Jump to contents

Researcher Information

last modified:2021/07/31

Professor OKAMOTO, Shigefumi

Mail Laboratory Website
Laboratory Website
Laboratory Website

Faculty, Affiliation

Institute for Frontier Science Initiative Innovative Integrated Bio-Research Core, Advanced Health Care Science Research Unit
Professor

College and School Educational Field

Division of Transdisciplinary Sciences,Graduate School of Frontier Science Initiative
Division of Health Sciences, Graduate School of Medical Science
Division of Transdisciplinary Sciences, Graduate School of Frontier Science Initiative
Division of Health Sciences,Graduate School of Medical Science
Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Advanced Health Care Science Research Unit / Department of Laboratory Sciences, Pathogenic Microbiology and Microbiome Science TEL:076-265-2597 FAX:076-265-2597

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tohoku University Graduate School of Dentistry Doctor Graduate School of Dentistry Clinical Dentistry (Oral Surgery) 199503 Completed
【Academic background(Bachelor's Degree)】
Tohoku University 199103
【Degree】
Ph. D.

Career

Japan Society for the Promotion of Science Research Fellowship for Young Scientist(1994/04/01-1996/03/31)
University of Southern California, Keck School of Medicine Dept. Mol. Microbiol. Immunol. Post Doctoral Fellow(1996/04/01-1998/10/31)
Osaka University  Sch. Dent. Dept. of Oral Microbioi. Research Associate (1998/11/15-2000/03/31)
Osaka University Graduate School of Dentistry Dept. Oral Mol. Microbiol. Research Associate(2000/04/01-2004/06/30)
Fukuoka Dental College Sec. Infect. Biol. Lecturer(2004/07/01-2006/03/31)
National Institute of Biomedical Innovation Lab. Virol. Vaccinol. Researcher(2006/04/01-2014/03/31)
Osaka University  Graduate School of Dentistry Guest Professor(2011/04/01-2013/03/31)
Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Health Sciences Professor(2014/04/01-2021/03/31)
Kanazawa University Institute for Frontier Science Initiative Professor(2021/04/01-)

Year & Month of Birth

1965/10

Academic Society







Award

Specialities

Bacteriology (including mycology)、Virology、Fundamental nursing、Morphological basic dentistry

Speciality Keywords

Strptococci,Superinfectious diseases, Pathogen, Microbiome

Research Themes

Analysis of pathogenicity of <i>Streptococcus</i>

Analysis of pathogenicity of <i>Streptococcus</i>

Causal relationship between changes in resident microbial flora and various infectious diseases

Causal relationship between changes in resident microbial flora and various infectious diseases

Epidemiological study toward the creation of new "preventive medicine and dentistry" and "health science" that are found by organically linking the oral and general conditions

Books

  •  岡本成史 ヒト常在菌叢と生理機能・全身疾患 シーエムシー出版 2020/08/31
  •  Shigefumi Okamoto Medical Science Clinical Microbiological Research (2nd Edition) 2016/11/01
  •  Kayo Sugitani, Yasuko Senda, Shigefumi Okamoto Medical Science Clinical Microbial Research (2nd Edition) 2016/11/01

Papers

  •  Association of Skin Microbiome with the Onset and Recurrence of Pressure Injury in Bedridden Elderly People Okamoto S, Ogai K, Mukai K, Sugama J. Microorganisms 9 8 1603 2021/07/27 
  •  GP96 drives exacerbation of secondary bacterial pneumonia following influenza A virus infection  Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S mBio 12 3 e03269-20 2021/06/11 
  •  Relationship between Decreased Mineral Intake Due to Oral Frailty and Bone Mineral Density: Findings from Shika Study Suzuki F, Okamoto S, Miyagi S, Tsujiguchi H, Akinori Hara A, Nguyen TTT, Shimizu Y, Hayashi K, Suzuki K, Nakai S, Miyagi M, Kannon T, Tajima A, Tsuboi H, Konoshita T, Nakamura H Nutrients 13 4 1193 2021/04/05 
  •  Comparative genome analysis of three Group A Streptococcus dysgalactiae subsp. equisimilis strains isolated in Japan Ishihara H, Ogura K, Nguyen VA, Miyohi-Akiyama T, Okamoto S, Takemoto N. Journal of Medical Microbiology 70 3 001322 2021/02/03 
  •  Amplicon-based skin microbiome profiles collected by tape stripping with different adhesive film dressings: a comparative study Ogai K, Shibata K, Takahashi N, Ogura K, Okamoto S, Sugama J. BMC Microbiology 21 1 54 2021/02/18 

