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Researcher Information

last modified:2017/05/23

Professor YOSHIOKA Katsuji

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Cancer Medicine, Graduate School of Medical Science
Division of Life Sciences, Graduate School of Natural Science and Technology
School of Natural System, College of Science and Engineering

Laboratory

Division of Molecular Cell Signaling TEL:076-264-6726 FAX:076-234-4532

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyushu University Doctor 198703 Completed
Kyushu University Master 198203 Completed
【Academic background(Bachelor's Degree)】
Kyushu University 1980

Career

Kanazawa University Cancer Research Institute(2001/10/01-)
Kitasato University School of Hygienic Sciences(1987/04/01-1990/12/31)
Kyushu University School of Medicine(1991/01/01-1994/05/06)

Year & Month of Birth

1958/02

Academic Society



Award

○Kato Memorial Foundation(1996/03/15)
○Uehara Memorial Foundation, Research Fellowship(1992/03/11)

Specialities

Molecular biology、Cell biology、Neurophysiology/General neuroscience

Speciality Keywords

cell siganling, cell differentiation, neural development

Research Themes

Study on MAP kinase cascade

Study on scaffold proteins for mammalian MAP kinase cascades

Study on neurogenesis

Books

Papers

  •  Displays of paternal mouse pup retrieval following communicative interaction with maternal mates Hong-Xiang Liu , Olga Lopatina , Chiharu Higashida, Katsuji Yoshiokaほか28名 Nature Communications 4 1346 2013/01
  •  Human microRNA-1245 down-regulates the NKG2D receptor in natural killer cells and impairs NKG2D-mediated functions Espinoza JL, Takami A, Yoshioka K, Nakata K, Sato T, Kasahara Y, Nakao S. HAEMATOLOGICA 97 9 1295-1303 2012/09
  •  SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation. Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RY, Yamashita K. JOURNAL OF CELL SCIENCE 124 2816-2825 2011/08
  •  N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease. Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A. JOURNAL OF BIOLOGICAL CHEMISTRY 286 9 7619-7628 2011/03
  •  Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors Sato T, Enkhbat A, Yoshioka K GENES TO CELLS 16 1 58-68 2011/01

