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Researcher Information

last modified:2018/05/24

Associate Professor YAMASHITA Tatsuya

Mail

Faculty, Affiliation

ADVANCED PREVENTIVE MEDICAL SCIENCES RESEARCH CENTER Department of Gastroenterology, Kanazawa University Hospital
Lecturer

College and School Educational Field

Division of Environmental Science, Graduate School of Medical Scienc
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Dept. of Gastroenterology, Kanazawa Univ. Hospital TEL:076-265-2248 FAX:076-234-4250

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor 1998 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1993

Career

Year & Month of Birth

1969/02

Academic Society










Award

Specialities

Gastroenterology、Tumor therapeutics、General internal medicine (including psychosomatic medicine)

Speciality Keywords

Hepatocellular carcinoma Chenotherapy Percutaneous ablation therapy

Research Themes

Research for community medicine in Ishikawa Prefacture

Hemodialysis therapy for HCV infection

INF combined hepatic arterial chemotherapy for advanced HCC

Books

  •  Regorafenib Treatment for Hepatocellular carcinoma 2017

Papers

  •  Delineation of regions important for heteromeric association of hepatitis C virus E1 and E2 VIROLOGY 231 1 119-129 1997/01
  •  Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity J Biol Chem 277 13,11149-11155 2002/03
  •  Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation Biochim Biophys Acta 1453 3 330-340 1999/03
  •  Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase HEPATOLOGY 33 3 728-737 2001/03
  •  Oligomeric interaction of hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase J Biol Chem 277 3 2132-2137 2002/01

