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Researcher Information

last modified:2019/08/23

Assistant Professor TANIGUCHI Tsuyoshi


Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Material Chemistry, Graduate School of Natural Science and Technology
Graduate School of Phamacy
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences


Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 200606 Unfinished course
【Academic background(Bachelor's Degree)】
Kanazawa University 200403
Doctor of Philosophy in Pharmaceutical Sciences


Division of Pharmaceutical Sciences, research associate(2006/07/01-2007/03/31)
Division of Pharmaceutical Sciences, assistant professor(2007/04/01-2008/03/31)
School of Pharmaceutical Sciences, assistant professor(2008/04/01-)

Year & Month of Birth


Academic Society

The Pharmaceutical Society of Japan
The Society of Synthetic Organic Chemistry


○Thieme Chemistry Journal Award 2015(2014/12/01)


Chemical pharmacy

Speciality Keywords

radical reactions, catalysis, main group chemistry, natural product synthesis, polymer synthesis

Research Themes

Development of new synthetic methodology

Total synthesis of polycyclic alkaloids


  •  Mark W. Zettler, Tsuyoshi Taniguchi e-EROS Encyclopedia of Reagents for Organic Synthesis Wiley 2017


  •  Esters as Radical Acceptors: β-NHC-borylalkenyl Radicals Induce Lactonization by C-C Bond Formation/Cleavage on Esters Masaki Shimoi, Katsuhiro Maeda, Steven J. Geib, Dennis P. Curran, Tsuyoshi Taniguchi ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 2019/03/19
  •  Triptycene-Based Ladder Polymers with One-Handed Helical Geometry Tomoyuki Ikai, Takumu Yoshida, Ken-ichi Shinohara, Tsuyoshi Taniguchi, Yuya Wada, Timothy M. Swager Journal of the American Chemical Society 141 4696–4703 2019/02/28
  •  Radical trans-hydroboration of alkynes with N-Heterocyclic Carbene Boranes Masaki Shimoi, Takashi Watanabe, Katsuhiro Maeda, Dennis P. Curran, Tsuyoshi Taniguchi ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57 9485–9490 2018/06/25
  •  Systematic Evaluation of 2-Arylazocarboxylates and 2-Arylazocarboxamides as Mitsunobu Reagents Daisuke Hirose, Martin Gazvoda, Janez Košmrlj, and Tsuyoshi Taniguchi The Journal of Organic Chemistry 83 4712–4729 2018/03/23
  •  Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury Takayuki Amano, Tatsuki Fukami, Takuo Ogiso, Daisuke Hirose, Jeffrey P. Jones, Tsuyoshi Taniguchi, Miki Nakajima Biochemical Pharmacology 151 69-78 2018/03

