last modified：2024/09/18
Associate Professor ENDO Yoshio
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Division of Frontier Engineering, Graduate School of Natural Science and Technology
Division of Pharmacy, Graduate School of Medical Science
Laboratory
Central Research Resource Branch
Academic Background
Career
Fellowship of the Japan Society for the Promotion of Science for Japanese Junior Scientist(1989/04/01-1991/03/31)
Cancer Research Institute,Kanazawa University Division of Experimental Therapeutics(1991/04/01-1996/06/30)
Kanazawa University Cancer Research Institute(1996/07/01-2002/01/31)
Kanazawa University Cancer Research Institute(2002/02/01-)
Year & Month of Birth
Academic Society
The Japanese Cancer Association
The Pharmaceutical Society of Japan
Award
The Pharmaceutical Society of Japan
Specialities
Molecular Oncology、Functional biochemistry、Cell biology、
Speciality Keywords
Cancer metastasis, angiogenesis, photodynamic therapy, drug screening, antitumor nucleoside, drug resistance
Research Themes
Antitumor mechanisms of photodynamic therapy using 5-aminolevulinic acid
A precursor of PpIX, 5-aminolevulinic acid (ALA), is currently widely used for photodynamic diagnosis and photodynamic therapy (ALA-PDT) of various cancers. We have demonstrated that the sensitivity of cancer cells to ALA-PDT is determined by the functional balance between oligopeptide transporter PEPT1 and ATP-binding cassette transporter ABCG2. Recently, we developed cell lines with acquired resistance to ALA-PDT, using human gastric cancer MKN-45 cells, which showed high sensitivity to ALA-PDT. To determine the molecular mechanism of ALA-PDT resistance, we examined the gene expression profiles in resistant cell lines by microarray analysis. Now, we attempt to identify the molecular targets of ALA-PDT acquired resistance.
Development of effective diagnosis and therapy for metastatic cancer
Development of angiogenesis inhibitors as an anticancer drug
Mechanisms of antitumor action and resistance to antitumor nucleosides
Books
- Yoshihiro Uto, Chiaki Abe, Mana Futawaka, Hisatsugu Yamada, Masahide Tominaga and Yoshio Endo The Enzymes: Chick Chorioallantoic Membrane Model and Precision Cancer Therapy Elsevier 2019/11
- Yoshio Endo The Enzymes: Chick Chorioallantoic Membrane Model and Precision Cancer Therapy Elsevier 2019/11
- Yonemura Y, Bandou E, Kinoshita K, Kawamura T, Takahashi S, Endou Y, Sasaki T Effective therapy for peritoneal dissemination in gastric cancer. W.B.SAUNDERS COMPANY 2003/07
- Cancer and Metastasis--Basic and Clinical Aspects Nippon Rinsho 2003年11月増刊 49-54 2003/11
- VEGF-C/VEGFRS and cancer and metastasis Kluwer Academic Publishers 2001/10
Papers
- Metformin suppresses esophageal cancer progression through the radiation induced cellular senescence of cancer associated fibroblasts Sugimoto Y, Okamoto K, Saito H, Yamaguchi T, Kinoshita J, Nakamura K, Takino T, Endo Y, Ninomiya I, Ohta T, Inaki N ONCOLOGY REPORTS 52 4 129 2024/10
- Development of UTX-143, a selective sodium-hydrogen exchange subtype 5 inhibitor, using amiloride as a lead compound. Shinohara Y, Komiya Y, Morimoto K, Endo Y, Terashima M, Suzuki T, Takino T, Ninomiya I, Yamada H, Uto Y. Bioorg Med Chem. 99 117603 2024/01/14
- Overlapping role of c-Jun N-terminal kinase (JNK) 1 and 2 in imidazole ketone erastin-induced ferroptosis. Ravdandorj Odongoo, I. Ketut Gunarta, Purev Erdenebaatar, Ryusuke Suzuki, Makiko Meguro-Horike, Shin-ichi Horike, Yoshio Endo, Toshihiro Fujii, Rikiro Fukunaga, Katsuji Yoshioka Gene Reports 33 101813 2023/12
- The Development of Peritoneal Metastasis from Gastric Cancer and Rationale of Treatment According to the Mechanism. (Commentary) Yonemura Y, Ishibashi H, Mizumoto A, Tukiyama G, Liu Y, Wakama S, Sako S, Takao N, Kitai T, Katayama K, Kamada Y, Taniguchi K, Fujimoto D, Endou Y, Miura M J Clin Med 11 2 458 2022/01/17
- Structure-activity relationships of UTX-121 derivatives for the development of novel matrix metalloproteinase-2/9 inhibitors. Hirari Yamahana, Yuki Komiya, Takahisa Takino, Yoshio Endo, Hisatsugu Yamada, Chikako Asada, Yoshihiro Uto Chem Pharm Bull (Tokyo) 69 10 1017-1028 2021/10/01
- A novel celecoxib analog UTX-121 inhibits HT1080 cell invasion by modulating membrane-type 1 matrix metalloproteinase Yamahana H, Takino T, Endo Y, Yamada H, Suzuki T, Uto Y Biochem Biophys Res Commun 521 1 137-144 2020/01/01
- Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma Bolidong D, Domoto T, Uehara M, Sabit H, Okumura T, Endo Y, Nakada M, Ninomiya I, Miyashita T, Wong RW, Minamoto T. Sci Rep. 10 1 11807 2020/07/16
- The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes. Murakami Y, Kimura Y, Kawahara A, Mitsuyasu S, Miyake H, Tohyama K, Endo Y, Yoshida N, Imamura Y, Watari K, Ono M, Okamura T, Kuwano M. Oncotarget 10 23 2270-2281 2019/03/19
- Chicken egg tumor model and its application in personalized medicine Tamanoi A, Endo Y, Uto Y, Kusuhashi Y, Futawaka M, Matsumoto K 37 1 88-92 2019/01/01
- Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy Shinohara Y, Endo Y, Abe C, Shiba I, Ishizuka M, Tanaka T, Yonemura Y, Ogura SI, Tominaga M, Yamada H, Uto Y Photodiagnosis Photodyn Ther 20 182-188 2017/12
- Design and Synthesis of Novel Anti-metastatic Hypoxic Cytotoxin TX-2137 Targeting AKT Kinase Shiba I, Kouzaki R, Yamada H, Endo Y, Takino T, Sato H, Kitazato K, Kageji T, Nagahiro S, Uto Y Anticancer Res. 37 7 3877-3883 2017/07
- Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA) Yonemura Y, Endo Y, Canbay E, Liu Y, Ishibashi H, Mizumoto A, Hirano M, Imazato Y, Takao N, Ichinose M, Noguchi K, Li Y, Wakama S, Yamada K, Hatano K, Shintani H, Yoshitake H, Ogura SI Cancers 9 3 23 2017/03/01
- Activation of Matrix Metalloproteinase (MMP)-9 by Membrane-Type-1 Matrix Metalloproteinase/MMP-2 axis Stimulates Tumor Metastasis. Li Z, Takino T, Endo Y, Sato H. Cancer Sci. 2016/12/17
- Selection of Patients by Membrane Transporter Expressions for Aminolevulinic Acid (ALA)-Guided Photodynamic Detection of Peritoneal Metastases. Yutaka Yonemura, Yoshio Endo, Emel Canbay, Yang Liu, Haruaki Ishibashi, Kazuyoshi Takeshita, Akiyoshi Mizumoto, Masamitu Hirano, Nobuyuki Takao, Masumi Ichinose Yan Li, Shun-ichirou Ogura International Journal of Sciences 4 2015/09
- 5-Aminolevulinic Acid Fluorescence in Detection of Peritoneal Metastases. Yonemura Y, Canbay E, Ishibashi H, Nishino E, Endou Y, Sako S, Ogura S. Yonemura Y, Canbay E, Ishibashi H, Nishino E, Endou Y, Sako S, Ogura S Asian Pac J Cancer Prev. 17 4 2271-2275 2016/04
- 5-Aminolevulinic Acid Enhances Ultrasound-mediated Antitumor Activity via Mitochondrial Oxidative Damage in Breast Cancer. Shimamura Y, Tamatani D, Kuniyasu S, Mizuki Y, Suzuki T, Katsura H, Yamada H, Endo Y, Osaki T, Ishizuka M, Tanaka T, Yamanaka N, Kurahashi T, Uto Y Anticancer Res. 36 7 3607-3612 2016/07
- Effects of plasma membrane ABCB6 on 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in vitro: Tumor cell response to hypoxia. Matsumoto K, Hagiya Y, Endo Y, Nakajima M, Ishizuka M, Tanaka T, Ogura SI Photodiagnosis Photodiagnosis Photodyn Ther. 12 1 45-51 2015
- Cytoreductive Surgery Under Aminolevulinic Acid-Mediated Photodynamic Diagnosis Plus Hyperthermic Intraperitoneal Chemotherapy in Patients with Peritoneal Carcinomatosis from Ovarian Cancer and Primary Peritoneal Carcinoma: Results of a Phase I Trial Liu, Yang; Endo, Yoshio; Fujita, Takuji; Ishibashi, Haruaki; Nishioka, Toshihiro; Canbay, Emel; Li, Yan; Ogura, Shunichiro; Yonemura, Yutaka Annals of Surgical Oncology 21 13 4256-4262 2014/01/01
- Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos Uto, Yoshihiro; Tamatani, Dai; Mizuki, Yusuke; Endo, Yoshio; Nakanishi, Ikuo; Ohkubo, Kei; Fukuzumi, Shunichi; Ishizuka, Masahiro; Tanaka, Tohru; Kuchiike, Daisuke; Kubo, Kentaro; Inui, Toshio; Hori, Hitoshi Anticancer Research 34 8 4583-4588 2014/01/01
- A gene ontology-based microarray gene expression data analysis for diagnosing pseudomyxoma peritonei Katagiri, Hideki; Uno, Takeshi; Kato, Kosuke; Kuwano, Hiroaki; Sasaki, Kohei; Yonemura, Yutaka; Endo, Yoshio 2014 IEEE 7th International Workshop on Computational Intelligence and Applications, IWCIA 2014 - Proceedings 83-88 2014/01/01
- Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man: report of a case. Canbay E, Ishibashi H, Sako S, Kitai T, Nishino E, Hirano M, Mizumoto A, Endo Y, Ogura SI, Yonemura Y Surg Today. 44 3 373-377 2014/02
- Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model. Abe C, Uto Y, Kawasaki A, Noguchi C, Tanaka R, Yoshitomi T, Nagasaki Y, Endo Y, Hori H J Control Release. 182 67-72 2014/05