show all

  •  RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein Mol Cell Biol 18 12 7546-7555 1998/12
  •  RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region J Biol Chem 273 25 15479-15486 1998/06
  •  Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component J Biol Chem 275 29 22568-22573 2000/07
  •  The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct Cancer Res 57 22 5137-5142 1997/11
  •  Direct interaction between nucleolin and hepatitis C virus NS5B. JOURNAL OF BIOCHEMISTRY 278 7 5105-5115 2003/02
  •  Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. BMC Cancer.  17 1 870 2017
  •  Prognosis of type 1 autoimmune pancreatitis after corticosteroid therapy-induced remission in terms of relapse and diabetes mellitus. Miyazawa M, Takatori H, Shimakami T, Kawaguchi K, Kitamura K, Arai K, Matsuda K, Sanada T, Urabe T, Inamura K, Kagaya T, Mizuno H, Fuchizaki U, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. PLoS One. 12 11 e0188549 2017
  •  Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S. J Gastroenterol. 2017
  •  Reactivation of hepatitis B virus from an isolated anti-HBc positive patient after eradication of hepatitis C virus with direct-acting antiviral agents. Suda T, Shimakami T, Shirasaki T, Yamashita T, Mizukoshi E, Honda M, Kaneko S. J Hepatol.  67 5 1108-1111 2017
  •  A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma. Hayashi T, Yamashita T, Okada H, Oishi N, Sunagozaka H, Nio K, Hayashi T, Hara Y, Asahina Y, Yoshida M, Hashiba T, Suda T, Shirasaki T, Igarashi Y, Miyanouchi K, Yamashita T, Honda M, Kaneko S. Anticancer Res.  37 7 3397-3403 2017
  •  Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma. Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S. Liver Cancer 6 3 236-249 2017
  •  Direct-acting antiviral agents improved nephrotic syndrome associated with refractory pleural effusion and ascites caused by hepatitis C virus-related nephropathy: a case report. Yamato M, Arai K, Takatori H, Shimakami T, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S. Nihon Shokakibyo Gakkai Zasshi 114 6 1031-1038 2017
  •  Association Between High-avidity T-cell Receptors, Induced by Alpha Fetoprotein-derived Peptides, and Anti-tumor Effects in Patients with Hepatocellular Carcinom Hidetoshi Nakagawa, Eishiro Mizukoshi, Eiji Kobayashi, Toshikatsu Tamai1, Hiroshi Hamana, Tatsuhiko Ozawa, Hiroyuki Kishi, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Noriho Iida, Kazumi Fushimi, Atsushi Muraguchi, Shuichi Kaneko Gastroenterology 2017
  •  Lidocaine spray alone is similar to spray plus viscous solution for pharyngeal observation during transoral endoscopy: a clinical randomized trial Tomoyuki Hayashi, Yoshiro Asahina, Yohei Waseda, Kazuya Kitamura, Takashi Kagaya, Takuya Seike, Kazuhiro Okada, Yuki Inada, Hisashi Takabatake, Noriaki Orita, Yuko Yanase, Tatsuya Yamashita, Itasu Ninomiya, Kenichi Yoshimura, Shuichi Kaneko Endosc Int Open 5 1 E47 2017
  •  Cellular Immune Responses for Squamous Cell Carcinoma Antigen Recognized by T Cells 3 in Patients with Hepatocellular Carcinoma Kiichiro Kaji, Eishiro Mizukoshi, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Hidetoshi Nakagawa, Kazutoshi Yamada, Takeshi Terashima, Masaaki Kitahara, Shuichi Kaneko PLoS One 12 1 e01702 2017
  •  Immunological features of T cells induced by human telomerase reverse transcriptase-derived peptides in patients with hepatocellular carcinoma Eishiro Mizukoshi, Hidetoshi Nakagawa, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Eiji Kobayashi, Hiroyuki Kishi, Atsushi Muraguchi, Shuichi Kaneko Cancer Lett. 364 2 98 2015
  •  Efficacy of continuous plasma diafiltration therapy in critical patients with acute liver failure Komura T, Taniguchi T, Sakai Y, Yamashita T, Mizukoshi E, Noda T, Okajima M, Kaneko S. J Gastroenterol Hepatol 29 4 782 2014
  •  Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma after sorafenib Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S. Hepatol Res 44 12 1179 2014
  •  Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang X, Kaneko S. Hepatology 60 5 1674 2014
  •  Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, Yamashita T, Sakai Y, Yamashita T, Okada H, Murai K, Nakamura M, Mizukoshi E, Kaneko S. Hepatology 59 3 828 2014
