Jump to contents

Researcher Information

last modified:2020/04/10

Professor YAMADA Masahito

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medical Science, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Neurology & Neurobiology of Aging, Kanazawa University Graduate School of Medical Science TEL:076-265-2290 FAX:076-234-4253

Academic Background

【Academic background(Doctoral/Master's Degree)】
Tokyo Medical and Dental University Doctor Graduate School, Division of Medicine Neurology 198403 Completed
【Academic background(Bachelor's Degree)】
Tokyo Medical and Dental University 198003

Career

Kanazawa University Graduate School of Medical Science(2001/04/01-)
Kanazawa University School of Medicine(2000/01/01-2001/03/31)
Tokyo Medical and Dental University Graduate School of Medical & Dental Sci(1999/04/01-1999/12/31)
University of California, San Diego School of Medicine(1988/07/01-2000/06/30)

Year & Month of Birth

1956/01

Academic Society




Japan Society for Dementia Research













Award






○Japan Medical Association Reserach Award(2006/11/01)

Specialities

Neurology

Speciality Keywords

Neurology

Research Themes

Study on Brain Aging, Dementia, and Amyloid

Development of novel diagnostic and therapeutic methods for Alzheimer's disease and other aging-related neurological disorders

Study on neuroinfection and neuroimmunology

Development of novel diagnostic and therapeutic methods for neuroinfectious and neuroimmunological disorders

Clinical study on stroke and other neurological disorders

Invedtigations of pathophysiology of stroke and other neurological disorders

Books

  •  Noguchi-Shinohara M, Hamaguchi T, Yamada M.  Curcumin for Neurological and Psychiatric Disorders  Elsevier 2019/06
  •  Yamada M, Yoshita M, Samuraki M, Komatsu J, Nakajima K. Dementia with Lewy Bodies Clinical and Biological Aspects Springer 2017/02
  •  Yamada M, Naiki H. Cerebral amyloid angiopathy.  Elsevier 2012/04
  •  Ono K, Noguchi-Shinohara M, Samuraki M, Matsumoto Y, Yanase D, Iwasa K, Naiki H, Yamada M.  Cerebrospinal fluid and plasma of Alzheimer patients promote β-amyloid fibril formation in vitro. Taylor & Francis Group 2007/07

Papers

  •  Higher blood vitamin C levels are associated with reduction of apolipoprotein E E4-related risks of cognitive decline in women: the Nakajima Study. Noguchi-Shinohara M, Abe C, Yuki-Nozaki S, Domoto C, Mori A, Hayashi K, Shibata S, Ikeda Y, Sakai K, Iwasa K, Yokogawa M, Ishimiya M, Nakamura H, Yokoji H, Komai K, Nakamura H, Yamada M.  J Alzheimer Dis 63 4 1289-1297 2018/05/30
  •  A clinical role for [123I]MIBG myocardial scintigraphy in the distinction between dementia of the Alzheimer's-type and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 71 583-588 2001
  •  A deletion polymorphism of a2-macroglobulin gene and cerebral amyloid angiopathy. STROKE 30 2277-2279 1999
  •  α2-macroglobulin polymorphism is not associated with AD or AD type neuropathology in Japanese. NEUROLOGY 54 443-446 2000
  •  Association of a1-antichymotrypsin polymorphism with cerebral amyloid angiopathy. Ann Neurol 44 129-131 1998

