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Researcher Information

last modified：2024/11/21

Associate Professor　SHIRASAKA Yoshiyuki

Mail Laboratory Website

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

Membrane Transpot and Pharmcokinetics　TEL:076-234-4422　FAX:076-264-6284

Academic Background

【Academic background(Doctoral/Master's Degree)】
Setsunan University　Doctor　Graduate School, Division of Pharmaceutical Sciences　200703　Completed
【Academic background(Bachelor's Degree)】
Setsunan University　200203
【Degree】
Ph.D.

Career

Kanazawa University　Faculty of Pharmacy　Associate Professor(2020/04-)
Tokyo University of Pharmacy and Life Sciences　School of Pharmacy(2017/04-2020/03)
Tokyo University of Pharmacy and Life Sciences　School of Pharmacy(2015/01-2017/03)
The Uehara Memorial Foundation　Research fellow(2014/01-2014/12)
University of Washington　School of Pharmacy　Visiting Scholar/Scientist(2012/01-2014/12)
JSPS　Postdoctoral Fellow for Research Abroad(2012/01-2014/01)
Kanazawa University　Faculty of Pharmacy　Assistant Professor(2008/04-2012/01)
Tokyo University of Science　Faculty of Pharmaceutical Sciences　Assistant Professor(2007/04-2008/03)

Year & Month of Birth

1978/12

Academic Society

The Academy of Pharmaceutical Science and Technology, Japan
The Japanese Society for the Study of Xenobiotics
The Japanese Gastroenterological Association
Japanese Society of Gout and Uric & Nucleic Acids
The American Society for Pharmacology and Experimental Therapeutics
Japanese Society of Pharmaceutical Health Care and Sciences
The Japanese Society of Digestion and Absorption
The Japanese Society of Toxicology
The Pharmaceutical Society of Japan
The Japanese Society of Clinical Pharmacology and Therapeutics
Forum for Pharmaceutical Technology Innovation
Japan Transporter Research Association
The International Society for the Study of Xenobiotics
The American Association of Pharmaceutical Scientists

Award

○APSTJ Focus Group Presentation Award(2008)
○10th International ISSX Poster Award, Finalist(2013)
○JSSX Best Presentation Award 2009, 1st Place(2009)
○JSSX Best Presentation Award 2009, Finalist(2010)
○DMPK Award for the Most Frequently Downloaded Article in 2006, 3rd Place(2008)
○JTRA Kanto Best Presentation Award 2018(2018)
○PSJ Hokuriku Best Presentation Award 2010(2010)
○APSTJ Global Education Seminar Presentation Award 2009(2009)
○PSJ Kanto Best Presentation Award 2018(2018)
○24th APSTJ Best Presentation Award(2009)
○3rd Asia/Pacific ISSX Best Presentation Award, 2nd Place(2009)
○JSSX Best Presentation Award 2021(2021)
○34th APSTJ Best Presentation Award(2019)
○YCPS 2021 Best Presentation Award(2021)
○PSJKB Award for Young Pharmaceutical Scientist 2018(2018)
○APSTJ Award for Young Pharmaceutical Scientist 2017(2017)
○4th Asia/Pacific ISSX Best Presentation Award, 1st Place(2011)
○JSPHCS 3rd Fresher's Conference Best Presentation Award(2019)
○Postdoctoral Presentation Award 2009(2009)
○YCPS 2019 Best Presentation Award(2019)
○JSSX Award for Young Scientists 2015(2015)
○JTRA Kanto Presentation Award 2019(2019)
○The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics, Best Poster Award(2019)
○JTRA Kanto Presentation Award 2008(2018)
○APSTJ Global Education Seminar Presentation Award 2013(2013)

Specialities

Pharmacokinetics

Speciality Keywords

Pharmacokinetics,Biopharmaceutics,Drug Absorption,Drug Interaction,Gastrointestinal Toxicity,Drug Transport,Drug Metabolism,Bioavailability

Research Themes

Kinetic Analysis on Counteracting Interplay of Influx and Efflux transporters on Intestinal Drud Absorption