  •  Transarterial chemoembolization failure/refractoriness: JSH-LCSGJ criteria 2014 update Kudo, M. Matsui, O. Izumi, N. Kadoya, M. Okusaka, T. Miyayama, S. Yamakado, K. Tsuchiya, K. Ueshima, K. Hiraoka, A. Ikeda, M. Ogasawara, S. Yamashita, T.Minami, T. Oncology 87 22 2014
  •  JSH Consensus-Based Clinical Practice Guidelines for the Management of Hepatocellular Carcinoma: 2014 Update by the Liver Cancer Study Group of Japan. Kudo M., Matsui O., Izumi N., Iijima H., Kadoya M., Imai Y., Okusaka T., Miyayama S., Tsuchiya K., Ueshima K., Hiraoka A., Ikeda M., Ogasawara S., Yamashita T., Minami T., Yamakado K., on behalf of the Liver Cancer Study Group of Japan  Liver Cancer 3 3-4 458 2014
  •  Severe Veno-occlusive Disease/Sinusoidal Obstruction Syndrome After Deceased-donor and Living-donor Liver Transplantation H. Takamura, , S. Nakanuma, H. Hayashi, H. Tajima, K. Kakinoki, M. Kitahara, S. Sakai, I. Makino, H. Nakagawara, T. Miyashita, K. Okamoto, K. Nakamura, K. Oyama, M. Inokuchi, I. Ninomiya, H. Kitagawa, S. Fushida, T. Fujimura, I. Onishi, M. Kayahara, T. Tani, K. Arai, Taro Yamashita, Tatsuya Yamashita, H. Kitamura, H. Ikeda, d, S. Kaneko, Y. Nakanuma, O. Matsui, T. Ohta Transplant Proc.  46 10 3523 2014
  •  P53, hTERT, WT-1, and VEGFR2 are the most suitable targets for cancer vaccine therapy in HLA-A24 positive pancreatic adenocarcinoma. Takeshi Terashima, Eishiro Mizukoshi, Kuniaki Arai,Tatsuya Yamashita, Mariko Yoshida, Hajime Ota, Ichiro Onishi, Masato Kayahara, Koushiro Ohtsubo, Takashi Kagaya, Masao Honda, Shuichi Kaneko Cancer Immunol Immunother. 63 5 479 2014
  •  The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial Yumie Takeshita, Toshinari Takamura, Masao Honda, Yuki Kita, Yoh Zen, Ken-ichiro KatoHirofumi MisuTsuguhito OtaMikiko NakamuraKazutoshi YamadaHajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko Diabetologia 57 5 878 2014
  •  Hypervascular hepatocellular carcinoma: Correlation between biologic features and signal intensity on gadoxetic acid - Enhanced MR images Kitao, Azusa; Matsui, Osamu; Yoneda, Norihide; Kozaka, Kazuto; Kobayashi, Satoshi; Koda, Wataru; Gabata, Toshifumi; Yamashita, Tatsuya; Kaneko, Shuichi; Nakanuma, Yasuni; Kita, Ryuichi; Arii, Shigeki Radiology 265 3 780-789 2012/11/30 
  •  Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy Terashima, Takeshi; Yamashita, Tatsuya; Iida, Noriho; Yamashita, Taro; Nakagawa, Hidetoshi; Arai, Kuniaki; Kitamura, Kazuya; Kagaya, Takashi; Sakai, Yoshio; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Hepatology Research 2014/01/01 
  •  Expression of chondroitin-glucuronate C5-epimerase and cellular immune responses in patients with hepatocellular carcinoma Mizukoshi, Eishiro; Fushimi, Kazumi; Arai, Kuniaki; Yamashita, Tatsuya; Honda, Masao; Kaneko, Shuichi Liver International 32 10 1516-1526 2012/11/01 
  •  [A case report of S-1 monotherapy for advanced hepatocellular carcinoma]. Yamashita, Tatsuya; Arai, Kuniaki; Terashima, Takeshi; Sunagozaka, Hajime; Shimakami, Tetsuro; Yamashita, Taro; Mizukoshi, Eishiro; Sakai, Akito; Honda, Masao; Kaneko, Shuichi Gan to kagaku ryoho. Cancer & chemotherapy 39 9 1435-1437 2012/09/01 
  •  Current status of hepatocellular carcinoma treatment in Japan: Hepatic arterial infusion chemotherapy Yamashita, Tatsuya Clinical Drug Investigation 32 SUPPL. 2 15-23 2012/08/13 
  •  Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma Sunagozaka, Hajime; Honda, Masao; Yamashita, Taro; Nishino, Ryuhei; Takatori, Hajime; Arai, Kuniaki; Yamashita, Tatsuya; Sakai, Yoshio; Kaneko, Shuichi International Journal of Cancer 129 7 1576-1585 2011/10/01 
  •  The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: Correlation with gadoxetic acid enhanced MR imaging Kitao, Azusa; Matsui, Osamu; Yoneda, Norihide; Kozaka, Kazuto; Shinmura, Rieko; Koda, Wataru; Kobayashi, Satoshi; Gabata, Toshifumi; Zen, Yoh; Yamashita, Tatsuya; Kaneko, Shuichi; Nakanuma, Yasuni European Radiology 21 10 2056-2066 2011/10/01 
  •  Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma Takata, Yoshiko; Nakamoto, Yasunari; Nakada, Akiko; Terashima, Takeshi; Arihara, Fumitaka; Kitahara, Masaaki; Kakinoki, Kaheita; Arai, Kuniaki; Yamashita, Taro; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Kaneko, Shuichi Cancer Letters 307 2 165-173 2011/08/28 
