last modified：2026/07/26
Associate Professor NAGAO, Chioko
Faculty, Affiliation
Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
Academic Background
Career
The University of Osaka Institute for Protein Research(2020/04-2026/03)
National Institutes of Biomedical Innovation, Health and Nutrition(2018/04-2020/03)
National Institutes of Biomedical Innovation, Health and Nutrition(2017/04-2018/03)
(2008/01-2017/03)
(2007/04-2007/12)
Year & Month of Birth
Academic Society
Award
Specialities
Life/Health/Medical informatics
Speciality Keywords
function,Protein
Research Themes
Books
Papers
- Protein Data Bank Japan: Computational Resources for Analysis of Protein Structures. Gert-Jan Bekker,Chioko Nagao,Matsuyuki Shirota,Tsukasa Nakamura,Toshiaki Katayama,Daisuke Kihara,Kengo Kinoshita,Genji Kurisu Journal of molecular biology 169013 2025/02/15
- Development of an RNA aptamer as a therapeutic agent for synucleinopathies. Kazuma Murakami,Thi Hong Van Nguyen,Leo Tsuda,Esha Chawla,Yangxia Wang,Yiran Chen,Nadia Stefanova,Chioko Nagao,Kenji Mizuguchi,Shouvik Manna,Samir K Maji,Hidehito Tochio,Gal Bitan Nature communications 2026/07/15
- Protein Data Bank Japan: A unified portal for integrating structural and chemical data to explore protein-ligand interactions in PDB and PubChem. Gert-Jan Bekker,Chioko Nagao,Satomi Niwa,Genji Kurisu Protein science : a publication of the Protein Society 35 8 e70702 2026/08
- Subset binding enables detection of multimodal patient subgroup patterns and drug target discovery in idiopathic pulmonary fibrosis Yayoi Natsume-Kitatani,Mari N Itoh,Yoshito Takeda,Masataka Kuroda,Haruhiko Hirata,Kotaro Miyake,Takayuki Shiroyama,Yuya Shirai,Yoshimi Noda,Yuichi Adachi,Takatoshi Enomoto,Saori Amiya,Jun Adachi,Ryohei Narumi,Satoshi Muraoka,Takeshi Tomonaga,Sadao Kurohashi,Fei Cheng,Ribeka Tanaka,Shuntaro Yada,Eiji Aramaki,Shoko Wakamiya,Yi-An Chen,Akiko Fukagawa,Chihiro Higuchi,Yosui Nojima,Takeshi Fujiwara,Chioko Nagao,Toshihiro Takeda,Yasushi Matsumura,Kenji Mizuguchi,Atsushi Kumanogoh,Naonori Ueda Briefings in Bioinformatics 27 2 2026/03/01
- Lysine-Targeting Inhibitors of Amyloidogenic Protein Aggregation: A Promise for Neurodegenerative Proteinopathies Kazuma Murakami,Thi Hong Van Nguyen,Chioko Nagao,Kenji Mizuguchi,Gal Bitan JACS Au 2025/08/11
- An adjuvant database for preclinical evaluation of vaccines and immunotherapeutics Yayoi Natsume-Kitatani,Kouji Kobiyama,Yoshinobu Igarashi,Taiki Aoshi,Noriyuki Nakatsu,Lokesh P. Tripathi,Junichi Ito,Johan Nyström-Persson,Yuji Kosugi,Rodolfo S. Allendes Osorio,Chioko Nagao,Burcu Temizoz,Etsushi Kuroda,Daron M. Standley,Hiroshi Kiyono,Kenji Nakanishi,Satoshi Uematsu,Isao Hamaguchi,Yasuhiro Yasutomi,Jun Kunisawa,Sho Yamasaki,Cevayir Coban,Hiroshi Yamada,Kenji Mizuguchi,Ken J. Ishii Cell Chemical Biology 2025/08
- Phosphoproteomic subtyping of gastric cancer reveals dynamic transformation with chemotherapy and guides targeted cancer treatment Hirokazu Shoji,Hidekazu Hirano,Yosui Nojima,Daigo Gunji,Akina Shinkura,Satoshi Muraoka,Yuichi Abe,Ryohei Narumi,Chioko Nagao,Masahiko Aoki,Kazutaka Obama,Kazufumi Honda,Kenji Mizuguchi,Takeshi Tomonaga,Yutaka Saito,Takaki Yoshikawa,Ken Kato,Narikazu Boku,Jun Adachi Cell Reports 114774 2024/10
- Familial Episodic Pain Syndrome: A Japanese Family Harboring the Novel Variant c.2431C>T (p.Leu811Phe) in SCN11A. Chioko Nagao,Hiroko Okuda,Gert-Jan Bekker,Atsuko Noguchi,Tsutomu Takahashi,Akio Koizumi,Shohab Youssefian,Tohru Tezuka,Shinji Akioka Biochemical genetics 2024/07/25
