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Researcher Information

last modified:2017/05/23

Professor MUKAIDA Naofumi

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Material Chemistry, Graduate School of Natural Science and Technology
Division of Cancer Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Division of Molecular Bioregulation TEL:076-265-2767 FAX:076-234-4520

Academic Background

【Academic background(Bachelor's Degree)】
Hokkaido University 1980

Career

Kanazawa University Cancer Research Instittue(2000/01/01-)
Kanazawa University Cancer Research Institute(1992/05/01-1999/12/31)
Tokyo Medical and Dental University School of Allied Health Sciences(1992/04/01-1993/04/30)
Tokyo Medical and Dental University Med. Technol. School, School Med.(1990/11/01-1991/03/31)
National Caner Institute, USA Laboratory of Molecular Bioregulation(1988/05/01-1990/10/31)
Jichi Medical School Dept. Clinical Pathology(1985/04/01-1989/04/30)
Jichi Medical School Dept. Clinical Pathology(1980/05/25-1985/03/31)

Year & Month of Birth

1956/01

Academic Society


Japanese Cancer Association
American Association of Immunologists

American Society of Investigative Pathology
Japanese Society of Metastasis Research
Japanse Society of Inflammation and Regneration

Award





Specialities

Immunology、Laboratory medicine、Experimental Pathology、Pathological Medical Biochemistry

Speciality Keywords

Pro-inflammatory cytokines

Research Themes

Study on pro-inflammatory cytokines and chemokines in tumor development and progression

It has been well recognized that inflammatory responses have crucial roles in the development, progression, and metastasis steps of cancer. Moreover, pro-inflammatory cytokines such as tumor necrosis factor and chemokines have been presumed to be indispensable for inflammatory resposense. We are investigating the roles of pro-inflammatory cytokines and chemokines in development, progression, and metastasis processes of cancer, mainly by using mouse models.

Elucidaiton on the roles of Pim kinases in cancer development and progression

We determined the amino acid sequence of a novel serine/threonine kinase, Pim-3. We further unraveled that Pim-3 expression is observed in malignant lesions but not normal tissues of endoderm-derived organs and that Pim-3 can promote the survival of tumor cells by counteracting the activities of pro-apoptosis molecules. We are now eluciding the regulatory mechanisms underlying Pim-3 activation and expression, in order to develop a novel type of anti-cancer drugs targeting Pim-3.

Study on roles of pro-inflammatory cytokines and chemokines in iflammation.

It has been widely accepted that pro-inflammatory cytokines such as tumor necrosis factor and chemokines are crucial in inflammation. We are investigating the regualatory mechanisms underlying pro-inflammatory cytokine and chemokine expression and their pathophysiological roles in inflamamtory reactions.

Books

  •  The Cytokine Handbook, 4th Edition Elsevier Science Ltd 2003/08
  •  Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, and Mukaida, N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages, and neovascularization. 118 2 335-345 2006/01
  •  Yang X, Lu P, Fujii C, Nakamoto Y, Gao J-L, Kaneko S, Murphy PM, and Mukaida N. Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. 118 8 1869-1876 2006/04

Papers

  •  MIP-1alpha/CCL3-mediated maintenance of leukemia initiating cells in the initiation process of chronic myeloid leukemia. 265. Baba T, Naka K, Morishita S, Komatsu N, Hirao A, and Mukaida N Journal of Experimental Medicine 210 12 2661 2013/11
  •  Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. Popivanova BK,Kostadinova FI,Furuichi K,Shamekh MM,Kondo T,Wada T,Egashira K,Mukaida N Cancer Res 69 19 7884-92 2009/10
  •  Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, and Mukaida N. JOURNAL OF CLINICAL INVESTIGATION 118 2 560-570 2008/02
  •  Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation. Tanabe Y, Sasaki S, Mukaida N, and Baba T Oncotarget 7 30 48335 2016
  •  Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice. 269. Sasaki S, Baba T, Shinagwa K, Matsushima K, and Mukaida N International Journal of Cancer 135 6 1297 2014/03