show all

  •  MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways Tanahashi H, Kito K, Ito T, Yoshioka K. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 494 1 94-100 2010/02
  •  Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RY, Yamashita K. CANCER RESEARCH 69 16 6438-6444 2009/08
  •  Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin Morfini GA, You YM, Pollema SL, Kaminska A, Liu K, Yoshioka K, Björkblom B, Coffey ET, Bagnato C, Han D, Huang CF, Banker G, Pigino G, Brady ST. NATURE NEUROSCIENCE 12 7 864-871 2009/07
  •  JNK-binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1 Yamaguchi T, Miyashita C, Koyano S, Kanda H, Yoshioka K, Shiba T, Takamatsu N, Ito M. CELL BIOLOGY INTERNATIONAL 33 3 364-368 2009/03
  •  The scaffold protein c-Jun NH2-terminal kinase-associated leucine zipper protein regulates cell migration through interaction with the G protein G(alpha 13) Gantulga D, Tuvshintugs B, Endo Y, Takino T, Sato H, Murakami S, Yoshioka K. JOURNAL OF BIOCHEMISTRY 144 6 693-700 2008/12
  •  Ablation of the scaffold protein JLP causes reduced fertility in male mice Iwanaga A, Wang G, Gantulga D, Sato T, Baljinnyam T, Shimizu K, Takumi K, Hayashi M, Akashi T, Fuse H, Sugihara K, Asano M, Yoshioka K TRANSGENIC RESEARCH IN PRESS 2008/12
  •  The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K MOLECULAR AND CELLULAR NEUROSCIENCE 39 4 569-578 2008/12
  •  RNA interference silencing of DRAL affects processing of amyloid precursor protein H. Tanahashi, K. Yoshioka NEUROSCIENCE LETTERS 439 3  293-297 2008/07
  •  Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death Iwanaga A, Sato T, Sugihara K, Hirao A, Takakura N, Okamoto H, Asano M, Yoshioka K NEUROSCIENCE LETTERS 429 1  43-48 2007/12
  •  Functional interaction of hepatitis C Virus NS5B with Nucleolin GAR domain Kusakawa, T., Shimakami, T., Kaneko, S., Yoshioka, K., Murakami, S. JOURNAL OF BIOCHEMISTRY 141 6  917-927 2007/06
  •  Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells M. Bayarsaikhan, T. Takino, D. Gantulga, H. Sato, T. Ito, K. Yoshioka BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353 2  357-362 2007/02
  •  2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation Zou H, Adachi M, Imai K, Hareyama M, Yoshioka K, Zhao S, Shinomura Y. CLINICAL CANCER RESEARCH 12 21  6532-6539 2006/11
  •  Isolation and characterization of recombinant Drosophila Copia aspartic proteinase Athauda SB, Yoshioka K, Shiba T, Takahashi K BIOCHEMICAL JOURNAL 399 3  535-542 2006/11
  •  Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain E. Miura, M. Fukaya, T. Sato, K. Sugihara, M. Asano, K. Yoshioka, M. Watanabe JOURNAL OF NEUROCHEMISTRY 97 5 1431-1436 2006/04
  •  Selective expression of the scaffold protein JSAP1 in spermatogonia and spermatocytes M. Bayarsaikhan, A. Shiratsuchi, D. Gantulga, Y. Nakanishi, K. Yoshioka REPRODUCTION 131 4 711-719 2006/04
  •  c-jun N-terminal kinase hyperphosphorylates R406W tau at the PHF-1 site during mitosis Tatebayashi Y, Planel E, Chui DH, Sato S, Miyasaka T, Sahara N, Murayama M, Kikuchi N, Yoshioka K, Rivka R, Takashima A FASEB JOURNAL 20 6  762-764 2006/04
  •  Identification and characterization of mouse PSF1-binding protein, SLD5 Kong L, Ueno M, Itoh M, Yoshioka K, Takakura N BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 339 4  1204-1207 2006/01
  •  Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1 T. Sato, K. Hidaka, A. Iwanaga, M. Ito, M. Asano, Y. Nakabeppu, T. Morisaki, K. Yoshioka BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338 2 1152-1157 2005/12
  •  JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration Takino T, Nakada M, Miyamori H, Watanabe Y, Sato T, Gantulga D, Yoshioka K, Yamada KM, Sato H JOURNAL OF BIOLOGICAL CHEMISTRY 280 45  37772-37782 2005/11
  •  Convergence of cell cycle regulation and growth factor signals on GRASP65 Yoshimura S, Yoshioka K, Barr FA, Lowe M, Nakayama K, Ohkuma S, Nakamura N JOURNAL OF BIOLOGICAL CHEMISTRY 280 24  23048-23056 2005/06
  •  Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation Ikeda F, Nishimura R, Matsubara T, Tanaka S, Inoue J, Reddy SV, Hata K, Yamashita K, Hiraga T, Watanabe T, Kukita T, Yoshioka K, Rao A, Yoneda T JOURNAL OF CLINICAL INVESTIGATION 114 4  475-484 2004/08
  •  Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells Akiyama S, Yonezawa T, Kudo TA, Li MG, Wang H, Ito M, Yoshioka K, Ninomiya-Tsuji J, Matsumoto K, Kanamaru R, Tamura S, Kobayashi T JOURNAL OF BIOLOGICAL CHEMISTRY 279 35  36616-36620 2004/08
  •  Scaffold proteins in mammalian MAP kinase cascades Yoshioka K. JOURNAL OF BIOCHEMISTRY 135 6 657-661 2004/06
  •  JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y EMBO JOURNAL 23 8  1889-1899 2004/04
  •  Scaffold protein JSAP1 is transported to growth cones of neurites independent of JNK signaling pathways in PC12h cells Sato S, Ito M, Ito T, Yoshioka K GENE 329  51-60 2004/03
  •  Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration Takino T, Miyamori H, Watanabe Y, Yoshioka K, Seiki M, Sato H CANCER RESEARCH 64 3  1044-1049 2004/02
  •  In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis P. Xu, K. Yoshioka, D. Yoshimura, Y. Tominaga, T. Nishioka, M. Ito, Y. Nakabeppu JOURNAL OF BIOLOGICAL CHEMISTRY 278 48 48422-48433 2003/11
  •  Caspase-mediated cleavage of JNK during stress-induced apoptosis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 306 4 837-842 2003/07
  •  A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated ONCOGENE 21 42 6488-6497 2002/09
  •  Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells JOURNAL OF BIOLOGICAL CHEMISTRY 277 44 42060-42065 2002/11
  •  Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: A new mode of regulation of the MAP kinase cascade JOURNAL OF BIOLOGICAL CHEMISTRY 277 43 40703-40709 2002/10
  •  The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9 Biochem. Biophys. Res. Commun. 287 4 9 2001/10
  •  Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system Neurosci. Res. 39 4 10 2001/04
  •  A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways J. Biol. Chem. 275 51 4 2000/12
  •  Isoforms of the JSAP1 scaffold protein generating through alternative splicing GENE 255 2 6 2000/09
  •  p300/CBP-dependent and -independent transcriptional interference between NF-kB RelA and p53 Biochem. Biophys. Res. Commun. 272 2 5 2000/06
  •  Immunosuppressant FK506 activates NF-kB through the proteasome-mediated degradation of IkBa J. Biol. Chem. 274 49 6 1999/12
  •  JSAP1, a novel Jun N-terminal protein kinase (JNK) that functions as a scaffold factor in the JNK signaling pathway Mol. Cell. Biol. 19 11 10 1999/11
  •  Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation ONCOGENE 18 50 8 1999/11
  •  A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase1 and TGFb-activated kinase1 FEBS Lett. 457 3 4 1999/09
  •  Activation of c-Jun N-terminal kinase during ischemia and reperfusion in mouse liver FEBS Lett. 420 2-3 4 1997/12
  •  A novel mechanism of JNK1 activation: Nuclear translocation and activation of JNK1 during ischemia and reperfusion J. Biol. Chem 272 26 6 1997/06

