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Researcher Information

last modified:2017/06/16

Associate Professor AKAGI, Tadayuki

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Cancer Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

 TEL:076-265-2207 FAX:076-234-4238

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo Doctor 200403 Completed
【Degree】
Ph.D

Career

Kanazawa University(2015/05/01-)
Kanazawa University(2008/09/01-2015/04/30)
UCLA School of Medicine, Cedars-Sinai Medical Center post-doc(2005/04/01-2008/08/31)
Kanazawa University(2004/04/01-2005/03/31)
Japan Society for the Promotion of Science Research Fellowship(2001/04/01-2004/03/31)

Year & Month of Birth

1974/10

Academic Society





Japan Cancer Assosication


International Society for Stem Cell Research
Molecular Biology

Award

Molecular Biology
Molecular Biology
Molecular Biology
Molecular Biology
Molecular Biology
Molecular Biology
Molecular Biology
Molecular Biology
○ASH Travel Award(2005/12)
○Stem Cell Grant, Cedars-Sinai Medical Center(2005/04)

Specialities

General medical chemistry

Speciality Keywords

ES cells, Oncogene, Transcription factor, Gene regulation

Research Themes

Analysis of Transcription Factor C/EBP in Hematopoiesis

Involvement of oncogene on regulation of stemness of ES cells.

Molecular mechanisms of naïve status for pluripotent stem cells.

Books

Papers

  •  Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma. Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP. Int J Oncol. 50 863-872 2017/03/01
  •  Role of the leucine zipper domain of CCAAT/enhancer binding protein-epsilon (C/EBPε) in neutrophil-specific granule deficiency. Wada T and Akagi T Critical Reviews™ in Immunology 36 349-358 2016
  •  Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3. Uranishi K, Akagi T, Koide H, Yokota T. Biochem Biophys Res Commun. 2016
  •  Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance Nowak, Daniel;Liem, Natalia L. M.;Mossner, Maximilian;Klaumuenzer, Marion;Papa, Rachael A.;Nowak, Verena;Jann, Johann C.;Akagi, Tadayuki;Kawamata, Norihiko;Okamoto, Ryoko;Thoennissen, Nils H.;Kato, Motohiro;Sanada, Masashi;Hofmann, Wolf-Karsten;Ogawa, Seishi;Marshall, Glenn M.;Lock, Richard B.;Koeffler, H. Phillip EXPERIMENTAL HEMATOLOGY 43 1 32-43 2015/01/01 
  •  Nanog positively regulates Zfp57 expression in mouse embryonic stem cells Yamaguchi, Yukari; Takamura, Hiroyuki; Tada, Yuhki; Akagi, Tadayuki; Oyama, Katsunobu; Miyashita, Tomoharu; Tajima, Hidehiro; Kitagawa, Hirohisa; Fushida, Sachio; Yokota, Takashi; Ohta, Tetsuo; Koide, Hiroshi Biochemical and Biophysical Research Communications 2014/09/29 

