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Researcher Information

last modified:2020/03/26

Professor YAMAGUCHI, Masaaki


Faculty, Affiliation

Faculty of Biological Science and Technology,Institute of Science and Engineering

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Natural System, Graduate School of Natural Science and Technology
Course in Aquatic Biology and Environmental Science, School of Biological Science and Technology, College of Science and Engineering


Evolutionary developmental biology TEL:076-264-6233 FAX:076-264-6236

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo Doctor 1985
【Academic background(Bachelor's Degree)】
The University of Tokyo 1980


Year & Month of Birth


Academic Society



Developmental biology、Evolutionary biology

Speciality Keywords

Echinoderms, Developmental biology, Evolutionary developmental biology

Research Themes

Animal-vegetal polarity of sea urchin eggs

Animal-vegetal polarity of sea urchin eggs

Evolution of echinoderms

Evolution of echinoderms


  •  Yamaguchi, S., Hano, Y., Hayashi, A., and Yamaguchi, M. The Hox genes of the direct-type developing sea urchin Peronella japonica 2000
  •  Yoshino, K., Takao, T., Hori, H., Suhara, M., Kitai, T., Nomura, K., Yamaguchi, M. and Suzuki, N. Primary structures of bromophenylalanine-containing sperm-activating peptides 1991
  •  Harumi, T., Yamaguchi, M., and Suzuki, N. Effects of cations on sea urchin sperm metabolisms activated by sperm activating peptide I 1991
  •  Yoshino, K., Yamaguchi, M., Suzuki, N., Takao, T., Shimonishi, Y., and Nomura, K. Further structural study of sperm-activating peptides isolated from the egg jelly of sea urchins, Tripneustes gratilla, Psuedoboletia maculata, Hetrocentrotus mammillatus and Clypeaster japonicus, using fastatom bonberdment mass sperctrometry 1991
  •  Shimizu, T., Kinoh, H., Yamaguchi, M., and Suzuki, N. Species specificity of the egg jelly molecule, a fucose sulfate glycoconjugate, in induction of the acrosome reaction of sea urchin spermatozoa 1991

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  •  Hara, Y., Yamaguchi, M., Amemiya, S. A PCR survey of Hox genes in the starked crinoid Metracrinus rotundus. 2004


  •  Polysaccharides sulfated at the time of gastrulation in embryos of the sea urchin Clypeaster japonicus. Exp. Cell Res. 59 353-365 1985
  •  Inhibition of the sulfated polysaccharide synthesis in thiocyanate-treated embryos of the sea urchin Clypeaster japonicus. Zool. Sci. 3 719-721 1986
  •  Species specific respiratory stimulation of sea urchin (Clypeaster japonicus) spermatozoa. Zool. Sci. 3 801-806 1986
  •  Speract binds exclusively to sperm tails and causes an electrophoretic mobility shift in a major sperm protein of sea urchin. Zool. Sci. 4 641-648 1987
  •  Purification and structure of mosact and its derivatives from the egg jelly of the sea urchin Clypeaster japonicus. Zool. Sci. 4 649-657 1987