Books

Papers

  • 　Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening　Moeno Kadoguchi,Hiroshi Arakawa,Ryokichi Honda,Kazuki Hotta,Yoshiyuki Shirasaka,Yoshiharu Deguchi,Ikumi Tamai　Pharmaceutical Research　2022/03
  • 　Effect of ingested fluid volume and solution osmolality on intestinal drug absorption: Impact on drug interaction with beverages　Yuta Funai,Miyuki Takemura,Katsuhisa Inoue,Yoshiyuki Shirasaka　European Journal of Pharmaceutical Sciences　172　106136　2022/05
  • 　Evaluation of Platinum Anticancer Drug-Induced Kidney Injury in Primary Culture of Rat Kidney Tissue Slices by Using Gas-Permeable Plates　Hiroshi Arakawa,Yurika Nagao,Shiho Nedachi,Yoshiyuki Shirasaka,Ikumi Tamai　Biological and Pharmaceutical Bulletin　45　3　316　2022/03　
  • 　Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics　Yoshiyuki Shirasaka,Maria Seki,Marie Hatakeyama,Yuko Kurokawa,Hiroki Uchiyama,Miyuki Takemura,Yugo Yasugi,Hisanao Kishimoto,Ikumi Tamai,Joanne Wang,Katsuhisa Inoue　Journal of Pharmaceutical Sciences　111　5　1531　2022/01
  • 　Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation　Miyuki Takemura,Yuki Tanaka,Katsuhisa Inoue,Ikumi Tamai,Yoshiyuki Shirasaka　Journal of Pharmaceutical Health Care and Sciences　7　1　29　2021/12　

