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Researcher Information

last modified:2021/06/07

Associate Professor HOSOMICHI, Kazuyoshi

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
Associate Professor

College and School Educational Field


Laboratory

Department of Bioinformatics and Genomics TEL:076-265-2716 FAX:076-234-4249

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tokyo University of Agriculture Doctor Graduate School of Agriculture 200503 Completed
【Academic background(Bachelor's Degree)】
Tokyo University of Agriculture Department of Animal Science 200003
【Degree】
PhD.

Career

National Institute of Genetics Division of Human Genetics, Dept. of Integrated Genetics Assistant Professor(2010/11/01-2015/01/31)
Tokai University School of Medicine Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine Post-doctoral fellow(2005/04/01-2010/10/31)

Year & Month of Birth

Academic Society

Japanese Society for Histocompatibility and Immunogenetics
The Japan Society of Human Genentics
The Molecular Biology Society of Japan
Society of Evolutionary Studies, Japan
Japanese Society of Animal Breeding and Genetics
Japanese Society of Animal Science

Award

Specialities

Genome biology

Speciality Keywords

Bioinformatics, Genomics, Immunogenetics, Medical genomics, Human genetics, Comparative genomics

Research Themes

Books

  •  日本臨床腫瘍学会(JSMO)・日本癌学会(JCA)・日本癌治療学会(JSCO) よくわかるがんゲノム医療 Q&A -あなたの疑問に専門医が答える!- 2020/12/25
  •  細道一善 次世代シークエンサー(NGS)による新規糖尿病遺伝子同定のピットフォール ~in silico解析による意義不明変異(VUS)の取り扱いについて~ 月刊糖尿病 医学出版 2020/09
  •  日本赤十字社HLA委員会、日本造血細胞移植学会 造血細胞移植のためのHLAガイドブック 2019/05/10
  •  細道一善、秋山雅人、岡田随象 バイオインフォマティクスを使い倒すために必要なこと 最新醫學 2019/02

Papers

  •  Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia Nomura A, Sato T, Tada H, Kannon T, Hosomichi K, Tsujiguchi H, Nakamura H, Takamura M, Tajima A, Kawashiri MA. J Hum Genet.  2021/05
  •  Molecular features of tumor-derived genetic alterations in circulating cell-free DNA in virtue of autopsy analysis.  Koba H, Kimura H, Yoneda T, Sone T, Ohkura N, Hara J, Hosomichi K, Tajima A, Kasahara K. Sci Rep. 11 1 8398 2021/04
  •  Identification of candidate PAX2-regulated genes implicated in human kidney development Yamamura Y, Furuichi K, Murakawa Y, Hirabayashi S, Yoshihara M, Sako K, Kitajima S, Toyama T, Iwata Y, Sakai N, Hosomichi K, Murphy PM, Tajima A, Okita K, Osafune K, Kaneko S, Wada T. Sci Rep. 11 1 9123 2021/04
  •  HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S Blood 2021/03
  •  Analysis of HLA gene polymorphisms in East Africans reveals evidence of gene flow in two Semitic populations from Sudan Aamer W, Hassan HY, Nakaoka H, Hosomichi K, Jaeger M, Tahir H, Abdelraheem MH, Netea MG, Inoue I Eur J Hum Genet 2021/03