show all

  •  Association of presenilin-1 polymorphism with cerebral amyloid angiopathy in the elderly. STROKE 28 2219-2221 1997
  •  Atherosclerosis is not implicated in association of apolipoprotein E e4 with Alzheimer's disease. NEUROLOGY 53 236-237 1999
  •  Butyrylcholinesterase K variant and cerebral amyloid angiopathy. STROKE 29 2488-2490 1998
  •  Involvement of the spinal posterior horn in Gerstamann-Sträussler-Scheinker's disease (PrP P102L). NEUROLOGY 52 260-265 1999
  •  No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer's disease. NEUROLOGY 53 1146-1148 1999
  •  Apolipoprotein E and the neuropathology of dementia. Itoh Y, Yamada M, NEW ENGLAND JOURNAL OF MEDICINE 334 599-600 1996/04
  •  The first Japanese case of variant Creutzfeldt-Jakob disease showing periodic electroencephalogram. Yamada M on behalf of the Variant CJD Working Group, CJD Surveillance Committee, Japan LANCET 36 9513 874-875 2006/03
  •  Monoclonal antibody to Theiler's murine encephalomyeltis virus defines a determinant on myelin and oligodendrocytes, and auguments demyelination in experimental allergic encephalomyeltitis. Yamada M, Zurbriggen A, Fujinami RS JOURNAL OF EXPERIMENTAL MEDICINE 171 6 1893-1907 1990/06
  •  Clinical features and diagnosis of dura mater graft-associated Creutzfeldt-Jakob disease. Noguchi-Shinohara M, Hamaguchi T, Kitamoto T, Sato T, Nakamura Y, Mizusawa H, Yamada M NEUROLOGY 69 4 360-367 2007/08
  •  Value of Iodine-123 MIBG radioactivity in the differential diagnosis of DLB from AD. Yoshita M, Taki J, Yokoyama K, Noguchi-Shinohara M, Matsumoto Y, Najajima K, Yamada M NEUROLOGY 66 12 1850-1854 2006/06
  •  The relationship between viral RNA, myelin-specific mRNAs, and demyelination in the central nervous system during Theiler's virus infection. Yamada M, Zurbriggen A, Fujinami RS. AMERICAN JOURNAL OF PATHOLOGY 137 6 1467-1479 1990/12
  •  Common immunologic determinant between human immunoeficiency virus type 1 gp-41 and astrocytes. Yamada M, Zurbriggen A, Oldstone MBA, Fujinami RS. JOURNAL OF VIROLOGY 65 3,1370-1376 1991/03
  •  A missense mutation ata codon 105 with 129 polymorphism of the prion protein gene in a new variant of Gerstmann-Sträussler-Scheinker desease. Yamada M, Itoh Y, Fujigasaki H, Naruse S, Kaneko K, Kitamoto T, Tateishi J, Otomo E, Hayakawa M, Tanaka J, Matsushita M, Miyatake T. NEUROLOGY 43 12 2723-2724 1993/12
  •  Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy. Maeda M, Yamada M, Itoh Y, Otomo E, Hayakawa M, Miyatake T. STROKE 24 12 1857-1864 1993/12
  •  Lack of the association between apolipoprotein E and cerebral amyloid angiopathy in the elderly Japanese. Yamada M, Itoh Y, Otomo E, Suematsu N, Matsushita M. ANNALS OF NEUROLOGY 39 5,683  1996 1996/05
  •  Dementia of the Alzheimer type (DAT) and related dementias in the elderly: DAT subgroups and "senile dementia of the neurofibrillary tangle (NFT) type". Yamada M, Itoh Y, Otomo E, Suematsu N, Matsushita M. NEUROPATHOLOGY 16 2 89-98 1996/06
  •  Apolipoprotein E genotype in elderly non-demented subjects without senile changes in the brain. Yamada M, Itoh Y, Otomo E, Suematsu N, Matsushita M. ANNALS OF NEUROLOGY 40 2 243-245 1996/08
  •  Immune reactions associated with cerebral amyloid angiopathy. Yamada M, Itoh Y, Shintaku M, Kawanura J, Jensson O, Thornsteinsson L, Matsushita M, Suematsu N, Otomo E. STROKE 27 7 1155-1162 1996/07
  •  An inherited prion disease with PrP P105L mutation: clinicopathological and PrP heterogeneity. Yamada M, Itoh Y, Inaba A, Wada Y, Takashima M, Satoh S, Kamata T, Okeda R, Kayano T, Suematsu N, Kitamoto T, Otomo E, Matsushita M, Mizusawa H. NEUROLOGY 53 1 181-188 1999/07
  •  No association of paraoxonase genotype or atherosclerosis with cerebral amyloid angiopathy. Yamada M, Sodeyama N, Itoh Y, Suematsu N, Otomo E, Matsushita M, Mizusawa H. STROKE 33 4 896-900 2002/04
  •  Sporadic Creutzfeldt-Jakob disease with MM1 type prion protein and plaques. Ishida C, Kakishima A, Okino S, Furukawa Y, Kano M, Oda Y, Nakanishi I, Makifuchi T, Kitamoto T, Yamada M. NEUROLOGY 60 3 514-517 2003/02
  •  Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. JOURNAL OF NEUROCHEMISTRY 87 1 172-181 2003/10
  •  Hypertrophic pachymeningitis as an initial and cardinal manifestation of microscopic polyangitis. Furukawa Y, Matsumoto Y, Yamada M. NEUROLOGY 63 9 1722-1724 2004/11
  •  Hereditary spastic paraplegia with frontal lobe dysfunction: a clinicopathologic study. Yanase D, Komai K, Hamaguchi T, Okino S, Yokoji H, Makifuchi T, Takano H, Yamada M. NEUROLOGY 63 11 2149-2152 2004/12
  •  MRI of segmental zoster paresis. Samuraki M, Yoshita M, Yamada M. NEUROLOGY 64 7 1138 2005/04
  •  Clinical diagnosis of MM2 type sporadic Creutzfeldt-Jakob disease. Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura, Y,Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Murayama S, Kohriyama T, Katayama S, Yamashita M, Yamamoto T, Udaka F, Kawakami A, Ihara Y, Nishinaka T, Kuroda S, Suzuki N, Shiga Y, Arai H, Maruyama M, Yamada M. NEUROLOGY 64 4 643-648 2005/02
  •  Transient occlusion of the middle cerebral artery by macroembolism during carotid stenting for traumatic dissection of the common carotid artery. Furui E, Okamoto Y, Kida S, Yamaahita J, Matsui O, Yamada M. CIRCULATION 112 1 33-34 2005/07
  •  Dementia with Lewy Bodies: Diagnosis and Management: Third Report of the DLB Consortium. Mckeith IG; Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, MD; Perry EK, Aarsland D, Arai H, Ballard C, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, MD; Lee VM-Y, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M. NEUROLOGY 65 12 1863-1872 2005/12
  •  Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. Ono K, Yamada M. JOURNAL OF NEUROCHEMISTRY 97 1 105-115 2006/04
  •  The MM2-cortical form of sporadic Creutzfeldt-Jakob disease presenting with visual disturbance. Nozaki I, Hamaguchi T, Noguchi-Shinohara M, Ono K, Shirasaki H, Komai K, Kitamoto T, Yamada M. NEUROLOGY 67 3 531-533 2006/08
  •  Neuronal atrophy and synaptic alteration in a model mouse of dentatorubral-pallidoluysian atrophy. Sakai K, Yamada M, Sato T, Yamada M, Tsuji S, Takahashi H. BRAIN 129 9 2353-2362 2006/09
  •  Ophthalmic surgery in prion diseases. Hamaguchi T, Noguchi-Shinohara M, Nakamura Y, Sato T, Kitamoto T, Mizusawa T, Yamada M. EMERGING INFECTIOUS DISEASES 13 1 162-164 2007/01
  •  Primary spinal intramedullary lymphoma mimicking ependymoma. Machiya T, Yoshita M, Iwasa K, Yamada M. NEUROLOGY 68 11 871 2007/03
  •  A successfully treated adult patient with L-2-hydoxyglutaric aciduria. Samuraki M, Komai K, Hasegawa Y, Kimura M, Yamaguchi S, Terada N, Yamada M. NEUROLOGY 70 13 1051-1052 2008/03
  •  Acute encephalitis caused by in intrafamilial transmission of enterovirus 71 in adult. Hamaguchi T, Fuisawa H, Sakai K, Okino S, Kurosaki N, Nishimura Y, Simizu H, Yamada M. EMERGING INFECTIOUS DISEASES 14 5 828-830 2008/05
  •  CSF/serum igG index is correlated correlated with medial temporal lobe atrophy in Alzheimer7s disease. Matsumoto Y, Yanase D, Noguchi-Shinohara M, Ono K, Yoshita M, Yamada M. Dementia Geriatr Cogn Disord 25 2 144-147 2008/02
  •  Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro. Hirohata M, Ono K, Morinaga A, Yamada M. NEUROPHARMACOLOGY 54 3 620-627 2008/03
  •  Clinical efficacy and cytokine network-modulating effects of tacrolimus in myasthenia gravis. Furukawa Y, Yoshikawa H, Iwasa K, Yamada M. JOURNAL OF NEUROIMMUNOLOGY 195 1-2 108-115 2008/03