show all

  • 　Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine　Hisanao Kishimoto,Kaori Miyazaki,Hiroshi Tedzuka,Ryosuke Ozawa,Hanai Kobayashi,Yoshiyuki Shirasaka,Katsuhisa Inoue　Molecules　26　21　6396　2021/10/22　
  • 　Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme　Satoru Suzuki,Katsuhisa Inoue,Ikumi Tamai,Yoshiyuki Shirasaka　Pharmaceutical Research　38　9　1585　2021/09　
  • 　3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.　Sho Konno,Kiyotaka Kobayashi,Miki Senda,Yuta Funai,Yuta Seki,Ikumi Tamai,Laura Schäkel,Kyousuke Sakata,Thanigaimalai Pillaiyar,Akihiro Taguchi,Atsuhiko Taniguchi,Michael Gütschow,Christa E Müller,Koh Takeuchi,Mikako Hirohama,Atsushi Kawaguchi,Masaki Kojima,Toshiya Senda,Yoshiyuki Shirasaka,Wataru Kamitani,Yoshio Hayashi　Journal of medicinal chemistry　65　4　2926　2021/07/27
  • 　Quantitative analysis of gastrointestinal physiology for better prediction of oral drug absorption and interaction.　Shirasaka Y　Yakugaku-Zasshi.　140　5　599　2020
  • 　Functional characterization of monocarboxylate transporter 12 (SLC16A12/MCT12) as a facilitative creatine transporter.　Takahashi M,Kishimoto H,Shirasaka Y,Inoue K　Drug Metab Pharmacokinet.　35　3　281　2020
  • 　Quantitative analysis of the effect of controlled-release formulation on nonlinear gastrointestinal absorption of P-glycoprotein substrate talinolol using physiologically based pharmacokinetic absorption model.　Suzuki S,Shirasaka Y,Okada R,Eguchi A,Kishimoto H,Langguth P,Inoue K　Journal of Drug Delivery Science and Technology　56　Part B　2020
  • 　Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine.　Miyazaki K,Kishimoto H,Muratani M,Kobayashi H,Shirasaka Y,Inoue K　Pharm Res.　36　11　162　2019
  • 　Effect of osmolality on the pharmacokinetic interaction between apple juice and atenolol in rats.　Funai Y,Shirasaka Y,Ishihara M,Takemura M,Ichijo K,Kishimoto H,Inoue K　Drug Metab Dispos.　47　4　386　2019
  • 　Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on D-luciferin–luciferase reaction in living cells by facilitating the intracellular accumulation of D-luciferin　Takahito Furuya,Issey Takehara,Asuka Shimura,Hisanao Kishimoto,Tomoya Yasujima,Kinya Ohta,Yoshiyuki Shirasaka,Hiroaki Yuasa,Katsuhisa Inoue　Biochemical and Biophysical Research Communications　495　3　2152　2018/01/15
  • 　Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse　Yoshiyuki Shirasaka,Nora Lee,Haichuan Duan,Horace Ho,Joanna Pak,Joanne Wang　Journal of Chemical Neuroanatomy　83-84　99　2017/10
  • 　Osmolality of Orally Administered Solutions Influences Luminal Water Volume and Drug Absorption in Intestine　Kazuki Ichijo,Rika Oda,Marika Ishihara,Ren Okada,Yuri Moteki,Yuta Funai,Takuya Horiuchi,Hisanao Kishimoto,Yoshiyuki Shirasaka,Katsuhisa Inoue　Journal of Pharmaceutical Sciences　106　9　2889　2017/09
  • 　Physiologically based pharmacokinetic model of all- trans-retinoic acid with application to cancer populations and drug interactions.　Jing J,Nelson C,Paik J,Shirasaka Y,Amory JK,Isoherranen N　Journal of Pharmacology and Experimental Therapeutics　361　5　385　2017/02
  • 　Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice　Yoshiyuki Shirasaka,Nora Lee,Weibin Zha,David Wagner,Joanne Wang　Drug Metabolism and Pharmacokinetics　31　5　385　2016/10
  • 　Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content　Y Shirasaka,A S Chaudhry,M McDonald,B Prasad,T Wong,J C Calamia,A Fohner,T A Thornton,N Isoherranen,J D Unadkat,A E Rettie,E G Schuetz,K E Thummel　The Pharmacogenomics Journal　16　4　375　2016/08　
  • 　Absorption-Enhancing Effect of Nitric Oxide on the Absorption of Hydrophobic Drugs in Rat Duodenum　Hisanao Kishimoto,Kaori Miyazaki,Yusuke Takizawa,Yoshiyuki Shirasaka,Katsuhisa Inoue　Journal of Pharmaceutical Sciences　105　2　729　2016/02
