Professor NISHIYAMA, Masaaki
Faculty, Affiliation
Institute for Frontier Science Initiative Social Brain Development Research Unit, Next Generation Medical Development Research Core
Professor
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Histology and Cell Biology, Graduate School of Medical Sciences TEL:076-265-2150 FAX:076-234-4220
Academic Background
Career
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University(1996/05-)
Japan Science and Technology Agency(2005/04-)
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University(2008/04-)
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University(2009/05-)
Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University(2017/06-)
Department of Histology and Cell Biology, Graduate School of Medical Sciences, Kanazawa University(2017/10-)
Graduate School of Medical Sciences, Kanazawa University(2018/04-2020/03)
Social Brain Development Research Unit, Next Generation Medical Development Research Core, Institute for Frontier Science Initiative, Kanazawa University(2024/01-)
Year & Month of Birth
Academic Society
THE JAPAN SOCIETY OF HEPATOLOGY
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
THE JAPANESE ASSOCIATION OF ANATOMISTS
Award
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
THE JAPANESE ASSOCIATION OF ANATOMISTS
Specialities
Molecular biology、Cell biology、Neurophysiology/General neuroscience、Psychiatric science、Tumor biology
Speciality Keywords
Research Themes
Functional analysis of candidate genes responsible for autism spectrum disorders
Regulatory mechanisms of aging and cancer by chromatin remodeling
Elucidating the mechanisms of spermatogenesis and male infertility
Books
Papers
- CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Yuta Katayama,*Masaaki Nishiyama,Hirotaka Shoji,Yasuyuki Ohkawa,Atsuki Kawamura,Tetsuya Sato,Mikita Suyama,Toru Takumi,Tsuyoshi Miyakawa,*Keiichi I Nakayama (*Corresponding authors) Nature 537 7622 675 2016/09/29
- A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain. Daisuke Ino,Yudai Tanaka,Hiroshi Hibino,Masaaki Nishiyama Nature methods 2022/09/22
- The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Toshiro Moroishi,Masaaki Nishiyama,Yukiko Takeda,Kazuhiro Iwai,Keiichi I Nakayama Cell metabolism 14 3 339 2011/09/07
- CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Masaaki Nishiyama,Kiyotaka Oshikawa,Yu-ichi Tsukada,Tadashi Nakagawa,Shun-ichiro Iemura,Tohru Natsume,Yuhong Fan,Akira Kikuchi,Arthur I Skoultchi,Keiichi I Nakayama Nature cell biology 11 2 172 2009/02
- Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells. Yoshiharu Muto,*Masaaki Nishiyama,Akihiro Nita,Toshiro Moroishi,*Keiichi I Nakayama (*Corresponding authors) Nature communications 8 16114 2017/07/17
- Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. Yoshiharu Muto,Toshiro Moroishi,Kazuya Ichihara,*Masaaki Nishiyama,Hideyuki Shimizu,Hidetoshi Eguchi,Kyoji Moriya,Kazuhiko Koike,Koshi Mimori,Masaki Mori,Yuta Katayama,*Keiichi I Nakayama (*Corresponding authors) The Journal of experimental medicine 216 4 950 2019/04/01
- The autism-associated protein CHD8 is required for cerebellar development and motor function. Atsuki Kawamura,Yuta Katayama,Wataru Kakegawa,Daisuke Ino,Masaaki Nishiyama,Michisuke Yuzaki,Keiichi I Nakayama Cell reports 35 1 108932 2021/04/06
- The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells. Akihiro Nita,Yoshiharu Muto,Yuta Katayama,Akinobu Matsumoto,*Masaaki Nishiyama,*Keiichi I Nakayama. (*Corresponding authors) Cell reports 34 5 108688 2021/02/02