  •  Effect of sample size for normal database on diagnostic performance of brain FDG PET for detection of Alzheimer's disease using automated image analysis. Chen W, Samuraki M, Yanase D, Shima K, Takeda N, Ono K, Yoshita M, Nishimura S, Yamada M, Matsunari I. NUCLEAR MEDICINE COMMUNICATIONS 29 3 270-276 2008/03
  •  Peripheral and multiple cranial neuropathies in a 74-year-old woman. Shibata-Hamaguchi A, Ishida C, Yamada M. NEUROPATHOLOGY 28 4 448-451 2008/08
  •  Epidemiology of familial amyloid polyneuropathy in Japan: Identification of a novel endemic focus. Kato-Motozaki Y, Ono K, Shima K, Morinaga A, Machiya T, Nozaki I, Shibata-Hamaguchi A, Furukawa Y, Yanase D, Ishida C, Sakajiri K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 270 1-2 133-140 2008/07
  •  A linear lesion along the brachial plexus on FDG-PET in neurolymphomatosis. Shima K, Ishida C, Okino S, Kotani T, Higashi K, Yamada M. INTERNAL MEDICINE 47 12 1159-1160 2008/12
  •  Basiparallel anatomic scanning-magnetic resonance imaging in vertebral artery dissection. Hamaguchi T, Yamada M. ARCHIVES OF NEUROLOGY 66 2 276-277 2009/02
  •  Medical procedures and risk of sporadic Creutzlfedt-Jakob disease, Japan, 1999-2008. Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M. EMERGING INFECTIOUS DISEASES 15 2 265-271 2009/02
  •  A neuropathological study of autosomal dominant chorea-acanthocytosis with a mutation of VPS13A. Ishida C, Makifuchi T, Saiki S, Hirose G, Yamada M. ACTA NEUROPATHOLOGICA 117 1 85-84 2009/01
  •  A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation. Ikeda Y, Abe K, Ishida C, Takahashi K, Hayasaka K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 277 1-2 9-12 2009/02
  •  Dura mater graft-associated Creutzfeldt-Jakob disease in Japan: Clinicopathological and molecular characterization of the two distinct subtypes. Yamada M, Noguchi-Shinohara M, Hamaguchi T, Nozaki I, Kitamoto T, Sato T, Nakamura Y, Mizusawa H. NEUROPATHOLOGY 29 5 609-618 2009/10
  •  Prevalence of spinocerebellar degenerations in the Hokuriku district, Japan. Shibata-Hamaguchi A, Ishida C, Iwasa K, Yamada M. Neuroepidemiology 32 3 176-183 2009/03
  •  CSF a-synuclein levels in dementia with Lewy bodies and Alzheimer's disease. Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, El-Agnaf OMA, Yamada M. BRAIN RESEARCH 1251 1-6 2009/01
  •  A case of adult onset type II citrullinemia with portal-systemic shunt. Noto D, Takahashi K, Hamaguchi T, Inamura K, Nobata K, Yazaki M, Ikeda S, Kobayashi K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 281 1-2 127-129 2009/01
  •  Polyethylene glycol interferon alfha-2b-induced immune-mediated polyradiculoneuropathy. Kato-Motozaki Y, Komai K, Takahashi K, Ishida C, Ueda M, Kusunoki S, Yamada M. INTERNAL MEDICINE 48 7 569-572 2009/07
  •  Reply: Chorea-acanthocytosis with an autosomal-dominant trait. Ishida C, Saiki S, Yamada M. ACTA NEUROPATHOLOGICA 117 1:97 98 2009/01
  •  The risk of iatrogenic Creutzfeldt-Jakob disease through medical and surgical procedures. Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Nakamura Y, Sato T, Kitamoto T, Mizusawa H, Yamada M. NEUROPATHOLOGY 29 625-631 2009/10
  •  Anti-aggregation and fibril-destabilizing effects of sex hormones on alpha-synuclein fibrils in vitro. Hirohata M, Ono K, Morinaga T, Ikeda T, Yamada M. EXPERIMENTAL NEUROLOGY 217 2 434-439 2009/06
  •  Geographic difference of mortality of Creutzfeldt-Jakob disease in Japan. Nakamura Y, Watanabe M, Nagoshi K, Yamada M, Mizusawa H. Journal of epidemiology 17 19-24 2007/01
  •  Vitamin A potently destablizes preformed alpha-synuclein fibrils in in vitro: implications for Lewy body diseases. Ono K, Yamada M. NEUROBIOLOGY OF DISEASE 25 2 446-454 2007/02
  •  Anti-amyloidogenic effect again Alzheimer's beta-amyloid fibrils in vitro is exerted by preferential and reversible binding of flavonoids to the amyloid fibril structure. Hirohata M, Hasegawa K, Tsutsumi-Yasuhara S, Ohhashi Y, Ookoshi T, Ono K, Yamada M, Naiki H. BIOCHEMISTRY 46 7 1888-1899 2007/02
  •  Blood-brain barrier permeability correlates with medial temporal loge atrophy, but not with amyloid-beta protain transport across the blood-brain barrier in Alzheimer's disease. Matsumoto Y, Yanase D, Noguchi-Shinohara M, Ono K, Yoshita M, Yamada M. Dement Geriatr Cogn Disord. 23 4 241-245 2007/04
  •  Anti-fibrillogenic and fibril-destabilizing activities of anti-Parkinsonian agents for alpha-synuclein fibrils in vitro. Ono K, Hirohata M, Yamada M. JOURNAL OF NEUROSCIENCE RESEARCH 85 7 1547-1557 2007/05
  •  Microscopic polyangitis presenting with temporal arteritis and multiple cranial neuropathies. Morinaga A, Ono K, Komai K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 256 1-2 81-83 2007/05
  •  Myasthenia gravis presenting with unusual neurogenic muscle atrophy. Samuraki M, Furui E, Komai K, Takamori M, Yamada M. MUSCLE & NERVE 36 3 394-399 2007/09
  •  Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution. Shiga Y, Satoh K, Kitamoto T, Kanno S, Nakashima I, Sato S, Fujihara K, Tkata H, Nobukuni K, Kuroda S, Takano H, Umeda Y, Konno H, Nagasato K, Satoh A, Matsuda Y, Hidaka M, Takahashi H, Sano Y, Kim K, Konishi T, Doh-ura K, Sato T, Sasaki K, Nakamura Y, Yamada M, Mizusawa H, Itoyama Y. JOURNAL OF NEPHROLOGY 254 11 1509-1517 2007/11
  •  Anti-fibrillogenic and fibril-destabilizing activity of nicotine in vitro: implications for the prevention and therapeutics of Lewy body diseases. Ono K, Hirohata M, Yamada M. EXPERIMENTAL NEUROLOGY 205 2 414-424 2007/06
  •  Partial Volume Effect Corrected FDG PET and Gray Matter Volume Loss in Patients with Mild Alzheimer's Disease. Samuraki M, Matsunari I, Chen WP, Yajima K, Yanase D, Fujikawa A, Takeda N, Nishimura S, Matsuda H, Yamada M. EUROPEAN JOURNAL OF NUCLEAR MEDICINE 34 10 1658-1669 2007/10
  •  Phenotypic heterogeneity in a family with FAP due to a TTR Leu58Arg mutation: a clinicopathologic study. Motozaki Y, Sugiyama Y, Ishida C, Komai K, Matsubara S, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 260 1-2 236-239 2007/09
  •  Long-term effect of intravenous immunoglobulin on anti-MuSK antibody-positive myasthenia gravis. Shibata-Hamaguchi A, Samuraki M, Furui E, Iwasa K, Yoshikawa H, Hayashi S, Yamada. M. ACTA NEUROLOGICA SCANDINAVICA 116 6 406-408 2007/12
  •  Donepezi-induced chorea in Alzheimer's disease. Nozaki I, Inao G, Yamada M. JOURNAL OF NEUROLOGY 254 12 1752-1753 2007/12
  •  B-cell neurolymphomatosis confined to the peripheral nervous system. Shibata-Hamaguchi A, Samuraki M, Furui E, Ishida C, Kitagawa S, Nakao S, Minato H, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 260 1-2 249-252 2007/09
  •  Estrogen has anti-amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro. Morinaga A, Hirohata M, Ono K, Yamada M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 359 3 697-702 2007/08
  •  Hereditary inclusion body myopathy with a novel mutation in the GNE gene associated with proximal leg weakness and necrotizing myopathy. Motozaki Y, Komai K, Hirohata M, Asaka T, Ono K, Yamada M. EUROPEAN JOURNAL OF NEUROLOGY 14 9 14-15 2007/09
  •  Comparison of 18F-FDG PET and optimized voxel-based morphometry for detection of Alzheimer's disease: aging effect on diagnostic performance. Nozaki I, Watanabe T, Kawaguchi M, Akatasu H, Tsuneyama K, Yamamoto Y, Ohe K, Yonekura H, Yamada M, Yamamoto H. JOURNAL OF NUCLEAR MEDICINE 48 12 1961-1970 2007/12
  •  Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains. Nozaki I, Watanabe T, Kawaguchi M, Akatasu H, Tsuneyama K, Yamamoto Y, Ohe K, Yonekura H, Yamada M, Yamamoto H. ARCHIVES OF HISTOLOGY AND CYTOLOGY 70 5 279-290 2007/12