- Peritoneal cancer treatment. Yonemura Y, Canbay E, Endou Y, Ishibashi H, Mizumoto A, Miura M, Li Y, Liu Y, Takeshita K, Ichinose M, Takao N, Hirano M, Sako S, Tsukiyama G Expert Opin Pharmacother. 15 5 623-636 2014/04
- Evaluation of the sonosensitizing activities of 5-aminolevulinic acid and Sn(IV) chlorin e6 in tumor-bearing chick embryos. Uto Y, Tamatani D, Mizuki Y, Endo Y, Nakanishi I, Ohkubo K, Fukuzumi S, Ishizuka M, Tanaka T, Kuchiike D, Kubo K, Inui T, Hori H Anticancer Res. 34 8 4583-4587 2014/08
- Cytoreductive surgery under aminolevulinic acid-mediated photodynamic diagnosis plus hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from ovarian cancer and primary peritoneal carcinoma: results of a phase I trial. Liu Y, Endo Y, Fujita T, Ishibashi H, Nishioka T, Canbay E, Li Y, Ogura S, Yonemura Y Ann Surg Oncol. 21 13 4256-4262 2014/12
- Degalactosylated/Desialylated Human Serum Containing GcMAF Induces Macrophage Phagocytic Activity and In Vivo Antitumor Activity Kuchiike, Daisuke;Uto, Yoshihiro;Mukai, Hirotaka;Ishiyama, Noriko;Abe, Chiaki;Tanaka, Daichi;Kawai, Tomohito;Kubo, Kentaro;Mette, Martin;Inui, Toshio;Endo, Yoshio;Hori, Hitoshi ANTICANCER RESEARCH 33 7 2881-2885 2013
- Expression levels of PEPT1 and ABCG2 playkey roles in 5-aminolevulinic acid(ALA)-induced tumor-specificprotoporphyrin IX (PpIX) accumulation inbladder cancer. Hagiya Y, Fukuhara H, Matsumoto K, Endo Y, Nakajima M, Tanaka T, Okura I, Kurabayashi A, Furihata M, Inoue K, Shuin T, Ogura S Photodiagnosis Photodyn Ther. 10 3 288-295 2013/09
- Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man: report of a case. Canbay E, Ishibashi H, Sako S, Kitai T, Nishino E, Hirano M, Mizumoto A, Endo Y, Ogura SI, Yonemura Y SURGERY TODAY Epub ahead of print 2013/02
- Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy. Kitano A, Shimasaki T, Chikano Y, Nakada M, Hirose M, Higashi T, Ishigaki Y, Endo Y, Takino T, Sato H, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T PLoS One 8 2 e55289 2013/02
- Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase. Guo L, Takino T, Endo Y, Domoto T, Sato H JOURNAL OF BIOCHEMISTRY 152 5 425-432 2012/11
- Mechanisms of action and resistance of purine and pyrimidine antimetabolites in hematological malignancies Hematology 65 4 511-522 2012/10
- Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro. Hagiya Y, Endo Y (equal contribution), Yonemura Y, Takahashi K, Ishizuka M, Abe F, Tanaka T, Okura I, Nakajima M, Ishikawa T, Ogura S Photodiagnosis Photodyn Ther. 9 3 204-214 2012/09
- Effects of neoadjuvant intraperitoneal/systemic chemotherapy (bidirectional chemotherapy) for the treatment of patients with peritoneal metastasis from gastric cancer. Yonemura Y, Elnemr A, Endou Y, Ishibashi H, Mizumoto A, Miura M, Li Y Int J Surg Oncol. 2012 2012 2012/07
- Tumor Suppressor Protein p53-dependent Cell Death Induced by 5-Aminolevulinic Acid (ALA)-based Photodynamic Sensitization of Cancer cells in Vitro. Hagiya Y, Endo Y (equal contribution), Yonemura Y, Okura I, Ogura S ALA-Porphyrin Science 1 1 23-31 2012/06
- Surgical results of patients with peritoneal carcinomatosis treated with cytoreductive surgery using a new technique named aqua dissection. Yonemura Y, Elnemr A, Endou Y, Ishibashi H, Mizumoto A, Miura M, Li Y Gastroenterol Res Pract. 2012 2012 521487 2012/05
- Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy 1. Teng L, Nakada M, Zhao SG, Endo Y, Furuyama N, Nambu E, Pyko IV, Hayashi Y, Hamada JI BRITISH JOURNAL OF CANCER 104 5 798-807 2011/03
- Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo 2. Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, Nakata E, Hori H JOURNAL OF RADIATION RESEARCH 52 2 208-214 2011/03
- A GO similarity measurement method based on information contents and semantic values. Hideki Katagiri, Ichiro Nishizaki, Tomohiro Hayashida, Yoshio Endo, Hisashi Miyamori and Junya Hirai Biomedical Soft Computing and Human Sciences 17 1 29-35 2011/01
- Surgical treatment for peritoneal carcinomatosis from gastric cancer. Yonemura Y,Endou Y,Sasaki T,Hirano M,Mizumoto A,Matsuda T,Takao N,Ichinose M,Miura M,Li Y EUROPEAN JOURNAL OF SURGICAL ONCOLOGY 36 12 1131-1138 2010/12