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  •  N-Heterocyclic Carbene Boranes are Hydrogen Donors in Masamune–Bergman Reactions of Benzo[3,4]cyclodec-3-ene-1,5-diynes Takashi Watanabe, Steven J. Geib, Dennis P. Curran, Tsuyoshi Taniguchi The Journal of Organic Chemistry 82 24 13034-13042 2017/11
  •  Recent Advances in Reactions of Heteroatom-Centered Radicals Tsuyoshi Taniguchi Synthesis 49 16 3511-3534 2017/07
  •  Borylative Radical Cyclizations of Benzo[3,4]cyclodec-3-ene-1,5-diynes and N-Heterocyclic Carbene-Boranes Takashi Watanabe, Daisuke Hirose, Dennis P Curran, Tsuyoshi Taniguchi Chemistry - A European Journal 23 23 5404-5409 2017/04
  •  Advances and mechanistic insight on the catalytic Mitsunobu reaction using recyclable azo reagents Daisuke Hirose, Martin Gazvoda, Janez Košmrlj, Tsuyoshi Taniguchi Chemical Science 7 8 5148-5159 2016/08
  •  The “Fully Catalytic System” in Mitsunobu Reaction Has Not Been Realized Yet Daisuke Hirose, Martin Gazvoda, Janez Košmrlj, Tsuyoshi Taniguchi Organic Letters 18 16 4036-4039 2016/08
  •  Catalytic Aerobic Oxidation of Arylhydrazides with Iron Phthalocyanine Takuma Hashimoto, Daisuke Hirose, Tsuyoshi Taniguchi Advanced Synthesis & Catalysis 357 14-15 3346-3352 2015/10
  •  Hydroboration of Arynes Formed by Hexadehydro−Diels−Alder Cyclizations with N-Heterocyclic Carbene Boranes Takashi Watanabe, Dennis P. Curran, Tsuyoshi Taniguchi Organic Letters 17 14 3450-3453 2015/06
  •  A New Method for the Synthesis of 1,4-Diols: C(sp3)-H Hydroxylation Induced by Iron-Catalyzed Redox Hydration of Alkenes Tsuyoshi Taniguchi, Daisuke Hirose, Takuma Hashimoto Synlett 2531-2535 2014/11
  •  Hydroboration of Arynes with N-Heterocyclic Carbene Boranes Tsuyoshi Taniguchi, Dennis P. Curran ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53 13150–13154 2014/10
  •  Redox Divergent Synthesis of Fawcettimine-Type Lycopodium Alkaloids Hisaaki Zaimoku, Tsuyoshi Taniguchi Chemistry-A European Journal 20 9613–9619 2014/07
  •  Direct Synthesis of 1,4-Diols from Alkenes by Iron-Catalyzed Aerobic Hydration and C−H hydroxylation Takuma Hashimoto, Daisuke Hirose, Tsuyoshi Taniguchi ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53 2730–2734 2014/03
  •  Aerobic radical multifunctionalization of alkenes using tert-butyl nitrite and water Daisuke Hirose, Tsuyoshi Taniguchi Beilstein Journal of Organic Chemistry 9 1713-171 2013/08
  •  α-Fluorohydrazones as useful precursors in nucleophilic substitutions Ryota Yunoki, Atsushi Yajima, Tsuyoshi Taniguchi, Hiroyuki Ishibashi  TETRAHEDRON LETTERS 54 4102-4105 2013/07
  •  Syntheses of (±)-Serratine, (±)-Lycoposerramine T, and (±)-Lycopoclavamine B Hisaaki Zaimoku, Hiroshi Nishide, Asami Nishibata, Naoya Goto, Tsuyoshi Taniguchi, Hiroyuki Ishibashi ORGANIC LETTERS 15 2140-2143 2013/05
  •  Recyclable Mitsunobu Reagents: Catalytic Mitsunobu Reactions with an Iron Catalyst and Atomospheric Oxygen Daisuke Hirose, Tsuyoshi Taniguchi, Hiroyuki Ishibashi ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 4613-4617 2013/04
  •  Reductions of aldehydes and ketones with a readily available N-heterocyclic carbene borane and acetic acid Vladimir Lamm, Xiangcheng Pan, Tsuyoshi Taniguchi, Dennis P. Curran Beilstein Journal of Organic Chemistry 9 675-680 2013/04
  •  Multifunctionalization of alkenes via aerobic oxynitration and sp3 C-H oxidation Tsuyoshi Taniguchi, Yuki sugiura, Takashi Hatta, Atsushi Yajima, Hiroyuki Ishibashi CHEMICAL COMMUNICATIONS 49 2198-2200 2013/02
  •  Synthesis of Alkaloids Using Radical Cyclizations Tsuyoshi Taniguchi, Hiroyuki Ishibashi HETEROCYCLES 87 527-545 2013/02
  •  Memory of chirality in rebound cyclizations of α-amide radicals Aniruddha Sasmal, Tsuyoshi Taniguchi, Peter Wipf, Dennis P. Curran CANADIAN JOURNAL OF CHEMISTRY 91 1-5 2013/01
  •  Iodine-Mediated α-Acetoxylation of 2,3-Disubstituted Indoles Hisaaki Zaimoku, Takashi Hatta, Tsuyoshi Taniguchi, Hiroyuki Ishibashi ORGANIC LETTERS 14 6088-6091 2012/11
  •  Silica Gel Promotes Reductions of Aldehydes and Ketones by N-Heterocyclic Carbene Borane Tsuyoshi Taniguchi, Dennis P. Curran ORGANIC LETTERS 14 4540-4543 2012/09
  •  Synthesis of the Core of Actinophyllic Acid Using a Transannular Acyl Radical Cyclization Hisaaki Zaimoku, Tsuyoshi Taniguchi, Hiroyuki Ishibashi ORGANIC LETTERS 14 1656-1658 2012/03
  •  Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N CANCER RESEARCH 103 107-115 2012/01