- The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis. Yasuyuki Kita,Yuta Katayama,Taichi Shiraishi,Takeru Oka,Tetsuya Sato,Mikita Suyama,Yasuyuki Ohkawa,Keishi Miyata,Yuichi Oike,Michiko Shirane,*Masaaki Nishiyama,*Keiichi I Nakayama (*Corresponding authors) Cell reports 23 7 1988 2018/05/15
- The complex etiology of autism spectrum disorder due to missense mutations of CHD8 Taichi Shiraishi,Yuta Katayama,Masaaki Nishiyama,Hirotaka Shoji,Tsuyoshi Miyakawa,Taisuke Mizoo,Akinobu Matsumoto,Atsushi Hijikata,Tsuyoshi Shirai,Kouta Mayanagi,Keiichi I. Nakayama Molecular Psychiatry 2024/03/05
- Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression. Kenta Nitahara,Atsuki Kawamura,Yuka Kitamura,Kiyoko Kato,Satoshi H Namekawa,Masaaki Nishiyama Nucleic acids research 2024/01/16
- Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis Yudai Tanaka,Takuto Nakata,Hiroshi Hibino,Masaaki Nishiyama,Daisuke Ino PLOS ONE 18 7 e0288930 2023/07/20
- Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons. Atsuki Kawamura,Masaaki Nishiyama Communications biology 6 1 593 2023/06/02
- Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism. Stanislav M Cherepanov,Maria Gerasimenko,Teruko Yuhi,Kazumi Furuhara,Chiharu Tsuji,Shigeru Yokoyama,Keiichi I Nakayama,Masaaki Nishiyama,Haruhiro Higashida BMC neuroscience 22 1 32 2021/05/01
- Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain. Atsuki Kawamura,Yoshifumi Abe,Fumiko Seki,Yuta Katayama,Masaaki Nishiyama,Norio Takata,Kenji F Tanaka,Hideyuki Okano,Keiichi I Nakayama Molecular brain 13 1 160 2020/11/23
- Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development. Yuhei Yamauchi,Akihiro Nita,Masaaki Nishiyama,Yoshiharu Muto,Hideyuki Shimizu,Hirokazu Nakatsumi,Keiichi I Nakayama Genes to cells : devoted to molecular & cellular mechanisms 25 6 427 2020/06
- Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice. Atsuki Kawamura,Yuta Katayama,*Masaaki Nishiyama,Hirotaka Shoji,Kota Tokuoka,Yoshifumi Ueta,Mariko Miyata,Tadashi Isa,Tsuyoshi Miyakawa,Akiko Hayashi-Takagi,*Keiichi I Nakayama. (*Corresponding authors) Human molecular genetics 29 8 1274 2020/05/28
- FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Takayoshi Yamauchi,*Masaaki Nishiyama,Toshiro Moroishi,Atsuki Kawamura,*Keiichi I Nakayama (*Corresponding authors) Molecular and cellular biology 37 8 2017/04/15
- FBXL12 regulates T-cell differentiation in a cell-autonomous manner. Akihiro Nita,*Masaaki Nishiyama,Yoshiharu Muto,*Keiichi I Nakayama (*Corresponding authors) Genes to cells : devoted to molecular & cellular mechanisms 21 5 517 2016/05
- FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Masaaki Nishiyama,Akihiro Nita,Kanae Yumimoto,Keiichi I Nakayama Stem cells (Dayton, Ohio) 33 11 3327 2015/11
- MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Takayoshi Yamauchi,Masaaki Nishiyama,Toshiro Moroishi,Kanae Yumimoto,Keiichi I Nakayama Molecular and cellular biology 34 17 3321 2014/09
- HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. Toshiro Moroishi,Takayoshi Yamauchi,Masaaki Nishiyama,Keiichi I Nakayama The Journal of biological chemistry 289 23 16430 2014/06/06
- Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L. Yasuyuki Kita,Masaaki Nishiyama,Keiichi I Nakayama Genes to cells : devoted to molecular & cellular mechanisms 17 7 536 2012/07
- Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. Masaaki Nishiyama,Arthur I Skoultchi,Keiichi I Nakayama Molecular and cellular biology 32 2 501 2012/01
- Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation. Yo Fujii,Masayoshi Yada,Masaaki Nishiyama,Takumi Kamura,Hidehisa Takahashi,Ryosuke Tsunematsu,Etsuo Susaki,Tadashi Nakagawa,Akinobu Matsumoto,Keiichi I Nakayama Cancer science 97 8 729 2006/08
- Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Ryosuke Tsunematsu,Masaaki Nishiyama,Shuhei Kotoshiba,Toru Saiga,Takumi Kamura,Keiichi I Nakayama Molecular and cellular biology 26 16 6157 2006/08
- Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Masaaki Nishiyama,Keiko Nakayama,Ryosuke Tsunematsu,Tadasuke Tsukiyama,Akira Kikuchi,Keiichi I Nakayama Molecular and cellular biology 24 19 8386 2004/10
- Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. Masayoshi Yada,Shigetsugu Hatakeyama,Takumi Kamura,Masaaki Nishiyama,Ryosuke Tsunematsu,Hiroyuki Imaki,Noriko Ishida,Fumihiko Okumura,Keiko Nakayama,Keiichi I Nakayama The EMBO journal 23 10 2116 2004/05/19
- Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. Ryosuke Tsunematsu,Keiko Nakayama,Yuichi Oike,Masaaki Nishiyama,Noriko Ishida,Shigetsugu Hatakeyama,Yasumasa Bessho,Ryoichiro Kageyama,Toshio Suda,Keiichi I Nakayama The Journal of biological chemistry 279 10 9417 2004/03/05
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「精巣－脳連関に基づく自閉症発症メカニズムの解明と新規治療法の開発」(2022-2023)
○「非ドメイン型バイオポリマーによるクロマチン制御と発がん機構の解明」(2022-2023)
○「クロマチンリモデリング異常による発達障害の包括的理解と治療応用」(2021-2023)
○2021「ヒト型モデルマウスを用いた自閉症の神経回路の同定と治療への応用」(2020-2021)
○2021「自閉症と聴覚障害の併発メカニズムの解明と治療への応用」(2020-2021)
○「自閉症は大人になっても治せるか？」(2018-2019)
○「ヒト型自閉症モデルマウスによる発症メカニズムの解明と創薬開発への応用」(2018-2020)
○「ヒト型自閉症モデルマウスによる個性の形成メカニズムの解明」(2017-2018)
○「新規自閉症モデルマウスにおけるグリア機能制御の解明と治療への応用」(2016-2017)
○「幹細胞老化と個体老化のエピジェネティック制御機構の解明」(2015-2017)
○「クロマチンリモデリングによる幹細胞老化と癌の制御機構の解明」(2015-2016)
○「ユビキチン化による鉄代謝制御システムの解明」(2013-2014)
○「クロマチンリモデリングによる老化と癌の制御機構の解明」(2012-2013)
○「CHD8/ヒストンH1複合体による老化とがんのエピジェネティック制御機構の研究」(2010-2011)
○「Duplin/CHD8によるp53の機能抑制と発がんに関する研究」(2008-2009)
○「クロマチンリモデリング因子CHD8によるアポトーシス制御機構の解明」(2007-2008)
○「p53シグナルを抑制する新規がん遺伝子Duplinの発見と機能解析」(2006-2007)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Histology(2022)
○Histology 1(2022)
○Histology 2(2022)
○Basic Human Anatomy(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Histology(2021)
○Presentation and Debate(2021)
○Histology(2020)
○Histology(2019)
○Histology(2018)
Classes (Graduate Schools)
○Histology and Cell Biology(2022)
○Principles of AnatomyⅠ(2022)
○Principles of AnatomyⅡ(2022)
○Human Body: Structures a(2022)
○Human Body: Structures b(2022)
○Introduction to Basic Medical Science(2022)
○Medical Sciences(2022)
○Integrated Nano Neuroscience(2022)
○Histology and Embryology(2021)
○Principles of AnatomyⅠ(2021)
○Principles of AnatomyⅡ(2021)
○Human Body: Structures a(2021)
○Human Body: Structures b(2021)
○Medical Sciences(2021)
○Integrated Nano Neuroscience(2021)
○Histology and Embryology(2020)
○Principles of AnatomyⅠ(2020)
○Principles of AnatomyⅡ(2020)
○Human Body: Structures a(2020)
○Human Body: Structures b(2020)
○Introduction to Basic Medical Science(2020)
○Introduction to Basic Medical Science(2020)
○Histology and Embryology(2019)
○Principles of Anatomy(2019)
○Human Body: Structures(2019)
○Medical Sciences(2019)
○Introduction to Basic Medical Science(2019)
○Introduction to Basic Medical Science(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○Histology and Embryology(2018)
○Principles of Anatomy(2018)
○Human Body: Structures(2018)
○Medical Sciences(2018)