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Researcher Information

last modified：2024/11/21

Professor　FUJINAGA, Yukako

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

Academic Background

Career

Year & Month of Birth

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Award

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Speciality Keywords

Research Themes

Books

Papers

  • 　Growth prolongation of human induced pluripotent stem cell aggregate in three-dimensional suspension culture system by addition of botulinum hemagglutinin　Riku Yamamoto,Ryo Sakakibara,Mee-Hae Kim,Yukako Fujinaga,Masahiro Kino-oka　Journal of Bioscience and Bioengineering　137　2　141　2023/12
  • 　Adult-onset botulism in a Japanese woman with prolonged spore excretion　Keigo Kihara,Yuta Kajiyama,Yasuyoshi Kimura,Shuhei Okazaki,Naoya Esa,Ryosuke Nobe,Kentaro Shimizu,Kiyoshi Ohno,Daisuke Motooka,Takuhiro Matsumura,Takeshi Shimazu,Shota Nakamura,Yukako Fujinaga,Hideki Mochizuki　Journal of Infection and Chemotherapy　29　12　1172　2023/12
  • 　Botulinum neurotoxin X lacks potency in mice and in human neurons　Brieana M. Gregg,Takuhiro Matsumura,Travis G. Wentz,William H. Tepp,Marite Bradshaw,Pål Stenmark,Eric A. Johnson,Yukako Fujinaga,Sabine Pellett　mBio　2024/02/13　
  • 　Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro.　Kobayashi N, Abe K, Akagi S, Kitamura M, Shiraishi Y, Yamaguchi A, Yutani M, Amatsu S, Matsumura T, Nomura N, Ozaki N, Obana N, Fujinaga Y.　Front Microbiol. 　13　720308　2022/02/03
  • 　Oral Corticosteroids Impair Mucin Production and Alter the Posttransplantation Microbiota in the Gut.　Okafuji H, Iida N, Kitamura K, Seishima J, Wang Z, Yutani M, Yoshio T, Yamashita T, Sakai Y, Honda M, Yamashita T, Fujinaga Y, Shinkura R, Hamaguchi Y, Mizukoshi E, Kaneko S.　Digestion　1-18　2022/02/18

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  • 　Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin.　Amatsu S, Matsumura T, Zuka M, Fujinaga Y.　.J Biol Chem.　299　3　102944　2023/01/25
  • 　Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis.　Iida N, Mizukoshi E, Yamashita T, Yutani M, Seishima J, Wang Z, Arai K, Okada H, Yamashita T, Sakai Y, Masuo Y, Agustina R, Kato Y, Fujinaga Y, Oshima M, Honda M, Lebreton F, Gilmore MS, Kaneko S　Nat.Cancer　2　10　1039-1054　2021/09/27
  • 　Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene. 　Takemori-Sakai Y, Satou K, Senda Y, Nakamura Y, Otani H, Maekawa A, Oe H, Oshima M, Yoneda-Nakagawa S, Miyagawa T, Sato K, Ogura H, Mori M, Wada T, Sakai Y, Yutani M, Matsumura T, Fujinaga Y, Gabata T, Wada T, Iwata Y.　J Infect Chemother.　28　5　651-656　2022/01/22
  • 　Effects of antibiotics on the viability of and toxin production by Clostridium botulinum.　Yutani M, Matsumura T, Fujinaga Y.　Microbiol Immunol.　65　10　432-437　2021/09/08
  • 　 Functional Analysis of Botulinum Hemagglutinin (HA).　Matsumura T, Fujinaga Y*.　 Methods Mol. Biol.　2132　191-200　2020
  • 　Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine.　Amatsu S, Fujinaga Y*　2132　183-190　2020
  • 　Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B　Matsumura T, Amatsu S, Misaki R, Yutani M, Du A, Kohda T, Fujiyama K, Ikuta K, Fujinaga Y*　Toxins　12　E302　2020
  • 　Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host. 　Seishima J, Iida N, Kitamura K, Yutani M, Wang Z, Seki A, Yamashita T, Sakai Y, Honda M, Yamashita T, Kagaya T, Shirota Y, Fujinaga Y, Mizukoshi E, Kaneko S.　Genome Biol.　20　1　252　2019/11/25
  • 　Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus.　Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, Yutani M, Fujinaga Y, Hase A, Morita H, Ohta T, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Kaneko S, Wada T. 　Int J Infect Dis 　91　22　2020/02/01
  • 　Maintenance of an undifferentiated state of human-induced pluripotent stem cells through botulinum hemagglutinin-mediated regulation of cell behavior. 　Shuzui E, Kim MH, Azuma K, Fujinaga Y, Kino-Oka M.　J Biosci Bioeng　127　6　744　2019/06/01
  • 　A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin.　Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M.　Biotechnol J.　13　2　2018/02/01
  • 　Translocation and dissemination of botulinum neurotoxin from the intestinal tract.　Fujinaga Y, Popoff MR.　Toxicon　S0041-1010　17　30324-0　2017/10/01
  • 　Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption.　Amatsu S, Matsumura T, Yutani M, Fujinaga Y.　Microbiol Immunol. 　62　2　80-89　2018/02/01
  • 　 Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies.　Kim MH, Sugawara Y, Fujinaga Y, Kino-oka M　Scientific Reports　7　93　2017/03/01

