- Top Page
- Profile
last modified：2025/03/29
Associate Professor HIRAYASU, Kohyuki
Faculty, Affiliation
Advanced Preventive Medical Sciences Research Center
College and School Educational Field
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Academic Background
Career
JSPS(2008/04/01-2010/03/31)
Osaka University(2010/04/01-2012/03/31)
Osaka University(2012/04/01-2017/12/31)
Kanazawa University(2018/01/01-)
Year & Month of Birth
1979/05
Academic Society
Japanese Society for Bacteriology
Award
Specialities
Immunology、Human genetics、Microbiology
Speciality Keywords
NK cell receptor, KIR, LILR, Leukocyte Receptor Complex (LRC)
Research Themes
Books
Papers
- Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Kouyuki Hirayasu,Fumiji Saito,Tadahiro Suenaga,Kyoko Shida,Noriko Arase,Keita Oikawa,Toshifumi Yamaoka,Hiroyuki Murota,Hiroji Chibana,Ichiro Nakagawa,Tomoko Kubori,Hiroki Nagai,Yuji Nakamaru,Ichiro Katayama,Marco Colonna,Hisashi Arase Nature microbiology 1 6 16054 2016/04/25
- Single nucleotide polymorphisms and outcome risk in unrelated mismatched hematopoietic stem cell transplantation: an exploration study Christian Harkensee,Akira Oka,Makoto Onizuka,Peter G. Middleton,Hidetoshi Inoko,Kouyuki Hirayasu,Koichi Kashiwase,Toshio Yabe,Hirofumi Nakaoka,Andrew R. Gennery,Kiyoshi Ando,Yasuo Morishima BLOOD 119 26 6365 2012/06
- Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA Kouyuki Hirayasu,Jun Ohashi,Koichi Kashiwase,Hathairad Hananantachai,Izumi Naka,Atsuko Ogawa,Minoko Takanashi,Masahiro Satake,Kazunori Nakajima,Peter Parham,Hisashi Arase,Katsushi Tokunaga,Jintana Patarapotikul,Toshio Yabe PLOS PATHOGENS 8 3 e1002565 2012/03
- Association of HLA-A, -B, and-DRB1 with pulmonary tuberculosis in western Javanese Indonesia Rika Yuliwulandari,Qomariyah Sachrowardi,Humiaki Nakajima,Koichi Kashiwase,Kouyuki Hirayasu,Akihiko Mabuchi,Abdul Salam Mudzakir Sofro,Katsushi Tokunaga HUMAN IMMUNOLOGY 71 7 697 2010/07
- Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians Kouyuki Hirayasu,Jun Ohashi,Hidenori Tanaka,Koichi Kashiwase,Atsuko Ogawa,Minoko Takanashi,Masahiro Satake,Guan Jun Jia,Nyam-Osor Chimge,Elena W. Sideltseva,Katsushi Tokunaga,Toshio Yabe AMERICAN JOURNAL OF HUMAN GENETICS 82 5 1075 2008/05
- Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection K Hirayasu,J Ohashi,K Kashiwase,M Takanashi,M Satake,K Tokunaga,T Yabe HUMAN GENETICS 119 4 436 2006/05
- Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules Yan Jiang,Noriko Arase,Masako Kohyama,Kouyuki Hirayasu,Tadahiro Suenaga,Hui Jin,Maki Matsumoto,Kyoko Shida,Lewis L. Lanier,Takashi Saito,Hisashi Arase INTERNATIONAL IMMUNOLOGY 25 4 235 2013/04