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

○Regulation of cell proliferation and apoptosis by MAPK cascades

Grant-in-Aid for Scientific Research

○「軸索輸送における足場タンパク質JSAPの役割とその分子メカニズム」(2011-2013) 
○「足場タンパク質JSAP1による小脳顆粒前駆細胞の増殖・分化制御機構の解析 」(2008-2010) 
○「発達期小脳における足場タンパク質JSAP1の機能解析」(2006-2007) 
○「哺乳動物のストレス応答MAPキナーゼ経路における足場タンパク質の解析」(2002-2006) 
○「JNKシグナル伝達路における足場タンパク質の同定とその機能解析」(2001-2003) 
○「JNKカスケードにおける足場タンパク質の同定とその解析」(2000-2000) 

Classes (Bachelors)

○Cell Biology(2017)
○Genetics Lab(2017)
○Molecular Biology(2017)
○Cell Biology(2017)
○Gene・Genome・Neuron・Time・Life(2016)
○Gene・Genome・Neuron・Time・Life(2016)
○Cell Biology(2016)
○Genetics Lab(2016)
○Genetics Lab(2016)
○Cell Biology(2016)
○Molecular Biology(2016)

Classes (Graduate Schools)

○Studies on Signal Transductio(2017)
○Studies on Signal Transductio(2017)
○Studies on Signal Transductio(2017)
○Medical Sciences(2017)
○Introduction to Medical Sciences(2017)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Cancer molecular pathology 1(2017)
○Molecular Oncology(2017)
○Cancer molecular pathology 1(2017)
○Biology of Cancer 1A(2017)
○Biology of Cancer 1B(2017)
○Medical Sciences(2016)
○Medical Sciences(2016)
○Cancer molecular pathology 1(2016)
○Molecular Oncology(2016)
○Biology of Cancer 1B(2016)
○Biology of Cancer 1A(2016)
○Studies on Signal Transductio(2016)
○Medical Sciences(2016)
○Medical Sciences(2016)
○Studies on Signal Transductio(2016)
○Studies on Signal Transductio(2016)
○Special Lecture on Systems Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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