Shuichi;Ueno, Yoshiyuki;Kikuchi, Kentaro;Shimoda, Shinji;Komori, Atsumasa;Harada, Kenichi;Sakisaka, Shotaro;Takikawa, Hajime;Onji, Morikazu;Onishi, Saburo;Tsubouchi, Hirohito;Nakanuma, Yasuni;Ishibashi, Hiromi HEPATOLOGY 54 0 1208A-1209A 2011
  •  Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection Yamashita, Taro;Honda, Masao;Kaneko, Shuichi JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 26 6 960-964 2011
  •  Comparative Analysis of Various Tumor-Associated Antigen-Specific T-Cell Responses in Patients with Hepatocellular Carcinoma Mizukoshi, Eishiro;Nakamoto, Yasunari;Arai, Kuniaki;Yamashita, Tatsuya;Sakai, Akito;Sakai, Yoshio;Kagaya, Takashi;Yamashita, Taro;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 53 4 1206-1216 2011

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  •  Therapeutic effect of adipose derived mesenchymal stem cell to murine NASH liver cirrhosis inactivating Kupffer/Macrophage and helper T cell Seki, Akihiro;Sakai, Yoshio;Komura, Takuya;Higashimoto, Mami;Fujinaga, Haruo;Honda, Masao;Wada, Takashi;Takamura, Toshinari;Ochiya, Takahiro;Kaneko, Shuichi HEPATOLOGY 56 0 1101A-1101A 2012
  •  MicroRNA expression profiling in serum and liver of patients with chronic hepatitis C Horii, Rika;Honda, Masao;Sakai, Akito;Nakamura, Mikiko;Kaneko, Shuichi HEPATOLOGY 56 0 692A-692A 2012
  •  Gene expression profile of primary hepatocytes and the differential innate antiviral response of IFN-alpha and IL28B Shirasaki, Takayoshi;Honda, Masao;Shimakami, Tetsuro;Okada, Hikari;Lemon, Stanley;Murakami, Seishi;Kaneko, Shuichi HEPATOLOGY 56 0 705A-705A 2012
  •  Impaired infiltration of immune regulatory cells into liver lobules of chronic hepatitis C patients with interferon-resistant IL28B genotype Honda, Masao;Sakai, Akito;Shirasaki, Takayoshi;Nakamura, Mikiko;Yamashita, Tatsuya;Arai, Kuniaki;Shimakami, Tetsuro;Sakai, Yoshio;Yamashita, Taro;Mizukoshi, Eishiro;Kaneko, Shuichi HEPATOLOGY 56 0 708A-708A 2012
  •  Involvement of chromatin remodeling enzyme CHD4 in chemoresistance of EpCAM plus hepatic cancer stem cells Nio, Kouki;Yamashita, Taro;Honda, Masao;Okada, Hikari;Kaneko, Shuichi HEPATOLOGY 56 0 278A-278A 2012
  •  Amplification of Jagged1 copy number in tumor DNA is associated with poor survival from hepatocellular carcinoma Kawaguchi, Kazunori;Honda, Masao;Yamashita, Taro;Takatori, Hajime;Ueda, Teruyuki;Mizuno, Hideki;Nishikawa, Masashi;Kaneko, Shuichi HEPATOLOGY 56 0 618A-618A 2012
  •  Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development Okada, Hikari;Honda, Masao;Campbell, Jean S.;Sakai, Yoshio;Yamashita, Taro;Shirasaki, Takayoshi;Tanaka, Takuji;Fausto, Nelson;Kaneko, Shuichi HEPATOLOGY 56 0 614A-614A 2012
  •  A phase I study of vaccination with human telomerase reverse transcriptase-derived peptide in patients with hepatocellular carcinoma Mizukoshi, Eishiro;Yamashita, Tatsuya;Arai, Kuniaki;Sunagozaka, Hajime;Yamashita, Taro;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 56 0 490A-490A 2012
  •  Acyclic retinoid and branched chain amino acids improve liver fibrosis and reduce tumorigenesis in mice fed an atherogenic high-fat diet Takegoshi, Kai;Honda, Masao;Okada, Hikari;Kondo, Mitsumasa;Yamashita, Taro;Matsuzawa, Naoto;Takamura, Toshinari;Tanaka, Takuji;Kaneko, Shuichi HEPATOLOGY 56 0 770A-770A 2012
  •  Efficacy and safety of hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma Yamashita, Tatsuya;Terashima, Takeshi;Arai, Kuniaki;Sunagozaka, Hajime;Yamashita, Taro;Mizukoshi, Eishiro;Sakai, Akito;Honda, Masao;Kaneko, Shuichi HEPATOLOGY 56 0 471A-471A 2012
  •  HCV INFECTIVITY VARIATION AND HVR1 QUASISPECIES SELECTION ARE ASSOCIATED WITH THE DISTRIBUTION OF HCV E1/E2 SYNONYMOUS MUTATIONS Kawaguchi, Kazunori;Honda, Masao;Shirasaki, Takayoshi;Emerson, Suzanne U.;Purcell, Robert H.;Kaneko, Shuichi HEPATOLOGY 54 0 1352A-1353A 2011