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  •  Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator Fujii, Yuka; Kakegawa, Madoka; Koide, Hiroshi; Akagi, Tadayuki; Yokota, Takashi Biochemical and Biophysical Research Communications 441 2 411-417 2013/11/15 
  •  ETS-related Transcription Factors ETV4 and ETV5 are Involved in Proliferation and Induction of Differentiation-associated Genes in ES cells. Akagi T, Kuure S, Uranishi K, Koide H, Costantini F, and Yokota T J Biol. Chem.  290 22460-22473 2015
  •  A novel in-frame deletion in the leucine zipper domain of C/EBP-epsilon leads to neutrophil-specific granule deficiency. Wada T, Akagi T, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A  J Immunol 195 80-86 2015
  •  Oct3/4 directly regulates expression of E2F3a in mouse embryonic stem cells. Kanai D, Ueda A, Akagi T, Yokota T, Koide H Biochem Biophys Res Commun 459 374-378 2015
  •  The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells. Tada Y, Yamaguchi Y, Kinjo T, Song X, Akagi T, Takamura H, Ohta T, Yokota T, Koide H. Oncogene 34 752-60 2015
  •  Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft. Garg M, Okamoto R, Nagata Y, Kanojia D, Venkatesan S, M T A, Braunstein GD, Said JW, Doan NB, Ho Q, Akagi T, Gery S, Liu LZ, Tan KT, Chng WJ, Yang H, Ogawa S, Koeffler HP. J Clin Endocrinol Metab. 100 725-35. 2015
  •  High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-Producing Cells. Hakim F, Kaitsuka T, Raeed JM, Wei FY, Shiraki N, Akagi T, Yokota T, Kume S, and Tomizawa K.  J Biol. Chem. 289 9623-38 2014
  •  Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. Nowak D, Liem NL, Mossner M, Klaumünzer M, Papa RA, Nowak V, Jann JC, Akagi T, Kawamata N, Okamoto R, Thoennissen NH, Kato M, Sanada M, Hofmann WK, Ogawa S, Marshall GM, Lock RB, Koeffler HP. Exp Hematol. 43 32-43 2014
  •  Dynamic CCAAT/enhancer binding protein (CEBP)-associated changes of DNA methylation in the angiotensinogen gene. 8. Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y. Hypertension 63 281-288 2014
  •  Nanog positively regulates Zfp57 expression in mouse embryonic stem cells. 6. Yamaguchi Y, Takamura H, Tada Y, Akagi T, Oyama K, Miyashita T, Tajima H, Kitagawa H, Fushida S, Yokota T, Ohta T, Koide H. Biochem Biophys Res Commun. 453 2014
  •  Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice. 7. Okamoto R, Gery S, Gombart AF, Wang X, Castellani LW, Akagi T, Chen S, Arditi M, Ho Q, Lusis AJ, Li Q, Koeffler HP.  PLoS ONE. 9 e85341 2014
  •  Novel Gemini vitamin D3 analogs: Large structure/function analysis and ability to induce antimicrobial peptide. INTERNATIONAL JOURNAL OF CANCER 134 207 2014/01
  •  Dax1 Associates with Esrrb and Regulates Its Function in Embryonic Stem Cells. MOLECULAR AND CELLULAR BIOLOGY 33 2056 2013/05
  •  Inecalcitol, an analog of 1α,25(OH)2D3, induces growth arrest of androgen-dependent prostate cancer cells. INTERNATIONAL JOURNAL OF CANCER 130 2464 2012/05
  •  Nonsteroidal Anti-inflammatory Drugs Suppress Glioma via 15-Hydroxyprostaglandin Dehydrogenase. CANCER RESEARCH 68 17 6978-6986 2008/09
  •  Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation EMBO JOURNAL 30 11 2190-204 2011/06
  •  In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response. 5 11 e15419 2010/11
  •  Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. HAEMATOLOGICA 95 9 1481-1488 2009/09
  •  Chromosomal abnormalities and novel disease-related regions in progression from Barrett’s esophagus to esophageal adenocarcinoma. INTERNATIONAL JOURNAL OF CANCER 125 10 2349-2359 2009/11
  •  Vitamin D compounds and MDS. Okamoto R, Akagi T, Koeffler HP. LEUKEMIA & LYMPHOMA 49 1 12-13 2008/01
  •  Hidden abnormalities and novel classification of t(15;17) APL based on genomic alterations. Akagi T, Shih LY, Kato M, Kawamata N, Yamamoto G, Sanada M, Okamoto R, Miller CW, Liang DC, Ogawa S, Koeffler HP. BLOOD 113 8 1741-1748 2009/02
  •  Molecular allelokaryotyping of T-cell prolymphocytic leukemia (T-PLL) cells with high density SNP arrays identifies novel common genomic lesions and acquired uniparental disomy (aUPD). Nowak D, Toriellec EL, Stern MH, Kawamata N, Akagi T, et al HAEMATOLOGICA 94 2 518-527 2009/04
  •  Dax1 Binds to Oct3/4 and Inhibits Its Transcriptional Activity in Embryonic Stem Cells Sun C, Nakatake Y, Akagi T, Ura H, Matsuda T et al MOLECULAR AND CELLULAR BIOLOGY 29 16 4574-4583 2009/08
  •  Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells. Akagi T, Shih LY, Ogawa S, Gerss J, Moore SR, et al HAEMATOLOGICA 94 9 1301-1306 2009/09
  •  Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells. Akagi T, Usuda M, Matsuda T, Ko MS, Niwa H, Asano M, et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331 1  23-30 2005/05
  •  Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA. Kawamura H, Tomozoe Y, Akagi T, Kamei D, Ochiai M, Yamada M. JOURNAL OF BIOLOGICAL CHEMISTRY 277 4  2732-2739 2002/01
  •  STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, et al JOURNAL OF BIOLOGICAL CHEMISTRY 283 15 9713-9723 2008/04
  •  Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells. Akagi T, Yin D, Kawamata N, Bartram CR, Hofmann WK, Song JH, et al. LEUKEMIA RESEARCH 33 7 991-996 2009/07
  •  Frequent genomic abnormalities in AML/MDS with normal karyotype. Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, et al. HAEMATOLOGIA 94 2 213-223 2009/02
  •  GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells. Kinoshita K, Ura H, Akagi T, Usuda M, Koide H, Yokota T. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 3 686-691 2007/02
  •  Induction of sodium iodide symporter gene and molecular characterisation of HNF3beta/FoxA2, TTF-1 and C/EBPbeta in thyroid carcinoma cells. Akagi T, Luong QT, Gui D, Said J, Selektar J, Yung A, et al. BRITISH JOURNAL OF CANCER 99 5 781-788 2008/09
  •  Molecular characterization of a mouse heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its tissue-specific expression. Akagi T, Kamei D, Tsuchiya N, Nishina Y, Horiguchi H, Matsui M, Kamma H, Yamada M GENE 245 2  267-273 2000/03
  •  Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells. Sun C, Nakatake Y, Ura H, Akagi T, Niwa H, Koide H, Yokota T BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372 1 91-6 2008/07
  •  Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells. Akagi T, Saitoh T, O'Kelly J, Akira S, Gombart AF, Koeffler HP BLOOD 111 6 2999-3004 2008/05
  •  Methylation analysis of asparagine synthetase gene in acute lymphoblastic leukemia cells. Akagi T, Yin D, Kawamata N, Bartram CR, Hofmann WK, Wolf I, et al. LEUKEMIA 20 7  1303-1306 2006/07
  •  Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells. Kumagai T, Akagi T, Desmond JC, Kawamata N, Gery S, Imai Y, et al. INTERNATIONAL JOURNAL OF CANCER 124 4 827-833 2009/02