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  •  MIP-1alpha/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, and Mukaida N. Blood 127 21 2607 2016
  •  Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses. 268. Hamano R, Baba T, Sasaki S, Tomaru U, Ishizu A, Kawano M, Yamagishi M, and Mukaida N European Journal of Immunology 44 4 1005 2014/02
  •  Chemokines in tumor development and progression. Mukaida N and Baba T EXPERIMENTAL CELL RESEARCH 318 2 95 2012/02
  •  Roles of Pim-3, a novel survival kinase, in tumorigenesis. Mukaida N,Wang YY,Li YY Cancer Science 102 8 1437-42 2011/08
  •  Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha. Iida N,Nakamoto Y,Baba T,Nakagawa H,Mizukoshi E,Naito M,Mukaida N,Kaneko S Cancer Res 70 16 6556-65 2010/08
  •  Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. Baba T,Nakamoto Y,Mukaida N JOURNAL OF IMMUNOLOGY 183 5 3053-63 2009/08
  •  Pivotal role of the CCL5-CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing.  Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, and Kondo T JOURNAL OF CLINICAL INVESTIGATION 122 2 711 2012/01
  •  Absence of IFN-gamma accelerates thrombus resolution through enhancing MMP-9 and VEGF expression in mice. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, and Kondo T JOURNAL OF CLINICAL INVESTIGATION 121 7 497 2011/07
  •  Gemcitabine induces cell senescence in human pancreatic cancer cell line Song Y, Baba T, and Mukaida N Biochem Biophys Res Commun 477 515 2016
  •  Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, and Mukaida N Cancer Letters 378 1 23 2016
  •  High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-posisitve T cells into tumor sites Naito T, Baba T, TakedaK, Sasaki S, Nakamoto Y, Mukaida N Cancer Letters 366 1 93 2015
  •  Inflammatory monocytes recruited to allergic skin acquire anti-inflammatory M2 phenotype via basophil-derived IL-4. Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, Minegishi Y, and Karasuyama H. IMMUNITY 38 3 570 2013/03
  •  Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities.  Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N. Cancer Science 13 1 107 2012/01
  •  Critical role of TNF-alpha-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization. Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Xhang X, and Mukaida N INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53 7 3516 2012/07
  •  Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a cocomitant reduction of TNF-alpha, IL-12, and IL-18 production JOURNAL OF IMMUNOLOGY 162 2 1049-1055 1999/01
  •  Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 LABORATORY INVESTIGATION 78 5 571-581 1998/05
  •  Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. AMERICAN JOURNAL OF PATHOLOGY 155 3 753-763 1999/09
  •  Activator protein (AP)-1 is the preferred transcription factor for cooperative interaction with nuclear factor (NF)-kappaB in respiratory syncytial virus-induced interleukin (IL)-8 gene expression in airway epithelium JOURNAL OF INFECTIOUS DISEASES 177 5 1275-1281 1998/05
  •  Anti-interleukin-8 monoclonal antibody reduces free radical production and improves hemodynamics and survival rate in endotoxic shock in rabbits. SURGERY 122 1 60-68 1997/07
  •  Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice JOURNAL OF LEUKOCYTE BIOLOGY 66 4 601-608 1999/10
  •  Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8 JOURNAL OF LEUKOCYTE BIOLOGY 62 4 444-449 1997/10
  •  CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 107 353-358 2001/02
  •  Chemokines in the bronchoalveola lavage fluid of patients with sarcoidosis INTERNAL MEDICINE 36 12 856-860 1997/12
  •  Combined therapy of multidrug-resistant human lung cancer with anti-P-glycoprotein antibody and monocyte chemoattractant protein-1 gene transdcution: the possibility of immunological overcomeing of multidrug resistance INTERNATIONAL JOURNAL OF CANCER 71 2 170-177 1997/04
  •  Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. MOLECULAR CARCINOGENESIS 26 2 119-129 1999/10
  •  Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of Src-family in a human monocyte chemoattractant protein-1 transgenic mouse Immmunobiology 201 3 4 432-449 2000/01
  •  Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW 264.7 : role of kappaB-3 biding protein CYTOKINE 12 3 207-219 2000/03
  •  Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2 JOURNAL OF IMMUNOLOGY 166 7104-7111 2001/06