  •  Immunoglobulin light-chain (AL) amyloidosis with myasthenic symptoms and echocardiographic features of dilated cardiomyopathy. Yoshita M, Ishida C, Yanase D, Yamada M. INTERNAL MEDICINE 45 3 159-162 2006/03
  •  Anti-parkinson agents have anti-amyloidogenic activity for Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. NEUROCHEMISTRY INTERNATIONAL 48 4 276-285 2006/03
  •  Neuromyelitis optica associated with myasthenia gravis: characteristic phenotype in Japanese population. Furukawa Y, Yoshikawa H, Yachie A, Yamada M. EUROPEAN JOURNAL OF NEUROLOGY 13 6 655-658 2006/06
  •  Acute autonomic sensory and motor neuropathy associated with central nervous system disturbance. Sakai K, Matsumoto Y, Nozaki I, Yamada M. JOURNAL OF CLINICAL NEUROSCIENCE 14 3 275-278 2007/03
  •  Alpha-lipoic acid exhibits anti-amyloidogenecity for beta-amyloid fibrils in vitro. Ono K, Hirohata M, Yamada M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 341 4 1046-1052 2006/03
  •  Allodynia in the flank after thalamic stroke. Yoshita M, Yamada M. JOURNAL OF CLUSTER SCIENCE 13 2 288-291 2006/02
  •  Voglibose inhibits postprandial hypotension in neurological disorders and elderly people. Maruta T, Komai K, Takamori M, Yamada M. NEUROLOGY 66 9 1432-1434 2006/05
  •  Fulminant Devic disease successfully treated by lymphocytapheresis. Nozaki I, Hamaguchi T, Komai K, Yamada M. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 77 9 1094-1095 2006/09
  •  Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma. Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, Watanabe H, Takaoka S, Suzuki Y, Takamori M, Yamada M. JOURNAL OF NEUROIMMUNOLOGY 178 1-2 169-175 2006/06
  •  CADASIL with a novel mutation in exon 7 of Notch3 gene (C388Y). Ishida C, Sakajiri K, Yoshita M, Joutel A, Riant F, Yamada M. INTERNAL MEDICINE 45 16 981-985 2006/08
  •  Blood-borne factors inhibit Alzheimer's beta-amyloid fibril formation in vitro. Exp Neurol Ono K, Noguchi-Shinohara M, Samuraki M, Matsumoto Y, Yanase D, Iwasa K, Naiki H, Yamada M. EXPERIMENTAL NEUROLOGY 202 1 125-132 2006/11
  •  Autopsy case of sporadic Creutzfeldt-Jakob disease presenting with signs suggestive of brainstem and spinal cord involvement. . Iwasaki Y, Iijima M, Kimura S, Yoshida M, Hashizume Y, Yamada M, NEUROPATHOLOGY 26 6 550-556 2006/12
  •  Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji,M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Nunomura A, Chiba S, Takahashi S, Tomita N, Ito J, Hanyu H, Kimura H, Kitamura S, Shinotoh H, Iwamoto H, Takahashi, M., Harigaya Y, Ikeda M, Amari M, Takahashi T, Nakano R, Nishizawa M, Suga M, Hasegawa M, Kawase Y, Honda K, Kumanishi T, Takeuchi Y, Ishikawa A, Morita M, Yoshii F, Akatsu H, Kosaka K, Yamada M, Hamaguchi T, Masuzugawa S, Matsubara E, Kawarabayashi T, Takao T, Ota N, Sasaki K, Fujisawa Y, Nakata K, Wakutani Y, Nakashima K, Hayabara T, Ooya T, Takahashi M, Yamada T, Miyakawa T, Uyama E, Yuzuriha T, Nakagawa R, Yoshimoto S, Serikawa K. HUMAN MOLECULAR GENETICS 15 13 2170-2182 2006/07
  •  Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques. Reply. Ishida C, Kitamoto T, Yamada M. NEUROLOGY 62 7 1239 2004/04
  •  Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. JOURNAL OF NEUROSCIENCE RESEARCH 75 6 742-750 2004/03
  •  Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1690 3]193-202 2004/11
  •  Vitamin A exhibits potent anti-amyloidogenic and fibril-destabilizing effects in vitro. Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. EXPERIMENTAL NEUROLOGY 189 2 380-392 2004/10
  •  Comparative study of pre-operative thymic imaging and pathology in patients with myasthenia gravis. Yasukawa Y, Yoshikawa H, Iwasa K, Yamada M, Takamori M. JOURNAL OF CLINICAL NEUROSCIENCE 11 6 610-613 2004/08
  •  Cytosolic Ca2+ alteration mediates both ryanodine receptor and IP3 receptor in TE671/RD cells. Edahiro S, Yoshikawa H, Iwasa K, Hashii M, Yamada M. BIOMEDICAL RESEARCH-TOKYO 25 6 255-261 2004/12
  •  Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts - Japan, 1979-2003. Nakamura Y, Watanabe M, Nagoshi K, Kitamoto T, Sato T, Yamada M, Mizusawa H, Maddox R, Sejvar J, Belay E, Schonberger LB. The journal of the American Medical Association 291 295-296 2004/01
  •  Plasma VEGF as a marker for the diagnosis and treatment of vasculitic neuropathy. Sakai K , Komai K, Yanase D, Yamada M. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 76 2 296 2005/02
  •  Involvement of the peripheral nervous system in human prion diseases including dural graft-associated Creutzfeldt-Jakob disease. Ishida C, Okino S, Kitamoto T, Yamada M. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 76 3 325-329 2005/03
  •  Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy. Hamaguchi T, Okino S, Sodeyama N, Itoh Y, Takahashi A, Otomo E, Matsushita M, Mizusawa H, Yamada M. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 76 5 696-699 2005/05
  •  Brain FDG PET study of normal aging in Japanese: effect of atrophy correction. Yanase D, Matsunari I, Yajima K, Chen W, Fujikawa A, Nishimura S, Matsuda H, Yamada M. EUROPEAN JOURNAL OF NUCLEAR MEDICINE 327 794-805 2005/07
  •  MRI of adult-onset type II citrullinemia. Sakai K, Matsumoto Y, Kobayashi K, Yamada M. INTERNAL MEDICINE 44 5 524-525 2005/05
  •  Peripheral neuropahty associated with chronic natural killer cell lymphocytosis. Noguchi M, Yoshita M, Sakai K, Matsumoto Y, Arahata M, Ontachi Y, Takami A, Nakao S, Sato K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 232 1-2 119-122 2005/05
  •  Reversible cortical lesions in primary Sjogren's syndrome presenting with meningoencephalitis as an initial manifestation. Hirohata M, Yasukawa Y, Ishida C, Komai K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 231 1-2 111-113 2005/05
  •  Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro. Ono K, Hasegawa K, Naiki H, Yamada M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 330 1 111-116 2005/04
  •  Embolic stroke with a patent foramen ovale and Behcet's disease. Ishida C, Furui E, Sakashita Y, Yamada M. INTERNAL MEDICINE 44 4 326-327 2005/04
  •  Transient occlusion of the middle cerebral artery by macroembolism during carotid stenting for traumatic dissection of the common carotid artery. Furui E, Okamoto Y, Kida S, Yamaahita J, Matsui O, Yamada M. CIRCULATION 112 2 e33-34 2005/07
  •  Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro. Ono K, Noguchi M, Matsumoto Y, Yanase D, Iwasa K, Naiki H, Yamada M. NEUROBIOLOGY OF DISEASE 20 2 233-240 2005/11
  •  Somatosensory-evoked cortical potential during attacks of paroxysmal dysesthesia in multiple sclerosis. Toru S, Yokota T, Tomimitsu H, Kanouchi T, Yamada M, Mizusawa H. EUROPEAN JOURNAL OF NEUROLOGY 12 3 233-234 2005/03
  •  A Rapid Scanning Protocol for Brain FDG PET: A Validation Study. Chen W, Matsunari I, Noda A, Yanase D, Yajima K, Yamada M, Minoshima S, Nishimura S. JOURNAL OF NUCLEAR MEDICINE 46 10 1633-1641 2005/10
  •  Decreased beta-amyloid peptiede42 in cerebrospinal fluiid of patients with progressive supranuclear palsy and corticobasal degeneration. Noguchi M, Yoshita M, Matsumoto Y, Ono K, Iwasa K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 237 1-2 61-65 2005/10
  •  Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Hirohata M, Ono K, Naiki H, Yamada M. NEUROPHARMACOLOGY 49 7 1088-1099 2005/12
  •  Contiguous and symmetrical disease expansion and massive necrosis of the cerebral white matter in a patient with neuromyelitis optica. Ishida C, Ikeda T, Komai K, Takahashi K, Noguchi-Shinohara M, Yamada M. Mult Scler J  24 9 1258-1261 2018/08