show all

  •  Skin Physiology and its Microbiome as Factors Associated with the Recurrence of Pressure Injuries Shibata K, Ogai K, Ogura K, Urai T, Aoki M, Arisandi D, Takahashi N, Okamoto S, Sanada H, Sugama J. Biological Research for Nursing 23 1 75-81 2021/01/23 
  •  Stability of Skin Microbiome at Sacral Regions of Healthy Young Adults, Ambulatory Older Adults, and Bedridden Older Patients After 2 Years Ogai K, Ogura K, Ohgi N, Park S, Aoki M, Urai T, Nagase S, Okamoto S, Sugama J. Biological Research for Nursing 23 1 82-90 2021/01/23 
  •  寝たきり高齢者における皮膚細菌叢の構成変化と皮膚傷害への影響 岡本成史 地域ケアリング 22 56-59 2020/11/28
  •  Novel Hyaluronate Lyase Involved in Pathogenicity of Streptococcus dysgalactiae subsp. equisimilis Nguyen VA, Ogura K, Matsue M, Takemoto N, Mukai K, Nakajima Y, Hoang TL, Iwata Y, Sakai N, Wada T, Hashimoto W, Okamoto S, Ichimura H Frontiers in Microbiology 11 552418 2020/09/24 
  •  Impact of Gut Microbiome on Hypertensive Patients with Low-Salt Intake: Shika Study Results Nagase S, Karashima S, Tsujiguchi H,Tsuboi H, Miyagi S, Kometani M, Aono D, Higashitani T, Demura M, Sakakibara H, Yoshida A, Hara A,Nakamura H, Takeda Y, Nambo H, Yoneda T,Okamoto S Frontiers in Medicine 7 475 2020/09/02 
  •  Antibacterial activity of medium chain fatty acids in coconut oil Shigefumi Okamoto 13 88-98 2020/04/25
  •  Exploring the Risk Factors for the Development of Recurrent Pressure Ulcer in Elderly Patients: A Prospective Observational Study Arisandi D, Ogai K, Urai T, Aoki M, Minematsu T, Okamoto S, Sanada H, Nakatani T, Sugama J Journal of Wound Care 29 4 S14-S24 2020/04/10 
  •  Distinct Skin Microbiome and Skin Physiological Functions Between Bedridden Older Patients and Healthy People: A Single-Center Study in Japan Nagase S, Ogai K, Urai T, Shibata K, Matsubara E, Murai K, Matsue M, Mori Y, Aoki M, Arisandi D, Sugama J, Okamoto S Frontiers in Medicine 7 101 2020/04/10 
  •  Prevalence and Genomic Characterization of Group A Streptococcus Dysgalactiae Subsp. Equisimilis Isolated From Patients With Invasive Infections in Toyama Prefecture, Japan Ishihara H, Ogura K, Miyohi-Akiyama T, Nakamura M, Kaya H, Okamoto S. Microbiology and Immunology 64 2 113-122 2020/02/04 
  •  Pathogenicity characterization of prevalent-type Streptococcus dysgalactiae subsp. equisimilis strains Matsue M, Ogura K, Sugiyama H, Miyoshi-Akiyama T,Takemori-Sakai Y, Iwata Y, Wada T, Okamoto S Frontiers in Microbiology 11 97 2020/02/04 
  •  Relationship between oral conditions and the gut microbiome in healthy adults in Ishikawa prefecture, Japan  Nagase S, Kotani Y, Nakamura M, Matsuoka A, Okamoto S Journal of Wellness and Health Care 43 2 1-10 2020/02/03 
  •  Food bolus-forming ability predicts incidence of aspiration pneumonia in nursing home older adults: a prospective observational study Hase T, Miura Y, Nakagami G, Okamoto S, Sanada H, Sugama J Journal of Oral Rehabilitation 47 1 53-60 2020/01/01 
  •  Measuring the antimicrobial activity of lauric acid against various bacteria in human gut microbiota by using a new method Matsue M, Mori Y, Nagase S, Sugiyama Y, Hirano R, Ogai K, Ogura K, Kurihira S, Okamoto S. Cell Transplantation 28 12 1528-1541 2019/12/18 
  •  Feasibility of microbial sample collection on the skin from people in Yaounde, Cameroon Benderli NC, Ogai K, Lloyd YM, Arios JP, Jiyarom B, Awanakam AH, Esemu LF, Hori A, Megnekou, R, Leke RGF, Kuraishi T, Okamoto S, Ekali GL Drug Discoveries and Thereupics 13 6 360-364 2019/12 