  •  Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases AMERICAN JOURNAL OF NEPHROLOGY 20 291-299 2000/07
  •  Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-alpha JOURNAL OF IMMUNOLOGY 160 9 4518-4525 1998/05
  •  Effect of thromboxane A2 antagonists on bronchial hyperresponsiveness induced immediately after interleukin-8 inhalation in guinea-pigs British Jounral of Pharmacology 122 6 1015-1020 1997/11
  •  Elevated chemokine levels in bronchoalveolar fluid of tuberculosis patients American Jounral of Respiratory and Critical Care Medicine 155 4 1474-1477 1997/04
  •  Endotoxin-induced uveitis is partially inhibited by anti-IL-8 antibody treatment Investigative Ophtalmoloy and Visual Science 40 11 2465-2470 1999/10
  •  Enhanced AP-1 and NF-kappaB activities and stability of interleukin 8 (IL-8) transcripts are implicated in IL-8 mRNA superinduction in lung epithelial H292 cells BIOCHEMICAL JOURNAL 330 1 429-435 1998/02
  •  Enhanced mobilization of hematopoietic progenitor cells by mouse MIP-2 and granulocyte colony-stimulating factor in mice JOURNAL OF LEUKOCYTE BIOLOGY 62 4 503-509 1997/10
  •  Eotaxin contributes to renal interstitial eosinophilia Nephrology Dialysis and Transplantation 14 1 76-80 1999/01
  •  Essential role of transcription factor nuclear factor kappaB in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aerginosa in respiratory epithelial cells INFECTION AND IMMUNITY 67 8 3872-3878 1999/08
  •  Helicobacter pylori-dependent ceramide psoduction may mediate increased interleukin 8 expression in human gastric cancer cell lines GASTROENTEROLOGY 116 6 1330-1341 1999/06
  •  Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response JOURNAL OF VIROLOGY 75 6095-6106 2001/07
  •  Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene JOURNAL OF VIROLOGY 71 7 5692-5695 1997/07
  •  Human T cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites CANCER RESEARCH 58 17 3993-4000 1998/09
  •  Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells CANCER RESEARCH 59 22 5822-5829 1999/11
  •  Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter MOLECULAR AND CELLULAR BIOLOGY 17 9 5097-5105 1997/09
  •  IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas CLINICAL CANCER RESEARCH 7 1812-1820 2001/06
  •  IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2 JOURNAL OF IMMUNOLOGY 167 366-374 2001/07
  •  IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration JOURNAL OF IMMUNOLOGY 164 5 2769-2775 2000/03
  •  Impairment of endotoxin-induced macrophage inflammatory protein 2 gene expression in alveolar macrophages in streptozotocin-induced diabetes in mice INFECTION AND IMMUNITY 68 5 2925-2929 2000/05
  •  Induction of dendritic cell differentiation by granulocyte-macrophagecolony-stimulating factor, stem cell factor, and tumor necrosis factor alpha in vitro from lineage phenotypes-negative c-kit+ murine hematopoietic progenitor cells BLOOD 90 12 4842-4853 1997/12
  •  Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1alpha by interacting mainly with a C-C chemokine receptor, CCR1 BLOOD 90 2 605-611 1997/07
  •  Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha EUROPEAN CYTOKINE NETWORK 9 1 47-55 1998/03
  •  Interleukin-8 gene repression by clarithromycin is mediated by activator protein-1 binding site in human bronchial epithelial cells American Journal of Respiratory Cellular and Molecular Biology 22 1 51-60 2000/01
  •  interleukin-8 inhalation directly provoke bronchoconstriction in guinea pigs ALLERGY 54 4 386-391 1999/04
  •  Interleukin-8 selectively enhances cytopathic effect (CPE) induced by positive-strand RNA viruses in the human WISH cell line Biochemical Biophysical Research Communication 235 3 774-778 1997/06
  •  Intervention in endotoxin shock by sulfatide (I3SO3-GalCer) with a concomitant reduction in tumor necrosis factor a production INFECTION AND IMMUNITY 65 4 1223-1227 1997/04
  •  Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice LIVER 20 465-474 2000/12
  •  Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45 INFECTION AND IMMUNITY 65 8 3218-3224 1997/08
  •  MIP-1 alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis KIDNEY INTERNATIONAL 56 3 995-1003 1999/09
  •  Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK JOURNAL OF BIOLOGICAL CHEMISTRY 274 19 13077-13084 1999/05