show all

  •  Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population Hirayasu K, Sun J, Hasegawa G, Hashikawa Y, Hosomichi K, Tajima A, Tokunaga K, Ohashi J, Hanayama R. J Hum Genet 2021/02/01
  •  A novel RFX6 heterozygous mutation (p.R652X) in maturity-onset diabetes mellitus: A case report Imaki S, Iizuka K, Horikawa Y, Yasuda M, Kubota S, Kato T, Liu Y, Takao K, Mizuno M, Hirota T, Suwa T, Hosomichi K, Tajima A, Fujiwara Y, Yamazaki Y, Kuwata H, Seino Y, Yabe D. J Diabetes Investig 2021/03
  •  MCPIP1 reduces HBV-RNA by targeting its epsilon structure Li Y, Que L, Fukano K, Koura M, Kitamura K, Zheng X, Kato T, Aly HH, Watashi K, Tsukuda S, Aizaki H, Watanabe N, Sato Y, Suzuki T, Suzuki HI, Hosomichi K, Kurachi M, Wakae K, Muramatsu M Sci Rep 10 1 20763 2020/11
  •  A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14) V. I. Romero, J. C. Pozo, S. Saenz, A. Llamos-Paneque, T. Liehr, K. Hosomichi, A. Tajima Human Genome Variation  7 1 2020/12
  •  HLA-B*39:01:01 is a novel risk factor for antithyroid drug-induced agranulocytosis in Japanese population Nakakura S, Hosomichi K, Uchino S, Murakami A, Oka A, Inoue I, Nakaoka H. Pharmacogenomics J 2020/09
  •  Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss Oka A, Takagi A, Komiyama E, Yoshihara N, Mano S, Hosomichi K Suzuki S, Haida Y, Motosugi N, Hatanaka T, Kimura M, Ueda MT, Nakagawa S, Miura H, Ohtsuka M, Tanaka M, Komiyama T, Otomo A, Hadano S, Mabuchi T, Beck S, Inoko H, Ikeda S EBioMedicine 2020/06
  •  Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically-defined gout patients Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T , Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M , Sugiyama R, Takada Y, Takada Y, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major T, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H Annals of the rheumatic diseases 2020/05
  •  A case of MODY5-like manifestations without mutations or deletions in coding and minimal promoter regions of the HNF1B gene Kuwabara-Ohmura Y, Iizuka K, Liu Y, Takao K, Nonomura K, Kato T, Mizuno M, Hosomichi K, Tajima A, Miyazaki T, Horikawa Y, Yabe D Endocr J 2020/05
  •  A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Nguyen MAT, Tran DC, Elbadry MIY, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S Haematologica 2020/05
  •  HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR Sakai K, Kuwana M, Tanaka H, Hosomichi K, Hasegawa J, Uyama H, Nishio K, Omae T, MHishizawa M, Matsui M, Iwato K, Okamoto A, Okuhiro K, Yamashita Y, Itoh M, Kumekawa H, Takezako N, Kawano N, Matsukawa T, Sano H, Oshiro K, Hayashi K, Ueda Y, Mushino T, Ogawa Y, Yamada Y, Murata M, Matsumoto M Blood 2020/04
  •  A catalogue of the pathogenic mutations of LDL receptor gene in Japanese familial hypercholesterolemia Tada H, Hori M, Nomura A, Hosomichi K, Nohara A, Kawashiri MA, Harada-Shiba M J Clin Lipidol 2020/03
  •  A Targeted Genetic Association Study of the Rare Type of Osteomyelitis  Yahara H, Horita S, Yanamoto S, Kitagawa Y, Asaka T, Yoda T, Morita K, Michi Y, Takechi M, Shimasue H, Maruoka Y, Kondo E, Kusukawa J, Tsujiguchi H, Sato T, Kannon T, Nakamura H, Tajima A, Hosomichi K, Yahara K. Journal of dental research 2020/01
  •  Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H Annals of the rheumatic diseases 2020/01
  •  A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis. Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, Yasutomo K The Journal of experimental medicine 2019/10
  •  Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanism. Matsumoto M, Tsuneyama K, Morimoto J, Hosomichi K, Matsumoto M, Nishijima H International immunology 2019/10
  •  Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H Annals of the rheumatic diseases. 2019/07
  •  Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia. Elbadry MI, Mizumaki H, Hosokawa K, Espinoza JL, Nakagawa N, Chonabayashi K, Yoshida Y, Katagiri T, Hosomichi K, Zaimoku Y, Imi T, Nguyen MAT, Fujii Y, Tajima A, Ogawa S, Takenaka K, Akashi K, Nakao S Haematologica. 2019/10
  •  Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese. Ogawa K, Okuno T, Hosomichi K, Hosokawa A, Hirata J, Suzuki K, Sakaue S, Kinoshita M, Asano Y, Miyamoto K, Inoue I, Kusunoki S, Okada Y, Mochizuki H Journal of neuroinflammation 16 1 162 2019/08