  •  IMPAIRED IFN SIGNALING IN CHRONIC HEPATITIS C WITH ADVANCED FIBROSIS STAGE TROUGH TGF-beta SIGNALING PATHWAY Tokumaru, Norihiro;Honda, Masao;Shirasaki, Takayoshi;Shimakami, Tetsuro;Kawaguchi, Kazunori;Kaneko, Shuichi HEPATOLOGY 54 0 1331A-1331A 2011
  •  Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors Kurosaki, Masayuki;Tanaka, Yasuhito;Nishida, Nao;Sakamoto, Naoya;Enomoto, Nobuyuki;Honda, Masao;Sugiyama, Masaya;Matsuura, Kentaro;Sugauchi, Fuminaka;Asahina, Yasuhiro;Nakagawa, Mina;Watanabe, Mamoru;Sakamoto, Minoru;Maekawa, Shinya;Sakai, Akito;Kaneko, Shuichi;Ito, Kiyoaki;Masaki, Naohiko;Tokunaga, Katsushi;Izumi, Namiki;Mizokami, Masashi JOURNAL OF HEPATOLOGY 54 3 439-448 2011
  •  Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. Yamashita T, Honda M, Takatori H, Nishino R, Minato H, Takamura H, Ohta T, Kaneko S. JOURNAL OF HEPATOLOGY 50 1 100-10 2009/01
  •  Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma. Ura S, Honda M, Yamashita T, Ueda T, Takatori H, Nishino R, Sunakozaka H, Sakai Y, Horimoto K, Kaneko S HEPATOLOGY 49 4 1098-112 2009/04
  •  Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Kitao A, Sato Y, Sawada-Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y AMERICAN JOURNAL OF PATHOLOGY 175 2 616-26 2009/08
  •  Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M NATURE GENETICS 41 10 1105-9 2009/10
  •  Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H, Honda M, Kaneko S, Usui S, Okajima M, Okada H, Sakai Y, Takamura T, Horimoto K, Takamura M. Circ Cardiovasc Genet. 3 1 68-77 2010/02
  •  CD14+monocytes are vulnerable and functionally impaired under ER stress in patients with type 2 diabetes. Komura T, Sakai Y, Honda M, Takamura T, Matsushima K, Kaneko S DIABETES 59 3 634-43 2010/03
  •  dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma. Takatori H, Yamashita T, Honda M, Nishino R, Arai K, Yamashita T, Takamura H, Ohta T, Zen Y, Kaneko S Liver Int. 30 3 438-46 2010/03
  •  Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma. Hodo Y, Hashimoto S, Honda M, Yamashita T, Suzuki Y, Sugano S, Kaneko S, Matsushima K GENOMICS 95 4 217-23 2010/04
  •  Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation. Yamashita T, Honda M, Nio K, Nakamoto Y, Yamashita T, Takamura H, Tani T, Zen Y, Kaneko S CANCER RESEARCH 70 11 4687-97 2010/06
  •  La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication. Shirasaki T, Honda M, Mizuno H, Shimakami T, Okada H, Sakai Y, Murakami S, Wakita T, Kaneko S JOURNAL OF INFECTIOUS DISEASES 202 1 75-85 2010/07
  •  Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, Tanaka Y, Tokunaga K, Mizokami M, Kaneko S; Hokuriku Liver Study Group GASTROENTEROLOGY 139 2 499-509 2010/08
  •  Differential gene expression profiling in blood from patients with digestive system cancers. Honda M, Sakai Y, Yamashita T, Yamashita T, Sakai A, Mizukoshi E, Nakamoto Y, Tatsumi I, Miyazaki Y, Tanno H, Kaneko S; Hokuriku Liver Study Group BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 400 1 7-15 2010/09
  •  ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C. Sakamoto N, Tanaka Y, Nakagawa M, Yatsuhashi H, Nishiguchi S, Enomoto N, Azuma S, Nishimura-Sakurai Y, Kakinuma S, Nishida N, Tokunaga K, Honda M, Ito K, Mizokami M, Watanabe M HEPATOLOGY RESEARCH 40 11 1063-1071 2010/11
  •  Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C. Honda M, Nakamura M, Tateno M, Sakai A, Shimakami T, Shirasaki T, Yamashita T, Arai K, Yamashita T, Sakai Y, Kaneko S JOURNAL OF HEPATOLOGY 53 5 817-26 2010/11
  •  A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S Cell Metab. 12 5 483-95 2010/11
  •  EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. amashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, Jia H, Ye Q, Qin LX, Wauthier E, Reid LM, Minato H, Kaneko S, Tang ZY, Wang XW. GASTROENTEROLOGY 136 3 1012-24 2009/03

