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Researcher Information

last modified:2022/05/30

Assistant Professor IMAMURA Ryu

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute Division of Tumor Dynamics and Regulation

College and School Educational Field

Division of Medical Science, Graduate School of Medical Science


Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University TEL:076-264-6764 FAX:076-234-4513

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kumamoto University Doctor Graduate School, Division of Medicine 199303 Completed
【Academic background(Bachelor's Degree)】
Kumamoto University 198903


DNAX Research Institute of Molecular and Cellular Biology Department of Cell Signaling(1994/05/17-1998/09/30)
Kumamoto University Hospital Department of Laboratory Medicine(1993/04/02-1994/05/16)

Year & Month of Birth


Academic Society

Japanese Cancer Association



Immunology、Molecular biology、Pathological medical chemistry

Speciality Keywords

Hepatocyte Growth Factoe, Met receptor, innate immunity, Fas ligand, inflammation, signal transduction, transcription factor

Research Themes

Molecular and in vivo analyses about Hepatocyte Growth Factor (HGF)/Met and development of its clinical application

NLR family and inflammation or tumor formation

Study on physiological role of Fas ligand

Study on Physiological Connection between Apoptosis and Inflammation



  •  Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer W. Miao, K. Sakai, H. Sato, R. Imamura, N. Jangphattananont, J. Takagi, M. Nishita, Y. Minami, and K. Matsumoto Cancer Sci. 2019
  •  Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis  K. Dodo, E. Kuboki, T. Shimizu, R. Imamura, M. Magarisawa, M. Takahashi, T. Tokuhiro, S. Yotsumoto, K. Asano, S. Nakao, N. Terayama, T. Suda, M. Tanaka, and M. Sodeoka ACS Medicinal Chemistry Letters 2019
  •   Bi-directional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation Y. Watanabe, Y. Nagai, H. Honda, N. Okamoto, T. Yanagibashi, M. Ogasawara, S. Yamamoto, R. Imamura, I. Takasaki, H. Hara, M. Sasahara, M. Arita, S. Hida, S. Taniguchi, T. Suda, and K. Takatsu FASEB J 2019
  •  Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach N. Jangphattananont, H. Sato, R. Imamura, K. Sakai, Y. Terakado, K. Murakami, N. Barker, H. Oshima, M. Oshima, J. Takagi, Y. Kato, S. Yano, and K. Matsumoto Int. J. Mol. Sci. 2019
  •  MET activation by a macrocyclic peptide agonist that couples to biological responses differently from HGF in a context-dependent manner W. Miao, K. Sakai, R. Imamura, K. Ito, H. Suga, T. Sakuma, T. Yamamoto, and K. Matsumoto Int. J. Mol. Sci. 2018