- Protein Data Bank Japan: Improved tools for sequence-oriented analysis of protein structures. Gert-Jan Bekker,Chioko Nagao,Matsuyuki Shirota,Tsukasa Nakamura,Toshiaki Katayama,Daisuke Kihara,Kengo Kinoshita,Genji Kurisu Protein science : a publication of the Protein Society 34 3 e70052 2025/03
- Developing a Kinase-Specific Target Selection Method Using a Structure-Based Machine Learning Approach. Arina Afanasyeva,Chioko Nagao,Kenji Mizuguchi Advances and applications in bioinformatics and chemistry : AABC 13 27 2020/12
- Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein. Makoto Tokunaga,Yoichi Miyamoto,Tatsuya Suzuki,Mayumi Otani,Shinsuke Inuki,Tsuyoshi Esaki,Chioko Nagao,Kenji Mizuguchi,Hiroaki Ohno,Yoshihiro Yoneda,Toru Okamoto,Masahiro Oka,Yoshiharu Matsuura Virology 541 41 2020/02
- Predicting Fraction Unbound in Human Plasma from Chemical Structure: Improved Accuracy in the Low Value Ranges. Watanabe R,Esaki T,Kawashima H,Natsume-Kitatani Y,Nagao C,Ohashi R,Mizuguchi K Molecular pharmaceutics 15 11 5302 2018/11
- Prediction of the secondary structure of short DNA aptamers. Arina Afanasyeva,Chioko Nagao,Kenji Mizuguchi Biophysics and physicobiology 16 287 2019
- High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives. Yuka Kataoka,Hiroto Fujita,Arina Afanaseva,Chioko Nagao,Kenji Mizuguchi,Yuuya Kasahara,Satoshi Obika,Masayasu Kuwahara Biochemistry 58 6 493 2019/02/12
- A prospective compound screening contest identified broader inhibitors for Sirtuin 1. Shuntaro Chiba,Masahito Ohue,Anastasiia Gryniukova,Petro Borysko,Sergey Zozulya,Nobuaki Yasuo,Ryunosuke Yoshino,Kazuyoshi Ikeda,Woong-Hee Shin,Daisuke Kihara,Mitsuo Iwadate,Hideaki Umeyama,Takaaki Ichikawa,Reiji Teramoto,Kun-Yi Hsin,Vipul Gupta,Hiroaki Kitano,Mika Sakamoto,Akiko Higuchi,Nobuaki Miura,Kei Yura,Masahiro Mochizuki,Chandrasekaran Ramakrishnan,A Mary Thangakani,D Velmurugan,M Michael Gromiha,Itsuo Nakane,Nanako Uchida,Hayase Hakariya,Modong Tan,Hironori K Nakamura,Shogo D Suzuki,Tomoki Ito,Masahiro Kawatani,Kentaroh Kudoh,Sakurako Takashina,Kazuki Z Yamamoto,Yoshitaka Moriwaki,Keita Oda,Daisuke Kobayashi,Tatsuya Okuno,Shintaro Minami,George Chikenji,Philip Prathipati,Chioko Nagao,Attayeb Mohsen,Mari Ito,Kenji Mizuguchi,Teruki Honma,Takashi Ishida,Takatsugu Hirokawa,Yutaka Akiyama,Masakazu Sekijima Scientific reports 9 1 19585 2019/12/20
- RDFization of Interview Forms for effective use of pharmaceutical documents Chioko Nagao,Mayumi Kamada,Masahiko Nakatsui,Akiko Fukagawa,Toshiaki Katayama,Shuichi Kawashima,Kenji Mizuguchi,Rika Abe Japanese Journal of Drug Informatics 24 4 187 2023/02
- Development of an in silico prediction system of human renal excretion and clearance from chemical structure information incorporating fraction unbound in plasma as a descriptor. Reiko Watanabe,Rikiya Ohashi,Tsuyoshi Esaki,Hitoshi Kawashima,Yayoi Natsume-Kitatani,Chioko Nagao,Kenji Mizuguchi Scientific reports 9 1 18782 2019/12/11
- Data Curation can Improve the Prediction Accuracy of Metabolic Intrinsic Clearance. Esaki T,Watanabe R,Kawashima H,Ohashi R,Natsume-Kitatani Y,Nagao C,Mizuguchi K Molecular informatics 38 1-2 e1800086 2018/09
- Computational Model To Predict the Fraction of Unbound Drug in the Brain. Tsuyoshi Esaki,Rikiya Ohashi,Reiko Watanabe,Yayoi Natsume-Kitatani,Hitoshi Kawashima,Chioko Nagao,Kenji Mizuguchi Journal of chemical information and modeling 59 7 3251 2019/07/22
