MATSUNAGA Tsukasa - Directory of Researchers at Kanazawa University

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last modified：2025/03/15

Professor　MATSUNAGA Tsukasa

Basic
Research
Education
Social Contribution

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Frontier Engineering, Graduate School of Natural Science and Technology
Division of Natural System, Graduate School of Natural Science and Technology
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Human Molecular Genetics　TEL:076-234-4487　FAX:076-234-4427

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Master　Graduate School, Division of Pharmaceutical Sciences　198603　Completed
Kanazawa University　Doctor　Graduate School, Division of Pharmaceutical Sciences　198609　Unfinished course
【Academic background(Bachelor's Degree)】
Kanazawa University　1983

Career

Kanazawa University　Faculty of Pharmaceutical Sciences(1986/10/01-1990/11/30)
Kanazawa University　Faculty of Pharmaceutical Sciences(1990/12/01-1996/06/30)
Kanazawa University　Faculty of Pharmaceutical Sciences(1996/07/01-1997/04/30)
Kanazawa University　Faculty of Pharmaceutical Sciences(1997/05/01-2002/03/31)
Kanazawa University　Faculty of Pharmaceutical Sciences(2002/04/01-)

Year & Month of Birth

1961/02

Academic Society

Japanese Cancer Association

The Pharmaceutical Society of Japan

Award

Specialities

Molecular biology Functional biochemistry Cell biology、Cell Biology Molecular biology Functional biochemistry、、Risk sciences of radiation and chemicals、Biological pharmacy

Speciality Keywords

DNA repair Hereditary disorder Cancer Signal transduction Cellular response Ultraviolet light

Research Themes

Molecular analysis of cellular responses to DNA damage

Functional analysis of DDB complex in cellular responses to DNA damage

Establishment and application of detection systems for UV-induced DNA damage

Books

Papers

　Topoisomerase I-driven repair of UV-induced damage in NER deficient cells.　Saha, L. K., Wakasugi, M., Akter, S., Prasad, R., Wilson, S. H., Shimizu, N., Sasanuma, H., Huang, S. -Y. N., Agama, K., Pommier, Y., Matsunaga, T., Hirota, K., Iwai, S., Nakazawa, Y., Ogi, T. and Takeda, S.　Proc. Natl. Acad. Sci. U.S.A.　117　25　14412-14420　2020/06/23
　Spironolactone-induced XPB degradation depends on CDK7 kinase and SCF^FBXL18 E3 ligase　Ueda, M., Matsuura, K., Kawai, H., Wakasugi, M. and Matsunaga, T.　Genes Cells　in press　2019/02/14
　PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.　Tsuda, M., Ogawa, S., Ooka, M., Kobayashi, K., Hirota, K., Wakasugi, M., Matsunaga, T., Sakuma, T., Yamamoto, T., Chikuma, S., Sasanuma, H., Debatisse, M., Doherty, A. J., Fuchs, R. P. and Takeda, S.　PLoS One　14　3　e0213383　2019/03/06
　Rapid G0/1 transition and cell cycle progression in CD8+ T cells compared to CD4+ T cells following in vitro stimulation.　Mishima, T., Fukaya, S., Toda, S., Ando, Y., Matsunaga, T. and Inobe, M.　61　168-175　2017
　Aquarius is required for proper CtIP expression and homologous recombination repair　69. Sakasai, R., Isono, M., Wakasugi, M., Hashimoto, M., Sunatani, Y., Matsui, T., Shibata, A., Matsunaga, T. and Iwabuchi, K.　Sci. Rep.　7　1　13808　2017/10