- Influence of cytidine deaminase on antitumor activity of 2'-deoxycytidine analogues in vitro and in vivo Yoshida T, Endo Y, Obata T, Kosugi Y, Sakamoto K, Sasaki T DRUG METABOLISM AND DISPOSITION 38 10 1814-1819 2010/10
- Influence of cytidine deaminase on antitumor activity of 2′-deoxycytidine analogs in vitro and in vivo Drug Metabolism and Disposition 38 10 1814-1819 2010/10/01
- Safety and efficacy of bidirectional chemotherapy for treatment of patients with peritoneal dissemination from gastric cancer: Selection for cytoreductive surgery Yonemura Y, Endou Y, Shinbo M, Sasaki T, Hirano M, Mizumoto A, Matsuda T, Takao N, Ichinose M, Mizuno M, Miura M, Ikeda M, Ikeda S, Nakajima G, Yonemura J, Yuuba T, Masuda S, Kimura H, Matsuki N JOURNAL OF SURGICAL ONCOLOGY 100 4 311-316 2009/08
- Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2 Nishida Y, Miyamori H, Thompson EW, Takino T, Endo Y, Sato H CANCER RESEARCH 68 21 9096-9104 2008/11
- The natural history of free cancer cells in the peritoneal cavity Yonemura Y, Kawamura T, Bandou E, Tsukiyama G, Endou Y, Miura M. Recent Results Cancer Res 169 11-23 2007
- Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth Abd El-Aziz SH, Endo Y, Miyamaori H, Takino T, Sato H Cancer Science 98 9 1330-1335 2007/09
- Antiangiogenic activity of TZT-1027 (soblidotin) on chick chorioallantoic membrane and human umbilical vein endothelial cells Watanabe J, Endo Y, Shimada N, Natsume T, Sasaki T, Kobayashi M. In Vivo 21 2 297-304 2007/03
- Recent advances in the treatment of peritoneal dissemination of gastrointestinal cancers by nucleoside antimetabolites Yonemura Y, Endo Y, Obata T, Sasaki T Cancer Science 98 1 11/18 2007/01
- Proliferative activity of micrometastases in the lymph nodes of patients with gastric cancer Yonemura Y, Endo Y, Hayashi I, Kawamura T, Yun HY, Bandou E. BRITISH JOURNAL OF SURGERY 94 6 731-736 2007/06
- Advances in the management of gastric cancer with peritoneal dissemination Yonemura Y, Kawamura T, Bandou E, Tsukiyama G, Nemoto M, Endou Y, Miura M. Recent Results Cancer Res 169 157-164 2007
- Cellular localization and functional characterization of the equilibrative nucleoside transporters of antitumor nucleosides Endo Y, Obata T, Murata D, Ito M, Sakamoto K, Fukushima M, Yamasaki Y, Yamada Y, Natsume N, Sasaki T Cancer Sci. 98 10 1633-1637 2007/10
- Cytoreduction and intraperitoneal chemotherapy for carcinomatosis from gastric cancer Yonemura Y, Bando E, Kawamura T, Ito H, Endo Y, Miura M, Kiyosaki K, Sasaki T. Cancer Treat Res 134 357-373 2007
- Development of an antitumor adenosine analog, 3'-ethynyladenosine Endo Y, Obata T, Nomura M, Fukushima M, Yamada Y, Matsuda A, Sasaki T NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 26 6-7 691-694 2007/06
- Cellular localization and functional characterization of the equilibrative nucleoside transporters of antitumor nucleosides Endo Y, Obata T, Murata D, Ito M, Sakamoto K, Fukushima M, Yamasaki Y, Yamada Y, Natsume N, Sasaki T Cancer Science 98 10 1633-1637 2007/10
- Long-term results of peritonectomy on the patients with peritoneal carcinomatosis. Yonemura Y, Ikeno T, Shinbo M, Maejima S, Hagiwara A, Endou Y, Masahiro M, Ogura S Gan To Kagaku Ryoho 34 12 1926-1930 2007/11
- Antitumor mechanism and drug resistance of nucleoside antimetabolites Endo Y and Sasaki T 115 1 51-55 2006/03
- Quantitative prognostic indicators of peritoneal dissemination of gastric cancer Yonemura Y, Bandou E, Kawamura T, Endou Y, Sasaki T. EUROPEAN JOURNAL OF SURGICAL ONCOLOGY 32 6 602-606 2006/08
- Neoadjuvant treatment of gastric cancer with peritoneal dissemination Yonemura Y, Bandou E, Sawa T, Yoshimitsu Y, Endou Y, Sasaki T EUROPEAN JOURNAL OF SURGICAL ONCOLOGY 32 6 661-665 2006/08
- Evaluation of lymphatic invasion in primary gastric cancer by a new monoclonal antibody, D2-40 Yonemura Y, Endou Y, Tabachi K, Kawamura T, Yun HY, Kameya T, Hayashi I, Bandou E, Sasaki T, Miura M HUMAN PATHOLOGY 37 9 1193-9 2006/09
- Role of VEGF-C and VEGF-D on lymphangiogenesis in gastric cancer Yonemura Y, Endo Y, Tabata K, Kawamura T, MD, Yun H, Bandou E, Sasaki T, Miura M Int J Clin Oncol. 10 5 318-327 2005/10
- Inhibition of invasion and metastasis in oral cancer by targeting urokinase-type plasminogen activator receptor Nozaki S, Endo Y, Nakahara H, Yoshizawa K, Hashida Y, Kawashiri S, Tanaka A, Nakagawa Y, Matsuoka Y, Koga M, Yamamoto E ORAL ONCOLOGY 41 10 971-977 2005/11