- Constructing an In Silico Three-Class Predictor of Human Intestinal Absorption With Caco-2 Permeability and Dried-DMSO Solubility. Tsuyoshi Esaki,Rikiya Ohashi,Reiko Watanabe,Yayoi Natsume-Kitatani,Hitoshi Kawashima,Chioko Nagao,Hiroshi Komura,Kenji Mizuguchi Journal of pharmaceutical sciences 108 11 3630 2019/11
- Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients Yayoi Natsume-Kitatani,Mari N Itoh,Yoshito Takeda,Masataka Kuroda,Haruhiko Hirata,Kohtaro Miyake,Takayuki Shiroyama,Yuya Shirai,Yoshimi Noda,Yuichi Adachi,Takatoshi Enomoto,Saori Amiya,Jun Adachi,Ryohei Narumi,Satoshi Muraoka,Takeshi Tomonaga,Sadao Kurohashi,Fei Cheng,Ribeka Tanaka,Shuntaro Yada,Eiji Aramaki,Shoko Wakamiya,Yi-An Chen,Chihiro Higuchi,Yosui Nojima,Takeshi Fujiwara,Chioko Nagao,Yasushi Matsumura,Kenji Mizuguchi,Atsushi Kumanogoh,Naonori Ueda 2022/03/29
- DruMAP: A Novel Drug Metabolism and Pharmacokinetics Analysis Platform Hitoshi Kawashima,Reiko Watanabe,Tsuyoshi Esaki,Masataka Kuroda,Chioko Nagao,Yayoi Natsume-Kitatani,Rikiya Ohashi,Hiroshi Komura,Kenji Mizuguchi Journal of Medicinal Chemistry 2023/07/14
- Attention network for predicting T-cell receptor–peptide binding can associate attention with interpretable protein structural properties Kyohei Koyama,Kosuke Hashimoto,Chioko Nagao,Kenji Mizuguchi Frontiers in Bioinformatics 3 2023/12/18
- Impact of Hydrogen Bonding on P-Glycoprotein Efflux Transport as Revealed by Evaluation of a De Novo Prediction Model Yulong Gou,Suyong Re,Kenji Mizuguchi,Chioko Nagao ACS Medicinal Chemistry Letters 2023/12/21
- Construction of a Tm-Value Prediction Model and Molecular Dynamics Study of AmNA-Containing Gapmer Antisense Oligonucleotide Masataka Kuroda,Yuuya Kasahara,Masako Hirose,Harumi Yamaguma,Masayuki Oda,Chioko Nagao,Kenji Mizuguchi Molecular Therapy - Nucleic Acids 102272 2024/07
- Improved pose and affinity predictions using different protocols tailored on the basis of data availability Philip Prathipati,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 30 9 817 2016/09
- Detecting subtle functional differences in ketopantoate reductase and related enzymes using a rule-based approach with sequence-structure homology recognition scores Sukanta Mondal,Chioko Nagao,Kenji Mizuguchi PROTEIN ENGINEERING DESIGN & SELECTION 23 11 859 2010/11
- Sagace: A web-based search engine for biomedical databases in Japan Mizuki Morita,Yoshinobu Igarashi,Maori Ito,Yi-An Chen,Chioko Nagao,Yuki Sakaguchi,Ryuichi Sakate,Tohru Masui,Kenji Mizuguchi BMC Research Notes 5 604 2012
- Computational design, construction, and characterization of a set of specificity determining residues in protein-protein interactions Chioko Nagao,Nozomi Izako,Shinji Soga,Samia Haseeb Khan,Shigeki Kawabata,Hiroki Shirai,Kenji Mizuguchi PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 80 10 2426 2012/10
- Expression, purification, crystallization and preliminary crystallographic study of FtsA from methicillin-resistant Staphylococcus aureus Junso Fujita,Yuma Miyazaki,Mika Hirose,Chioko Nagao,Eiichi Mizohata,Yoshimi Matsumoto,Kenji Mizuguchi,Tsuyoshi Inoue,Hiroyoshi Matsumura ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 69 Pt 8 895 2013/08
- Prediction of Detailed Enzyme Functions and Identification of Specificity Determining Residues by Random Forests Chioko Nagao,Nozomi Nagano,Kenji Mizuguchi PLOS ONE 9 1 e84623 2014/01
