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Researcher Information

last modified:2020/04/10

Associate Professor KAWASHIRI Masaaki


Faculty, Affiliation

 Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine

College and School Educational Field

Graduate School of Phamateutical Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences


Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University TEL:076-265-2251 FAX:076-234-4251

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine Internal medicine II Completed
【Academic background(Bachelor's Degree)】
Niigata University 199403


Kanazawa University Hospital Internal medicine 2(1994/05/12-1995/03/31)
Kanazawa University(2002/07/01-2003/04/30)
Kanazawa University Hospital Department of Internal Medicine(2003/05/01-)
University of Pennsylvania, School of Medicine Institute for Human Gene Therapy(1998/10/01-2000/10/31)

Year & Month of Birth


Academic Society

Japan Atherosclerosis Society
Japanese Society of Internal Medicine
Japanese Circulation Society
The Japanese College of Cardiology
The Japan Geriatric Society
The Japan Society of Human Genetics
Japanese Society of Cardiovascular Imaging & Dynamics
European Society of Cardiology



Cardiovascular medicine

Speciality Keywords

atherosclerosis, coronary artery disease, dyslipidemia

Research Themes

Molecular Genetic Research of Atherosclerogenesis

Risk Factor of Atherosclerotic Cardiovascular Disease

Inhereted Dyslipidemia

Diagnostic Imaging of Atherosclerosis



  •  Plasma homocysteine level and development of coronary artery disease. CORONARY ARTERY DISEASE 10 7 443-7 1999/10
  •  Prolonged correction of hyperlipidemia in mice with familial hypercholesterolemia using an adeno-associated viral vector expressing VLDL receptor. MOLECULAR THERAPY 2 3 256 2000/09
  •  Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia. AMERICAN JOURNAL OF CARDIOLOGY 86 8 840-5 2000/08
  •  High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis. Kawashiri MA, Maugeais C, Rader DJ. 2 5 363-72 2000/09
  •  Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice. JOURNAL OF LIPID RESEARCH 42 6 943 2001/01