  •  A Comparison of Techniques for Collecting Skin Microbiome Samples: Swabbing versus Tape-Stripping  Kazuhiro Ogai, Satoshi Nagase, Kanae Mukai, Terumi Iuchi, Yumiko Mori, Miki Matsue, Kayo Sugitani, Junko Sugama Shigefumi Okamoto Frontiers in Microbiology 9 2362 2018/11/20 
  •  Pathogenic mechanisms of invasive group A Streptococcus (GAS) infections by influenza virus-GAS superinfection Shigefumi Okamoto, Satoshi Nagase Microbiology and Immunology 62 3 141-149 2018/03/25 
  •  Changes in the constitution of the skin resident microflora in bedridden elderly Shigefumi Okamoto, Kazuhiro Ogai, Junko Sugama BioClinica 32 13 1300-1307 2017/12/01
  •  Comparison of antimicrobial spectrum and mechanisms of organic virgin coconut oil and lauric acid against bacteria Nagase S, Matsue M, Mori Y, Honda-Ogawa M, Sugitani K, Sumitomo T, Nakata M, Kawabata S, Okamoto S. Journal of Wellness and Health Care 41 1 87-95 2017/09/01 
  •  Toll-like receptor 9 ligand D-type oligodeoxynucleotide D35 as a broad inhibitor for influenza A virus replication that is associated with suppression of neuraminidase activity Yamada H, Nagase S, Takahashi K, Sakoda Y, Kida H, Okamoto S. Antiviral Research 129 81-92 2016/05/01 
  •  Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza library Haredy AM, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Okamoto S, Okuno Y, Yamanishi K.  Journal of General Virology 95 11 2365-2371 2014/11 
  •  Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated withthe emergence of specific mutations in the neuraminidase glycoprotein Yamada H, Nagao C, Haredy AM, Mori Y, Mizuguchi K, Yamanishi K, Okamoto S Antiviral Research 111 2 69-77 2014/11 
  •  An MDCK cell culture-derived formalin-inactivated influenza virus whole-virion vaccine from an influenza virus library confers cross-protective immunity by intranasal administration in mice Haredy AM, Takenaka N, Yamada H, Sakoda Y, Okamatsu M, Yamamoto N, Omasa T, Ohtake H, Mori Y, Kida H, Yamanishi K, Okamoto S Clinical and Vaccine Immunology 20 7 998-1007 2013/07 
  •  Influenza virus neuraminidase contributes to the dextran sulfate-dependent suppressive replication of some influenza A virus strains Yamada H, Moriishi E, Haredy AM, Takenaka N, Mori Y, Yamanishi K, Okamoto S ANTIVIRAL RESEARCH 96 3 344-352 2012/12 
  •  Comparison of the cross-reactive anti-influenza neutralizing activity of polymeric and monomeric IgA monoclonal antibodies Tanimoto T, Haredy AM, Takenaka N, Tamura S, Okuno Y, Mori Y, Yamanishi K. Okamoto S VIRAL IMMUNOLOGY 25 5 433-439 2012/10 
  •  Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient Kawai T, Saito M, Nishikomori R, Yasumi T, Izawa K, Murakami T, Okamoto S, Mori Y, Nakagawa N, Imai K, Nonoyama S, Wada T, Yachie A, Ohmori K, Nakahata T, Heike T JOURNAL OF CLINICAL IMMUNOLOGY 32 4 690-697 2012/09 
  •  A community-based survey of varicella-zoster virus-specific immune responses in the elderly Tang H, Moriishi E, Okamoto S, Okuno Y, Iso H, Asada H, Yamanishi K, Mori Y, for the Shozu Herpes Zoster (SHEZ) Study group JOURNAL OF CLINICAL VIROLOGY 55 1 46-50 2012/09 
  •  Intranasal immunization with formalin-inactivated human influenza A whole-virion vaccine alone and with split-virion vaccine with mucosal adjuvants show similar cross-protection Okamoto S, Matsuoka S, Takenaka N, Haredy AM, Tanimoto T, Gomi Y, Ishikawa T, Akagi T, Akashi M, Okuno Y, Mori Y, Yamanishi K Clinical and Vaccine Immunology 19 7 979-990 2012/07 