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「ゲノム網羅的解析によるB型肝炎ウイルス感染の病態関連遺伝子の同定と新規診断法の開発」(2014-2016) 
○「C型肝炎の新たな治療関連因子及び治癒後の病態進展・改善に関連する宿主因子等の同定を目指したゲノムワイド研究」(2016-2018) 
○「C型肝炎における慢性肝炎から発がんに至る病態の解明と制御に関する研究」(2016-2018) 
○「肝炎ウイルス治療後の肝発癌機序とバイオマーカーの同定に関する研究」(2015-2017) 
○「IFNλ4 の機能的役割の解明及び新規診断法・治療法の開発」(2016-2018) 
○「内分泌器官としての肝臓病学の確立」(2014-2018) 
○「C型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立」(2012-2014) 
○「過栄養状態の肝臓が産生するタンパクと生活習慣病の関連」(2011-2013) 
○「肝炎ウイルス複製を支持する新規肝癌由来培養細胞の樹立」(2014-2015) 
○「C型肝炎の新規診断法や新規治療法を開発するためのゲノムワイド関連解析の手法を用いた宿主因子の解析に関する研究」(2013-2015) 
○「ウイルス性肝炎に対する応答性を規定する宿主因子も含めた情報のデータベース構築・治療応用に関する研究」(2010-2012) 
○「肝がんの新規治療法に関する研究」(2009-2011) 
○「肝炎ウイルスの培養系を用いた新規肝炎治療法の開発」(2007-2009) 
○「テーラーメイド治療を目指した肝炎ウイルスデータベース構築に関する研究」(2007-2009) 
○「末梢血単核球の発現プロファイルと肝病態」(2007-2008) 
○「C型慢性肝炎インターフェロン療法の応答・不応答に関わる宿主遺伝子の探索」(2009-2011) 
○「C型肝炎ウイルスの蛋白翻訳開始機構に関する検討」(1998-1999) 
○「インターフェロンによるC型肝炎ウイルス蛋白翻訳抑制機構の解明」(2000-2001) 
○「包括的1細胞遺伝子発現解析を用いたB型肝炎ウイルス感染機構の解明」(2016-) 

Classes (Bachelors)

○Pathogenic Microbiology 2(2017)
○Lecture and Practice of Virology(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Experimental Course of Clinical Physiology(2017)
○Introduction of Clinical Medicine(2017)
○Introduction of Clinical Medicine(2017)
○Introduction to Practical Medicine(2017)
○Laboratory of Serology and Immunology(2017)
○Microbiology Genetics(2017)
○Introduction to Practical Medicine(2017)
○Introduction to Region-studies(2016)
○Presentation and Debate (Freshman Seminar II)(2016)
○Pathogenic Microbiology 2(2016)
○Microbiology Genetics(2016)
○Introduction of Clinical Medicine(2016)
○Lecture and Practice of Virology(2016)
○Laboratory of Serology and Immunology(2016)
○Introduction of Clinical Medicine(2016)
○Freshman Seminar I(2016)

Classes (Graduate Schools)

○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Fostering the independence of researchers(2017)
○Advanced Laboratory Oncology: Research(2017)
○Laboratory Oncology: Seminar(2017)
○Laboratory Oncology: Lecture(2017)
○Introduction to Medicine(2017)
○Laboratory Oncology: Research(2017)
○Molecular Biology of Tumor: Seminar(2017)
○omics(2017)
○Molecular Biology of Tumor: Lecture(2017)
○Laboratory Oncology: Seminar(2016)
○Laboratory Oncology: Research(2016)
○Molecular Biology of Tumor: Seminar(2016)
○Molecular Biology of Tumor: Lecture(2016)
○An Introduction to Medical Laboratory Sciences:Lec(2016)
○Research Design in Health Science: Lecture(2016)
○Introduction to Medicine(2016)
○Advanced Laboratory Oncology: Research(2016)
○Laboratory Oncology: Lecture(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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