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Researcher Information

last modified:2017/05/23

Assistant Professor SHIRASAKI Takayoshi

Mail

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Academic Background

Career

Year & Month of Birth

1980/07

Academic Society

Award

Department of Laboratory Sciences,School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Specialities

Laboratory medicine、Virology

Speciality Keywords

Research Themes

Books

Papers

  •  La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication. Shirasaki T,Honda M,Mizuno H,Shimakami T,Okada H,Sakai Y,Murakami S,Wakita T,Kaneko S Journal of Infectious Disesase 202 1 75-85 2010
  •  Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Honda M,Sakai A,Yamashita T,Nakamoto Y,Mizukoshi E,Sakai Y,Yamashita T,Nakamura M,Shirasaki T,Horimoto K,Tanaka Y,Tokunaga K,Mizokami M,Kaneko S,Hokuriku Liver Study Group Gastroenterology 139 2 499-509 2010
  •  Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C. Honda M,Nakamura M,Tateno M,Sakai A,Shimakami T,Shirasaki T,Yamashita T,Arai K,Yamashita T,Sakai Y,Kaneko S Journal of Hepatology 53 5 817-26 2010
  •  Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C. Honda M,Takehana K,Sakai A,Tagata Y,Shirasaki T,Nishitani S,Muramatsu T,Yamashita T,Nakamoto Y,Mizukoshi E,Sakai Y,Yamashita T,Nakamura M,Shimakami T,Yi M,Lemon SM,Suzuki T,Wakita T,Kaneko S,Hokuriku Liver Study Group Gastroenterology 141 1 128-140 2011
  •  Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma. Mizuno H,Honda M,Shirasaki T,Yamashita T,Yamashita T,Mizukoshi E,Kaneko S Liver International 32 7 1146-55 2012

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  •  Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. Okada H, Honda M, Jean C, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunakozaka H, Tanaka T, Nelson F, Kaneko S Cancer Research 72 17 4459-71 2012
  •  MicroRNA-27a Regulates Lipid Metabolism and Inhibits Hepatitis C Virus Replication in Human Hepatoma Cells. Shirasaki T,Honda M,Shimakami T,Horii R,Yamashita T,Sakai Y,Sakai A,Okada H,Watanabe R,Murakami S,Yi M,Lemon SM,Kaneko S Journal of Virology 87 9 5270-86 2013
  •  Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes.  Takayama H, Misu H, Iwama H, Chikamoto K, Saito Y, Murao K, Teraguchi A, Lan F, Kikuchi A, Saito R, Tajima N, Shirasaki T, Matsugo S, Miyamoto K, Kaneko S, Takamura T The Journal Of Biological Chemistry 289 1 335-345 2014
  •  Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes.  Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E, Kaneko S Hepatology 59 3 828-838 2014
  •  The Acyclic Retinoid Peretinoin Inhibits Hepatitis C Virus Replication and Infectious Virus Release in Vitro.  Shimakami T, Honda M, Shirasaki T, Takabatake R, Liu F, Murai K, Shiomoto T, Funaki M, Yamane D, Murakami S, Lemon SM, Kaneko S Scientific Reports 2014
  •  Impaired IFN signaling in chronic hepatitis C patients with advanced fibrosis via the TGF-β signaling pathway. Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S Hepatology 60 5 1519-30 2014
  •  Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.  Selitsky S, Gale J, Honda M, Yamane D, Masaki T, Fannin E, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford R, Lemon SM, Sethupathy P Scientific Reports 2015
  •  Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice.  Okada H, Honda M, Campbell JS, Takegoshi K, Sakai Y, Yamashita T, Shirasaki T, Takabatake R, Nakamura M, Tanaka T, Kaneko S. Cancer Science 106 9 1143-52 2015
  •  Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.  Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. Journal of Infectious Disesase 213 7 1096-106 2016
  •  Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer. Kawaguchi K, Honda M, Yamashita T, Okada H, Shirasaki T, Nishikawa M, Nio K, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S. Am J Pathol 186 8 2055-67 2016
  •  Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems.  Liu F, Shimakami T, Murai K, Shirasaki T, Funaki M, Honda M, Murakami S, Yi M, Tang H, Kaneko S Scientific Reports 2016
  •  Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection.  Murata K, Asano M, Matsumoto A, Sugiyama M, Nishida N, Tanaka E, Inoue T, Sakamoto M, Enomoto N, Shirasaki T, Honda M, Kaneko S, Gatanaga H, Oka S, Kawamura YI, Dohi T, Shuno Y, Yano H, Mizokami M Gut 2016

Conference Presentations

  • A liver-derived secretory protein, LECT2, activates pDCs and protects hepatocytes against HBV infection. (conference:67th AASLD The Liver Meeting)(2016)
  • A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication. (conference:67th AASLD The Liver Meeting)(2016)
  • A liver-derived secretory protein, LECT2, enhances the innate immune response and suppresses HCV replication.(conference:23rd International Symposium on Hepatitis C virus and Related Viruses)(2016)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「C型慢性肝炎に対するIFN応答・不応答メカニズムの解明」(2013-2015)
○「C型肝炎ウイルス感染特異的な長鎖ノンコーディングRNAの探索」(2012-) 
○「肝疾患におけるIFNλ4の機能的役割の解明」(2016-) 

Classes (Bachelors)

○Clinial Practice of Pathologic Microbiology(2017)
○Pathogenic Microbiology 2(2017)
○Lecture and Practice of Virology(2017)
○Freshman Seminar I(2017)
○Parasitology(2017)
○Exercise on Recombinant DNA Technology(2017)
○Parasitology(2017)
○Introduction to Region-studies(2016)
○Pathogenic Microbiology 2(2016)
○Parasitology(2016)
○Exercise on Recombinant DNA Technology(2016)
○Parasitology(2016)
○Clinial Practice of Pathologic Microbiology(2016)
○Lecture and Practice of Virology(2016)
○Presentation and Debate (Freshman Seminar II)(2016)
○Freshman Seminar I(2016)

Classes (Graduate Schools)

○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Molecular Biology of Tumor: Seminar(2017)
○Molecular Biology of Tumor: Lecture(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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