- Crystal structure of FtsA from Staphylococcus aureus Junso Fujita,Yoko Maeda,Chioko Nagao,Yuko Tsuchiya,Yuma Miyazaki,Mika Hirose,Eiichi Mizohata,Yoshimi Matsumoto,Tsuyoshi Inoue,Kenji Mizuguchi,Hiroyoshi Matsumura FEBS LETTERS 588 10 1879 2014/05
- Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein Hiroshi Yamada,Chioko Nagao,Ahmad M. Haredy,Yasuko Mori,Kenji Mizuguchi,Koichi Yamanishi,Shigefumi Okamoto ANTIVIRAL RESEARCH 111 69 2014/11
- Development of a pharmacokinetics prediction system using multiscale integrated modeling: 2. Classification of aqueous solubility measured using the dried-DMSO method Tsuyoshi Esaki,Reiko Watanabe,Hitoshi Kawashima,Yayoi Natsume-Kitatani,Chioko Nagao,Rikiya Ohashi,Kenji Mizuguchi Chem-Bio Informatics Society Annual Meeting 2017/10
- Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using phage display Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa CYTOKINE 48 1-2 111 2009/10
- Bioinformatics Approaches for Analysis of Protein-Ligand Interactions Munazah Andrabi,Chioko Nagao,Kenji Mizuguchi,Shandar Ahmad Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery 267 2009/12/01
- Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system Yasuo Yoshioka,Hikaru Watanabe,Tomohiro Morishige,Xinglei Yao,Shinji Ikemizu,Chioko Nagao,Shandar Ahmad,Kenji Mizuguchi,Shin-ichi Tsunoda,Yasuo Tsutsumi,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa BIOMATERIALS 31 7 1935 2010/03
- Relationships between functional subclasses and information contained in active-site and ligand-binding residues in diverse superfamilies Chioko Nagao,Nozomi Nagano,Kenji Mizuguchi PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 78 10 2369 2010/08
- Observation of the ''isomerization states'' of HCP by stimulated emission pumping spectroscopy: Comparison between theory and experiment H Ishikawa,C Nagao,N Mikami,RW Field JOURNAL OF CHEMICAL PHYSICS 106 7 2980 1997/02
- Correlation between evolutionary structural development and protein folding C Nagao,TP Terada,T Yomo,M Sasai PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102 52 18950 2005/12
- Observation of the highly excited vibrational levels of HCP: Application of IR-UV-SEP triple resonance spectroscopy H Ishikawa,C Nagao,N Mikami CHEMISTRY LETTERS 9 941 1999/09
- Observation of the nu(CH) excited vibrational levels in the (A)over-tilde(1)A '' state of HCP by IR-UV double resonance spectroscopy H Ishikawa,C Nagao,N Mikami JOURNAL OF MOLECULAR SPECTROSCOPY 194 1 52 1999/03
- Spectroscopic investigation af the generation of "isomerization" states: Eigenvector analysis of the bend-CP stretch polyad H Ishikawa,C Nagao,N Mikami,RW Field JOURNAL OF CHEMICAL PHYSICS 109 2 492 1998/07
Conference Presentations
Others
- トクシュウ AI × ビッグデータ ガ ジツゲン スル ソウヤク DX 296 1 8 2026/01/03
- 間質性肺炎 診断と予後 新薬創出を加速する人工知能の開発 特発性肺線維症への取り組み 伊藤 眞里,武田 吉人,木田 博,木庭 太郎,野島 陽水,藤原 大,長尾 知生子,夏目 やよい,武田 理宏,松村 泰志,熊ノ郷 淳,水口 賢司 日本呼吸器学会誌 8 増刊 167 2019/03
- 「新薬創出を加速する人工知能の開発」特発性肺線維症への取り組み 伊藤眞里,武田吉人,木田博,木庭太郎,野島陽水,藤原大,長尾知生子,夏目やよい,武田理宏,松村泰志,熊ノ郷淳,水口賢司 日本呼吸器学会誌(Web) 8 167 2019/03/10
- プレシジョンメディシンと創薬 5 創薬における計算機の果たす役割―プレシジョンメディシンに向けて― 長尾知生子,夏目やよい,水口賢司 月刊Precision Medicine 1 1 28‐31 2018/10/25
- 人工知能(AI)がもたらす創薬イノベーション 7.データベース・計算環境~知識データベース・AI基盤 長尾知生子,種石慶 医薬ジャーナル 54 9 2063‐2067 2018/09/01
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「タンパク質の深層学習を用いた改変ポリメラーゼデザイン法の開発 」(2025-2027)
○「神経変性疾患における超硫黄化アミロイドの役割に関する国際共同研究」(2024-2028)
○「人工核酸アプタマーの新規デザイン法の開発
」(2021-2024)