  •  Late Jomon male and female genome sequences from the Funadomari site in Hokkaido, Japan KANZAWA-KIRIYAMA Hideaki, JINAM Timothy A., KAWAI Yosuke, SATO Takehiro, HOSOMICHI Kazuyoshi, TAJIMA Atsushi, ADACHI Noboru, MATSUMURA Hirofumi, KRYUKOV Kirill, SAITOU Naruya, SHINODA Ken-ichi Anthropological science 127 2 83-108 2019/08
  •  New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report Aoyama KI, Kimura M, Yamazaki H, Uchibori M, Kojima R, Osawa Y, Hosomichi K, Ota Y, Tanaka M, Yamada S, Nishimura G. BMC Med Genet. 20 1 126 2019/07
  •  Genetic and phenotypic landscape of the major histocompatibilty complex region in the Japanese population. Hirata J, Hosomichi K, Sakaue S, Kanai M, Nakaoka H, Ishigaki K, Suzuki K, Akiyama M, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Hirata M, Matsuda K, Momozawa Y, Inoue I, Kubo M, Kamatani Y, Okada Y Nature genetics. 2019/01
  •  Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G. Morimoto J, Nishikawa Y, Kakimoto T, Furutani K, Kihara N, Matsumoto M, Tsuneyama K, Kozono Y, Kozono H, Hozumi K, Hosomichi K, Nishijima H, Matsumoto M Journal of immunology. 2018/11
  •  Orthognathic surgery induces genome-wide changes longitudinally in DNA methylation in saliva. Yamaguchi T, Hosomichi K, Takahashi M, Shugo H, Nakawaki T, Hikita Y, Maki K, Tajima A Oral diseases. 2018/10
  •  High Order Formation and Evolution of Hornerin in Primates. Romero V, Nakaoka H, Hosomichi K, Inoue I Genome biology and evolution. 2018/09
  •  Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease. Tada H, Kawashiri MA, Nomura A, Teramoto R, Hosomichi K, Nohara A, Inazu A, Mabuchi H, Tajima A, Yamagishi M Journal of clinical lipidology. 2018/08
  •  Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology. Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Marazita ML, Weinberg SM, Maki K, Tajima A Archives of oral biology. 96 33-38 2018/08
  •  Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations. Koba H, Kimura H, Nishikawa S, Sone T, Abo M, Hara J, Hosomichi K, Tajima A, Kasahara K Lung cancer. 122 146-150 2018/08
  •  No novel, high penetrant gene might remain to be found in Japanese patients with unknown MODY. Horikawa Y, Hosomichi K, Enya M, Ishiura H, Suzuki Y, Tsuji S, Sugano S, Inoue I, Takeda J Journal of human genetics  63 7 821-829 2018/07
  •  Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes. Takahashi M, Hosomichi K, Yamaguchi T, Nagahama R, Yoshida H, Maki K, Marazita ML, Weinberg SM, Tajima A Oral diseases. 2018/06
  •  Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia. Imi T, Katagiri T, Hosomichi K, Zaimoku Y, Hoang Nguyen V, Nakagawa N, Tajima A, Yoshizato T, Ogawa S, Nakao S Blood advances. 2 1000-1012 2018/05
  •  Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism. Maruyama K, Aotsuka N, Kumano Y, Sato N, Kawashima N, Onda Y, Maruyama H, Katagiri T, Zaimoku Y, Nakagawa N, Hosomichi K, Ogawa S, Nakao S. Biol Blood Marrow Transplant. 24 43-49 2018/01
  •  Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE). Nishijima H, Kajimoto T, Matsuoka Y, Mouri Y, Morimoto J, Matsumoto M, Kawano H, Nishioka Y, Uehara H, Izumi K, Tsuneyama K, Okazaki IM, Okazaki T, Hosomichi K, Shiraki A, Shibutani M, Mitsumori K, Matsumoto M. J Autoimmun. 86 75-92 2018/01
  •  Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia. Zaimoku Y, Takamatsu H, Hosomichi K, Ozawa T, Nakagawa N, Imi T, Maruyama H, Katagiri T, Kishi H, Tajima A, Muraguchi A, Kashiwase K, Nakao S. Blood. 129 2908-2916 2017
  •  Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing. Yamaguchi T, Hosomichi K, Yano K, Kim Y, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I. Hum Genome Var. 4 17005 2017
  •  Rapid and cost-effective high-throughput sequencing for identification of germline mutations of BRCA1 and BRCA2. Ahmadloo S, Nakaoka H, Hayano T, Hosomichi K, You H, Utsuno E, Sangai T, Nishimura M, Matsushita K, Hata A, Nomura F, Inoue I. J Hum Genet. 62 561-567 2017
  •  Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals.  Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A.  Hum Genome Var. 4 16046 2017