  • 　Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins　Jia Yin,Haichuan Duan,Yoshiyuki Shirasaka,Bhagwat Prasad,Joanne Wang　Drug Metabolism and Disposition　43　12　1872　2015/12　
  • 　TheCYP2C19Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers withCYP2C19*35andCYP2C19*2Alleles　Amarjit S. Chaudhry,Bhagwat Prasad,Yoshiyuki Shirasaka,Alison Fohner,David Finkelstein,Yiping Fan,Shuoguo Wang,Gang Wu,Eleni Aklillu,Sarah C. Sim,Kenneth E. Thummel,Erin G. Schuetz　Drug Metabolism and Disposition　43　8　1226　2015/08　
  • 　Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1　Yoshiyuki Shirasaka,Takanori Mori,Yukiko Murata,Takeo Nakanishi,Ikumi Tamai　Pharmaceutical Research　31　8　2035　2014/08　
  • 　Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions　Yoshiyuki Shirasaka,Shu-Ying Chang,Mary F. Grubb,Chi-Chi Peng,Kenneth E. Thummel,Nina Isoherranen,A. David Rodrigues　Drug Metabolism and Disposition　41　8　1566　2013/08　
  • 　Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions　Yoshiyuki Shirasaka,Jennifer E. Sager,Justin D. Lutz,Connie Davis,Nina Isoherranen　Drug Metabolism and Disposition　41　7　1414　2013/07　
  • 　A role of prostaglandin transporter in regulating PGE(2) release from human bronchial epithelial BEAS-2B cells in response to LPS　Yoshiyuki Shirasaka,Megumi Shichiri,Taku Kasai,Yasuhiro Ohno,Takeo Nakanishi,Kazuyuki Hayashi,Akio Nishiura,Ikumi Tamai　JOURNAL OF ENDOCRINOLOGY　217　3　265　2013/06
  • 　Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption　Yoshiyuki Shirasaka,Megumi Shichiri,Yukiko Murata,Takanori Mori,Takeo Nakanishi,Ikumi Tamai　Drug Metabolism and Disposition　41　3　615　2013/03
  • 　Major Active Components in Grapefruit, Orange, and Apple Juices Responsible for OATP2B1-Mediated Drug Interactions　Yoshiyuki Shirasaka,Megumi Shichiri,Takanori Mori,Takeo Nakanishi,Ikumi Tamai　Journal of Pharmaceutical Sciences　102　1　280　2013/01
  • 　Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions　Yoshiyuki Shirasaka,Megumi Shichiri,Takanori Mori,Takeo Nakanishi,Ikumi Tamai　Journal of Pharmaceutical Sciences　102　9　3418　2013/09
  • 　MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid.　Munehiro Kugai,Kazuhiko Uchiyama,Toshifumi Tsuji,Hiroyuki Yoriki,Akifumi Fukui,Ying Qin,Yasuki Higashimura,Katsura Mizushima,Naohisa Yoshida,Kazuhiro Katada,Kazuhiro Kamada,Osamu Handa,Tomohisa Takagi,Hideyuki Konishi,Nobuaki Yagi,Toshikazu Yoshikawa,Yoshiyuki Shirasaka,Ikumi Tamai,Yuji Naito,Yoshito Itoh　Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology　32　4　942　2013
  • 　Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5　Hiroshi Arakawa,Yoshiyuki Shirasaka,Makoto Haga,Takeo Nakanishi,Ikumi Tamai　BIOPHARMACEUTICS & DRUG DISPOSITION　33　6　332　2012/09
  • 　Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites　Yoshiyuki Shirasaka,Takanori Mori,Megumi Shichiri,Takeo Nakanishi,Ikumi Tamai　Drug Metabolism and Pharmacokinetics　27　3　360　2012/06
  • 　Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na+/Glucose Cotransporter 1 (SGLT1)-Mediated D-Glucose Uptake　Shinji Sakuma,Shun Kanamitsu,Yumi Teraoka,Yoshie Masaoka,Makoto Kataoka,Shinji Yamashita,Yoshiyuki Shirasaka,Ikumi Tamai,Masahiro Muraoka,Yohji Nakatsuji,Toshiyuki Kida,Mitsuru Akashi　MOLECULAR PHARMACEUTICS　9　4　922　2012/04
  • 　Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells (PTCs) in Primary Culture　Takeo Nakanishi,Akimasa Fukushi,Masanobu Sato,Mayuko Yoshifuji,Tomoka Gose,Yoshiyuki Shirasaka,Kazuyo Ohe,Masato Kobayashi,Keiichi Kawai,Ikumi Tamai　MOLECULAR PHARMACEUTICS　8　6　2142　2011/11
