Jump to contents

Researcher Information

last modified:2024/06/24

Assistant Professor TSUNO, Yusuke

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


Department of Integrative Neurophysiology TEL:076-265-2173 FAX:076-234-4224

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo, Department of Physiology, Graduate School of Medicine Doctor 2009 Completed
The University of Tokyo, Department of Physiology, Graduate School of Medicine Master 2005 Completed
【Academic background(Bachelor's Degree)】
The University of Tokyo, Laboratory of Neurobiophysics, Faculty of Pharmaceutical Sciences 2003


Kanazawa University, Graduate School of Medical Science Department of Integrative Neurophysiology Assistant Professor(2018/04-)
University of Utah Department of Neurobiology and Anatomy Postdoctoral Fellow(2015/09-2018/03)
Boston University Department of Psychological and Brain Sciences Postdoctoral Associate(2010/01-2015/08)
Boston University Department of Biology Research Associate(2009/04-2009/12)

Year & Month of Birth

Academic Society

The Japan Neuroscience Society
Society for Neuroscience
Japanese Society for Chronobiology
The Physiological Society of Japan


○The 2019-2020 Interstellar Initiative, Outstanding Team Presentation Award(2020/02/21)


Neurophysiology/General neuroscience

Speciality Keywords

Electrophysiology, Imaging, Learning, Memory, Sleep, Olfactory System, Circadian Rhythm, Acetylcholine

Research Themes



  •  In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus Kaito Onodera,Yusuke Tsuno,Yuichi Hiraoka,Kohichi Tanaka,Takashi Maejima,Michihiro Mieda Scientific Reports 13 1 16974 2023/10/09
  •  In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Mohan Wang,Ayako Matsui,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda PLOS Biology 21 8 e3002281 2023/08/29
  •  Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons. Md Tarikul Islam,Florian Rumpf,Yusuke Tsuno,Shota Kodani,Takeshi Sakurai,Ayako Matsui,Takashi Maejima,Michihiro Mieda Current Biology 32 18 3871 2022/07/29
  •  Cell Type-Specific Genetic Manipulation and Impaired Circadian Rhythms in Vip tTA Knock-In Mice. Yubo Peng,Yusuke Tsuno,Ayako Matsui,Yuichi Hiraoka,Kohichi Tanaka,Shin-Ichi Horike,Takiko Daikoku,Michihiro Mieda Frontiers in Physiology 13 895633 2022/05/03
  •  GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behavior. Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda Proceedings of the National Academy of Sciences 118 e2010168118 2021/02/09 

show all

  •  Circadian rhythm mechanism in the suprachiasmatic nucleus and its relation to the olfactory system. Yusuke Tsuno, Michihiro Mieda Front. Neural Circuits 18 1385908 2024/03/25

Conference Presentations

  • In vivo analysis of suprachiasmatic nucleus circadian rhythm using neuronal cell type-specific knockout mice(conference:Joint Congress of the 45th Annual Meeting of Japanese Society of Sleep Research, the 30th Annual Meeting of Japanese Society for Chronobiology)(2023/09/15)


Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research

○Grant-in-Aid for Scientific Research(C)「Elucidation of circadian rhythm mechanisms using cell type-specific photometry」(2023-2025) 
○Grant-in-Aid for Scientific Research(C)「In vivo analysis of suprachiasmatic nucleus AVP neurons using multiple type sensors」(2020-2022) 
○Grant-in-Aid for Research Activity start-up「Cell-type specific calcium imaging of suprachiasmatic nucleus with fiber photometry」(2018-2019) 

Competitive research funding,Contribution

○"Cholinergic input in accelerated versus slow cognitive decline upon aging" Interstellar Initiative Beyond (Japan Agency for Medical Research and Development)(2022-2022)
○"Cholinergic input in fast versus slow cognitive decline upon aging" Healthy Longevity Global Grand Challenge, Catalyst Award  (Japan Agency for Medical Research and Development)(2020-2021)

Collaborative research,Consignment study

Classes (Bachelors)


Classes (Graduate Schools)

○The Function of the Human Body(2023)
○The Function of the Human Body(2022)
○Molecular Neuroscience and Integrative Physiology(2021)
○The Function of the Human Body(2021)
○Molecular Neuroscience and Integrative Physiology(2020)
○The Function of the Human Body(2020)
○Molecular Neuroscience and Integrative Physiology(2019)
○The Function of the Human Body(2019)
○Molecular Neuroscience and Integrative Physiology(2018)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top