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  •  The participation of speract in the acrosome reaction of Hemicentrotus pulcherrimus. Devolop. Growth and Differ. 30 159-167 1988
  •  Some more speract derivatives associated with eggs of sea urchins, Pseudocentrotus depressus, Strongylocentrotus purpuratus, Hemicentrotus pulcherrimus and Anthocidaris crassispina. Comp. Biochem. Physiol. 89C 687-693 1988
  •  A novel group of sperm activating peptides of the sea urchin Glyptocidaris crenularis. Comp. Biochem. Physiol. 90C 305-311 1988
  •  Dermatan sulfate formed in gastrula-stage embryos of the sea urchin Clypeaster japonicus. J. Biochem. 106 158-162 1989
  •  Induction of the acrosome reaction of Hemicentrotus pulcherrimus spermatozoa by the egg jelly molecules, fucose-rich glycoconjugate and sperm-activating peptide I. Develop. Growth and Differ. 31 233-239 1989
  •  A halogenated amino acid-containing sperm activating peptide and its related peptides isolated from the egg jelly of sea urchins, Tripneustes gratilla, Pseudoboletia maculata, Strongylocentrotus nudus, Echinometra mathaei and Hetrocentrotus mammillatus. Comp. Biochem. Physiol. 94B 739-751 1989
  •  A species-specific sperm-activating peptide from the egg jelly of the sea urchin Diadema setosum. Comp. Biochem. Physiol. 95B 423-429 1990
  •  Derivatives of sperm-activating peptide III (SAP-III) associated with eggs of sand dollarClypeaster japonicus and Astriclypeus manni. Comp. Biochem. Physiol. 97B 679-68 1990
  •  Purification and characterization of the egg jelly macromolecules, sialoglycoprotein and fucose sulfate glycoconjugate, of the sea urchin Hemicentrotus pulcherrimus. Develop. Growth and Differ. 32 473-487 1990
  •  The primary structure of the rat guanylyl cyclase A/atrial natriuretic peptide receptor gene. J Biol Chem 265 20414-20420 1990
  •  The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian metalloprotease family BIOCHEMISTRY 30 6115-6123 1991
  •  Identification of a novel amino acid, o-bromo-L-phenylalanine, in egg-associated peptides that activate spermatozoa Yoshino, K., Takao, T., Suhara, M., Kitai, T., Hori, H., Nomura, K., Yamaguchi, M., Shimonishi, Y., and Suzuki, N. BIOCHEMISTRY 30 6203-6209 1991
  •  Receptors for sperm-activating peptides, SAP-I and SAP-IIB, on spermatozoa of sea urchins, Hemicentrotus pulcherrimus and Glyptocidaris crenularis. Dev Growth Differ 33 67-73 1991
  •  Fractioantion of micromeres, mesomeres, and macromeres of 16-cell stage sea urchin embryos by elutriation. Dev Growth Differ 36 381-387 1994
  •  Transcripts containing the sea urchin retroposon family 1 (SURF1) in embryos of the sea urchin Anthocidaris crassispina Yamaguchi, M. and Ohba, Y. ZOOLOGICAL SCIENCE 14 10 947-952 1997
  •  Hox genes of the direct-type developing sea urchin Peronella japonica Zoological Science 18 353-359 2001/03
  •  Transient activation of the micro1 homeobox gene family in the sea urchin (Hemicentrotus pulcherrimus) micromere Development Genes & Evolution 212 1-10 2002/02
  •  The development of the enteropneust hemichordate Balanoglossus misakiensis. ZOOLOGICAL SCIENCE 21 533-540 2004
  •  Structure, regulation, and function of the micro1 in the sea urchin Hemicentrotus pulcherrimus DEVELOPMENT GENES AND EVOLUTION 214 526-536 2004
  •  The micro1 gene is necessary and sufficient for micromere differentiation and mid/hindgut-inducing activity of the sea urchin embryo Yamazaki, A., Kawabata, R., Shiomi, K., Amemiya, S., Sawaguchi, S., Nakatsubo-Mitsunaga, K., and Yamaguchi, M. Development Genes & Evolution 215 1 450-459 2005
  •  Expression patterns of Hox genes in larvae of the sea lily Metacrinus rotundus Hara, Y., Yamaguchi, M., Akasaka, K., Nakano, H., Nonaka, M., and Amemiya, S. Development Genes & Evolution 216 1 797-809 2006
  •  Kruppel-like is required for nonskeletogenic mesoderm specification in the sea urchin embryo Atsuko Yamazaki, Rika Kawabata, Kosuke Shiomi, Jun Tsuchimoto, MasatoKiyomoto, Shonan Amemiya, Masaaki Yamaguchi Developmental Biology 314 2 433-442 2008/02
  •  Expression Patterns of three Par-related genes in sea urchin embryos Shiomi, K. and Yamaguchi, M. Gene Expression Patterns 8 5 323-330 2008/05
  •  Structure-function correlation of micro1 for micromere specification in sea urchin embryos Yamazaki, A., Ki, S., Kokubo, T., and Yamaguchi, M. MECHANISMS OF DEVELOPMENT 126 611-623 2009/06
  •  The Hox8 of the hemichordate Balanoglossus misakiensis Urata, M., Tsuchimoto, J., Yasui, K., and Yamaguchi, M. DEVELOPMENT GENES AND EVOLUTION in press 2009/08
  •  Evolutionary modification of T-brain (tbr) expression patterns in sand dollar Minemura, K., Yamaguchi, M., and Minokawa, T. GENE EXPRESSION PATTERNS 9 7 468-474 2009/10
  •  Conserved early expression patterns of micromere specification genes in two echinoid species belonging to the order Clypeasteroida and Echinoida. Atsuko Yamazaki, Yousuke Furuzawa, and Masaaki Yamaguchi  Developmental Dynamics 239 3391-3403 2010/11
  •  Unusual coelom formation in the direct-type developing sand dollar Peronella japonica DEVELOPMENTAL DYNAMICS 240 11 2432-2439 2011/10
  •  The extracellular-matrix retaining cyanobacterium Nostoc verrucosum accumulates trehalose but is sensitive to desiccation. Toshio Sakamoto, Keisuke Kumihashi, Shinpei Kunita, Takuya Masaura, Kaori Inoue-Sakamoto, and Masaaki Yamaguchi FEMS MICROBIOLOGY ECOLOGY 77 385-394 2011/05
  •  Par6 regulates skeletogenesis and gut differentiation in sea urchin larvae. Kosuke Shiomi, Atsuko Yamazaki, Mitsuyoshi Kagawa, Masato Kiyomoto, Masaaki Yamaguchi DEVELOPMENT GENES AND EVOLUTION 222 5 269–378 2012/05

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

○Evolutionary Developmental Biology(2017)
○Experiments in Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Developmental Biology Lab(2017)
○Developmental Biology(2017)
○Research Seminar in Biology (2)(2017)
○Research Work in Biology(1)(2017)
○Research Work in Biology(2)(2017)
○Research Seminar in Biology (1)(2017)
○Guide to Biology and Earth Sciences(2017)
○Research Seminar in Biology (1)(2016)
○Developmental Biology Lab(2016)
○Guide to Biology and Earth Sciences(2016)
○Research Work in Biology(1)(2016)
○Evolutionary Developmental Biology(2016)
○Research Work in Biology(2)(2016)
○Developmental Biology(2016)
○Molecular and Cellular Biology(2016)
○Molecular and Cellular Biology(2016)
○Molecular and Cellular Biology(2016)
○Molecular and Cellular Biology(2016)
○Molecular and Cellular Biology(2016)
○Molecular and Cellular Biology(2016)
○Research Seminar in Biology (2)(2016)

Classes (Graduate Schools)

○Integrated Systems Biology A(2017)
○Integrated Systems Biology B(2017)
○Evo-Devo of Echinoderms(2017)
○Evo-Devo of Echinoderms(2017)
○Evo-Devo of Echinoderms(2017)
○Evo-Devo of Echinoderms(2017)
○Integrated Systems Biology A(2016)
○Research work in Systems Biology(2016)
○Basic Exercise in Systems Biology(2016)
○Evo-Devo of Echinoderms(2016)
○Research work in Systems Biology(2016)
○Integrated Systems Biology B(2016)
○Research Skills B(2016)
○Basic Systems Biology A(2016)
○Basic Systems Biology B(2016)
○Research Skills A(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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