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  •  Characterization of Innate and Adaptive Immune Responses in PYNOD-deficient mice. S. Nakajima, R. Imamura, M. Yoshino, M. Sakurai, K. Tsuchiya, K. Sugihara, M. Asano, and T. Suda ImmunoHorizons 2 129-141 2018
  •  Anti-inflammatory activity of PYNOD and its mechanism in human and mice 184 5874-5884 2010/05
  •  The involvement of p38MAPK in impaired neutrophil bactericidal activity of hemodialysis patients. Y. Kamikawa, N. Sakai, T. Miyake, A. Sagara, Y. Shinozaki, S. Kitajima, T. Toyama, A. Hara, Y. Iwata, M. Shimizu, K. Furuichi, R. Imamura, T. Suda, S. Kaneko, and T. Wada Therapeutic Apheresis and Dialysis  2018
  •  Hepatocyte Growth Factor in Physiology and Infectious Diseases R. Imamura, K. Matsumoto Cytokine in press 2017
  •  Distinct NFAT family proteins are involved in the nuclear NFAT-DNA bunding complexes from human thymocyte subsets J. Immunol. 160 5 2324-2333 1998/03
  •  Signalling into the T cell nucleus: NFAT regulation Cell. Signal. 10 9 599-611 1998/10
  •  The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity Eur.J.Immunol. 31 8 2504-2511 2001/08
  •  Genomic structure and inducible expression of the IL-22 receptor a chain in mice GENES AND IMMUNITY 4 153-159 2003/02
  •  Pypaf3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1b secretion. T. Kinoshita, Y. Wang, M. Hasegawa, R. Imamura, and T. Suda J. Biol. Chem. 280 23 21720-21725 2005/06
  •  Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production. H. Kidoya, M. Umemura, T. Kawabe, G. Matsuzaki, A. Yahagi, R. Imamura, and T. Suda J. Immunol. 175 8024-8031 2005/10
  •  Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1. T. Kinoshita, C. Kondoh, M. Hasegawa, R. Imamura, and T. Suda Int. Immunol. 8 12 1701-1706 2006/09
  •  Mechanism of ASC-mediated apoptosis: Bid-dependent apoptosis in type II cells. Oncogene M. Hasegawa, K. Kawase, N. Inohara, R. Imamura, WC. Yeh, T. Kinoshita, and T. Suda Oncogene 26 1748-1756 2007/09
  •  Mechanism and repertoire of apoptosis-asscosiated speck-like protein containing a caspase recruitment domain-mediated gene expression. JOURNAL OF IMMUNOLOGY 182 2009/06
  •  Different growth and metastatic phenotypes associated with cell-intrinsic changeof Met in matastatic melanoma E. adachi, K. Sakai, T. Nishiuchi, R. Imamura, H. Sato, and K. Matsumoto Oncotarget in press 70779-70793 2016
  •  NLRP3 Mediates NF-κB Activation and Cytokine Induction in Microbially Induced and Sterile Inflammation T. Kinoshita, R. Imamura, H. Kushiyama, T. Suda PLoS One 2015
  •  Pyropotic cells externalize eat-me and release find-me signals and efficiently engulfed by macrophages. Wang, Q., Imamura, R., Motani, K., Kushiyama, H., Nagata, S., and Suda, T. 25 363-372 2013/06
  •  Fas ligand has a greater impact than TNF-alpha on apoptosis and inflammation in ischemic acute kidney injury. Furuichi, K., Kokubo, S., Hara, A., Imamura, R., Wang, Q., Kitajima, S., Toyama, T., Okumura, T., Matsushima, K., Suda, T., Mukaida, N., Kaneko, S., and Wada, T. 2 27-38 2012/01
  •  Caspase-1 induces apoptosis-associated speck-like protein containing caspase-recruitment domain (ASC)-mediated necrosis independently of its caspase activity 2011/08
  •  Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production. N. Matsumoto, R. Imamura, and T.Suda FEBS J. 274 2376-2384 2007/03
  •  NFATz: a novel rel similarity domain containing protein Biochem. Biophys. Res. Commun. 272 3 765-776 2000/01
  •  Pathogen-associated molecular patterns sensitize macrophages to Fas ligand-induced apoptosis and IL-1b release. M. Fukui, R. Imamura, M. Umemura, T. Kawabe, and T. Suda J. Immunol. 171 1868-1874 2003/08
  •  Involvement of L-17 in Fas ligand-induced inflammation. M. Umemura, T. Kawabe, K. Shudo, H. Kidoya, M. Fukui, M. Asano, Y. Iwakura, G. Matsuzaki, R. Imamura, and T. Suda. Int.Immunol 16 8 1099-1108 2004/07
  •  Fas ligand induces cell-autonomous NF-kB activation and Interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-a_ R. Imamura, K. Konaka, N. Matsumoto, M. Hasegawa, M. Fukui, N. Mukaida, T. Kinoshita, and T. Suda J. Biol. Chem. 279 45 46415-46423 2004/11
  •  ASC-mediated NF-kB activation leading to Interleukin-8 production requires caspase-8 and is inhibited by CLARP. M. Hasegawa, R. Imamura, T. Kinoshita, N. Matsumoto, J. Masumoto, N. Inohara, and T. Suda J. Biol. Chem. 280 15 15122-15130 2005/04
  •  Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. 101 1822-1827 2010/08
  •  Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells J. Immunol. 161 7 3455-3463 1998/10
  •  Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells.  Harashima, N., Inao, T., Imamura, R., Okano, S., Suda. T., and Harada:, M. 61 667-676 2012/05
  •  Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain Mol. Cell. Biol. 17 4 2066-2075 1997/04

Conference Presentations

  • Novel Biological Function of HGF receptor Met in Immune Response.(conference:The 1st NanoLSI International Symposium)(2018/02/21)
  • NLRP3 mediates NF-κB activation and cytokine gene induction under various cellular stress conditions.(conference:5th Annual Meeting of the International Cytokine & Interferon Society)(2017/10/30)
  • Intrinsic HGF induced by cancer cells promotes lung metastasis in Met-high expressing melanomas(2017/09/30)
  • Cellular Signaling and Gene Expression Profiles Evoked by Artificial MET/HGF Receptor-Agonist of Macrocyclic Peptide.(conference:Frontiers in Biomedical Sciences 11th International Symposium of the Institute Network)(2017/01/26)
  • Purification and functional analyses of multi-functional cytokine Lect2.(2016/11/30)

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  • Different growth and metastatic phenotypes associated with a cell-intrinsic changes of Met in metastatic melanoma(2016/10/08)
  • Role of PYNOD (NLRP10) in the migration of effector T cells to inflamed tissues(2014/12/10)
  • HDAC inhibitors (HDACI) induce IL-1βproduction in human monocytes by activating NLRP3 inflammasome.(2015/01/21)
  • Migration of skin antigen-transporting cells in PYNOD-deficient mice.(2014/12/10)
  • Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach(2019/12/04)
  • Novel Biological Function of HGF receptor Met in Immune Response.(conference:The Joint Symposium Tumor Microenvironment and Precision Oncology)(2019/05/13)
  • Localization of two-chain HGF and activated MET receptor in developing stomach(2018/11/28)


  •  Interleukin-14 Clinical Immunology & Aalergology All of the cytokines 57 suppl.21 97-102 2012/05/25

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Competitive research funding,Contribution

○Determination of EML4-ALK fusion protein structure by HS-AFM(2020-2020)

Collaborative research,Consignment study

○Development of a new strategy towards drug design for cancer immunotherapy(2018-2019)

Classes (Bachelors)

Classes (Graduate Schools)

○Tumor Biology(2017)
○Tumor Biology(2017)
○Tumor Biology(2016)
○Tumor Biology(2016)
○Seminar on Tumor Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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