  •  Structure and evolution of the filaggrin gene repeated region in primates. Romero V, Hosomichi K, Nakaoka H, Shibata H, Inoue I. BMC Evol Biol. 17 10 2017
  •  RXRB Is an MHC-Encoded Susceptibility Gene Associated with Anti-Topoisomerase I Antibody-Positive Systemic Sclerosis. Oka A, Asano Y, Hasegawa M, Fujimoto M, Ishikawa O, Kuwana M, Kawaguchi Y, Yamamoto T, Takahashi H, Goto D, Endo H, Jinnin M, Mano S, Hosomichi K, Mabuchi T, Ueda MT, Nakagawa S, Beck S, Bahram S, Takehara K, Sato S, Ihn H. J Invest Dermatol. 137 1878-1886 2017
  •  AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway. Akatsuka H, Kuga S, Masuhara K, Davaadorj O, Okada C, Iida Y, Okada Y, Fukunishi N, Suzuki T, Hosomichi K, Ohtsuka M, Tanaka M, Inoue I, Kimura M, Sato T. Biochem Biophys Res Commun. 491 1098-1104 2017
  •  Identification of a novel variant of the RET proto-oncogene in a novel family with Hirschsprung's disease. Kawano T, Hosomichi K, Inoue I, Shimono R, Onishi S, Nakame K, Kaji T, Matsufuji H, Ieiri S. Pediatr Surg Int. 33 1041-1046 2017
  •  Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals. Shinmyo Y, Terashita Y, Dinh Duong TA, Horiike T, Kawasumi M, Hosomichi K, Tajima A, Kawasaki H. Cell Rep. 20 2131-2143 2017
  •  Multiple common and rare variants of ABCG2 cause gout. Higashino T, Takada T, Nakaoka H, Toyoda Y, Stiburkova B, Miyata H, Ikebuchi Y, Nakashima H, Shimizu S, Kawaguchi M, Sakiyama M, Nakayama A, Akashi A, Tanahashi Y, Kawamura Y, Nakamura T, Wakai K, Okada R, Yamamoto K, Hosomichi K, Hosoya T, Ichida K, Ooyama H, Suzuki H, Inoue I, Merriman TR, Shinomiya N, Matsuo H. RMD Open. 3 e000464 2017
  •  Germline Variants of Prostate Cancer in Japanese Families. Hayano T, Matsui H, Nakaoka H, Ohtake N, Hosomichi K, Suzuki K, Inoue I.  PLoS One. 11 e0164233 2016
  •  Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy. Watanabe H, Goto S, Mori H, Higashi K, Hosomichi K, Aizawa N, Takahashi N, Tsuchida M, Suzuki Y, Yamada T, Horii A, Inoue I, Kurokawa K, Narita I Nephrol Dial Transplant. 32 2072-2079 2016
  •  A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan. Kanzawa-Kiriyama H, Kryukov K, Jinam TA, Hosomichi K, Saso A, Suwa G, Ueda S, Yoneda M, Tajima A, Shinoda KI, Inoue I, Saitou N. J Hum Genet. 62 213-221 2016
  •  Allelic imbalance in regulation of ANRIL through chromatin interaction at 9p21 endometriosis risk locus.  Nakaoka H, Gurumurthy A, Hayano T, Ahmadloo S, Omer WH, Yoshihara K, Yamamoto A, Kurose K, Enomoto T, Akira S, Hosomichi K, Inoue I. PLoS Genet. 12 e1005893 2016
  •  A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing.  Tada H, Hosomichi K, Okada H, Kawashiri MA, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K. Clin Chim Acta. 453 194-6 2016
  •  A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis. Polat M, Takeshima SN, Hosomichi K, Kim J, Miyasaka T, Yamada K, Arainga M, Murakami T, Matsumoto Y, de la Barra Diaz V, Panei CJ, González ET, Kanemaki M, Onuma M, Giovambattista G, Aida Y.  Retrovirology. 16 4 2016
  •  CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation.  Shinmyo Y, Tanaka S, Tsunoda S, Hosomichi K, Tajima A, Kawasaki H.  Sci Rep. 62 20611 2016
  •  Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel.  Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S.  Clin Exp Nephrol. 21 63-75 2016
  •  Correction of the HLA-DQB1*04:01:01 sequence at position 79 in exon 1.  Okudaira Y, Hosomichi K, Ozaki Y, Takashi S, Mitsunaga S. HLA 87 57-58 2015
  •  Identification of novel exonic mobile element insertions in epithelial ovarian cancers.  Hayano T, Yamada S, Hosomichi K, Nakaoka H, Yoshihara K, Adachi S, Kashima K, Tanaka K, Enomoto T, Inoue I.  Human Genome Variation 2 15030 2015
  •  Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients.  Mitsunaga S, Hosomichi K, Okudaira Y, Nakaoka H, Suzuki Y, Kuwana M, Sato S, Kaneko Y, Homma Y, Oka A, Shiina T, Inoko H, Inoue I J Hum Genet. 60 449-54 2015
  •  Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients. Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H. Sci Rep. 5 10455 2015
  •  The impact of next-generation sequencing technologies on HLA research. Hosomichi K, Shiina T, Tajima A, Inoue I. J Hum Genet. 60 665-73 2015

