Associate Professor USUI Soichiro
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
Department of Cardiovascular Medicine TEL:076-265-2259 FAX:076-234-4251
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medical Sciences 200409 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199703
【Degree】
PhD
Career
UMDNJ Postdoctoral Fellow(2005/04/01-2008/03/31)
Kanazawa University Hospital Department of Cardiology University Hosp assistant professor(2008/10/01-2009/03/31)
Kanazawa University Hospital Department of Cardiology University Hosp assistant professor(2009/04/01-2019/05/31)
Kanazawa University Hospital (2019/06/01-2023)
Year & Month of Birth
1971/05
Academic Society
Japan Circulation Society
Japanease Society of Internal Medicine
American Heart Association
European Society of Cardiology
Japanese Association of Cardiac Rehabilitation
Japanese Society for Regenerative Medicine
Award
○AHA Basic Cardiovascular Sciences New Investigator Travel Award(2007/07/31)
○Melvin L. Marcus Young Investigation Awards(2007/11/05)
○Japan Heart Foundation/Novartis Grant for Research Award on Molecular and Cellular Cardiol(2010/04/01)
○Paul Dudley White International Scholar Award(2020/07/14)
○Paul Dudley White International Scholar Award(2020/07/14)
Specialities
Cardiovascular medicine
Speciality Keywords
Cardiac remodeling,heart failure,Caldiology
Research Themes
Study of adipose-derived regenerative cells for ischemic heart failure
Impact of Liver Dysfunction during Cardiac Remodeling
The role of MAFbx in cardiac remodeling
Books
- Current Therapy in Cardiovascular Diseases 2020/01/30
Papers
- Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB CIRCULATION RESEARCH 109 2 287 2011/07
- Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M, Sadoshima J CIRCULATION RESEARCH 100 9 1344-1352 2007/05
- Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart PLOS one 8 1 51632 2013/01
- Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice HYPERTENSION RESEARCH 35 3 287 2012/03
- Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research. Usui S, Yeh I, Tian B, Sadoshima J. 41 2 219-222 2006/08
- S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Takuwa N,Ohkura S,Takashima S,Ohtani K,Okamoto Y,Tanaka T,Hirano K,Usui S,Wang F,Du W,Yoshioka K,Banno Y,Sasaki M,Ichi I,Okamura M,Sugimoto N,Mizugishi K,Nakanuma Y,Ishii I,Takamura M,Kaneko S,Kojo S,Satouchi K,Mitumori K,Chun J,Takuwa Y Cardiovasc Res 85 3 484-93 2010/02
- Altered hepatic gene expression profiles associated with myocardial ischemia. Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M Circ Cardiovasc Genet 3 1 68-77 2010/02
- Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. JOURNAL OF BIOLOGICAL CHEMISTRY 279 13 12300-12311 2004/03
- Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. Ryu Y,Takuwa N,Sugimoto N,Sakurada S,Usui S,Okamoto H,Matsui O,Takuwa Y Circ Res 90 3 325-32 2002/02
- Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A Maejima, Yasuhiro; Usui, Soichiro; Zhai, Peiyong; Takamura, Masayuki; Kaneko, Shuichi; Zablocki, Daniela K.; Yokota, Mitsuhiro; Isobe, Mitsuaki; Sadoshima, Junichi Circulation: Heart Failure 7 3 479-490 2014/01/01
- Rho-kinase activation in leukocytes plays a pivotal role in myocardial ischemia/reperfusion injury Kitano, Katsunori; Usui, Soichiro; Ootsuji, Hiroshi; Takashima, Shinichiro; Kobayashi, Daisuke; Murai, Hisayoshi; Furusho, Hiroshi; Nomura, Ayano; Kaneko, Shuichi; Takamura, Masayuki PLoS ONE 9 3 2014/03/17
- Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia. Oto Inoue,Chiaki Goten,Daiki Hashimuko,Kosei Yamaguchi,Yusuke Takeda,Ayano Nomura,Hiroshi Ootsuji,Shinichiro Takashima,Kenji Iino,Hirofumi Takemura,Manasi Halurkar,Hee-Woong Lim,Vivian Hwa,Joan Sanchez-Gurmaches,Soichiro Usui,Masayuki Takamura Cell reports. Medicine 4 12 101337 2023/12/19
- Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease. Hayato Tada,Kan Yamagami,Kenji Sakata,Soichiro Usui,Masa-Aki Kawashiri,Masayuki Takamura European journal of clinical investigation e14093 2023/09/15
- Important Role of Endogenous Nerve Growth Factor Receptor in the Pathogenesis of Hypoxia-Induced Pulmonary Hypertension in Mice Goten C, Usui S, Takashima SI, Inoue O, Yamaguchi K, Hashimuko D, Takeda Y, Nomura A, Sakata K, Kaneko S, Takamura M. Int J Mol Sci . 2023/01/18