  •  Poly-γ-glutamic acid nanoparticles and aluminum adjuvant used as an adjuvant with a single dose of Japanese encephalitis virus-like particles provides effective protection from Japanese encephalitis virus Okamoto S, Yoshii H, Matsuura M, Kojima A, Ishikawa T, Akagi T, Akashi M, Takahashi M, Yamanishi K, Mori Y Clinical and Vaccine Immunology 19 1 17-22 2012/01 
  •  Systematic characterization of mucosal and systemic immune responses elicited by interleukins as mucosal vaccine adjuvant against influenza virus Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y JOURNAL OF VIROLOGY 84 24 12703-12712 2010/12 
  •  Rapid and efficient introduction of a foreign gene into bacterial artificial chromosome-cloned varicella vaccine by Tn7-mediated site-specific transposition Somboonthum P, Koshizuka T, Okamoto S, Matsuura M, Gomi Y, Takahashi M, Yamanishi K, Mori Y VIROLOGY 402 1 215-221 2010/04 
  •  Comparison of varicella-zoster virus-specific immunity of patients with diabetes mellitus and healthy individuals Okamoto S, Hata A, Sadaoka K, Yamanishi K, Mori Y JOURNAL OF INFECTIOUS DISEASES 200 10 1606-1610 2009/11 
  •  Poly(gamma-glutamic acid) nano-particles combined with mucosal influenza virus hemagglutinin vaccine protects against influenza virus infection in mice Okamoto S,Matsuura M,Akagi T, Akashi M, Tanimoto T, Ishikawa T, Takahashi M, Yamanishi K, Mori Y. VACCINE 27 42 5896-5905 2009/09 
  •  A novel streptococcal leucine zipper protein (Lzp) binds to human immunoglobulins Okamoto S, Terao Y, Hasuike K, Hamada S, Kawabata S BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377 4 1128-1134 2008/12 
  •  Measurement of varicella-zoster virus (VZV)-specific cell-mediated immunity — Comparison of VZV-skin test and interferon-γ ELISPOT assay Sadaoka K, Okamoto S, Gomi Y, Tanimoto T, Yoshikawa T, Asano Y, Yamanishi K, Mori Y JOURNAL OF INFECTIOUS DISEASES 198 9 1327-1333 2008/11 
  •  Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes Okamoto S, Terao Y, Tamura Y, Hamada S, Kawabata S FEMS MICROBIOLOGY LETTERS 281 1 73-81 2008/04 
  •  Molecular and biological characterization of histidine triad protein in group A streptococci Kunitomo E, Terao Y, Okamoto S, Rikimaru T, Hamada S, Kawabata S MICROBES AND INFECTION 10 4 414-423 2008/04 
  •  Single dose of inactivated Japanese encephalitis vaccine with poly (γ-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus Okamoto S, Yoshii H, Ishikawa T, Akagi T, Akashi M, Takahashi M, Yamanishi K, Mori Y VACCINE 26 5 589-594 2008/01 
  •  Generation of a recombinant Oka varicella vaccine expressing a mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine Somboonthum P, Yoshii H, Okamoto S, Koike M, Gomi Y, Uchiyama Y, Takahashi M, Yamanishi K, Mori Y. VACCINE 27 52 8741-8755 2007/11 
  •  Influenza hemagglutinin vaccine with poly (γ-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity Okamoto S, Yoshii H, Akagi T, Akashi M, Ishikawa T, Okuno Y, Takahashi M, Yamanishi K, Mori Y VACCINE 25 49 8270-8278 2007/10 
  •  Water-insoluble α-glucans from Streptococcus sobrinus induce inflammatory immune responses Okamoto S,Terao Y,Kaminishi H,Hamada S,Kawabata S Interface Oral Health Science 2007 243-247 2007/09
  •  Inflammatory immune responses by water-insoluble α-glucans Okamoto S, Terao Y, Kaminishi H, Hamada S, Kawabata S JOURNAL OF DENTAL RESEARCH 86 3 242-248 2007/03 