show all

　Optimized gene silencing by co-expression of multiple shRNAs in a single vector.　Ishigaki, Y., Nagao, A. and Matsunaga, T.　Methods in Molecular Biology　623　109-121　2010
　Stress-activated MAP kinases JNK and p38 target Cdc25B for degradation.　58. Uchida, S., Yoshioka, K., Kizu, R., Nakagama, H., Matsunaga, T., Ishizaka, Y., Poon, R. Y. C. and Yamashita K.　CANCER RESEARCH　69　16　6438-6444　2009/07
　Physical and functional interaction between DDB and XPA in nucleotide excision repair.　Wakasugi, M., Kasashima, H., Fukase, Y., Imura, M., Imai, R., Yamada, S., Cleaver, J. E. and Matsunaga, T.　NUCLEIC ACIDS RESEARCH　37　2　516-525　2009/02
　A mutation in the uvi4 gene promotes progression of endo-reduplication and confers increased tolerance towards ultraviolet B light.　Hase, Y., Trung, K. H., Matsunaga, T., Tanaka, A.　PLANT JOURNAL　46　2　317-326　2006/04
　Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding.　Uchida, S., Kubo, A., Kizu, R., Nakagama, H., Matsunaga, T., Ishizaka, Y and Yamashita, K.　JOURNAL OF BIOCHEMISTRY　139　4　761-769　2006/04
　Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.　Matsumoto, M., Yaginuma, K., Igarashi, A., Imura, M., Hasegawa, M., Iwabuchi, K., Date, T., Mori, T., Ishizaki, K., Yamashita, K., Inobe, M. and Matsunaga, T.　JOURNAL OF CELL SCIENCE　120　6　1104-1112　2007/03
　DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells.　Wakasugi, M., Matsuura, K., Nagasawa, A., Fu, D., Shimizu, H., Yamamoto, K., Takeda, S. and Matsunaga, T.　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　364　 771-777　2007/12
　Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair.　Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y. and Tanaka, K.　JOURNAL OF BIOLOGICAL CHEMISTRY　283　 940-950　2008/01
　A new disorder in UV-induced skin cancer with defective DNA repair distinct from xeroderma pigmentosum or Cockayne syndrome.　Hashimoto, S., Egawa, K., Ihn, H., Igarashi, A., Matsunaga, T., Tateishi, S., and Yamaizumi, M.　JOURNAL OF INVESTIGATIVE DERMATOLOGY　128　 694-701　2008/03
　Multiple shRNA expressions in a single plasmid vector improve RNAi against the XPA gene.　Nagao, A., Zhao, X., Takegami, T., Nakagawa, H., Matsui, S., Matsunaga, T. and Ishigaki, Y.　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　370　 301-305　2008/05
　Cleavage-mediated activation of Chk1 during apoptosis.　Matsuura, K., Wakasugi, M., Yamashita, K. and Matsunaga, T.　JOURNAL OF BIOLOGICAL CHEMISTRY　283　 25485-25491　2008/09
　Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A.　J. Biol. Chem.　276　18　15434-15440　2001/05
　DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair.　J. Biol. Chem.　277　3　1637-1640　2002/01
　Effects of photoreactivation of cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidone photoproducts on ultraviolet mutagenesis in SOS-induced repair-deficient Escherichia coli.　MUTAGENESIS　16　1　1-6　2001/01
　In situ visualization of ultraviolet light-induced DNA damage repair in locally irradiated human fibroblasts.　J. Invest. Dermatol.　117　5　1156-1161　2001/11
　Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene.　Mol. Cell. Biol.　19　3　2366-2372　1999/03
　Respective roles of cyclobutane pyrimidine dimers, (6-4)photoproducts, and minor photoproducts in ultraviolet mutagenesis of repair-deficient xeroderma pigmentosum A cells.　Cancer Res.　60　6　1729-1735　2000/03
　cDNA cloning of the chicken DDB1 gene encoding the p127 subunit of damaged DNA-binding protein.　GENES & GENETIC SYSTEMS　78　169-177　2003/04
　Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers.　MUTATION RESEARCH-DNA REPAIR　1　629-643　2002/08
　A gene for a Class II DNA photolyase from Oryza sativa: cloning of the cDNA by dilution-amplification.　MOLECULAR GENETICS AND GENOMICS　269　4　508-516　2003/07
　Antibodies specific for (6-4) DNA photoproducts: cloning, antibody modeling and construction of a single-chain Fv derivative.　Biochim. Biophys. Acta　1385　1　17-32　1998/06
　Amplified UvrA protein can ameliorate the ultraviolet sensitivity of an Escherichia coli recA mutant.　Mutation Res.　487　3-4　149-156　2001/12
　Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B.　JOURNAL OF CELL SCIENCE　117　14　3011-3020　2004/06
　Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method.　MOLECULAR AND CELLULAR BIOLOGY　24　9　3712-3719　2004/05
　Nuclear export signal in CDC25B.　Biochem. Biophys. Res. Commun.　316　1　226-232　2004/03
　Characterization of pathways dependent on the uvde, uvrA1, or uvrA2 gene product for ultraviolet resistance in Deinococcus radiodurans.　Tanaka, M., Narumi, I., Funayama, T., Kikuchi, M., Watanabe, H., Matsunaga, T., Nikaido, O. and Yamamoto, K.　JOURNAL OF BACTERIOLOGY　187　11　3693-3697　2005/06
　Functional and physical interactions between ERCC1 and MSH2 for resistance to cis-platinum in mammalian cells.　DNA Repair　3　2　135-143　2004/02
　Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen.　Biochemical and Biophysical Research Communications　321　1　183-191　2004/08
　Disruption of the AtREV3 gene causes hypersensitivity to ultraviolet B light and gamma-rays in Arabidopsis: inplication of the presence of a translesion synthesis mechanism in plants.　PLANT CELL　15　9　2042-2057　2003/09