  •  Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Ono K, Hirohata M, Yamada M. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 336 2 444-449 2005/10
  •  Update: Creutzfeldt-Jakob disease associated with cadaveric dura mater grafts-Japan, 1979-2008. Nakamura Y, Uehara R, Watanabe M, Sadakane A, Yamada M, Mizusawa H, Maddox R, Sejvar J, Belay E, Schonberger L. MMWR 57 42 1152-1154 2008/10
  •  Update: dura mater graft-associated creutzfeldt-jakob disease - Japan, 1975-2017. Ae R, Hamaguchi T, Nakamura Y, Yamada M, Tsukamoto T, Mizusawa H, Belay ED, Schonberger LB. MMWR Morb Mortal Wkly Rep 67 9 274-278 2018/03/09
  •  Recommendations for the diagnosis and management of dementia with Lewy bodies. Fourth report of the DLB consortium.  McKeith I, Boeve B, Dickson D, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard C, Bayston A, Beach T, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda J, El-Agnaf O, Feldman H, Ferman T, Ffytche D, Fujishiro H, Galasko D, Graff-Radford N, Goldman J, Gomperts S, Honing L, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee V, Leverenz J, Lippa C, Lewis S, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine T, Moreno E, Mori E, Murray M, O'Brien J, Orimo S, MD; Postuma R, Ramaswamy S, Ross O, Salmon D, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo J, Trojanowski J, Tsuang D, Walker Z, Yamada M, Kosaka K.  Neurology 89 1 88-100 2017/07/04
  •  Multisite assessment of aging-related tau astrogliopathy (ARTAG). Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ. J Neuropathol Exp Neurol 76 7 605-619 2017/07/01
  •  Pathological progression of genetic Creutzfeldt-Jakob disease with a PrP V180I mutation. Akagi A, Iwasaki Y, Mimuro M, Kitamoto T, Yamada M, Yoshida M. Prion 21 54-62 2018/01/02
  •  Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Atarashi R,Satoh K,Sano K,Fuse T,Yamaguchi N,Ishibashi D,Matsubara T,Nakagaki T,Yamanaka H,Shirabe S,Yamada M,Mizusawa H,Kitamoto T,Klug G,McGlade A,Collins SJ,Nishida N Nat Med 17 2 175-8
  •  Up-regulation of MHC class I and class II in the skeletal muscles of myasthenia gravis. Iwasa K,Kato-Motozaki Y,Furukawa Y,Maruta T,Ishida C,Yoshikawa H,Yamada M J Neuroimmunol 225 1-2 171-4
  •  Charcot-Marie-Tooth disease type 2D with a novel glycyl-tRNA synthetase gene (GARS) mutation. Hamaguchi A,Ishida C,Iwasa K,Abe A,Yamada M J Neurol 257 7 1202-4
  •  Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation. Hirohata M,Ono K,Morinaga A,Ikeda T,Yamada M Neurosci Lett 491 1 48-52
  •  Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers. Morinaga A,Hasegawa K,Nomura R,Ookoshi T,Ozawa D,Goto Y,Yamada M,Naiki H Biochim Biophys Acta 1804 4 986-95
  •  Cervical pachymeningeal hypertrophy as the initial and cardinal manifestation of mucopolysaccharidosis type I in monozygotic twins with a novel mutation in the alpha-L-iduronidase gene. Furukawa Y,Hamaguchi A,Nozaki I,Iizuka T,Sasagawa T,Shima Y,Demura S,Murakami H,Kawahara N,Okuyama T,Iwasa K,Yamada M J Neurol Sci 302 1-2 121-5
  •  Neuromyelitis optica after Japanese encephalitis vaccination. Furukawa Y,Komai K,Yamada M Eur J Neurol 18 2 e26-7
  •  Prospective 10-year surveillance of human prion diseases in Japan. Nozaki I,Hamaguchi T,Sanjo N,Noguchi-Shinohara M,Sakai K,Nakamura Y,Sato T,Kitamoto T,Mizusawa H,Moriwaka F,Shiga Y,Kuroiwa Y,Nishizawa M,Kuzuhara S,Inuzuka T,Takeda M,Kuroda S,Abe K,Murai H,Murayama S,Tateishi J,Takumi I,Shirabe S,Harada M,Sadakane A,Yamada M BRAIN 133 10 3043-57
  •  Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly. Itoh Y, Yamada M, Suematsu N, Matsushita M, Otomo E. 27 2 216-218 1996/02
  •  Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. Hirohata M,Ono K,Yamada M Curr Pharm Des 14 30 3280-94
  •  Prion diseases in Japan : analysis of 918 patients YAMADA Masahito Clinical neurology. 47 11 805-808 2007/11
  •  Evaluation of MMN evoked by missing oddball task in patients with early Alzheimer disease : A MEG study Technical report of IEICE. HIP 107 369 141-145 2007/11
  •  Neurobiology of Brain Aging and Dementia YAMADA Masahito The Journal of the Japanese Orthopaedic Association 81 10 872-876 2007/10
  •  Genetic factors for cerebral amyloid angiopathy Brain and nerve 60 11 1275-1283 2008/11
  •  Epidemiology and surveillance system of prion disease in Japan Japanese journal of clinical medicine 65 8 1379-1383 2007/08
  •  Imaging for brain and heart in dementia with Lewy bodies 49 7 699-705 2007/07
  •  Carotid duplex ultrasonography during head-up tilt in patients with orthostatic hypotension. EUROPEAN NEUROLOGY 57 4 219-222 2007/04
  •  Creutzfeldt-Jakob disease Japanese journal of clinical medicine 65 0 295-298 2007/03
  •  Amyloidosis 57 0 1238-1241 2008/04
  •   Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances α-synuclein fibril formation in vitro. Ono K, Noguchi-Shinohara M, Yoshita M, Naiki H, Yamada M. EXPERIMENTAL NEUROLOGY 203 2 579-583 2007/02
  •  Prion diseases Japanese journal of molecular psychiatry 7 4 396-398 2007/10
  •  Disease Prevention in our Society Composed Largely of Elderly People : From the University to the Community Yamada Masahito Journal of the Juzen Medical Society 115 3 2006/12
  •  Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-2008 Emerg Infect Dis 15 2 265-271 2009/02
  •  Anti-amyloidogenic/protein-misfolding therapies in amyloidosis and other protein-misfolding disorders. CURRENT PHARMACEUTICAL DESIGN 14 30 3203-3204 2008/10
  •  Two cases of superficial hemosiderosis 51 4 615-616 2008/07
  •  Autoantibody to dihydropyridine receptor in myasthenia gravis JOURNAL OF NEUROIMMUNOLOGY 208 1 125-129 2009/03
  •  Molecular epidemiology of familial amyloid polyneuropathy 229 5 357-362 2009/05
  •  CSF tau protein is a useful marker for effective treatment of superficial siderosis of the central nervous system: Two case reports CLINICAL NEUROLOGY AND NEUROSURGERY 112 1 62-64 2010/01
  •  A Search for Antiamyloidogenic Compounds Based on a Nucleation-Dependent Polymerization Model YAKUGAKU ZASSHI 130 4 503-509 2010
  •  The first Japanese patient with variant Creutzfeldt-Jakob disease (vCJD).  Shinde A, Kunieda T, Kinoshita Y, Wate R, Nakano S, Ito H, Yamada M, Kitamoto T, Nakamura Y, Matsumoto S, Kusaka H. NEUROPATHOLOGY 29 6 713-719 2009/12
  •  Phenolic compounds prevent Alzheimer’s pathology through different effects on the amyloid β aggregation pathway. Am J Pathol  Hamaguchi T, Ono K, Murase A, Yamada M.  AMERICAN JOURNAL OF PATHOLOGY 175 6 2557-2565 2009/12
  •  Prion disease surveillance in Japan : analysis of 1,241 patients Clinical neurology. 49 11 939-942 2009/11
  •  Over view 49 11 2009/11
  •  Cerebral amyloid angiopathy 231 5 445-451 2009/10
  •  Hereditary rimmed vacuole myopathy showing interstitial amyloid deposition in muscle tissue.  Kojima Y, Sakai K, Ishida C, Asaka T, Hamaguchi T, Nozaki I, Fukushima K, Tsuchiya A, Kametani F, Yazaki M, Okino S, Yamada M. MUSCLE & NERVE 40 3 472-475 2009/09
  •  A novel presenilin 1 mutation (L282F) in familial Alzheimer’s disease.  JOURNAL OF NEUROLOGY 256 9 1575-1577 2009/09
  •  Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy.  Hirohata M, Yoshita M, Ishida C, Ikeda S-I, Tamaoka A, Kuzuhara S, Shoji M, Ando Y, Tokuda T, Yamada M.  EUROPEAN JOURNAL OF NEUROLOGY 17 6 823-829 2010/06
  •   Idiopathic sphenoidal defects detected by 3D-computed tomography.  Hamaguchi A, Takahashi R, Iwasa K, Yamada M. NEUROLOGY 73 2 157-158 2009/07
  •  Polyneuropathy caused by cobalt-chromium metallosis after total hip replacement Muscle and Nerve 42 10 140-143 2010/07