  •  Protective immunity against Streptococcus pyogenes challenge in mice following immunization with fibronectin-binding protein Terao Y, Okamoto S, Kataoka K, Hamada S, Kawabata S JOURNAL OF INFECTIOUS DISEASES 192 12 2081-2091 2005/12 
  •  Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice Okamoto S, Tamura Y, Terao Y, Hamada S, Kawabata S. VACCINE 23 40 4852-4859 2005/09 
  •  The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection Okamoto S, Kawabata S, Terao Y, Fujitaka H, Okuno Y, Hamada S. INFECTION AND IMMUNITY 72 10 6068-6073 2004/10 
  •  Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase/Streptococcus pyrogenic exotixin B. Tamura F, Nakagawa R, Akuta T, Okamoto S, Hamada S, Maeda H, Kawabata S, Akaike T INFECTION AND IMMUNITY 72 8 4836-4847 2004/08 
  •  Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza-Streptococcus pyogenes superinfection Okamoto S, Kawabata S, Fujitaka H, Uehira T, Okuno Y, Hamada S VACCINE 22 21-22 2887-2893 2004/07 
  •  A model of invasive type of Streptococcus pyogenes infection after intranasal infection in influenza A virus Okamoto S,Kawabata S,Nakagawa I,Okuno Y,Goto T,Sano K,Hamada S International Congress Series 1263 733-736 2004/07
  •  Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice Okamoto S, Kawabata S, Nakagawa I, Okuno Y, Goto T, Sano K, Hamada S. JOURNAL OF VIROLOGY 77 7 4104-4112 2003/04 
  •  Administration of superantigens protects mice from lethal Listeria monocytogenes infection by enhancing cytotoxic T cells. Okamoto S, Kawabata S, Nakagawa I, Hamada S. INFECTION AND IMMUNITY 69 11 6633-6642 2001/11 
  •  Extracellular nicotinamide adenine dinucleotide induces T cell apoptosis in vivo and in vitro Liu ZX, Ajipa O, Okamoto S, Govindarajan S, Dennert G JOURNAL OF IMMUNOLOGY 167 9 4942-4947 2001/11 
  •  Fas-mediated apoptosis causes elimination of virus-specific cytotoxic T cells in the virus-infected liver. Liu ZX, Govindarajan S, Okamoto S, Dennert G JOURNAL OF IMMUNOLOGY 166 5 3035-3041 2001/03 
  •  NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection Liu ZX, Govindarajan S, Okamoto S, Dennert G JOURNAL OF IMMUNOLOGY 164 12 6480-6486 2000/06 
  •  Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice.  Liu ZX, Govindarajan S, Okamoto S, Dennert G.  HEPATOLOGY 31 3 665-673 2000/03 
  •  Expression of ADP-ribosyltransferase on normal T lymphocytes and effects of nicotinamide adenine dinucleotide on their function.  Okamoto S, Azhipa O, Yu Y, Russo E, Dennert G JOURNAL OF IMMUNOLOGY 160 9 4190-4198 1998/05 
  •  Superantigenicity of helper T-cell mitogen (SPM-2) isolated from culture supernatants of Streptococcus pyogenes.  Rikiishi H, Okamoto S, Sugawara S, Tamura K, Liu ZX, Kumagai K. IMMUNOLOGY 91 3 406-413 1997/04 
  •  Molecular cloning of a functional murine arginine-specific mono ADP ribosyltransferase and its expression in lymphoid cells.  Yu Y, Okamoto S, Nemoto E, Dennert G DNA AND CELL BIOLOGY 16 2 235-244 1997/02 
  •  Isolation of a new superantigen with potent mitogenic activity to murine T cells from Streptococcus pyogenes.  Nemoto E, Rikiishi H, Sugawara S, Okamoto S, Tamura K, Maruyama Y, Kumagai K.  FEMS Immunology and Medical Microbiology 15 2-3 81-91 1996/09 
  •  Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice.  Ohteki T, Okamoto S, Nakamura M, Nemoto E, Kumagai E.  IMMUNOLOGY LETTERS 36 2 145-152 1993/05 