- Effect of intraperitoneal chemotherapy on experimental peritoneal dissemination of gastric cancer Yonemura Y, Endou Y, Tochiori S, Bando E, Kawamura T, Shimada T, Miyamoto K, Tanaka M, Sasaki T. Japanese Journal of Cancer and Chemotherapy 32 11 1635-1639 2005/10
- Pharmacokinetic advantage of intraperitoneal injection of docetaxel in the treatment for peritoneal dissemination of cancer in mice JOURNAL OF PHARMACY AND PHARMACOLOGY 57 2 177-81 2005/02
- In vitro chemosensitivity test for human genito-urinary tumors using collagen gel matrix INTERNATIONAL JOURNAL OF UROLOGY 12 1 67-72 2005/01
- S100A4 regulates E-cadherin expression in oral squamous cell carcinoma Moriyama-Kita M, Endo Y, Yonemura Y, Heizmann CW, Miyamori H, Sato H, Yamamoto E, Sasaki T. CANCER LETTERS 230 2 211-218 2005/12
- Correlation of S100A4 expression with invasion and metastasis in oral squamous cell carcinoma ORAL ONCOLOGY 40 5 496-500 2004/05
- The association of expression and gene polymorphism of the thymidylate synthase gene with 5-fluoro-5'-deoxyuridine sensitivity in gastric cancer cell lines Kaneko M, Kawakami K, Oyama K, Endo Y, Tanaka M, Sasaki T, Watanabe G. Japanese Journal of Cancer and Chemotherapy 31 9 1347-1350 2004/09
- Oral Administration of Uracil-Tegafur (UFT) Inhibits Liver Micrometastasis of Human Colon Cancer in an Orthotopic Nude Mouse Model and Its Early Detection System Takahashi Y, Yamashita K, Endo Y, Sasaki T, Mai M. SURGERY TODAY 34 10 855-859 2004
- Effect of intraperitoneal administration of docetaxel on peritoneal dissemination of gastric cancer CANCER LETTERS 210 2 189-196 2004/07
- Antitumor effect of radioimmunotherapy in a mouse model of testicular tumor with micrometastases defined by polymerase chain reaction ONCOLOGY REPORTS 9 6 1261-1266 2002/11
- Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers ONCOLOGY REPORTS 9 6 1319-22 2002/11
- Multifunctional anti-angiogenic activity of the cyclic peroxide ANO-2 with antitumor activity INTERNATIONAL JOURNAL OF CANCER 100 2 220-227 2002/07
- REG gene expression is associated with the infiltrating growth of gastric carcinoma CANCER 98 7 1394-1340 2003/10
- Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer Gastric Cancer 6 1 30-38 2003/05
- K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function J Virol 76 2 802-16 2002/01
- A novel affinity chromatography method for the co-purification of deoxycytidine kinase and cytidine deaminase Nucleosides Nucleotides Nucleic Acids 20 9 1647-54 2001/09
- Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma Int J Oncol 18 4 715-20 2001/04
- Significance of integrin alpha2/beta1 in peritoneal dissemination of a human gastric cancer xenograft model Int J Oncology 18 4 809-815 2001/04
- Lymphangiogenesis and the vascular endothelial growth factor receptor (VEGFR)-3 in gastric cancer Eur J Cancer 37 7 918-23 2001/05
- Prediction of peritoneal micrometastasis by peritoneal lavaged cytology and reverse transcriptase-polymerase chain reaction for matrix metalloproteinase-7 mRNA Clin Cancer Res 7 6 1647-53 2001/06
- Diagnostic value of preoperative RT-PCR-based screening method to detect carcinoembryonic antigen-expressing free cancer cells in the peritoneal cavity from patients with gastric cancer ANZ J Surg 71 9 521-8 2001/09
- Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides Jpn J Cancer Res 92 7 793-8 2001/07
- Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study Hepatogastroenterology 48 42 1776-82 2001/11
- Multidisciplinary therapy for peritoneal dissemination using peritonectomy 28. Yonemura Y, Kinoshita K, Takahashi S, Bando E, Kawamura S, Maeda A, Nagata S, Uesaka K, Yamaguchi S, Tsubosa Y, Sasaki T, Endo Y, Tanaka M, Sawa T, Matsuki N. Japanese Journal of Cancer and Chemotherapy 29 12 2178-2183 2002/11
- Inhibition of peritoneal dissemination in human gastric cancer by MMP-7-specific antisense oligonucleotide 20 2 205-215 2001/06
- Role of MMP-7 in the formation of peritoneal dissemination in gastric cancer 3 2 63-70 2000/09
- Alternation of s-catenin expression in esophageal squamous-cell carcinoma INTERNATIONAL JOURNAL OF CANCER 85 6 757-61 2000/05
- Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer CLINICAL CANCER RESEARCH 6 11 4234-4242 2000/11
- Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer Clin Exp Metastasis 18 4 321-7 2000/04
- Antimetastatic and antitumor activity of 2,4-diamino-6-(pyridine-4-yl)-1,3,5- triazine (4PyDAT) in mice transplanted with the high lung metastatic colon 26 tumor Anticancer Drug Des 15 3 217-23 2000/06
- Clinical significance of S100A4 and E-cadherin-related adhesion molecules in non-small cell lung cancer Int J Oncol 16 6 1125-31 2000/06
- KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells BLOOD 95 4 1151-1157 2000/02
- Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer 18 4 321-327 2000/04
- Dominant role of E-cadherin in the progression of bladder cancer UROLOGY 161 2 692-8 1999/02
- Isolation of deoxycytidine kinase from Ehrlich carcinoma cells by affinity chromatography based on a substrate analog, 2'-C-cyano-2'-deoxy-1-s-D- arabinofuranosyl-N4-palmitoylcytosine Biol Pharm Bull 22 1 83-6 1999/01
- Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer Clin Cancer Res 5 7 1823-9 1999/07
- Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine Int J Oncol 14 3 543-9 1999/05
- A human seminoma xenograft model with regional lymph node metastasis J Urology 161 1 342-8 1999/01
- A new surgical approach (peritonectomy) for the treatment of peritoneal dissemination HEPATO-GASTROENTEROLOGY 46 25 601-9 1999/01
- The scaffold protein c-Jun NH2-terminal kinase-associated leucine zipper protein regulates cell migration through interaction with the G protein G alpha13 Gantulga D, Tuvshintugs B, Endo Y, Takino T, Hiroshi S, Murakami S, Yoshioka K JOURNAL OF BIOCHEMISTRY 144 6 693-700 2008/12
- Prognostic significance of c-erbB-2 gene expression in the poorly differentiated type of adenocarcinoma of the stomach CANCER DETECTION AND PREVENTION 22 2 139-146 1998/01
- The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor (c-met), autocrine motility factor receptor, and urokinase- type plasminogen activator receptor CANCER 82 11 2112-22 1998/06
- Significance of plasminogen activator inhibitor-2 as a prognostic marker in primary lung cancer: association of decreased plasminogen activator inhibitor-2 with lymph node metastasis Br J Cancer 78 6 833-9 1998/09
- Immunohistochemical localization of a urokinase-type plasminogen activator system in squamous cell carcinoma of the oral cavity ORAL ONCOLOGY 34 1 58-62 1998/01
- Immunohistochemical localization of a urokinase-type plasminogen activator system in squamous cell carcinoma of the oral cavity: association with mode of invasion and lymph node metastasis Oral Oncol 24 1 58-62 1998/01
- Immunohistochemical study of MT-MMP tissus status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis Oncol Rep 5 6,1483-8 1998 1998/11
- Development and biochemical characterization of a 2'-C-cyano-2'-deoxy-1-s-D-arabino-pentofuranosylcytosine (CNDAC)-resistant variant of the human fibrosarcoma cell line HT-1080 Cancer Lett 123 1 53-61 1998/01
- A chick embryo model for metastatic human prostate cancer Eur Urol 34 2 154-60 1998/08
- Correlation between expression of urokinase-type plasminogen activator receptor and metastasis in gastric carcinoma Oncol Rep 4 1229-1234 1997
- Angiogenic and HIV inhibition functions of KSHV-encoded chemokines Boshoff C, Endo Y, Collins PD, Simmons G, Takeuchi Y, Schweickart VL, Reeves JD, Siani M, Moore P, Sasaki T, Williams TJ, Gray PW, Clapham PR, Chang Y, Weiss R A SCIENCE 278 5336 290-4 1997/10/10
- Correlation of peritoneal dissemination and integrin alpha3 expression in gastric cancer Oncol Rep 4 549-555 1997
- Early detection of peritoneal dissemination of gastricintestinal cancers by reverse-transcriptase polymerase chain reaction Oncol Rep 4 1015-1019 1997
- Enhanced tumorigenic and metastatic potential of an androgen sensitive human prostate cancer cell line, LNCaP, by intratesticular inoculation in SCID mice Int J Oncol 11 513-519 1997
- Relationship between microlymphatic vessel density within tumors and lymph node metastasis Ohta Y, Tanaka M, Endo Y, Murakami S, Oda M, Sasaki T, Watanabe Y. ONCOLOGY REPORTS 4 889-892 1997
- Expression of a-smooth-muscle actin antigen in thymoma and thymic cancer Oncol Rep 4 893-897 1997
- Vascular endothelial growth factor and lymph node metastasis in primary lung cancer Br J Cancer 76 8 1041-5 1997