  • 　Estimation of Michaelis-Menten constant of efflux transporter considering asymmetric permeability　Kiyohiko Sugano,Yoshiyuki Shirasaka,Shinji Yamashita　INTERNATIONAL JOURNAL OF PHARMACEUTICS　418　2　161　2011/10
  • 　Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide and/or P-glycoprotein　Yoshiyuki Shirasaka,Kensuke Suzuki,Takeo Nakanishi,Ikumi Tamai　Journal of Pharmaceutical Sciences　100　9　3843　2011/09
  • 　Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats　Masanobu Sato,Tomohiko Wakayama,Hideaki Mamada,Yoshiyuki Shirasaka,Takeo Nakanishi,Ikumi Tamai　Biochimica et Biophysica Acta (BBA) - Biomembranes　1808　6　1441　2011/06
  • 　Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes　Takeo Nakanishi,Yuta Shibue,Yoko Fukuyama,Kenji Yoshida,Hajime Fukuda,Yoshiyuki Shirasaka,Ikumi Tamai　DRUG METABOLISM AND DISPOSITION　39　6　984　2011/06
  • 　The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans　Junko Imanaga,Tsutomu Kotegawa,Hiromitsu Imai,Kimiko Tsutsumi,Tsuneaki Yoshizato,Tetsuji Ohyama,Yoshiyuki Shirasaka,Ikumi Tamai,Tomonori Tateishi,Kyoichi Ohashi　PHARMACOGENETICS AND GENOMICS　21　2　84　2011/02
  • 　Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans　Takeo Nakanishi,Tsunemitsu Haruta,Yoshiyuki Shirasaka,Ikumi Tamai　DRUG METABOLISM AND DISPOSITION　39　1　117　2011/01
  • 　Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1　Yoshiyuki Shirasaka,Kensuke Suzuki,Megumi Shichiri,Takeo Nakanishi,Ikumi Tamai　DRUG METABOLISM AND PHARMACOKINETICS　26　2　171　2011
  • 　Carnitine Precursor gamma-Butyrobetaine is a Novel Substrate of the Na+- and Cl--dependent GABA Transporter Gat2　Takeo Nakanishi,Yoko Fukuyama,Masaharu Fujita,Yoshiyuki Shirasaka,Ikumi Tamai　DRUG METABOLISM AND PHARMACOKINETICS　26　6　632　2011
  • 　Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide　Yoshiyuki Shirasaka,Kensuke Suzuki,Takeo Nakanishi,Ikumi Tamai　Pharmaceutical Research　27　10　2141　2010/10　
  • 　Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem: Involvement of Human OATP Family in Apical Membrane Transport　Kazuhiko Kato,Yoshiyuki Shirasaka,Erika Kuraoka,Akihiro Kikuchi,Maki Iguchi,Hisashi Suzuki,Shigeki Shibasaki,Tohru Kurosawa,Ikumi Tamai　MOLECULAR PHARMACEUTICS　7　5　1747　2010/09
  • 　Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake　Shinji Sakuma,Yumi Teraoka,Tomokazu Sagawa,Yoshie Masaoka,Makoto Kataoka,Shinji Yamashita,Yoshiyuki Shirasaka,Ikumi Tamai,Yusuke Ikumi,Toshiyuki Kida,Mitsuru Akashi　EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS　75　3　366　2010/08
  • 　Quantitation of Talinolol in Rat Plasma By LC-MS-MS　Yan Li,Yoshiyuki Shirasaka,Peter Langguth,Ikumi Tamai　JOURNAL OF CHROMATOGRAPHIC SCIENCE　48　5　367　2010/05
  • 　Involvement of Choline Transporter-Like Proteins, CTL1 and CTL2, in Glucocorticoid-Induced Acceleration of Phosphatidylcholine Synthesis via Increased Choline Uptake　Toshimichi Nakamura,Ryohei Fujiwara,Naoki Ishiguro,Masanobu Oyabu,Takeo Nakanishi,Yoshiyuki Shirasaka,Tomoji Maeda,Ikumi Tamai　BIOLOGICAL & PHARMACEUTICAL BULLETIN　33　4　691　2010/04
  • 　Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates　Tatsuhiko Tachibana,Satoshi Kitamura,Motohiro Kato,Tetsuya Mitsui,Yoshiyuki Shirasaka,Shinji Yamashita,Yuichi Sugiyama　PHARMACEUTICAL RESEARCH　27　3　442　2010/03
  • 　Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human　Masanobu Sato,Hideaki Mamada,Naohiko Anzai,Yoshiyuki Shirasaka,Takeo Nakanishi,Ikumi Tamai　BIOLOGICAL & PHARMACEUTICAL BULLETIN　33　3　498　2010/03
  • 　Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat　Yoshiyuki Shirasaka,Erika Kuraoka,Hildegard Spahn-Langguth,Takeo Nakanishi,Peter Langguth,Ikumi Tamai　Journal of Pharmacology and Experimental Therapeutics　332　1　181　2010/01　