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○Research on anti-cancer drugs targeting cellular responses to DNA damage

Grant-in-Aid for Scientific Research

○「NER反応中間体のプロセッシングと生物影響の解明」(2023-2025)　
○「BioID法を利用したヌクレオチド除去修復反応の高精細・動的モデルの構築」(2023-2025)　
○「タンパク質間の特異的相互作用を活用する高選択的バイオコンジュゲーション法の開発」(2021-2022)　
○「ヌクレオチド除去修復機構解明に向けたケミカルアプローチ」(2019-2021)　
○「NER中間体がもたらす新たなDNA損傷生成とその防御応答の解析」(2019-2021)　
○「新規DNA修復阻害剤を活用したメカニズム解析と癌治療への応用」(2016-2018)　
○「哺乳類細胞に潜在する未知DNA修復反応の解明」(2016-2017)　
○「DNA損傷応答ネットワークを標的にした合成致死に基づく癌治療戦略」　
○「シスプラチン抵抗性関連因子ＥＲＣＣ１の分解を誘導する新規低分子化合物の解析」(2013-2014)
○「ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析」(2013-2015)
○「細胞内高次環境におけるヌクレオチド除去修復とその制御のメカニズム」
○「化合物ライブラリーより発見された新規ＤＮＡ修復阻害物質の創薬研究」
○「ヌクレオチド除去修復を阻害する新規化合物を利用したメカニズム解析とその応用」
○「ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析」(2013-2015)　
○「シスプラチン抵抗性関連因子ERCC1の分解を誘導する新規低分子化合物の解析」(2013-2014)　
○「ゲノム損傷応答機構におけるCul4-DDB1ユビキチンリガーゼの新機能の解明」(2009-2011)　
○「ヌクレオチド除去修復のバックアップ機構に関する研究」(2004-2004)　
○「DNA修復関連因子を利用したDNA損傷検出系の開発」(1999-)　
○「除去修復エンドヌクレアーゼの機能とその欠損による分子病態に関する研究」(1998-)　
○「ヌクレオチド除去修復反応の細胞内調節機構に関する研究」(2000-2004)　
○「ヒト細胞におけるヌクレオチド除去修復のバックアップ機構に関する研究」(2003-2004)　
○「ヌクレオチド除去修復反応を調節する細胞内因子の解析」(1997-)　
○「除去修復エンドヌクレアーゼの機能とその欠損による分子病態の生化学的解析」(1997-)　

Competitive research funding,Contribution

Collaborative research,Consignment study

○Analysis of DNA repair mechanisms in human keratinocytes(2006-2010)

Classes (Bachelors)

○Introduction to Graduation Research in Medical and Pharmaceutical Sciences(2023)
○Medical and Pharmaceutical Sciences Researcher Training 2(2023)
○Molecular and Cellular Biology 3(2023)
○Career Plan 1(2023)
○Introduction to Life Science(2023)
○Career Plan 3(2023)
○Carrer Plan 2(2023)
○Basic Health Science 1(2023)
○Introduction to Graduation Research in Pharmacy 1(2023)
○Molecular and Cellular Biology(2023)
○Advanced Molecular Cell Biology(2017)
○Molecular and Cellular Biology 3(2017)
○Molecular and Cellular Biology(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology 3(2016)
○Laboratory Rotation 1(2016)
○Molecular and Cellular Biology(2016)
○Molecular and Cellular Biology(2016)
○Advanced Molecular Cell Biology(2016)

Classes (Graduate Schools)

○Molecular Biology of Cancer(2017)
○Advanced Course of Biopharmaceutical Drug Discovery(2017)
○Maintenance of Genomic Integrity(2017)
○Advanced Seminar on Biopharmaceutical Sciences(2017)
○Maintenance of Genomic Integrity(2016)

Professor　MATSUNAGA Tsukasa

Faculty, Affiliation

College and School Educational Field

Laboratory

Academic Background

Career

Year & Month of Birth

Academic Society

Award

Specialities

Speciality Keywords

Research Themes

Molecular analysis of cellular responses to DNA damage

Functional analysis of DDB complex in cellular responses to DNA damage

Establishment and application of detection systems for UV-induced DNA damage

Books

Papers

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

Professor MATSUNAGA Tsukasa

Faculty, Affiliation

College and School Educational Field

Laboratory

Academic Background

Career

Year & Month of Birth

Academic Society

Award

Specialities

Speciality Keywords

Research Themes

Molecular analysis of cellular responses to DNA damage

Functional analysis of DDB complex in cellular responses to DNA damage

Establishment and application of detection systems for UV-induced DNA damage

Books

Papers

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

Professor　MATSUNAGA Tsukasa