Conference Presentations

  • Hyaluronate lyase involved in nutrient acquisition and pathogenicity of Streptococcus dysgalactiae(2021/03/23)
  • Distinct skin microbiome and skin physiological functions between bedridden older patients and healthy people: A single-center study in Japan.(conference:11th International Conference on Skin Aging and Challenges)(2020/11/04)
  • Comparison of skin microbiome and skin physiological function between bedridden elderly with high risk of pressure injury and healthy people with low risk of pressurre injury. (conference:ASM Microbe 2019)(2019/06/20)
  • Tape strips technique for collecting skin microbiome samples-comparison with swab methods.(conference:Skin Microbiome Congress)(2019/05/29)
  • Techniques for Collecting Skin Microbiome Samples: Limits and Perspective(conference:10th International Conference on Skin Aging and Challenges)(2019/02/25)

show all

  • A novel and simple measuring method for antimicrobial activity of medium-chain fatty acids by using an optical density meter. (conference:The 5th Congress of the Asia Association of Medical Laboratory Scientists)(2017/09/22)
  • Comparison of techniques for colletion of skin microbiome samples: swabbing method versus tape-stripping method (conference:The 5th Congress of the Asia Association of Medical Laboratory Scientists)(2017/09/22)
  • A comparative study of skin bacterial communities in healthy-young individuals and bedridden-aged inpatients in Japan(conference:World Union of Wound Healing Societies 2016)(2016/09/25)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「リンパ浮腫に続発するレンサ球菌での蜂窩織炎発症機序とその予防・緩和ケア対策」(2021-2024) 
○「スマートホームケア構想実現のための非侵襲的リキッドアセスメント技術の開発」(2020-2023) 
○2022「アドバンストスキンケア開発を目指した創閉鎖後の脆弱な皮膚環境と褥瘡再発との関連」(2020-2022) 
○「HIV感染による皮膚粘膜細菌叢変化と皮膚粘膜感染症の関連性と緩和ケアへの応用」(2019-2022) 
○「皮膚常在菌叢の変化に着目した褥瘡後感染症の原因解析及びその予防・緩和ケアの検討」(2017-2020) 
○「東南アジア諸国における肺炎球菌の疫学解析と新規病原性の探索」(2016-2019) 
○「インフルエンザウイルス―口腔細菌混合感染による致死的感染症発症とその機構」(2014-2016) 
○「鳥インフルエンザウイルスの増殖能を決定するアミノ酸変異の解析.」(2012-2014) 
○「粘膜免疫により産生される粘膜分泌型抗インフルエンザ抗体の交叉防御機構の解析」(2011-2013) 
○「インフルエンザ感染による肺炎レンサ球菌の組織侵入増強に関わる分子群同定とその機能」(2009-2010) 
○「ヒトヘルペスウイルスの病原性発現に関与する因子の同定と機能解析.」(2008-2010) 
○「インフルエンザ―細菌の混合感染での重症肺炎発症に関する病原因子の検索」(2006-2007) 
○「 A群レンサ球菌のフィブロネクチン結合タンパクの感染防御抗原としての可能性」(2006-2007) 
○「口腔レンサ球菌由来の不溶性グルカンによる炎症性免疫応答と歯周病発症との関連」(2004-2005) 
○「免疫担当細胞に対して分子凝態を呈するレンサ球菌由来タンパク質の同定および機能解析」(2004-2005)
○「ゲノム機能解析による口腔内経粘膜レンサ球菌感染症の分子病態の解明」(2002-2004) 
○「インフルエンザウイルスとの混合感染で発症する劇症型A群レンサ球菌感染症の病因解析」(2002-2003) 
○「A群レンサ球菌表層タンパクを介する細胞侵入機構の解析および同感染症制御法への応用」(2002-2003) 
○「劇症型GAS感染症と好中球、筋細胞表面ADPリボシル転移酵素活性との因果関係」(2000-2001) 
○「歯周病原性細菌の線毛DNAワクチン接種によるマウスの粘膜免疫応答の誘導」(2000-2001) 
○「将来出現が予想される新型インフルエンザに即応できる次世代ワクチンの臨床応用に向けた研究」 