  • 　Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption　Toshimichi Nakamura,Takeo Nakanishi,Tsunemitsu Haruta,Yoshiyuki Shirasaka,John P. Keogh,Ikumi Tamai　MOLECULAR PHARMACEUTICS　7　1　187　2010/01
  • 　Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats　Masaharu Fujita,Takeo Nakanishi,Yuta Shibue,Daisuke Kobayashi,Richard H. Moseley,Yoshiyuki Shirasaka,Ikumi Tamai　AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　297　4　G681　2009/10
  • 　Oseltamivir (Tamiflu) Is a Substrate of Peptide Transporter 1　Takuo Ogihara,Takashi Kano,Tamae Wagatsuma,Sho Wada,Hikaru Yabuuchi,Shigeki Enomoto,Kaori Morimoto,Yoshiyuki Shirasaka,Shoko Kobayashi,Ikumi Tamai　DRUG METABOLISM AND DISPOSITION　37　8　1676　2009/08
  • 　Organic anion transporter OAT1 is involved in renal handling of citrulline　Masanori Nakakariya,Yoichiro Shima,Yoshiyuki Shirasaka,Keisuke Mitsuoka,Takeo Nakanishi,Ikumi Tamai　AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY　297　1　F71　2009/07
  • 　Expression levels of human P-glycoprotein inIn Vitrocell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells　Yoshiyuki Shirasaka,Reiko Konishi,Nana Funami,Yuko Kadowaki,Yuri Nagai,Toshiyuki Sakaeda,Shinji Yamashita　Biopharmaceutics & Drug Disposition　30　3　149　2009/04　
  • 　Transport Characteristics of L-Citrulline in Renal Apical Membrane of Proximal Tubular Cells　Keisuke Mitsuoka,Yoshiyuki Shirasaka,Akimasa Fukushi,Masanobu Sato,Toshimichi Nakamura,Takeo Nakanishi,Ikumi Tamai　BIOPHARMACEUTICS & DRUG DISPOSITION　30　3　126　2009/04
  • 　Concentration-Dependent Effect of Naringin on Intestinal Absorption of beta(1)-Adrenoceptor Antagonist Talinolol Mediated by P-Glycoprotein and Organic Anion Transporting Polypeptide (Oatp)　Yoshiyuki Shirasaka,Yan Li,Yuta Shibue,Erika Kuraoka,Hildegard Spahn-Langguth,Yukio Kato,Peter Langguth,Ikumi Tamai　PHARMACEUTICAL RESEARCH　26　3　560　2009/03
  • 　Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(gamma-glutamic acid)　Shinji Sakuma,Tomokazu Sagawa,Yoshie Masaoka,Makoto Kataoka,Shinji Yamashita,Yoshiyuki Shirasaka,Ikumi Tamai,Yusuke Ikumi,Toshiyuki Kida,Mitsuru Akashi　JOURNAL OF CONTROLLED RELEASE　133　2　125　2009/01
  • 　Scaling of in Vitro Membrane Permeability to Predict P-glycoprotein-Mediated Drug Absorption in Vivo　Yoshiyuki Shirasaka,Yoshie Masaoka,Makoto Kataoka,Shinji Sakuma,Shinji Yamashita　Drug Metabolism and Disposition　36　5　916　2008/05　
  • 　Characterization of gastrointestinal drug absorption in cynomolgus monkeys　Masayuki Takahashi,Takuo Washio,Norio Suzuki,Katsuhiro Igeta,Yoshimine Fujii,Masahiro Hayashi,Yoshiyuki Shirasaka,Shinji Yamashita　MOLECULAR PHARMACEUTICS　5　2　340　2008/03
  • 　Effect of P‐Glycoprotein Expression Levels on the Concentration‐Dependent Permeability of Drugs to the Cell Membrane　Yoshiyuki Shirasaka,Toshiyasu Sakane,Shinji Yamashita　Journal of Pharmaceutical Sciences　97　1　553　2008/01
  • 　Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein　Kaori Morimoto,Masanori Nakakariya,Yoshiyuki Shirasaka,Chihaya Kakinuma,Takuya Fujita,Ikumi Tamai,Takuo Ogihara　DRUG METABOLISM AND DISPOSITION　36　1　6　2008/01
  • 　Effects of Angiotensin II Receptor Blockers on Renal Handling of Uric Acid in Rats　Yan Li,Masanobu Sato,Yuichi Yanagisawa,Hideaki Mamada,Akimasa Fukushi,Kentaro Mikami,Yoshiyuki Shirasaka,Ikumi Tamai　DRUG METABOLISM AND PHARMACOKINETICS　23　4　263　2008
  • 　Evaluation of Human P-Glycoprotein (MDR1/ABCB1) ATPase Activity Assay Method by Comparing with in Vitro Transport Measurements: Michaelis-Menten Kinetic Analysis to Estimate the Affinity of P-Glycoprotein to Drugs　Yoshiyuki Shirasaka,Yuko Onishi,Aki Sakurai,Hiroshi Nakagawa,Toshihisa Ishikawa,Shinji Yamashita　Biological and Pharmaceutical Bulletin　29　12　2465　2006/12　