show all

  •  Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 39 5 380-384 2001/05
  •  Hyperhomocysteinemia, diabetes mellitus, and carotid atherosclerosis independently increase atherosclerotic vascular disease outcome in Japanese CLINICAL NEPHROLOGY 56 2 132-139 2001/08
  •  Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of methylenetetrahydrofolate reductase gene in Japanese. ATHEROSCLEROSIS 164 2 321-328 2002/10
  •  Combined effects of cholesterol reduction and apolipoprotein A-I expression on atherosclerosis in LDL receptor deficient mice. ATHEROSCLEROSIS 165 1 15 2002/11
  •  Dual effects on HDL metabolism by cholesteryl ester transfer protein inhibition in HepG2 cells. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 284 6 E1210-1219 2003/06
  •  Haplotype analyses of cholesteryl ester transfer protein gene promoter: a clue to an unsolved mystery of TaqIB polymorphism. JOURNAL OF MOLECULAR MEDICINE-JMM 81 4 246-255 2003/04
  •  Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 23 10 1914-20 2003/08
  •  In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux. Yancey PG, Kawashiri MA, Moore R, Glick JM, Williams DL, Connelly MA, Rader DJ, Rothblat GH. JOURNAL OF LIPID RESEARCH 45 2 337-46 2003/11
  •  Clinical applications of long-term LDL-apheresis on and beyond refractory hypercholesterolemia. Mabuchi H, Higashikata T, Kawashiri MA. 30 3 233-43. 2004/06
  •  Detailed analysis of serum lipids and lipoproteins from Japanese type III hyperlipoproteinemia with apolipoprotein E2/2 phenotype. Todo Y, Kobayashi J, Higashikata T, Kawashiri M, Nohara A, Inazu A, Koizumi J, Mabuchi H. CLINICA CHIMICA ACTA 348 1-2 35-40 2004/10
  •  Identification of two novel missense mutations (p.R1221C and p.R1357W) in the ABCC6 (MRP6) gene in a Japanese patient with pseudoxanthoma elasticum (PXE). Noji Y, Inazu A, Higashikata T, Nohara A, Kawashiri MA, Yu W, Todo Y, Nozue T, Uno Y, Hifumi S, Mabuchi H. INTERNAL MEDICINE 43 12 1171-6. 2004/12
  •  Cutoff point separating affected and unaffected familial hypercholesterolemic patients validated by LDL-receptor gene mutants. Mabuchi H, Higashikata T, Nohara A, Lu H, Yu WX, Nozue T, Noji Y, Katsuda S, Kawashiri MA, Inazu A, Kobayashi J, Koizumi J. 12 1 35-40. 2005/01
  •  ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects. Miwa K, Inazu A, Kobayashi J, Higashikata T, Nohara A, Kawashiri M, Katsuda S, Takata M, Koizumi J, Mabuchi H. CLINICAL SCIENCE 109 2 183-8 2005/08
  •  Efficacy of colestimide coadministered with atorvastatin in Japanese patients with heterozygous familial hypercholesterolemia (FH). 69 5 515-520 2005/05
  •  Type III hyperlipoproteinemia exaggerated by Sheehan\'s syndrome with advanced systemic atherosclerosis: a 28-year clinical course. 69 6 746-751 2005/06
  •  Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. Mabuchi H, Higashikata T, Kawashiri M, Katsuda S, Mizuno M, Nohara A, Inazu A, Koizumi J, Kobayashi J. 12 2 111-9 2005/02
  •  Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL(Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis.  Higashikata T, Mizuno M, Takata M, Katsuda S, Miwa K, Nozue T, Nohara A, Inazu A, Kobayashi J, Koizumi J, Mabuchi H. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 2005/12
  •  Cholesterol-years score is associated with development of senile degenerative aortic stenosis in heterozygous familial hypercholesterolemia.  2006/12
  •  Comparison of effects of pitavastatin and atorvastatin on plasma coenzyme Q10 in heterozygous familial hypercholesterolemia: results from a crossover study.  Nohara A, Tada H, Mori M, Tsuchida M, Katsuda S, Inazu A, Kobayashi J, Koizumi J, Mabuchi H, Yamagishi M. CLINICAL PHARMACOLOGY & THERAPEUTICS 2008/05
  •  Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient with familial hypercholesterolemia.  Tsuchida M, Kawashiri MA, Tada H, Takata M, Nohara A, Ino H, Inazu A, Kobayashi J, Koizumi J, Mabuchi H, Yamagishi M. 2009/05
  •  Apolipoprotein B gene mutations and fatty liver in Japanese hypobetalipoproteinemia.  Katsuda S, Kawashiri MA, Inazu A, Tada H, Tsuchida M, Kaneko Y, Nozue T, Nohara A, Okada T, Kobayashi J, Michishita I, Mabuchi H, Yamagishi M. CLINICA CHIMICA ACTA 2009/01
  •  Impact of severe earthquake on the occurrence of acute coronary syndrome and stroke in a rural area of Japan.  Tsuchida M, Kawashiri MA, Teramoto R, Takata M, Sakata K, Omi W, Okajima M, Takamura M, Ino H, Kita Y, Takegoshi T, Inaba H, Yamagishi M. 2009/06
  •  Pictures in clinical medicine. Huge apertures in the aortic valve due to Libman-Sachs endocarditis.  Tada H, Kawashiri MA, Watanabe G, Yamagishi M. INTERNAL MEDICINE 2009/05
  •  An enhanced device for transluminal retrieval of vascular stents without surgical procedures: experimental studies.  Tsuchida M, Kawashiri MA, Uchiyama K, Sakata K, Nakanishi C, Tsubokawa T, Takabatake S, Konno T, Ino H, Yamagishi M. 2010/06
  •  Occult aneurysms in aorto-coronary saphenous vein grafts.  Tada H, Kawashiri MA, Masuta E, Yamagishi M. INTERNAL MEDICINE 2010/06
  •  Impact of out-stent plaque volume on in-stent intimal hyperplasia: Results from serial volumetric analysis with high-gain intravascular ultrasound.  Tada H, Kawashiri MA, Sakata K, Takabatake S, Tsubokawa T, Konno T, Hayashi K, Uchiyama K, Ino H, Yamagishi M. INTERNATIONAL JOURNAL OF CARDIOLOGY 2011/02
  •  Impact of bezafibrate and atorvastatin on lipoprotein subclass in patients with type III hyperlipoproteinemia: result from a crossover study.  Kawashiri MA, Kobayashi J, Nohara A, Noguchi T, Tada H, Nakanishi C, Inazu A, Mabuchi H, Yamagishi M. CLINICA CHIMICA ACTA 2011/05
  •  High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.  Nohara A, Kawashiri MA, Claudel T, Mizuno M, Tsuchida M, Takata M, Katsuda S, Miwa K, Inazu A, Kuipers F, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2007/04
  •  Intravascular ultrasound appearance of scattered necrotic core as an index for deterioration of coronary flow during intervention in acute coronary syndrome.  Sakata K, Kawashiri MA, Ino H, Matsubara T, Uno Y, Yasuda T, Miwa K, Kanaya H, Yamagishi M. HEART AND VESSELS
  •  A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene.  Tada H, Kawashiri MA, Ohtani R, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M. ATHEROSCLEROSIS 2011/08

Conference Presentations

Arts and Fieldwork


Theme to the desired joint research

Grant-in-Aid for Scientific Research


Classes (Bachelors)

Classes (Graduate Schools)

○Internal Medicine(2017)
○Internal Medicine(2017)
○Internal Medicine(2016)
○Internal Medicine(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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