  •  Molcular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastrci cancer cell lines Digestive Disease Science 43 9 Supplement 174S-180S 1998/09
  •  Monocyte chemoattractant protein-1 gene modification of multidrug-resistant human lung cancer enhances antimetastatic effect of therapy with anti-P-glycoprotein antibody in SCID mice INTERNATIONAL JOURNAL OF CANCER 80 5 773-780 1999/03
  •  Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocyte chemoattractant protein-1 gene transfection in severe combined immunodeficient mice CANCER RESEARCH 60 7002-7007 2000/12
  •  NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells BLOOD 93 10 3241-3249 1999/05
  •  Nitirc oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 18 10 905-912 1998/10
  •  NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor LEUKEMIA 15 1092-1101 2001/07
  •  Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53 CANCER RESEARCH 61 673-678 2001/01
  •  Participation of endogenously produced interferon gamma in interleukin 4-meidated tumor rejection HUMAN GENE THERAPY 11 5 659-668 2000/03
  •  PEA3 and AP-1 are required for constitutive IL-8 gene expression in hepatoma cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279 166-171 2000/12
  •  Physiologic regulation of postovulatory neutrophil migration into vagina in mice by a C-X-C chemokine(s) JOURNAL OF IMMUNOLOGY 160 12 6159-6165 1998/06
  •  Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8 LABORATORY INVESTIGATION 77 2 119-125 1997/08
  •  Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8 CLINICAL CANCER RESEARCH 6 2735-2740 2000/07
  •  Regulation of placental monocyte chemotactic and activating factor during pregnancy and chorioamnionitis MOLECULAR HUMAN REPRODUCTION 4 4 393-400 1998/04
  •  Stimulation of interleukin-8 production by acidic polysaccharide from the root of Panax ginseng Immunopharmacolgy 38 3 287-294 1998/01
  •  Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kB activation JOURNAL OF BIOLOGICAL CHEMISTRY 272 24 15366-15372 1997/06
  •  The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha JOURNAL OF EXPERIMENTAL MEDICINE 186 7 1077-1085 1997/10
  •  The differential ability of IL-8 and neutrophil-activating peptide-2 to induce attenuation of chemotaxis is mediated by their divergent capabilities to phosphorylate CXCR2 (IL-8 receptor B) JOURNAL OF IMMUNOLOGY 158 12 5927-5933 1997/06
  •  The immediate early gene 1 product of human cytomegalovirus is sufficient for up-regulation of interleukin-8 gene expression. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279 298-304 2000/12
  •  The participation of IL-8 in the synovial lesions at an early stage of rheumatoid arthritis TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 188 1 75-87 1999/05
  •  The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein-2 in primary listeriosis in mice PATHOLOGY INTERNATIONAL 49 6 519-532 1999/06
  •  Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice BRITISH JOURNAL OF CANCER 81 4 647-653 1999/10
  •  Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 122 207-211 2000/12
  •  Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis INFECTION AND IMMUNITY 65 5 1892-1898 1997/05
  •  Up-regulation of monocye chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy KIDNEY INTERNATIONAL 58 1492-1499 2000/10
  •  Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy JOURNAL OF LEUKOCYTE BIOLOGY 63 4 493-499 1998/04
  •  Prevention of endotoxin shock through targeting leukocyte adhesion molecules Progress in Clinical and Biological Research 397 327-334 1998
  •  Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1, in human hepatomas. AMERICAN JOURNAL OF PATHOLOGY 162 4 1249-1258 2003/04
  •  The essential involvement of cross-talk betweeen IFN-gamma and TGF-beta in the skin wound healing process JOURNAL OF IMMUNOLOGY 172 3 1848-1855 2004/02
  •  Essential involvement of INF-gamma in Clostidium difficile toxin A-induced enteritis JOURNAL OF IMMUNOLOGY 172 5 3018-3025 2004/03
  •  Aberrant expression of Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines INTERNATIONAL JOURNAL OF CANCER 114 209-218 2005
  •  Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, and Mukaida N EUROPEAN JOURNAL OF IMMUNOLOGY 36 4 1028-1038 2006/04
  •  Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway Ishida Y, Kondo T, Kimura A, Matsushima K, and Mukaida, N JOURNAL OF IMMUNOLOGY 176 9 1028-1038 2006/05