  • 　Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport　Yoshiyuki Shirasaka,Masae Kawasaki,Toshiyasu Sakane,Hideaki Omatsu,Yuka Moriya,Tsutomu Nakamura,Toshiyuki Sakaeda,Katsuhiko Okumura,Peter Langguth,Shinji Yamashita　Drug Metabolism and Pharmacokinetics　21　5　414　2006
  • 　Apple juice relieves loperamide-induced constipation in rats by downregulating the intestinal apical sodium-dependent bile acid transporter ASBT　Qiunan Zhu,Ryusuke Iwai,Takehiro Okaguchi,Yoshiyuki Shirasaka,Ikumi Tamai　Food & Function　14　10　4836　2023/05　
  • 　SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM1　Ryuto Tomabechi,Hisanao Kishimoto,Taeka Sato,Naoki Saito,Keisuke Kiyomiya,Tappei Takada,Kei Higuchi,Yoshiyuki Shirasaka,Katsuhisa Inoue　PNAS Nexus　1　3　2022/07　
  • 　The GlycosylatedN-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane　Kaori Miyazaki,Hisanao Kishimoto,Hanai Kobayashi,Ayaka Suzuki,Kei Higuchi,Yoshiyuki Shirasaka,Katsuhisa Inoue　Molecular Pharmacology　103　3　166　2023/03　
  • 　Food effects on gastrointestinal physiology and drug absorption　Atsushi Kambayashi,Yoshiyuki Shirasaka　Drug Metabolism and Pharmacokinetics　48　100488　2023/02
  • 　Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model　Satoru Suzuki,Katsuhisa Inoue,Ikumi Tamai,Yoshiyuki Shirasaka　The AAPS Journal　25　3　2023/04/20　
  • 　Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A3　Ryuto Tomabechi,Miki Miyasato,Taeka Sato,Tappei Takada,Kei Higuchi,Hisanao Kishimoto,Yoshiyuki Shirasaka,Katsuhisa Inoue　Molecular Pharmaceutics　20　1　491　2023/01　
  • 　Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats　Yuta Funai,Kazuki Ichijo,Satoru Suzuki,Yuta Tateishi,Katsuhisa Inoue,Ikumi Tamai,Yoshiyuki Shirasaka　Scientific Reports　13　1　2023/10/14　
  • 　Magnitude of Fruit Juice–Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices　Miyuki Takemura,Katsuhisa Inoue,Ikumi Tamai,Yoshiyuki Shirasaka　Biological and Pharmaceutical Bulletin　47　1　72　2024/01/01　
  • 　Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα　Shinya Usui,Qiunan Zhu,Hisakazu Komori,Yui Iwamoto,Takumi Nishiuchi,Yoshiyuki Shirasaka,Ikumi Tamai　Drug Metabolism and Pharmacokinetics　52　100512　2023/10
  • 　Potentiation of the Uricosuric Effect of Dotinurad byTrans-Inhibition of the Uric Acid Reabsorptive Transporter URAT1　Kazuki Fujita,Qiunan Zhu,Hiroshi Arakawa,Yoshiyuki Shirasaka,Ikumi Tamai　Drug Metabolism and Disposition　DMD　2023/08/29　
  • 　The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells　Koki Sugiyama,Hiroe Shimano,Masaki Takahashi,Yuta Shimura,Asuka Shimura,Takahito Furuya,Ryuto Tomabechi,Yoshiyuki Shirasaka,Kei Higuchi,Hisanao Kishimoto,Katsuhisa Inoue　Journal of Pharmaceutical Sciences　2023/12
  • 　Quantitative analysis of the impact of membrane permeability on intestinal first‐pass metabolism of CYP3A substrates　Yugo Yasugi,Yoshiyuki Shirasaka,Ikumi Tamai　Biopharmaceutics & Drug Disposition　2023/12/12　
  • 　Induction of open-form bile canaliculus formation by hepatocytes for evaluation of biliary drug excretion.　Hiroshi Arakawa,Yuya Nakazono,Natsumi Matsuoka,Momoka Hayashi,Yoshiyuki Shirasaka,Atsushi Hirao,Ikumi Tamai　Communications biology　6　1　866　2023/08/22
  • 　Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug–ADC Interaction in Cancer Chemotherapy　Keisuke Kiyomiya,Ryuto Tomabechi,Naoki Saito,Kenta Watai,Tappei Takada,Yoshiyuki Shirasaka,Hisanao Kishimoto,Kei Higuchi,Katsuhisa Inoue　Molecular Pharmaceutics　2023/11/16　
  • 　Food effects on oral drug absorption: Recent advances in understanding mechanisms and quantitative prediction　Yoshiyuki Shirasaka,Atsushi Kambayashi　Drug Metabolism and Pharmacokinetics　54　100533　2024/02