  •  Value of 123I-MIBG radioactivity in the differential diagnosis of DLB Psychiatry 14 5 373-379 2009/05
  •  Epidemiology and clinical characteristics of cerebral amyloid angiopathy 229 5 409-414 2009/05
  •  In vitro differentiation of lineage-negative bone marrow cells into microglia-like cells EUROPEAN JOURNAL OF NEUROSCIENCE 31 7 1155-1163 2010/04
  •   New therapeutic strategy for amyloidosis. Morinaga A, Ono K, Yamada M. FUTURE NEUROLOGY 4 3 287-289 2009/05
  •  Acute disseminated encephalomyelitis with medial temporal lesions mimicking acute limbic encephalitis Sakai K,Yoshita M,Samuraki M,Yamada M CLINICAL NEUROLOGY AND NEUROSURGERY 113 1 72-74 2011/01
  •  Cerebrospinal fluid from patients with multiple system atrophy promotes in vitro α-synuclein fibril formation Hirohata M, Ono K, Morinaga A, Ikeda T, Yamada M. NEUROSCIENCE LETTERS 491 1 48-52 2011/03
  •  Fisher Syndrome Associated with Immune Thrombocytopenic Purpura Furukawa Y,Iwasa K,Ono Ko,Yamada M INTERNAL MEDICINE 50 6 631-633 2011/03
  •  Low-n oligomers as therapeutic targets of Alzheimer's disease Ono K, Yamada M. JOURNAL OF NEUROCHEMISTRY 117 1 19-28 2011/04
  •  Cervical flexion myelopathy in a patient showing apparent long tract signs: A severe form of Hirayama disease JOINT BONE SPINE 78 3 316-318 2011/05
  •  Prion disease surveillance in Japan 66 5 1032-1038 2011/05
  •  Duration of Prion Disease is Longer in Japan Than in Other Countries Journal of Epidemiology 21 4 255-262 2011/07
  •  Multiple Skull Metastases from Hepatocellular Carcinoma Successfully Treated with Radiotherapy INTERNAL MEDICINE 49 23 2631-2634 2010/12
  •  Risk factors for Alzheimer disease Brain and nerve 62 7 679-690 2010/07
  •  Curcumin and Alzheimer’s disease.  Hamaguchi T, Ono K, Yamada M.  CNS neuroscience & therapeutics. 16 5 285-297 2010/10
  •  Familial Parkinson disease mutations influence α-synuclein assembly Ono K, Ikeda T, Takasaki J, Yamada M. NEUROBIOLOGY OF DISEASE 43 3 715-724 2011/09
  •  Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N. NATURE MEDICINE 17 2 175-178 2011/02
  •  Effects of sex hormones on Alzheimer's disease-associated β-amyloid oligomer formation in vitro Morinaga A, Ono K, Takasaki J, Ikeda T, Hirohata M, Yamada M. EXPERIMENTAL NEUROLOGY 228 2 298-302 2011/04
  •  Cervical pachymeningeal hypertrophy as the initial and cardinal manifestation of mucopolysaccharidosis type I in monozygotic twins with a novel mutation in the alpha-L-iduronidase gene. Furukawa Y, Hamaguchi A, Nozaki I, Iizuka T, Sasagawa T, Shima Y, Demura S, Murakami H, Kawahara N, Okuyama T, Iwasa K, Yamada M. JOURNAL OF THE NEUROLOGICAL SCIENCES 302 1-2 121-125 2011/03
  •  Neuromyelitis optica after Japanese encephalitis vaccination Furukawa Y, Komai K, Yamada M. l 18 2 e26-e27 2011/02
  •  Familial ALS with G298S Mutation in TARDBP: A Comparison of CSF Tau Protein Levels with those in Sporadic ALS INTERNAL MEDICINE 49 12 1209-1212 2010/06
  •  Progression of Cerebrovascular Lesions in Pneumococcal Meningitis INTERNAL MEDICINE 49 12 1261-1262 2010/06
  •  Reply to the Letter by Rizzetti MC, et al. Cobalt toxiciety after total hip replacement: a neglected adverse effect.  Ikeda T, Takahashi K, Kabata T, Sakagoshi D, Tomita K, Yamada M.  MUSCLE & NERVE 43 1 147 2011/01
  •  Early-stage progressive supranuclear palsy with degenerative lesions confined to the subthalamic nucleus and substantia nigra. Sakai K, Yamada M.  NEUROPATHOLOGY 37 1 77-81 2011/02
  •  The efficacy of radiation monotherapy for Tolosa-Hunt syndrome JOURNAL OF NEUROLOGY 257 2 288-290 2010/02
  •  Alternative BSE risk assessment methodology for beef and beef offal imported into Japan Yoshikawa Y, Horiuchi M, Ishiguro N, Kadohira M, Kai S, Mizusawa H, Nagata C, Onodera T, Sata T, Tsutsui T, Yamada M, Yamamoto S. The Journal of veterinary medical science 74 8 959-968 2012/08
  •  Vitamin A and Alzheimer's disease Ono K, Yamada M. Geriatrics & gerontology international 12 2 180-188 2012/04
  •  Predicting cerebral amyloid angiopathy-related intracerebral hemorrhages and other cerebrovascular disorders in Alzheimer's disease Yamada M. Frontiers in neurology 3 64 1-8 2012/05
  •  Cross-seeding effects of amyloid β-protein and α-synuclein. Ono K, Takahashi R, Ikeda T, Yamada M. JOURNAL OF NEUROCHEMISTRY 122 5 883-890 2012/09
  •  Multiple cerebral infarcts with a few vasculitic lesions in the chronic stage of cerebral amyloid angiopathy-related inflammation Sakai K, Hayashi S, Sanpei K, Yamada M, Takahashi H. NEUROPATHOLOGY 32 5 551-556 2012/10
  •  Parkinson's disease showing progressive conduction aphasia Sakai K, Ono K, Harada H, Shima K, Notoya M, Yamada M. NEUROLOGICAL SCIENCES 33 2 399-402 2012/04
  •  An easy diagnostic tool distinguishing lateral medullary infarction from peripheral vertigo Nozaki I, Yamada M. CLINICAL NEUROLOGY AND NEUROSURGERY 114 1 68-69 2012/01
  •  Vitamin A has anti-oligomerization effects on amyloid-β in vitro Takasaki J, Ono K, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M. Journal of Alzheimer's disease 27 2 271-280 2011/10
  •  Anti-amyloidogenic effects of soybean isoflavones in vitro: fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils Hirohata M, Ono K, Takasaki J, Takahashi R, Ikeda T, Morinaga A, Yamada M. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1822 8 1316-1324 2012/08
  •  Coenzyme Q10 therapy in hereditary motor sensory neuropathy type VI with novel mitofusin 2 mutation Takahashi R, Ikeda T, Hamaguchi A, Iwasa K, Yamada M. Internal medicine 51 7 791-793 2012/07
  •  Effects of intravenous immunoglobulin therapy in Japanese patients with polymyositis and dermatomyositis resistant to corticosteroids: a randomized double-blind placebo-controlled trial Miyasaka N, Hara M, Koike T, Saito E, Yamada M, Tanaka Y. Modern rheumatology 22 3 382-393 2012/06
  •  Health professions and risk of sporadic Creutzfeldt-Jakob disease, 1965 to 2010 Alcalde-Cabero E, Almazan-Isla J, Brandel JP, Breithaupt M, Catarino J, Collins S, Hayback J, Hoftberger R, Kahana E, Kovacs GG, Ladogana A, Mitrova E, Molesworth A, Nakamura Y, Pocchiari M, Popovic M, Ruiz-Tovar M, Taratuto A, van Duijn C, Yamada M, Will RG, Zerr I, de Pedro Cuesta J. Euro surveillance 17 15 pii:20144 2012/04
  •  Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M. JOURNAL OF BIOLOGICAL CHEMISTRY 287 18 14631-14643 2012/04
  •  An autopsy case of an aged patient with spinocerebellar ataxia type 2 NEUROPATHOLOGY 31 5 510-518 2011/10
  •  Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study Nakajima K, Okuda K, Matsuo S, Yoshita M, Taki J, Yamada M, Kinuya S. EUROPEAN JOURNAL OF OPHTHALMOLOGY 39 1 113-119 2012/01
  •  Multicentre, multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt–Jakob disease: a reliability and agreement study Fujita K, Harada M, Sasaki M, Yuasa T, Sakai K, Hamaguchi T, Sanjo N, Shiga Y, Satoh K, Atarashi R, Shirabe S, Nagata K, Maeda T, Murayama S, Izumi Y, Kaji R, Yamada M, Mizusawa H. BMJ Open 2 1 e000649 2012/01
  •  Effect of an age-mismatched and sex-mismatched normal database on the diagnostic performance of ¹⁸F-FDG PET for Alzheimer's disease: the Ishikawa Brain Imaging Study Chen WP, Samuraki M, Shima K, Yanase D, Takeda N, Miyazaki Y, Ono K, Yoshita M, Nishimura S, Yamada M, Matsunari I. NUCLEAR MEDICINE COMMUNICATIONS 32 12 1128-1133 2011/12
  •  Reply: Prion protein gene M232R variation is probably an uncommon polymorphism rather than a pathogenic mutation Ichiro Nozaki, Kenji Sakai, Tetsuyuki Kitamoto, Masahito Yamada BRAIN 135 2 e210 2011/11