  •  Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulation of intrarenal multidrug resistance-associated protein 1 expression. Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, and Kondo T AMERICAN JOURNAL OF PATHOLOGY 169 4 1118-1128 2006/10
  •  Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines Li Y-Y, Popivanova BK, Nagai Y, Ishikura H, Fujii C, and Mukaida N CANCER RESEARCH 66 13 6741-6747 2006/07
  •  Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced anti-angiogenic factor expression Lu P, Li L, Kuno K, Wu Y, Baba T, Li Y-Y, Zhang X, and Mukaida N. JOURNAL OF IMMUNOLOGY 180 6 4283-4291 2008/03
  •  Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, and Kaneko S. JOURNAL OF IMMUNOLOGY 178 1 574-583 2007/01
  •  IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappaB activation. JOURNAL OF IMMUNOLOGY 178 11 7385-7394 2007/06
  •  Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yashiro K, Moss J, and Hirayama T JOURNAL OF IMMUNOLOGY 180 7 5017-5027 2008/04
  •  A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 11 1534-1541 2000/08
  •  Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, and Matsushima K BLOOD 111 12 5457-5466 2008/06
  •  CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fiborblasts, and promotes angiogenesis in murine lung metastasis process. JOURNAL OF IMMUNOLOGY 181 9 6384-6394 2008/11
  •  Gemcitabine-induced CXCL8 expression counteracts its action by inducing tumor neovascularization Song Y, Baba T, Li Y-Y, Furukawa K, Tanabe Y, Matsugo S, Sasaki S, and Mukaida N.  Biochem Biophys Res Commun 458 2 341 2015
  •  IFN-gammais protective in cisplatin-induced renal injury by enhancing autophagic flux. Kimura A, Ishida, Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, and Kondo T KIDNEY INTERNATIONAL 82 10 1093 2012/10
  •  CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, and Ota T. DIABETES 61 7 1680 2012/07
  •  Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver. Wu Y,Wang YY,Nakamoto Y,Li YY,Baba T,Kaneko S,Fujii C,Mukaida N ONCOGENE 29 15 2228-37 2010/08
  •  Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice. Kostadinova FI,Baba T,Ishida Y,Kondo T,Popivanova BK,Mukaida N J Leukoc Biol 88 1 133-43 2010/07
  •  Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. Li YY,Wang YY,Taniguchi T,Kawakami T,Baba T,Ishibashi H,Mukaida N Int J Cancer 127 2 474-84 2010/02
  •  Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. Nosaka M,Ishida Y,Kimura A,Kuninaka Y,Inui M,Mukaida N,Kondo T J Clin Invest 121 7 2911-20 2011/07
  •  Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney. Shimizu K,Furuichi K,Sakai N,Kitagawa K,Matsushima K,Mukaida N,Kaneko S,Wada T Hypertens Res 34 6 747-52 2011/06
  •  Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice. Kakinoki K,Nakamoto Y,Kagaya T,Tsuchiyama T,Sakai Y,Nakahama T,Mukaida N,Kaneko S J Gene Med 12 12 1002-13 2010/12
  •  Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression. Inui M,Ishida Y,Kimura A,Kuninaka Y,Mukaida N,Kondo T J Immunol 186 1 423-31 2011/01
  •  Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization. Nakamoto Y,Mizukoshi E,Kitahara M,Arihara F,Sakai Y,Kakinoki K,Fujita Y,Marukawa Y,Arai K,Yamashita T,Mukaida N,Matsushima K,Matsui O,Kaneko S Clin Exp Immunol 163 2 165-77 2011/02
  •  Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice. Fujii H,Baba T,Ishida Y,Kondo T,Yamagishi M,Kawano M,Mukaida N Arthritis Rheum 63 1 96-106 2011/01
  •  Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells. Seo JY,Yu JH,Lim JW,Mukaida N,Kim H J Physiol Pharmacol 60 Suppl 7 101-6 2009/09
  •  The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation. Kimura A,Ishida Y,Wada T,Hisaoka T,Morikawa Y,Sugaya T,Mukaida N,Kondo T Am J Pathol 176 1 40-50 2010/01
  •  Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. Lu P,Li L,Liu G,Zhang X,Mukaida N Invest Ophthalmol Vis Sci 50 10 4761-8 2009/10
  •  Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Lu P,Li L,Liu G,van Rooijen N,Mukaida N,Zhang X Cornea 28 5 562-9 2009/05
  •  Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells. Li YY,Wu Y,Tsuneyama K,Baba T,Mukaida N Cancer Sci 100 3 396-404 2009/03
  •  Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist. Ishibe T,Kimura A,Ishida Y,Takayasu T,Hayashi T,Tsuneyama K,Matsushima K,Sakata I,Mukaida N,Kondo T Lab Invest 89 1 68-79 2009/01