Conference Presentations

  • Intestinal Absorption of Drugs Controlled by Influx/Efflux Transporters(conference：131st PSJ Annual Meeting)(2011/03/29)
  • Contribution of Metabolites to Drug-Drug Interactions(conference：36th JSCPT Annual Meeting)(2015/12/10)
  • Mechanistic and Kinetic Analysis of Intestinal Drug Absorption Mediated by Transporters and Metabolic Enzymes(conference：30th JSSX Annual Meeting)(2015/11/13)
  • Multiple Binding Sites (MBS) Hypothesis: Substrate- and Dose-Dependent Drug Interactions Caused by Multiple Binding Sites on OATP2B1(conference：1st APSTJ Drug Interaction Focus Group Symposium)(2015/02/17)
  • Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions(conference：The 7th SUGIYAMA Laboratory (RIKEN) Open Symposium)(2016/02/16)

show all

  • Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions(conference：28th APSTJ Annual Meeting)(2013/05/25)
  • Species Difference in the Transporter-Mediated Drug Absorption between Human and Rat -Impact of OATP and P-gp on Grapefruit Juice-Drug Interaction-(conference：University of Washington, Special Seminar)(2012/09/27)
  • Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in the Diplotypes(conference：10th International ISSX Meeting)(2013/09/30)
  • Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation(conference：International Symposium on BA/BE of Oral Drug Products)(2011/06/30)
  • Multiple Transport Mechanisms Involved in the Intestinal Absorption and Disposition of Antidiabetic Metformin(conference：19th North American ISSX Meeting/29th JSSX Meeting)(2014/10/19)
  • Research Activities at University of Washington -Risk Assessment of Cytochrome P450-Mediated Drug-Drug Interactions-(conference：Kanazawa University, Special Seminar)(2013/05/27)
  • Research Activities at University of Washington -Predictions of Transporter- and Metabolic Enzymes (P450)-Mediated Drug-Drug Interactions-(conference：Ritsumeikan University, Special Seminar)(2013/05/28)
  • Research Activities at University of Washington –Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics-(conference：Setsunan University, Special Lecture)(2013/05/29)
  • Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in Gene Diplotypes and Cytochrome P450 Oxidoreductase Content(conference：2014 AAPS Annual Meeting and Exposition)(2014/11/02)
  • Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions(conference：18th North American Regional ISSX Meeting)(2012/10/15)
  • Inhibition of CYP2C19 and CYP3A4 by Omeprazole and its Metabolites(conference：18th International Conference on Cytochrome P450)(2013/06/19)
  • Impact of CYP3A5 Expression on CYP3A-Mediated Drug-Drug Interactions –Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics-(conference：28th APSTJ Global Education Seminar Workshop)(2013/05/25)
  • The Movement of History -Ten Years since the Beginning of SNPEE-(conference：30th APSTJ Annual Meeting SNPEE2015)(2015/05/22)
  • Kinetic Analysis of Physiological Functions of Gastrointestinal Tract to Predict Oral Drug Absorption(conference：32nd APSTJ Annual Meeting)(2017/05/13)
  • Characteristic and kinetic analysis of gastrointestinal water dynamics: Impact on oral drug absorption(conference：DMPK Forum in Kanazawa)(2018/06/26)
  • Quantitative Analysis of the Impact of Controlled-Release Formulation on Oral Absorption and Bioavailability of P-gp/CYP3A4 Substrates(conference：4th International Symposium on BA/BE of Oral Drug Products (Session 3))(2022/11/18)
  • New challenges of pharmaceutical-pharmacokinetic collaboration in innovative drug development(2017/05/13)
  • Characteristic and Kinetic Analysis of Gastrointestinal Water Dynamics: Impact on Oral Drug Absorption(conference：3rd International Symposium on BA/BE of Oral Drug Products (Session 2))(2018/10/11)
  • Now is the time to unify pharmaceutical education into the six-year system: Influence of disarray in an education system between national/public and private universities on fostering of researchers in future generations(conference：33rd APSTJ Annual Meeting)(2018/06/01)
  • Characteristic and Kinetic Analysis of Gastrointestinal Water Dynamics to Predict Oral Drug Absorption and Interaction(conference：7th International Postgraduate Conference on Pharmaceutical Sciences (iPoPS2020))(2020/02/29)
  • Characteristic and Kinetic Analysis of Gastrointestinal Drug Concentration: Impact on Drug Absorption, Transport and Delivery(conference：University of Washington, School of Pharmacy, Special Seminar)(2016/11/18)
  • Impact of Water Absorption/Secretion on the Intestinal Drug Absorption and Drug-Beverage Interactions(conference：2016 AAPS Annual Meeting and Exposition)(2016/11/13)
  • Characteristic and Kinetic Analysis of Gastrointestinal Water Dynamics to Predict Oral Drug Absorption and Interaction(conference：University of Washington, School of Pharmacy, Special Seminar)(2019/07/18)
  • Role of Drug Absorption and Pharmacokinetics in Drug Discovery: Mechanistic and Kinetic Analysis of Intestinal Drug Absorption(conference：University of Hyogo Leading Program International Symposium 2017)(2017/12/04)
  • Characteristic and Kinetic Analysis of Gastrointestinal Water Dynamics: Impact on Drug Absorption, Transport and Interaction(2019/02/05)
  • Education of Pharmacists and Pharmaceutical Researchers in Japan: Current Problems, Suggestions and Future Challenges(conference：7th Conference of Asia Pacific Pharmacy Education Network (AP-PEN))(2018/10/07)

Others

  • 　1st Meeting on Oral Absorption Focus Group, Shizuoka Camp　PHRM TECH JAPAN　27　7　2011/07
  • 　Kinetic Analysis on Counteracting Interplay of Influx/Efflux Transporters on Intestinal Drug Absorption　Drug Deliverly System　23　6　2008/06
  • 　Quantitative Evaluation of the Effect of Transporters on Intestinal Absorption of Drugs　Journal of Pharmaceutical Science and Technology, Japan　70　2　2010/02

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「有機アニオン輸送体を介した薬物の肝移行性調節とその種差」(2007-2008)　
○「吸収／排泄型トランスポーターの優位性に基づいた消化管吸収性評価システムの構築」(2008-2009)　
○「細胞内オルガネラ膜トランスポーター活性の定量的可視化による薬物の細胞毒性評価」(2009-2010)　
○「尿酸動態調節機構の解明に基づく血清尿酸値変動評価システムの樹立」(2009-2011)　
○「部位差を考慮した薬物の消化管吸収性評価システムの構築とその製剤設計最適化への応用」(2011-2013)　
○「尿酸結合タンパク質CD38を介した尿酸による炎症応答調節」(2023-2024)　
○「Quantitative Evaluation of the Effect of Transporters and Metabolic Enzymes on Oral Drug Absorption」(2012-2013)　
○「消化管水分調節機構の定量的解明に基づく薬物吸収動態予測システムの確立」(2020-2023)　
○「小腸絨毛上皮モデルを用いた革新的in vitro薬物吸収性予測システムの開発」(2016-2018)　
○「吸収/排泄型トランスポーターの相殺性に基づく薬物吸収動態予測」(2009-2010)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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