  •  Effect of cognitive and aerobic training intervention on older adults with mild or no cognitive impairment: a derivative study of the nakajima project Sugano K, Yokogawa M, Yuki S, Dohmoto C, Yoshita M, Hamaguchi T, Yanase D, Iwasa K, Komai K, Yamada M. Source  DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2 1 69-80 2012/01
  •  Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease Wang J, Zhao Z, Lin E, Zhao W, Qian X, Freire D, Bilski AE, Cheng A, Vempati P, Ho L, Ono K, Yamada M, Pasinetti GM. 8 6 e65232 2013/06
  •  Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells. Kobayashi S, Yokoyama S, Maruta T, Negami M, Muroyama A, Mitsumoto Y, Iwasa K, Yamada M, Yoshikawa H. JOURNAL OF NEUROIMMUNOLOGY 257 1-2 102-106 2013/04
  •  SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; Alzheimer Disease Genetics Consortium, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. PLoS One 8 4 e58618 2013/04
  •  Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion diseases Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H. PLoS One 8 3 e60003 2013/03
  •  Characteristics of progressive multifocal leukoencephalopathy clarified through internet-assisted laboratory surveillance in Japan. Nakamichi K, Mizusawa H, Yamada M, Kishida S, Miura Y, Shimokawa T, Takasaki T, Lim CK, Kurane I, Saijo M. BMC Neurol 12 121 2012/10
  •  Imaging findings of familial dementia with a tau R406W mutation Komatsu J, Ono K, Yanase D, Samuraki M, Shima K, Kuwano R, Matsunari I, Yamada M. ACTA NEUROLOGICA BELGICA 111 4 374-375 2011/12
  •  Posterior cingulate atrophy and metabolic decline in early stage Alzheimer's disease Shima K, Matsunari I, Samuraki M, Chen WP, Yanase D, Noguchi-Shinohara M, Takeda N, Ono K, Yoshita M, Miyazaki Y, Matsuda H, Yamada M. NEUROBIOLOGY OF AGING 33 9 2006-2017 2012/09
  •  Effect of melatonin on α-synuclein self-assembly and cytotoxicity Ono K, Mochizuki H, Ikeda T, Nihira T, Takasaki J, Teplow DB, Yamada M. NEUROBIOLOGY OF AGING 33 9 2172-2185 2012/09
  •  Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy Takahashi R, Ono K, Ikeda T, Akagi A, Noto D, Nozaki I, Sakai K, Asakura H, Iwasa K, Yamada M. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 19 3 129-132 2012/09
  •   Acquried cerebral amyloid angiopathy: an emerging conept.  Yamada M, Hamaguchi T, Sakai K. Prog Mol Biol Transl Sci 168 85-95 2019/06/18
  •  Chorea-acanthocytosis with a novel mutation in the vacuolar protein sorting 13 homolog A gene: a case report.  Tada Y, Hamaguchi T, Ikeda Y, Iwasa K, Nishida Y, Nakamura M, Sano A, Yamada M. J Neurol Sci 412 116731 2020/02/20
  •  Treatment with Rituximab in the acute phase of relapsing remitting multiple sclerosis. Shima A, Hamaguchi T, Tada Y, Yamada M. Intern Med 59 1 121-124 2020/01/01
  •  Nationwide survey on cerebral amyloid angiopathy in Japan. Sakai K, Ueda M, Fukushima W, Tamaoka A, Shoji M, Ando Y, Yamada M. Eur J Neurol 26 12 1487-1493 2019/11/04
  •  Delusions and visual hallucinations in a patient with Parkinson's disease with dementia showing pronounced Lewy body pathology in the nucleus basalis of Meynert. Sakai K, Ikeda T, Ishida C, Komai K, Yamada M. Neuropathology. 39 4 319-323 2019/08/01
  •  Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease.  Oji Y, Hatano T, Ueno SI, Funayama M, Ishikawa K, Okuzumi A, Noda S, Sato S, Satake W, Toda T, Li YP, Hino-Takai T, Kakuta S, Tsunemi T, Yoshino H, Nishioka K, Hattori T, Mizutani Y, Mutoh T, Yokochi F, Ichinose Y, Koh K, Shindo K, Takiyama Y, Hamaguchi T, Yamada M, Farrer MJ, Uchiyama Y, Akamatsu W, Wu YR, Matsuda J, Hattori N. Brain In press 2020/01
  •  Presence of a synergistic interaction between current cigarette smoking and diabetes mellitus on development of dementia in older adults.  Noguchi-Shinohara M, Hirako K, Fujiu M, Sagae M, Samuta H, Nakamura H, Yamada M. J Alzheimers Dis 71 3 833-840 2019/10/01
  •  Costs and Resource Use associated with community-dwelling patients with Alzheimer’s disease in Japan: Baseline results from the prospective observational GERAS-J Study.  Nakanishi M, Igarashi A, Ueda K, Brnabic AJM, Treuer T, Sato M, Kahle-Wrobleski K, Meguro K, Yamada M, Mimura M, Arai H. J Alzheimers Dis In press 2020/01/19
  •  The author’s reply: Cerebellar stroke-like lesions?  Muramatsu D, Yamaguchi H, Iwasa K, Yamada M. Intern Med 58 21 3207 2019/11/01
  •  Cerebellar hyperintensity lesions on diffusion-weighted MRI in MELAS.  Muramatsu D, Yamaguchi H, Iwasa K, Yamada M. Intern Med 58 12 1797-1798 2019/06/15
  •  Neuronal intranuclear inclusion disease showing blepharoptosis and positive serum anti-acetylcholine receptor antibody without myasthenia gravis. Hayashi K, Hamaguchi T, Sakai K, Nakamura K, Wakabayashi K, Shirasaki H, Yamada M. J Neurol Sci 400 119-121 2019/05/15
  •  Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.  Hamaguchi T, Komatsu J, Sakai K, Noguchi-Shinohara M, Aoki S, Ikeuchi T, Yamada M. J Neurol Sci 399 3-5 2019/04/15
  •  Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion. Hase T, Shishido S, Yamamoto S, Yamashita R, Nukima H, Taira S, Toyoda T, Abe K, Hamaguchi T, Ono K, Noguchi-Shinohara M, Yamada M, Kobayashi S. Sci Rep 9 1 8711 2019/06/18
  •  Transthyretin deposition in the eye in the era of effective therapy for hereditary ATTRV30M amyloidosis Buxbaum JN, Brannagan T 3rd, Buades-Reinés J, Cisneros E, Conceicao I, Kyriakides T, Merlini G, Obici L, Plante-Bordeneuve V, Rousseau A, Sekijima Y, Imai A, Waddington Cruz M, Yamada M. Amyloid 26 1 10-14 2019/03
  •  Age of onset in genetic prion disease and the design of preventive clinical trials.  Minikel EV, Vallabh S, Orseth M, Brandel JP, Haïk S, Laplanche JL, Zerr I, Parchi P, Capellari S, Safar J, Kenny J, Fong J, Takada L, Ponto C, Hermann P, Knipper T, Stehmann C, Kitamoto T, Ae R, Hamaguchi T, Sanjo N, Tsukamoto T, Mizusawa H, Collins S, Chiesa R, Roiter I, de Pedro-Cuesta J, Calero M, Geschwind M, Yamada M, Nakamura Y, Mead S. Neurology 93 2 e125-e134 2019/03
  •  123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multi-center three-year follow-up study.  Komatsu J, Samuraki M, Nakajima K, Arai H, Arai H, Arai T, Asada T, Fujishiro H, Hanyu H, Iizuka O, Iseki E, Kashihara K, Kosaka K, Maruno H, Mizukami K, Mizuno Y, Mori E, Nakamura H, Nakano S, Nakashima K, Nishio Y, Orimo S, Takahashi A, Taki J, Tokuda T, Urakami K, Utsumi K, Wada K, Washimi Y, Yamashina S, Yamasaki J, Yoshita M, Yamada M.  J Neurol Neurosurg Psychiatry  89 11 1167-1173 2018/11
  •  Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene.  Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T.  Prion 12 5-6 315-319 2018/11/13
  •  Programmed cell death ligand 1 expression is upregulated in the skeletal muscle of patients with myasthenia gravis.  Iwasa K, Yoshikawa H, Furukawa Y, Yamada M.  J Neuroimmunol 325 74-78 2018/12/15
  •  Transthyretin deposition in the eye in the era of effective therapy for hereditary amyloid polyneuropathy.  Buxbaum JN, Brannagan III TH, Cisneros-Barroso E, Buades J, Conceição I, Kyriakides T, Obici L, Merlini G, Planté-Bordeneuve V, Rousseau A, Sekijima Y, Waddington M, Yamada M (*The consortium for the analysis of ocular TTR deposition). Amyloid  24 1-5 2019/01
  •  Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.  Hamaguchi T, Komatsu J, Sakai K, Noguchi-Shinohara M, Aoki S, Ikeuchi T, Yamada M. J Neurol Sci 399 3-5 2019/02/01
  •  A domain responsible for spontaneous conversion of bank vole prion protein.  Kobayashi A, Matsuura Y, Takeuchi A, Yamada M, Miyoshi I, Mohri S, Kitamoto T.  Brain Pathol 29 2 155-163 2019/03