- Association of progression and reduced expression of VLA-2 in gastric cancer Oncol Rep 4 1265-1269 1997
- Inhibition of lymph node metastasis by an anti-angiogenic agent, TNP-470 Br J Cancer 75 4 512-515 1997
- Antitumor mechanisms of 3'-ethynyluridine and 3'-ethynylcytidine as RNA synthesis inhibitors: Development and characterization of 3'-ethynyluridine-resistant cells 71. Tabata S, Tanaka M, Endo Y, Obata T, Matsuda A, Sasaki T. CANCER LETTERS 116 2 225-31 1997/06
Conference Presentations
- Enhancing effect of novel Schiff base derivative combined with tyrosine kinase inhibitor on ALA-PDT(conference：The 83rd Annual Meeting of the Japanese Cancer Association)(2024/09/19)
- Development of a novel TKI derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy.(conference：The 82th Annual Meeting of the Japanese Cancer Association)(2023/09/21)
- Enhancing effect of novel Schiff base derivative combined with tyrosine kinase inhibitor on photodynamic therapy using 5-ALA(conference：he 81th Annual Meeting of the Japanese Cancer Association)(2022/09/29)
- PANCREATIC SENESCENT STROMA INFLUENCE ON PROGNOSIS IN PDAC(conference：Digestive Disease Week (DDW2019))(2019/05/20)
- Development of a Novel Celecoxib Derivative UTX-121 as an Antimetastatic Agent(conference：The 79th Annual Meeting of the Japanese Cancer Association)(2020/10/01)
- Mechanism of acquired resistance to photodynamic therapy using 5-aminolevulinic acid(conference：The 137th Annual Meeting of the Pharmaceutical Society of Japan)(2017/03/27)
- Development of novel Schiff base derivative for enhancing the anticancer potential of ALA-based photodynamic therapy(conference：The 76th Annual Meeting of the Japanese Cancer Association)(2017/09/28)
- An iron metabolism-targeting drug with antitumor activity enhances the effect of 5-ALA-based photodynamic therapy(conference：The 79th Annual Meeting of the Japanese Cancer Association)(2020/10/01)
- Structure-activity relationships of UTX-121 derivatives derived from celecoxib as an antimetastatic lead compound.(conference：The 80th Annual Meeting of the Japanese Cancer Association)(2021/10/01)
- Development of NHE5 selective inhibitor UTX-143 based on the structure-activity relationship of amiloride derivatives(conference：The 80th Annual Meeting of the Japanese Cancer Association)(2021/10/02)
- Enhancing effect of novel Schiff base derivatives on 5-aminolevulinic acid-based photodynamic therapy(2020/03/25)
- Enhancing effect of novel Schiff base derivatives on photodynamic therapy using 5-aminolevulinic acid(conference：The 78th Annual Meeting of the Japanese Cancer Association)(2019/09/28)
- Aberrant glycogen synthase kinase (GSK)3 participates in proliferation of esophageal squamous cell carcinoma (ESCC)(conference：The 76th Annual Meeting of the Japanese Cancer Association)(2017/09/28)
- Overcoming acquired resistance to photodynamic therapy using 5-aminolevulinic acid in gastric cancer cells(conference：The 77th Annual Meeting of the Japanese Cancer Association)(2018/09/27)
- Development of novel Schiff base derivative for enhancing the anticancer potential of ALA-based photodynamic therapy(2018/03/28)
- Effect of targeting GSK3b against esophageal squamous cellcarcinoma (ESCC) inducing cell cycle arrest and apoptosis(conference：The 78th Annual Meeting of the Japanese Cancer Association.)(2019/09/27)
- Mechanism of acquired resistance to photodynamic therapy using 5-aminolevulinic acid.(conference：The 75th Annual Meeting of the Japanese Cancer Association)(2016/10/06)
- JIP3 is a substrate for c-Abl and Arg tyrosine kinases(conference：The 75th Annual Meeting of the Japanese Cancer Association)(2016/10/06)
- Development of antimetastatic hypoxic cytotoxin TX-2282 targeting for Akt/protein kinase B based on TX-2137(2015/01/21)
- Schiff base derivative TX-816 enhances the effect of photodynamic therapy using 5-aminolevulinic acid(2015/10/08)
- Evaluation of the Sonosensitizing Activities of 5-Aminolevulinic Acid in Breast Tumor-Bearing Chick Embryos and Mice Model(2015/10/08)
- Detection of peritoneal metastasis by photodynamic diagnosis using aminolevulinic acid(2015/10/08)
- Immunohistochemistry, DNA ploidy, and microRNAs in pseudomyxoma peritonei (2015/10/08)