Conference Presentations

  • Baf53a is involved in proliferation of ES cells by regulating p53-p21 pathway and Baf53b compensates for Baf53a function.(conference:ISSCR 2017 Annual Meeting)(2017/06/14)
  • Involvement of chromatin remodeling factor Baf53a in proliferation of mouse ES cells by regulating p53 and p21.(2017/06/03)
  • Baf53a deficiency inhibits cell proliferation and Baf53b substitutes for functions of Baf53a in mouse embryonic stem cells.(2017/05/26)
  • Functional Analyses of ETS-related Transcription Factors ETV4/5 in Proliferation and Differentiation of Mouse ES Cells.(conference:CiRA/ISSCR 2016 International Symposium)(2016/03/22)
  • Zfp296 associates with Klf4 and regulates its activity as an activator and a repressor.(conference:The 13th Stem Cell Research Symposium.)(2015/05/29)

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  • Molecular characterization of a novel 2 amino acids deletion of C/EBP epsilon in SGD.(2015/10/16)
  • The Nanog/Zfp57 axis regulates anchorage-independent growth(2014/05/30)
  • Zfp296 functions as transcriptional repressor and activator together with histon modification enzymes.(2014/11/25)
  • Identification of an ES-specific gene Zfp57 as a novel oncogene(2013/05/17)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「がん遺伝子を介した幹細胞性制御機構の新たな分子基盤の解明」(2017-2019) 
○「Baf53aとOct3/4を介したES細胞の自己複製制御機構の解析」(2012-2013) 
○「胚性幹細胞における自己複製機構の解析」(2010-2012) 
○「がん遺伝子を介したES細胞の自己複製機構の解析」(2009-2010) 
○「ES細胞のにおけるOct-3/4の機能制御因子の探索」(2001-2003) 

Classes (Bachelors)

○Basic Health Science(2017)
○Practical Medical Research(2017)
○Freshman Seminar I(2017)
○Freshman Seminar I(2016)
○Basic Health Science(2016)
○医薬保健学基礎(2015)

Classes (Graduate Schools)

○Stem Cell Biology(2017)
○Environment and Heredity(2017)
○Stem Cell Biology(2017)
○Medical Sciences(2016)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)
○Environment and Heredity(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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