Conference Presentations

  • Possible iatrogenic transmission of cerebral amyloid antipathy and subpial Aβ deposition via cadaveric dura mater grafting. (conference:5th International CAA Conference)(2016/09/08)
  • Epidemiological and clinical features of human prion diseases in Japan: Prospective 17-year surveillance.(conference:PRION 2016)(2016/05/13)
  • From prion disease to Alzheimer's disease.(conference:PRION 2016)(2016/05/11)
  • Natural phenolic compounds as therapeutic and preventive agents for Alzheimer’s disease.(conference:Seminar in Neurosciences, UCSD)(2016/04/04)

Arts and Fieldwork

Patent

Theme to the desired joint research

○Development of diagnostic, therapeutic, and preventive methods for dementia and aging-related neurological disorders

Grant-in-Aid for Scientific Research

○「アルツハイマー型神経病理変化形成の危険因子に関する研究」(2000-2004) 
○「アミロイドーシスに関する調査研究」(2005-2007) 
○「アミロイドーシスに関する調査研究」(2008-2010) 
○「脳アミロイドアンギオパチーの生体試料収集に関する研究」(2009-2009) 
○「脳アミロイドアンギオパチー関連脳出血のリスク評価法および予防法の開発」(2008-2011) 
○「脳アミロイドアンギオパチーの分子病態および治療法開発に関する研究」(2002-2004) 
○「ヒト脳脊髄液によるアミロイドβ蛋白繊維化抑制現象の解析と臨床応用」(2004-2007) 
○「プリオン病及び遅発性ウイルス感染症に関する調査研究」(2008-2010) 
○「アルツハイマー病発症と進展の客観的評価法確立のための多施設縦断臨床研究:JーADNIコアスタディ」(2007-2009) 
○「プリオン病及び遅発性ウイルス感染症に関する調査研究」(2005-2007) 
○「アミロイドーシスの画期的診断・治療法に関する研究」(2006-2007) 
○「ICD-10分類に準拠した脳血管性痴呆の診断手順に関する研究」(2004-2005) 
○「プリオン病の画期的治療法に関する臨床研究と基礎研究」(2004-2004) 
○「プリオン病及び遅発性ウイルス感染症に関する調査研究」(2002-2005) 
○「アミロイドーシスに関する研究」(2002-2004) 
○「プリオン病のサーベイランスと感染予防に関する調査研究 」(2018-2019) 
○「プリオン病及び遅発性ウイルス感染症に関する調査研究 」(2017-2019) 
○「脳神経外科手術による続発性脳アミロイドアンギオパチー」(2019-2021) 
○「プリオン病のサーベイランスと感染予防に関する調査研究 」(2014-2015) 
○「アミロイドーシスに関する調査研究 」(2014-2016) 
○「プリオン病のサーベイランスと感染予防に関する調査研究」(2013-2013) 
○「大規模ゲノム疫学共同研究による認知症の 危険因子および防御因子の解明」(2013-2015) 
○「アミロイドーシスに関する調査研究」(2011-2013) 
○「大脳皮質基底核変性症由来iPS細胞の樹立とタウオパチーの新規治療戦略の確立」(2007-2007) 
○「アルツハイマー病発症と進展の客観的評価法確立のための多施設縦断臨床研究:J-ADNIコアスタディ」(2007-2009) 
○「J-ADNIコアスタディ:画像・バイオマーカーの解析・活用と臨床研究体制の確立」(2010-2012) 
○「プリオン病及び遅発性ウイルス感染症に関する調査研究」(2011-2013) 
○「プリオン病のサーベイランスと感染予防に関する調査研究」(2010-2012) 
○「医療行為や食品等によるアルツハイマー病の伝播あるいは発症促進に関する研究」(2010-2012) 

Classes (Bachelors)

○Neurology(BSL)(2017)
○Neurology(2017)
○Neurology(2016)
○Neurology(BSL)(2016)

Classes (Graduate Schools)

○Special Lectures of Dementia(2018)
○Special Lectures of Dementia(2018)
○Practice of Clinical Pathology of Dementia and Intractable Neurological Diseases(2018)
○Pathology and Pathogenesis(2018)
○Human Body: Diseases(2018)
○Principles of Neurology and Brain Aging(2018)
○Basics of Dementia(2018)
○Symptomatology of Dementia(2018)
○Pathology and Pathogenesis(2018)
○Practice of Epidemiology, Prevention and Care of Dementia(2018)
○Dementia Conference 4(2018)
○Symptomatology of Dementia(2018)
○Examination and Diagnosis of Dementia(2018)
○Treatment and Prevention of Dementia(2018)
○Diseases of Dementia 1(2018)
○Practice of Clinical Pathology of Dementia and Intractable neurological diseases(2018)
○Dementia Conference 1(2018)
○Dementia Conference 2(2018)
○Dementia Conference 3(2018)
○Diseases of Dementia 2(2018)
○Dementia Conference 1(2018)
○Dementia Conference 2(2018)
○Dementia Conference 3(2018)
○Dementia Conference 4(2018)
○Practice of Epidemiology, Prevention and Care of Dementia(2018)
○Principles of Neurology and Brain Aging(2018)
○Basics of Dementia(2018)
○Examination and Diagnosis of Dementia(2018)
○Treatment and Prevention of Dementia(2018)
○Care, Rehabilitation, Community Support, and Ethics for Dementia(2018)
○Diseases of Dementia 1(2018)
○Diseases of Dementia 2(2018)
○Care, Rehabilitation, Community Support, and Ethics for Dementia(2018)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top