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Pathogenic Microbiology 1(2020)
○Immunology(2020)
○Clinial Practice of Pathologic Microbiology(2020)
○General Microbiology(2020)
○Practice in Pathogenic Microbiology(2020)
○Basic Health Science 1(2020)
○Customized Research Project(2020)
○Public Health(2020)
○Introduction to Infection Control(2020)
○Pathogenic Microbiology 1(2019)
○Immunology(2019)
○Clinial Practice of Pathologic Microbiology(2019)
○Pathogenic Microbiology 1(2019)
○General Microbiology(2019)
○General Microbiology(2019)
○Practice in Pathogenic Microbiology(2019)
○Public Health(2019)
○Introduction to Infection Control(2019)
○Basic Health Science 1(2019)
○Presentation and Debate (Freshman Seminar II)(2018)
○Clinial Practice of Pathologic Microbiology(2018)
○Practice in Pathogenic Microbiology(2018)
○Immunology(2018)
○Pathogenic Microbiology 1(2018)
○Introduction to Infection Control(2018)
○General Microbiology(2018)
○Practice in Pathogenic Microbiology(2017)
○Bacterial Toxicology(2017)
○Clinial Practice of Pathologic Microbiology(2017)
○Introduction to Infection Control(2017)
○Immunology(2017)
○Pathogenic Microbiology 1(2017)
○General Microbiology(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Presentation and Debate (Freshman Seminar II)(2017)

Classes (Graduate Schools)

○Fostering the independence of researchers(2020)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2020)
○Molecular Biology for Laboratory Medicine: Seminar(2020)
○Molecular Biology for Laboratory Medicine: Lecture(2020)
○Preventive Medicine(2020)
○Molecular Biology for Laboratory Medicine:Research(2020)
○Infectious/Pathogenic Agents: Seminar(2020)
○Infectious/Pathogenic Agents: Lecture(2020)
○Management of opportunistic infection affecting tissue viability of human skin and mucosa of oral cavity or pharynx(2019)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2019)
○Research Design in Health Science(Basic): Lecture(2019)
○Fostering the independence of researchers(2019)
○Molecular Biology for Laboratory Medicine:Research(2019)
○Preventive Medicine(2019)
○Infectious/Pathogenic Agents: Seminar(2019)
○Infectious/Pathogenic Agents: Lecture(2019)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2018)
○Molecular Biology for Laboratory Medicine: Seminar(2018)
○Molecular Biology for Laboratory Medicine: Lecture(2018)
○Management of opportunistic infection affecting tissue viability of human skin and mucosa of oral cavity or pharynx(2018)
○Research Design in Health Science(Basic): Lecture(2018)
○Molecular Biology for Laboratory Medicine:Research(2018)
○Infectious/Pathogenic Agents: Seminar(2018)
○Infectious/Pathogenic Agents: Lecture(2018)
○An Introduction to Medical Laboratory Sciences:Lec(2018)
○Preventive Medicine(2018)
○Infectious/Pathogenic Agents: Seminar(2017)
○Infectious/Pathogenic Agents: Lecture(2017)
○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Molecular Biology for Laboratory Medicine: Seminar(2017)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2017)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2017)
○Infectious/Pathogenic Agents: Seminar(2017)
○Infectious/Pathogenic Agents: Seminar(2017)
○Molecular Biology for Laboratory Medicine: Seminar(2017)
○Molecular Biology for Laboratory Medicine:Research(2017)
○Molecular Biology for Laboratory Medicine:Research(2017)
○Molecular Biology for Laboratory Medicine:Research(2017)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2017)
○Molecular Biology for Laboratory Medicine: Seminar(2017)
○Molecular Biology for Laboratory Medicine: Lecture(2017)
○Adv. Mol. Biol. for Laboratory Medicine: Research(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top