  •  Oxidative NItration of Alkenes with tert-Butyl Nitrite and Oxygen Tsuyoshi Taniguchi, Atsushi Yajima, Hiroyuki Ishibashi ADVANCED SYNTHESIS & CATALYSIS 353 2643-2647 2011/10
  •  Esterification via Iron-Catalyzed Activation of Triphenylphosphine with Air Tsuyoshi Taniguchi, Daisuke Hirose, Hiroyuki Ishibashi ACS Catalysis 1 1469-1474 2011/10
  •  Synthesis of β-hydroxyphosphonates by iron-catalyzed oxidative addition of phosphonyl radicals to alkenes Tsuyoshi Taniguchi, Atsushi Idota, Shin’ichi Yokoyama, Hiroyuki Ishibashi TETRAHEDRON LETTERS 52 4768-4770 2011/08
  •  Iron-catalyzed sulfonyl radical formations from sulfonylhydrazides and oxidative addition to alkenes Tsuyoshi Taniguchi, Atsushi Idota, Hiroyuki Ishibashi Organic & Biomolecular Chemistry 9 3151–3153 2011/04
  •  A Mild Oxidative Aryl Radical Addition into Alkenes with Aerobic Oxidation of Arylhydrazines Tsuyoshi Taniguchi, Hisaaki Zaimoku, Hiroyuki Ishibashi CHEMISTRY-A EUROPEAN JOURNAL 17 4307-4312 2011/04
  •  Iron-mediated one-pot formal nitrocyclization onto unactivated alkenes Organic & Biomolecular Chemistry 9 653-655 2011/02
  •  Iron-Mediated Radical Halo-Nitration of Alkenes 75  8126–8132 2010/12
  •  Iron-Catalyzed Oxidative Addition of Alkoxycarbonyl Radicals to Alkenes with Carbazates and Air ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  49 10154-10157 2010/12
  •  Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability INTERNATIONAL JOURNAL OF CANCER 127 474–484 2010/07
  •  Iron-Mediated Radical Nitro-Cyclization Reaction of 1,6-Dienes ORGANIC LETTERS 12 124–126 2010/01
  •  Iron-Catalyzed Redox Radical Cyclizations of 1,6-Dienes and Enynes ORGANIC LETTERS 12 112–115 2010/01
  •  Water in Amine-Mediated Single Electron Transfer Reaction of N-Allylic Trichloroacetamides HETEROCYCLES 80  657–662 2010/01
  •  Asymmetric Total Synthesis and Revised Structure of Cephalezomine H JOURNAL OF ORGANIC CHEMISTRY 74 19  7592-7594 2009/10
  •  Novel Synthesis of 3-Aminopropionitriles by Ring Opening of 2-Oxazolidinones with Cyanide Ion TETRAHEDRON LETTERS 50 34  4857-4858 2009/08
  •  Reductive Addition of Benzenethiyl Radical to Alkynes by Amine-Mediated Single Electron Transfer Reaction to Diphenyl Disulfide ORGANIC LETTERS 11 15  3298-3301 2009/08
  •  Formal Total Synthesis of Haouamine A JOURNAL OF ORGANIC CHEMISTRY 74 6  2624-2626 2009/03
  •  8-Endo-Selective Aryl Radical Cyclization Leading to 3-Benzazocines HETEROCYCLES 77 1  575-585 2009/01
  •  Total synthesis of (±)-stemonamide, (±)-isostemonamide, (±)-stemonamine, and (±)-isostemonamine using a radical cascade TETRAHEDRON 64 37  8773-8779 2008/09
  •  Short Synthesis of (-)-Cephalotaxine Using a Radical Cascade ORGANIC LETTERS 10 18  4129-4131 2008/09
  •  Role of 1,4-dimethylpiperazine in radical cyclization Arkivoc 14, 7-16 2008/08
  •  Synthesis of (-)-trachelanthamidine using a single electron transfer reaction in 1,4-dimethylpiperazine. TETRAHEDRON 64 33  7771-7773 2008/08
  •  Synthesis of nitrogen-containing heterocycles using exo- and endo-selective radical cyclizations onto enamides TETRAHEDRON 64 11  2634-2641 2008/03
  •  Total Synthesis of (±)-Stemonamide and (±)-Isostemonamide Using a Radical Cascade ORGANIC LETTERS 10 2  197-199 2008/01
  •  A Short Synthesis of Lennoxamine Using a Radical Cascade ORGANIC LETTERS 7 20  4389-4390 2005/09
  •  Concise Synthesis of the Tricycllic Skeleton of Cylindricines Using a Radical Cascade Involving 6-Endo Selective Cyclization SYNLETT 7  1179-1181 2005/04
  •  7-endo Selective Aryl Radical Cyclization onto Enamides Leading to 3-Benzazepines; Concise Construction of a Cephalotaxine Skeleton JOURNAL OF ORGANIC CHEMISTRY 70 5  1922-1925 2005/03

Conference Presentations

  • Radical borylation of perfluoroarenes with N-heterocyclic carbene-boranes(2019/03/18)
  • Radical Reactions of Alkynes with N-Heterocyclic Carbene Boranes(conference:International Congress on Pure & Applied Chemistry (ICPAC) 2018)(2018/03/07)
  • Radical Reactions of Alkynes with N-Heterocyclic Carbene Boranes(conference:3rd International Symposium on Center of Excellence for Innovative Material Sciences Based on Supramolecules)(2017/10/16)

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Experiments in Organic Chemistry(2017)
○Experiments in Fundamental Chemistry(2017)
○Experiments in Organic Chemistry(2016)
○Freshman Seminar I(2016)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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