- Different Responses of Muscle Sympathetic Nerve Activity to Dapagliflozin Between Patients With Type 2 Diabetes With and Without Heart Failure. Hamaoka T, Murai H, Hirai T, Sugimoto H, Mukai Y, Inoue O, Takashima S, Kato T, Takata S, Usui S, Sakata K, Kawashiri MA, Takamura M. J Am Heart Assoc. 2021/11/16
- Circulating nerve growth factor receptor positive cells are associated with severity and prognosis of pulmonary arterial hypertension Goten C, Usui S, Takashima S, Inoue O, Okada H, Shimojima M, Sakata K, Kawashiri M, Takamura M Pulm Circ 2021/02/09
- Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells. Takashima, S.,Usui, S., Inoue, O., Goten, C., Yamaguchi, K., Takeda, Y., Cui, S., Sakai, Y., Hayashi, K., Sakata, K., Kawashiri, M. A., Takamura, M Sci Rep 2021/01/15
- Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271+ subpopulation in adipose tissue. Inoue O, Usui S, Takashima SI, Nomura A, Yamaguchi K, Takeda Y, Goten C, Hamaoka T, Ootsuji H, Murai H, Kaneko S, Takamura M. Biochem Biophys Res Commun. 517 2 369 2019/07/27
- Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury. Kitano T, Usui S, Takashima SI, Inoue O, Goten C, Nomura A, Yoshioka K, Okajima M, Kaneko S, Takuwa Y, Takamura M. Biochem Biophys Res Commun. 511 3 179 2019/03/26
- Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction. Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, Kaneko S, Sadoshima J, Takamura M. J Mol Cell Cardiol. 126 1 1 2019/01
- Endogenous Selenoprotein P, a Liver-Derived Secretory Protein, Mediates Myocardial Ischemia/Reperfusion Injury in Mice Chadani H, Usui S, Inoue O, Kusayama T, Takashima SI, Kato T, Murai H, Furusho H, Nomura A, Misu H, Takamura T, Kaneko S, Takamura M. Int J Mol Sci. 19 3 E878 2018
- Long-Term Administration of Eicosapentaenoic Acid Improves Post-Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization. Takamura M, Kurokawa K, Ootsuji H, Inoue O, Okada H, Nomura A, Kaneko S, Usui S. J Am Heart Assoc 6 2 2017
- The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S Eur J Immunol. 47 12 2163 2017
- Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6. Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y. PLoS One. 2017/08/03
- Altered gene expression in T-cell receptor signalling in peripheral blood leucocytes in acute coronary syndrome predicts secondary coronary events. Takashima S, Usui S, Kurokawa K, Kitano T, Kato T, Murai H, Furusho H, Oda H, Maruyama M, Nagata Y, Usuda K, Kubota K, Takeshita Y, Sakai Y, Honda M, Kaneko S, Takamura M. Open Heart. 2016
- Adipose-derived regenerative cells exert beneficial effects on systemic responses following myocardial ischemia/reperfusion. Takamura M, Usui S, Inoue O, Ootsuji H, Takashima SI, Nomura A, Kato T, Murai H, Furusho H, Sakai Y, Kaneko S. Cardiol J. 2016
- Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response. Takatori O, Usui S, Okajima M, Kaneko S, Ootsuji H, Takashima SI, Kobayashi D, Murai H, Furusho H, Takamura M. J Cardiovasc Pharmacol Ther. 2016
Conference Presentations
Others
- Global changes in gene expression during cardiac hypertrophy:a new direction of cardiac signaling research Usui, S., Yeh, I., Tian B, Sadoshima, J J Mol Cell Cardiol. 41 219 2006
- Targeted deletion of muscle atrophy F-box attenuates pressure overload induced cardiac hypertrophy Usui S, Takamura M, Sadoshima J Experimental & Clinical Cardiology 14 2 27 2009//2
- The Regulation of Cardiac Remodeling by Mst1 Matusda T, Usui S, Nakako N, Matusi Y, Sadoshima J SHUJUNSHA 26 4 381-385 2007/04
- Sphingosine-1-phosphate and Vascular Smooth Muscle Cell Usui S, Takuwa Y 6 4 55-61 2005/08
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「CD271陽性エリート細胞を標的とした肺高血圧症に対する新規治療開発」(2019-2023)
○「ヒト皮下脂肪間質細胞を用いた拍動心筋細胞の心不全治療応用へ向けた研究」(2021-2023)
○「心不全状態での肝臓機能の破綻が心臓リモデリングへ与える影響」(2015-2017)
○「心筋梗塞後リモデリングにおけるタンパク質分解系の役割」(2012-2014)
○「タンパク質品質管理機構の心不全病態形成への関与」(2010-2011)
○「筋特異的ユビキチン連結酵素MAFbxの不全心病態形成における役割の検討」(2008-2009)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Cardiology(2023)
○Cardiology(2023)
○Cardiology(2022)
○Cardiology(2022)
Classes (Graduate Schools)
○Internal Medicine(2023)
○Internal Medicine(2023)
○Internal Medicine(2023)
○Internal Medicine(2023)
○Introduction to MedicineⅡ(2023)
○Internal Medicine(2022)
○Internal Medicine(2022)
○Internal Medicine(2022)
○Internal Medicine(2022)
○Disease Control and Homeotasis(2021)
○Internal Medicine(2021)
○Internal Medicine(2021)
○Disease Control and Homeotasis(2020)
○Internal Medicine(2020)
○Internal Medicine(2020)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2016)
○Disease Control and Homeotasis(2016)