Conference Presentations

  • Endogenous production and neurotoxicity of novel botulinum neurotoxin (BoNT/X) in a clinical isolate(2023/03/16)
  • Development of genetic manipulation methods for group I Clostridium botulinum. (conference：Interagency Botulinum Research Coordinating Committee)(2022/10/17)
  • New insights into the pathobiology of Clostridium botulinum enteric infection (conference：The 15th Korea-Japan International Symposium on Microbiology)(2022/10/13)
  • New insights into the pathobiology of Clostridium botulinum enteric infection(conference：The 20th Awaji International Forum on Infection and Immunity)(2022/09/07)
  • Mechanisms of intestinal absorption of botulinum neurotoxin complex.(conference：Toxins 2017)(2017/01/19)

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  • Intestinal absorption mechanism of type B1 botulinum progenitor toxin produced by strain Okra.(conference：54th Interagency Botulism Research Coordinating Committee(IBRCC))(2017/10/22)
  • E-cadherin機能阻害活性を維持した最小化ボツリヌス菌ヘマグルチニン由来物質の開発(conference：第６５回トキシンシンポジウム)(2018/07/11)
  • Therapeutic and preventive effect of fully human monoclonal antibodies against type B botulinum intoxication.(conference：55th Interagency Botulism Research Coordinating Committee(IBRCC))(2018/10/24)
  • Human-Derived monoclonal antibodies effectively neutralize botulinum neurotoxin.(conference：TOXINS 2019)(2019/01/16)
  • Mechanism of pathogenesis of botulinum neurotoxin complex and its application. (conference：CLOSTPATH 11)(2019/08/19)
  • Molecular engineering of Nano-HA, a minimal protein that inhibits E-cadherin-mediated cell-cell adhesion derived from Clostridium botulinum hemagglutinin.(conference：56th IBRCC 2019)(2019/10/27)
  • New insights on the pathophysiology of intestinal Clostridium botulinum infection : Learning from intestinal botulism. (conference：World Microbe Forum 2021)(2021/06/14)
  • Clostridium botulinum enteric infections: Novel insights into the interplay between C. botulinum and gut microbiota (2022/02/04)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Medical Bacteriology(2019)
○Medical Bacteriology(2018)
○Medical Bacteriology(2017)
○Medical Bacteriology(2016)

Classes (Graduate Schools)

○Basic Training on Medical Researches(2019)
○Intensive Lectures on Medical Researches(2019)
○Bacterial Infections(2019)
○Medical Sciences(2019)
○Bacterial Infections(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○Bacterial Infections(2018)
○Bacterial Infections(2018)
○Bacterial Infections(2018)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Introduction to Basic Medical Science(2016)
○Bacterial Infections(2016)
○Bacterial Infections(2016)
○Bacterial Infections(2016)

International Project

International Students

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