Conference Presentations

  • Genomic Medicine in Japan(conference:The 8th Prince of Songkla University – Kanazawa University Joint Workshop on “ Precision Medicine and Translational Medical Research ”)(2021/03/22)
  • NEW NGS HLA TYPING BY TARGETED ENRICHMENT PROCEDURE –CAPTURE METHOD– (conference:ASHI 42nd Annual Meeting)(2016/09/26)
  • HLA-based precision medicine can be a clinical reality(2016/09/15)
  • High-throughput sequencing method of the KIR haplotype for integrated HLA-KIR genotyping approach for clinical applications (conference:ICHG2016)(2016/04/03)
  • The impact of NGS on HLA research.(conference:YARSI GENOMIC MEDICINE CONFERENCE 2015)(2015/05/06)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「HLAハプロタイプの多様性にもとづくヤポネシア人進化の解明」(2021-2022) 
○「個別化医療を目指したゲノムコホートにおける統合HLAタイピング情報の有益性の検討」(2020-2021) 
○「HLA遺伝子の多様性にもとづくヤポネシア人進化の解明」(2019-2020) 
○「ネオ・セルフの遺伝子解析」(2016-2020) 
○「遺伝統計学に基づく日本人集団のゲノム個別化医療の実装」(2019-2024) 
○「 横断的オミクス解析と全ゲノムシークエンスを駆使した疾患病態と組織特異性の解明」(2019-2021) 
○「集学的な機能ゲノミクスによる希少MODYの成因探索」(2018-2020) 
○「再生不良性貧血におけるHLAクラスIアレル拘束性自己抗原の同定」(2019-2021) 
○「糖尿病人口急増地域における糖尿病発症リスクのゲノム解析:バングラデシュ調査研究」(2019-2022) 
○「ヒト心筋生検検体を用いたRNA-Seqによる心臓サルコイドーシスの病態解明」(2019-2021) 
○「ゲノムコホートを対象にしたHLA-omicsに基づく薬剤副作用予防診断システム」(2017-2018) 
○「トロンボポエチン受容体作動薬ロミプロスチムの造血への影響とDNA修復効果の検証」(2020-2022) 
○「ゲノム不安定性を示す難治性遺伝性疾患群の診断センター運用及びゲノム・分子機能解析による創薬ターゲットの創出」(2017-2017) 
○「アレル優位性を有するクロマチン高次構造解析による子宮内膜症の分子機序解明」(2015-2017) 
○「免疫遺伝情報に基づく非血縁移植統合データベースの構築と最適なドナー・さい帯血の選択」(2016-2016) 
○「同種造血幹細胞移植成績向上を目指したKIRハプロタイプ解析手法の確立」(2014-2016) 
○「ゲノム不安定性を示す難治性遺伝性疾患群の症例収集とゲノム・分子機能解析による病態解明研究 」(2014-2016)

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Human Genetics(2019)

Classes (Graduate Schools)

○Itemized Lectures of Bioinformatics and Genomics(2020)
○Itemized Lectures of Bioinformatics and Genomics(2020)
○Environment and Heredity(2020)
○Genome Practical Training(2020)
○Bioinformatics(2020)
○omics(2020)
○The Human Body in Health and Disease Curriculum 3(2020)

International Project

International Students

Lecture themes

Others (Social Activities)

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