- DigiTag assay for multiplex single nucleotide polymorphism typing with high success rate N Nishida,T Tanabe,K Hashido,K Hirayasu,M Takasu,A Suyama,K Tokunaga ANALYTICAL BIOCHEMISTRY 346 2 281 2005/11
- Leukocyte Immunoglobulin-Like Receptor (LILR). Hirayasu K,Arase H Encyclopedia of Signaling Molecules. 2nd Edition. Springer. 2854 2018/01
- Donor killer immunoglobulin-like receptor (KIR) genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T cell-replete unrelated bone marrow transplantation Toshio Yabe,Keitaro Matsuo,Kouyuki Hirayasu,Koichi Kasbiwase,Sumiyo Kawamura-Ishii,Hidenori Tanaka,Astuko Ogawa,Minoko Takanshi,Masahiro Satake,Kazunori Nakajima,Katsushi Tokunaga,Hidetoshi Inoko,Hiroo Saji,Seishi ogawa,Takeo Juji,Takehiko Sasazuki,Yoshihisa Kodera,Yasuo Morishima BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 14 1 75 2008/01
- A motif in LILRB2 critical for Angptl2 binding and activation Mi Deng,Zhigang Lu,Junke Zheng,Xuan Wan,Xiaoli Chen,Kouyuki Hirayasu,Hanzi Sun,Yeeling Lam,Liping Chen,Qihui Wang,Chun Song,Niu Huang,George F. Gao,Youxing Jiang,Hisashi Arase,Cheng Cheng Zhang BLOOD 124 6 924 2014/08
- Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild‐type KIT patients Noriko Arase,Mari Wataya‐Kaneda,Hiroyuki Murota,Yukinobu Nakagawa,Toshifumi Yamaoka,Saori Itoi‐Ochi,Kouyuki Hirayasu,Hisashi Arase,Manabu Fujimoto,Ichiro Katayama The Journal of Dermatology 47 4 426 2020/04
- Negative regulation of DSS-induced experimental colitis by PILR alpha Kazuki Kishida,Masako Kohyama,Yosuke Kurashima,Yuta Kogure,Jing Wang,Kouyuki Hirayasu,Tadahiro Suenaga,Hiroshi Kiyono,Jun Kunisawa,Hisashi Arase INTERNATIONAL IMMUNOLOGY 27 6 307 2015/06
- Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion Tadahiro Suenaga,Maki Matsumoto,Fuminori Arisawa,Masako Kohyama,Kouyuki Hirayasu,Yasuko Mori,Hisashi Arase JOURNAL OF BIOLOGICAL CHEMISTRY 290 32 19833 2015/08
- LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration Mi Deng,Xun Gui,Jaehyup Kim,Li Xie,Weina Chen,Zunling Li,Licai He,Yuanzhi Chen,Heyu Chen,Weiguang Luo,Zhigang Lu,Jingjing Xie,Hywyn Churchill,Yixiang Xu,Zhan Zhou,Guojin Wu,Chenyi Yu,Samuel John,Kouyuki Hirayasu,Nam Nguyen,Xiaoye Liu,Fangfang Huang,Leike Li,Hui Deng,Haidong Tang,Ali H. Sadek,Lingbo Zhang,Tao Huang,Yizhou Zou,Benjamin Chen,Hong Zhu,Hisashi Arase,Ningshao Xia,Youxing Jiang,Robert Collins,M. James You,Jade Homsi,Nisha Unni,Cheryl Lewis,Guo-Qiang Chen,Yang-Xin Fu,X. Charlene Liao,Zhiqiang An,Junke Zheng,Ningyan Zhang,Cheng Cheng Zhang Nature 562 7728 605 2018/10 ?
- Heightened BRAF and BRAF pseudogene expression levels in 2 Japanese patients with Erdheim-Chester disease Yukako Murakami,Mari Wataya-Kaneda,Kazuko Kitayama,Noriko Arase,Hiroyuki Murota,Kouyuki Hirayasu,Hisashi Arase,Ichiro Katayama Journal of Cutaneous Immunology and Allergy 1 1 16 2018/04 ?
- Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Fumiji Saito,Kouyuki Hirayasu(co-first authors),Takeshi Satoh,Christian W Wang,John Lusingu,Takao Arimori,Kyoko Shida,Nirianne Marie Q Palacpac,Sawako Itagaki,Shiroh Iwanaga,Eizo Takashima,Takafumi Tsuboi,Masako Kohyama,Tadahiro Suenaga,Marco Colonna,Junichi Takagi,Thomas Lavstsen,Toshihiro Horii,Hisashi Arase Nature 552 7683 101 2017/12/07
- Myeloperoxidase/HLA Class II Complexes Recognized by Autoantibodies in Microscopic Polyangiitis. Ryosuke Hiwa,Koichiro Ohmura,Noriko Arase,Hui Jin,Kouyuki Hirayasu,Masako Kohyama,Tadahiro Suenaga,Fumiji Saito,Chikashi Terao,Tatsuya Atsumi,Hirotsugu Iwatani,Tsuneyo Mimori,Hisashi Arase Arthritis & rheumatology (Hoboken, N.J.) 69 10 2069 2017/10
- Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations Kouyuki Hirayasu,Hisashi Arase JOURNAL OF HUMAN GENETICS 60 11 703 2015/11
- beta 2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome Kenji Tanimura,Hui Jin,Tadahiro Suenaga,Satoko Morikami,Noriko Arase,Kazuki Kishida,Kouyuki Hirayasu,Masako Kohyama,Yasuhiko Ebina,Shinsuke Yasuda,Tetsuya Horita,Kiyoshi Takasugi,Koichiro Ohmura,Ken Yamamoto,Ichiro Katayama,Takehiko Sasazuki,Lewis L. Lanier,Tatsuya Atsumi,Hideto Yamada,Hisashi Arase BLOOD 125 18 2835 2015/04
- Engineering large viral DNA genomes using the CRISPR-Cas9 system Tadahiro Suenaga,Masako Kohyama,Kouyuki Hirayasu,Hisashi Arase MICROBIOLOGY AND IMMUNOLOGY 58 9 513 2014/09
- Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Hui Jin,Noriko Arase,Kouyuki Hirayasu,Masako Kohyama,Tadahiro Suenaga,Fumiji Saito,Kenji Tanimura,Sumiko Matsuoka,Kosuke Ebina,Kenrin Shi,Noriko Toyama-Sorimachi,Shinsuke Yasuda,Tetsuya Horita,Ryosuke Hiwa,Kiyoshi Takasugi,Koichiro Ohmura,Hideki Yoshikawa,Takashi Saito,Tatsuya Atsumi,Takehiko Sasazuki,Ichiro Katayama,Lewis L Lanier,Hisashi Arase Proceedings of the National Academy of Sciences of the United States of America 111 10 3787 2014/03/11
- Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2. Akihito Sakoguchi,Fumiji Saito,Kouyuki Hirayasu,Kyoko Shida,Sumiko Matsuoka,Sawako Itagaki,Wataru Nakai,Masako Kohyama,Tadahiro Suenaga,Shiroh Iwanaga,Toshihiro Horii,Hisashi Arase Biochemical and biophysical research communications 548 167 2021/04/09
- Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice. Mei-Tzu Su,Masanori Inui,Yi Li Wong,Maika Takahashi,Akiko Sugahara-Tobinai,Karin Ono,Shotaro Miyamoto,Keiichi Murakami,Ari Itoh-Nakadai,Dai Kezuka,So Itoi,Shota Endo,Kouyuki Hirayasu,Hisashi Arase,Toshiyuki Takai International immunology 33 8 447 2021/07/23
- Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. Kouyuki Hirayasu,Jinwen Sun,Gen Hasegawa,Yuko Hashikawa,Kazuyoshi Hosomichi,Atsushi Tajima,Katsushi Tokunaga,Jun Ohashi,Rikinari Hanayama Journal of human genetics 66 7 739 2021/07
- Molecular mechanism of the recognition of bacterially cleaved immunoglobulin by the immune regulatory receptor LILRA2 Rika Yamazaki,Atsushi Furukawa,Kouyuki Hirayasu,Kohei Yumoto,Hideo Fukuhara,Hisashi Arase,Katsumi Maenaka Journal of Biological Chemistry 295 28 9531 2020/07/10
- 免疫活性化受容体LILRA2のANGPTL6認識機構の解明(The understanding of binding mechanism of LILRA2 and ANGPTL6) 王 嘉き,古川 敦,山崎 莉佳,平安 恒幸,門松 毅,尾池 雄一,荒瀬 尚,前仲 勝実 日本薬学会年会要旨集 141年会 28P01 2021/03