- Enhancing efficacy of ALA-PDT by using the Schiff base derivative TX-816(conference：The 73rd Annual Meeting of the Japanese Cancer Association)(2014/09/27)
- Development of antimetastatic hypoxic cytotoxin TX-2282 targeting for Akt/protein kinase B based on TX-2137(conference：The 73rd Annual Meeting of the Japanese Cancer Association)(2014/09/27)
- A gene ontology-based microarray gene expression data analysis for diagnosing pseudomyxoma peritonei.(conference：2014 IEEE 7th International Workshop on Computational Intelligence and Applications)(2014/11/07)
- Enhanced effect of ALA-PDT using dipyridamole(2013/10/03)
- Development of antimetastatic hypoxic cytotoxin TX-2137 targeting for Akt/protein kinase B(2013/10/03)
- Development of Immunomodulatory Cancer Therapy Based on Gc protein-derived Macrophage Activating Factor (GcMAF)(conference：7th International Symposium on Nanomedicine (ISNM2013))(2013/11/07)
- A GO-based gene expression data analysis method of searching biomarker genes for pseudomyxoma peritonei.(conference：International Symposium on Tumor Biology in Kanazawa & Academic Drug Discovery Symposium.)(2014/01/23)
- Visualization and detection small PC by 5-aminolevulinic acid (5-ALA)(conference：Yutaka Yonemura, Endo Yoshio, Shun-ichiro Ogura, Akiyoshi Mizumoto, Haruki Ishibashi, Candy Emel)(2012/09/19)
- Molecular mechanism underlying ALA-PDT resistance in human cancer cells(2012/09/20)
- Pivotal Role of PEPT1 and ABCG2 on 5-Aminolevulinic Acid (ALA)-based Photodynamic Sensitization of Gastric Cancer Cells in Vitro.(2011/10/04)
- Significance of membrane transporters in determining the ALA-PDT sensitivity in human cancer cells(2011/10/04)
- A new concept regarding the mechanism of peritoneal carcinomatosis: Trans-lymphatic metastasis.(2011/10/03)
- 腫瘍移植鶏卵を用いたエタニダゾールのin vivo放射線増感剤活性評価(2011/10/03)
- Increased secretion of cytidine deaminase protein in cancer cells resistant to antitumor 2'-deoxycytidine analogues(2009/10)
- Effect of experimental photodynamic therapy with 5-aminolevulinic acid on hu man gastric cancer cells(2009/10/01)
- Enzymatic activity and protein levels of cytidine deaminase in serum from patients with lung cancer. (2008/10/28)
- Development of an in vivo evaluation system of antioxidants for their vascular protective activities using the chick embryo chorioallantoic membrane.(2008/08/03)
Others
- The molecular targets of antitumor 2'-deoxycytidine analogues 4 4 305-13 2003/05
- Recent advances in the treatment of peritoneal dissemination of gastrointestinal cancers by nucleoside antimetabolites Yonemura Y, Endo Y, Obata T, Sasaki T 98 1 11-18 2007/01
- Targeting urokinase-type plasminogen activator and its receptor for cancer therapy Nozaki S, Endo Y, Nakahara H, Yoshizawa K, Ohara T, Yamamoto E 17 10 1109-17 2006/11
- Molecular mechanism of peritoneal dissemination Yonemura Y, Endo Y, Miura M 2010//3
Arts and Fieldwork
Patent
Theme to the desired joint research
○Development of effective diagnosis and therapy for metastatic cancer
○Mechanisms of antitumor nucleosides
Grant-in-Aid for Scientific Research
○「多機能性チロシンキナーゼ阻害薬の創出とがん光線力学療法への応用研究」(2021-2023)
○「消化器癌におけるNa+/H+交換輸送体5の機能解析と特異的阻害薬の開発」(2020-2022)
○「大腸癌における Na+/H+交換輸送体阻害による新規抗癌治療法の開発」(2016-2018)
○「膜輸送系を標的とする光線力学的治療の効果増強剤の新薬シーズ開発」(2014-2016)
○「細胞膜輸送系の機能修飾に基づく光線力学的治療の効果増強法の基礎開発」(2011-2014)
○「腹膜偽粘液腫の本邦における発生頻度・病態の解明・治療法の開発」(2012-2013)
○「腹膜偽粘液腫の本邦における発生頻度・病態の解明・治療法の開発」(2011-2011)
○「臨床効果を的確に予測する抗腫瘍性ヌクレオシドの薬剤感受性規定因子」(2005-2006)
Competitive research funding,Contribution
Collaborative research,Consignment study
○Development of diagnosis and therapy for metastatic gastric cancer using 5-ALA(2010-2011)
○Photodynamic evaluation of metastatic gastric cancer using 5-aminolevulinic acid(2008-2009)
○Evaluation of antitumor activity of therapeutic monoclonal antibody for peritoneal dissemination-related protein(2008-2009)
○Detection of peritoneal dissemination of gastric cancer using 5-nminolevulinate(2007-2008)
○Evaluation of chemosensitivity in human cancer expressing drug resistant-related gene(2005-2007)
Classes (Bachelors)
Classes (Graduate Schools)
○An Introduction to Cellular Function(2017)
○An Introduction to Cellular Function(2017)
○An Introduction to Cellular Function(2016)
○Seminar on Tumor Biology(2016)
○An Introduction to Cellular Function(2016)