  •  Effect of vitamin K2 on the recurrence of hepatocellular carcinoma Yoshida, Haruhiko; Shiratori, Yasushi; Kudo, Masatoshi; Shiina, Shuichiro; Mizuta, Toshihiko; Kojiro, Masamichi; Yamamoto, Kyosuke; Koike, Yukihiro; Saito, Kenichi; Koyanagi, Nozomu; Kawabe, Takao; Kawazoe, Seiji; Kobashi, Haruhiko; Kasugai, Hiroshi; Osaki, Yukio; Araki, Yasuyuki; Izumi, Namiki; Oka, Hiroko; Tsuji, Kunihiko; Toyota, Joji; Seki, Toshihito; Osawa, Toshiya; Masaki, Naohiko; Ichinose, Masao; Seike, Masataka; Ishikawa, Akihisa; Ueno, Yoshiyuki; Tagawa, Kazumi; Kuromatsu, Ryoko; Sakisaka, Shotaro; Ikeda, Hiroshi; Kuroda, Hidekatsu; Kokuryu, Hiroyuki; Yamashita, Tatsuya; Sakaida, Isao; Katamoto, Tetsuo; Kikuchi, Kentaro; Nomoto, Minoru; Omata, Masao Hepatology 54 2 532-540 2011/08/01 
  •  Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C Honda, Masao; Takehana, Kenji; Sakai, Akito; Tagata, Yusuke; Shirasaki, Takayoshi; Nishitani, Shinobu; Muramatsu, Takahiko; Yamashita, Tatsuya; Nakamoto, Yasunari; Mizukoshi, Eishiro; Sakai, Yoshio; Yamashita, Taro; Nakamura, Mikiko; Shimakami, Tetsuro; Yi, MinKyung; Lemon, Stanley M.; Suzuki, Tetsuo; Wakita, Takaji; Kaneko, Shuichi Gastroenterology 141 1 128-14000 2011/07/01 
  •  Current status of hepatocellular carcinoma treatment in Japan: Case study and discussion-voting system Kudo, Masatoshi; Tateishi, Ryosuke; Yamashita, Tatsuya; Ikeda, Masafumi; Furuse, Junji; Ikeda, Kenji; Kokudo, Norihiro; Izumi, Namiki; Matsui, Osamu Clinical Drug Investigation 32 SUPPL. 2 37-51 2012/08/13 
  •  Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes Takeshita, Yumie; Takamura, Toshinari; Kita, Yuki; Ando, Hitoshi; Ueda, Teruyuki; Kato, Kenichiro; Misu, Hirofumi; Sunagozaka, Hajime; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Metabolism: Clinical and Experimental 61 10 1388-1394 2012/10/01 
  •  Diagnostic benefits of adrenocortical scintigraphy in hepatic adrenal rest tumor Ishida, Kosuke; Horii, Rika; Yamashita, Tatsuya; Arai, Kuniaki; Yamashita, Taro; Kagaya, Takashi; Sakai, Yoshio; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi Journal of Japanese Society of Gastroenterology 111 10 2004-2012 2014/01/01 
  •  A phase I/II study of S-1 with sorafenib in patients with advanced hepatocellular carcinoma Ooka, Yoshihiko; Chiba, Tetsuhiro; Ogasawara, Sadahisa; Arai, Kuniaki; Suzuki, Eiichiro; Tawada, Akinobu; Yamashita, Tatsuya; Kanai, Fumihiko; Kaneko, Shuichi; Yokosuka, Osamu Investigational New Drugs 32 4 723-728 2014/01/01 
  •  Revision process for the Japanese practice guidelines for hepatocellular carcinoma 2013 Kokudo, Norihiro; Takayama, Tadatoshi; Izumi, Namiki; Tateishi, Ryosuke; Yamashita, Tatsuya; Sakamoto, Michiie; Nakayama, Hisashi Acta Hepatologica Japonica 55 10 571-588 2014/01/01 
  •  Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts Takamura, Hiroyuki; Nakanuma, Shinichi Ichi; Hayashi, Hironori; Tajima, Hidehiro; Kakinoki, Kaheita; Sakai, Seisyo; Makino, Isamu; Nakagawara, Hisatoshi; Miyashita, Tomoharu; Okamoto, Koichi; Nakamura, Keishi; Oyama, Katunobu; Inokuchi, Masashi; Ninomiya, Itasu; Kitagawa, Hirohisa; Fushida, Sachio; Fujimura, Takashi; Ohnishi, Ichiro; Kayahara, Masato Sato; Tani, Takashi; Arai, Kuniaki; Yamashita, Taro; Yamashita, Tatsuya; Kitamura, Hoshiko; Ikeda, Hiroko; Kaneko, Shuichi; Nakanuma, Yasuni; Matsui, Osamu; Ohta, Tetsuo Oncology Reports 30 4 1561-1574 2013/10/01 
  •  Increase in CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis Arihara, Fumitaka; Mizukoshi, Eishiro; Kitahara, Masaaki; Takata, Yoshiko; Arai, Kuniaki; Yamashita, Tatsuya; Nakamoto, Yasunari; Kaneko, Shuichi Cancer Immunology, Immunotherapy 62 8 1421-1430 2013/08/01 
  •  Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma Yamashita, Taro; Honda, Masao; Nakamoto, Yasunari; Baba, Masayo; Nio, Kouki; Hara, Yasumasa; Zeng, Shasha; Hayashi, Takehiro; Kondo, Mitsumasa; Takatori, Hajime; Yamashita, Tatsuya; Mizukoshi, Eishiro; Ikeda, Hiroko; Zen, Yoh; Takamura, Hiroyuki; Wang, Xin Wei; Kaneko, Shuichi Hepatology 57 4 1484-1497 2013/04/01 
  •  Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma Mizukoshi, Eishiro; Yamashita, Tatsuya; Arai, Kuniaki; Sunagozaka, Hajime; Ueda, Teruyuki; Arihara, Fumitaka; Kagaya, Takashi; Yamashita, Taro; Fushimi, Kazumi; Kaneko, Shuichi Hepatology 57 4 1448-1457 2013/04/01 

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Classes (Bachelors)

Classes (Graduate Schools)

○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2017)
○Disease Control and Homeotasis(2016)
○Disease Control and Homeotasis(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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