Conference Presentations

Arts and Fieldwork

Patent

○Stemonamide synthesis intermediates and pharmaceutical composition for prevention and/or treatment of cancer(country:Japan, United States of America)

Theme to the desired joint research

○Anti-inflammatory therapy targeting chemokines
○Anti-tumor therapy targeting chemokines
○Screening of genes expressed selectively in chronic liver injury
○Development of a novel type of anti-cancer drug targeting a novel serine/threonine kinase, Pim-3

Grant-in-Aid for Scientific Research

○「新規のケモカイン・ファミリー分子の分子生物学的方法による検索」(1997-) 
○「新規のケモカイン・ファミリー分子の分子生物学的方法による検索」(1998-) 
○「ケモカインならびにレセプターの分析法の開発とその病態検査学的意義の検討」(1998-) 
○「ケモカインならびにレセプターの病態生理学的役割の解析を通した抗炎症剤の開発」(1999-) 
○「ケモカインならびにレセプターの分析法の開発とその病態検査学的意義の検討」(1999-) 
○「肝障害の遷延化に関与する因子の検索に基づく、慢性肝障害の新規の早期診断法の開発」(1999-) 
○「ケモカインならびにレセプターの分析法の開発とその病態検査学的意義の検討」(2000-) 
○「肝傷害の遷延化に関与する因子の検索に基づく、慢性肝傷害の新規の早期診断法の開発」(2000-) 
○「ケモカインならびにレセプターの分析法の開発とその病態検査学的意義の検討」(2001-) 
○「肝障害の遷延化に関与する因子の検索に基づく,慢性肝障害の新規の早期診断法の開発」(2001-) 
○「微小転移巣での発現遺伝子の包括的解析に基づく、新規がんマーカーの検索」(2004-) 
○「微小転移巣での発現遺伝子の包括的解析に基づく、新規がんマーカーの検索」(2005-) 
○「微小転移巣での発現遺伝子の包括的解析に基づく、新規がんマーカーの検索」(2006-) 
○「膵癌選択的に発現しているキナーゼPim-3を分子標的とした新たな治療法の開発」(2006-) 
○「膵癌選択的に発現しているキナーゼPim-3を分子標的とした新たな治療法の開発」(2007-) 
○「新規セリン/スレオニン・キナーゼPim-3の膵臓がんの進展過程における役割の解明」(2006-) 
○「新規セリン/スレオニン・キナーゼPim-3の膵臓がんの進展過程における役割の解明」(2007-) 
○「炎症を基盤とするがん化過程における腫瘍壊死因子・ケモカインの役割の解析」(2007-) 
○「新規セリン/スレオニン・キナーゼPim-3の膵臓がんの進展機構における役割の解明」(2008-) 
○「炎症性サイトカイン・ケモカインを標的とした大腸がん予防の基礎的検討」(2007-) 
○「炎症を基盤とするがん化過程における腫瘍壊死因子・ケモカインの役割の解析」(2008-) 
○「炎症性サイトカイン・ケモカインを標的とした大腸がん予防の基礎的検討」(2008-) 
○「炎症を基盤とするがん化過程における腫瘍壊死因子・ケモカインの役割の解析」(2009-) 
○「炎症を基盤とするがん化過程における腫瘍壊死因子・ケモカインの役割の解析」(2009-2011) 

Classes (Bachelors)

Classes (Graduate Schools)

○Molecular Oncology(2017)
○Seminars on Cytokines(2017)
○Seminars on Cytokines(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Seminars on Cytokines(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Biology of Cancer 2B(2017)
○Biology of Cancer 2A(2017)
○Seminars on Cytokines(2016)
○Seminars on Cytokines(2016)
○Biology of Cancer 2A(2016)
○Biology of Cancer 2B(2016)
○Molecular Oncology(2016)
○Cancer molecular pathology 2(2016)
○Medical Sciences(2016)
○Seminars on Cytokines(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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