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Researcher Information

last modified:2021/03/20

Associate Professor HIRAYASU, Kohyuki

Mail

Faculty, Affiliation

ADVANCED PREVENTIVE MEDICAL SCIENCES RESEARCH CENTER

College and School Educational Field


School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Academic Background

Career

JSPS(2008/04/01-2010/03/31)
Osaka University(2010/04/01-2012/03/31)
Osaka University(2012/04/01-2017/12/31)
Kanazawa University(2018/01/01-)

Year & Month of Birth

1979/05

Academic Society

Japanese Society for Bacteriology

Award






Specialities

Immunology、Human genetics、Microbiology

Speciality Keywords

NK cell receptor, KIR, LILR, Leukocyte Receptor Complex (LRC)

Research Themes

Books

Papers

  •  LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang F, Li L, Deng H, Tang H, Sadek AH, Zhang L, Huang T, Zou Y, Chen B, Zhu H, Arase H, Xia N, Jiang Y, Collins R, You MJ, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao XC, An Z, Zheng J, Zhang N, Zhang CC Nature. 562 605-609 2018
  •  Leukocyte Immunoglobulin-Like Receptor (LILR). Hirayasu K, Arase H. Encyclopedia of Signaling Molecules (2nd Edition). 2854-2861 2018
  •  Heightened BRAF and BRAF pseudogene expression levels in two Japanese patients with Erdheim-Chester disease. Murakami Y, Wataya-Kaneda M, Kitayama K, Arase N, Murota H, Hirayasu K, Arase H, Katayama I. J Cutan Immunol Allergy 1 16-22 2018
  •  Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Saito F., Hirayasu K. (Co-first author), Satoh T., Wang CW., Lusingu J., Arimori T., Shida K., Palacpac NMQ., Itagaki S., Iwanaga S., Takashima E., Tsuboi T., Kohyama M., Suenaga T., Colonna M., Takagi J., Lavstsen T., Horii T., Arase H. Nature. 552 101-105 2017
  •  Myeloperoxidase/HLA class II complexes recognized by microscopic polyangiitis autoantibodies. Hiwa R., Ohmura K., Arase N., Jin H., Hirayasu K., Kohyama M., Suenaga T., Saito F., Terao C., Atsumi T., Iwatani H., Mimori T, & Arase H. Arthritis Rheumatol. 69 2069-2080 2017

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  •  Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Hirayasu K., Saito F., Suenaga T., Shida K., Arase N., Oikawa K., Yamaoka T., Murota H., Chibana H., Nakagawa I., Kubori T., Nagai H., Nakamaru Y., Katayama I., Colonna M. & Arase H. Nature Microbiology 1 16054 2016
  •  beta2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Tanimura K., Jin H., Suenaga T., Morikami S., Arase N., Kishida K., Hirayasu K., Kohyama M., Ebina Y., Yasuda S., Horita T., Takasugi K., Ohmura K., Yamamoto K., Katayama I., Sasazuki T., Lanier L. L., Atsumi T., Yamada H. & Arase H. Blood. 125 2835-2844 2015
  •  Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations. Hirayasu K, Arase H. J Hum Genet. 60 703-708 2015
  •  Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion. Suenaga T., Matsumoto M., Arisawa F., Kohyama M., Hirayasu K., Mori Y. & Arase H. J Biol Chem. 290 19833-19843 2015
  •  Negative regulation of DSS-induced experimental colitis by PILRα. Kishida K., Kohyama M., Kurashima Y., Kogure Y., Wang J., Hirayasu K., Suenaga T., Kiyono H., Kunisawa J. & Arase H. Int Immunol. 27 307-314 2015
  •  Engineering large viral DNA genomes using the CRISPR-Cas9 system. Suenaga T., Kohyama M., Hirayasu K. & Arase H. Microbiol Immunol. 58 513-522 2014
  •  Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Jin H., Arase N., Hirayasu K., Kohyama M., Suenaga T., Saito F., Tanimura K., Matsuoka S., Ebina K., Shi K., Toyama-Sorimachi N., Yasuda S., Horita T., Hiwa R., Takasugi K., Ohmura K., Yoshikawa H., Saito T., Atsumi T., Sasazuki T., Katayama I., Lanier L. L. & Arase H. Proc Natl Acad Sci USA. 111 3787-3792 2014
  •  A motif in LILRB2 critical for Angptl2 binding and activation. Deng M., Lu Z., Zheng J., Wan X., Chen X., Hirayasu K., Sun H., Lam Y., Chen L., Wang Q., Song C., Huang N., Gao G. F., Jiang Y., Arase H. & Zhang C. C. Blood. 124 924-935 2014
  •  Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. Jiang Y., Arase N., Kohyama M., Hirayasu K., Suenaga T., Jin H., Matsumoto M., Shida K., Lanier L. L., Saito T. & Arase H. Int Immunol. 25 235-246 2013
  •  Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. Hirayasu K., Ohashi J., Kashiwase K., Hananantachai H., Naka I., Ogawa A., Takanashi M., Satake M., Nakajima K., Parham P., Arase H., Tokunaga K., Patarapotikul J. & Yabe T. PLoS Pathog. 8 e1002565 2012
  •  Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study. Harkensee C., Oka A., Onizuka M., Middleton P. G., Inoko H., Hirayasu K., Kashiwase K., Yabe T., Nakaoka H., Gennery A. R., Ando K., Morishima Y. Blood. 119 6365-6372 2012
  •  Association of HLA-A, -B, and-DRB1 with pulmonary tuberculosis in western Javanese Indonesia. Yuliwulandari R., Sachrowardi Q., Nakajima H., Kashiwase K., Hirayasu K., Mabuchi A., Sofro A. S. M. & Tokunaga K. Hum Immunol. 71 697-701 2010
  •  Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation. Yabe T., Matsuo K., Hirayasu K., Kasbiwase K., Kawamura-Ishii S., Tanaka H., Ogawa A., Takanshi M., Satake M., Nakajima K., Tokunaga K., Inoko H., Saji H., Ogawa S., Juji T., Sasazuki T., Kodera Y. & Morishima Y. Biol Blood Marrow Transplant. 14 75-87 2008
  •  Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians. Hirayasu K., Ohashi J., Tanaka H., Kashiwase K., Ogawa A., Takanashi M., Satake M., Jia G. J., Chimge N. O., Sideltseva E. W., Tokunaga K. & Yabe T.  Am J Hum Genet. 82 1075-1083 2008
  •  Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection. Hirayasu K, Ohashi J, Kashiwase K, Takanashi M, Satake M, Tokunaga K, Yabe T. Hum Genet. 119 436-443 2006
  •  DigiTag assay for multiplex single nucleotide polymorphism typing with high success rate. Nishida N, Tanabe T, Hashido K, Hirayasu K, Takasu M, Suyama A, Tokunaga K. Anal Biochem. 346 281-288 2005

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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